This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in ... See more...

Aliases for TNFAIP3 Gene

Aliases for TNFAIP3 Gene

  • TNF Alpha Induced Protein 3 2 3 5
  • Tumor Necrosis Factor Alpha-Induced Protein 3 3 4
  • Putative DNA-Binding Protein A20 3 4
  • OTU Domain-Containing Protein 7C 3 4
  • Zinc Finger Protein A20 3 4
  • OTUD7C 3 4
  • Tumor Necrosis Factor, Alpha Induced Protein 3 3
  • Tumor Necrosis Factor, Alpha-Induced Protein 3 2
  • Tumor Necrosis Factor Inducible Protein A20 3
  • TNF Alpha-Induced Protein 3 4
  • EC 3.4.19.12 4
  • EC 2.3.2.- 4
  • TNFA1P2 3
  • AISBL 3
  • A20 3

External Ids for TNFAIP3 Gene

Previous GeneCards Identifiers for TNFAIP3 Gene

  • GC06P137811
  • GC06P138035
  • GC06P138123
  • GC06P138169
  • GC06P138230
  • GC06P135750
  • GC06P138188

Summaries for TNFAIP3 Gene

Entrez Gene Summary for TNFAIP3 Gene

  • This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for TNFAIP3 Gene

TNFAIP3 (TNF Alpha Induced Protein 3) is a Protein Coding gene. Diseases associated with TNFAIP3 include Autoinflammatory Syndrome, Familial, Behcet-Like and Iridocyclitis. Among its related pathways are 14-3-3 and Regulation of BAD Activity and TNF signaling (REACTOME). Gene Ontology (GO) annotations related to this gene include ligase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is OTUD7B.

UniProtKB/Swiss-Prot Summary for TNFAIP3 Gene

  • Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.

Gene Wiki entry for TNFAIP3 Gene

Additional gene information for TNFAIP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFAIP3 Gene

Genomics for TNFAIP3 Gene

GeneHancer (GH) Regulatory Elements for TNFAIP3 Gene

Promoters and enhancers for TNFAIP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J137861 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 780.2 +2.1 2106 14.1 ZNF785 ZNF24 SP1 ZBTB40 CTCF SREBF1 LCORL FOXA1 MLX RBPJ TNFAIP3 WAKMAR2 NONHSAG044958.2
GH06J137819 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 774.6 -43.2 -43199 7.4 ZNF362 RELA HLF DACH1 MNT CSDE1 MLLT1 ZNF687 CREM CREB1 TNFAIP3 WAKMAR2 lnc-TNFAIP3-1
GH06J137810 Enhancer 1.6 VISTA FANTOM5 ENCODE dbSUPER 53.8 -54.1 -54129 3.7 ZNF24 SP1 LCORL MLX RBPJ SMARCE1 POLR2A USF2 NR2F6 CREB1 lnc-PERP-11 lnc-TNFAIP3-12 TNFAIP3 WAKMAR2 HEBP2 lnc-TNFAIP3-1
GH06J137733 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 26.8 -130.0 -130033 4.7 RBPJ NR2F1 NR2F6 CREB1 MIXL1 HLF RERE ELF3 SP1 CEBPG TNFAIP3 WAKMAR2 PBOV1 lnc-TNFAIP3-14 lnc-TNFAIP3-8 LINC02539 ENSG00000230533
GH06J137704 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.3 -158.5 -158487 6.1 ZNF24 CTCF RBPJ NR2F6 ATF1 CREB1 HCFC1 MIXL1 MYC CC2D1A ENSG00000220412 LOC442263 TNFAIP3 WAKMAR2 IFNGR1 lnc-TNFAIP3-10 ENSG00000230533
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFAIP3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TNFAIP3 Gene

Genomic Locations for TNFAIP3 Gene
chr6:137,866,317-137,883,314
(GRCh38/hg38)
Size:
16,998 bases
Orientation:
Plus strand
chr6:138,188,351-138,204,449
(GRCh37/hg19)
Size:
16,099 bases
Orientation:
Plus strand

Genomic View for TNFAIP3 Gene

Genes around TNFAIP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP3 Gene

Proteins for TNFAIP3 Gene

  • Protein details for TNFAIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21580-TNAP3_HUMAN
    Recommended name:
    Tumor necrosis factor alpha-induced protein 3
    Protein Accession:
    P21580
    Secondary Accessions:
    • B2R767
    • E1P588
    • Q2HIX9
    • Q5VXQ7
    • Q9NSR6

    Protein attributes for TNFAIP3 Gene

    Size:
    790 amino acids
    Molecular mass:
    89614 Da
    Quaternary structure:
    • Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6; the interaction is inhibited by HTLV-1 protein Tax.

    Three dimensional structures from OCA and Proteopedia for TNFAIP3 Gene

neXtProt entry for TNFAIP3 Gene

Post-translational modifications for TNFAIP3 Gene

  • Proteolytically cleaved by MALT1 upon TCR stimulation; disrupts NF-kappa-B inhibitory function and results in increased IL-2 production. It is proposed that only a fraction of TNFAIP3 colocalized with TCR and CBM complex is cleaved, leaving the main TNFAIP3 pool intact.
  • Ubiquitination at Lys541, Lys621, Lys643, Lys676, and Lys722
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for TNFAIP3

No data available for DME Specific Peptides for TNFAIP3 Gene

Domains & Families for TNFAIP3 Gene

Gene Families for TNFAIP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for TNFAIP3 Gene

Suggested Antigen Peptide Sequences for TNFAIP3 Gene

GenScript: Design optimal peptide antigens:
  • Truncated tumor necrosis factor alpha-induced protein 3 (D3TTY4_HUMAN)
  • Truncated tumor necrosis factor alpha-induced protein 3 (D3TTY6_HUMAN)
  • Truncated tumor necrosis factor alpha-induced protein 3 (D3TTY8_HUMAN)
  • Truncated tumor necrosis factor alpha-induced protein 3 (D3TTY9_HUMAN)
  • Truncated tumor necrosis factor alpha-induced protein 3 (D3TTZ0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P21580

UniProtKB/Swiss-Prot:

TNAP3_HUMAN :
  • The A20-type zinc fingers mediate the ubiquitin ligase activity. The A20-type zinc finger 4 selectively recognizes 'Lys-63'-linked polyubiquitin. The A20-type zinc finger 4-7 are sufficient to bind polyubiquitin.
  • Belongs to the peptidase C64 family.
Domain:
  • The A20-type zinc fingers mediate the ubiquitin ligase activity. The A20-type zinc finger 4 selectively recognizes 'Lys-63'-linked polyubiquitin. The A20-type zinc finger 4-7 are sufficient to bind polyubiquitin.
  • The OTU domain mediates the deubiquitinase activity.
Family:
  • Belongs to the peptidase C64 family.
genes like me logo Genes that share domains with TNFAIP3: view

Function for TNFAIP3 Gene

Molecular function for TNFAIP3 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269 PubMed:14748687, ECO:0000269 PubMed:17961127, ECO:0000269 PubMed:18164316, ECO:0000269 PubMed:23827681, ECO:0000269 PubMed:27732584};.
UniProtKB/Swiss-Prot Induction:
By TNF.
GENATLAS Biochemistry:
tumor necrosis factor,alpha-induced protein 3

Enzyme Numbers (IUBMB) for TNFAIP3 Gene

Phenotypes From GWAS Catalog for TNFAIP3 Gene

Gene Ontology (GO) - Molecular Function for TNFAIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 18223652
GO:0003677 DNA binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 15258597
GO:0004843 thiol-dependent ubiquitin-specific protease activity TAS 20392859
genes like me logo Genes that share ontologies with TNFAIP3: view
genes like me logo Genes that share phenotypes with TNFAIP3: view

Human Phenotype Ontology for TNFAIP3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TNFAIP3 Gene

MGI Knock Outs for TNFAIP3:

Animal Model Products

CRISPR Products

miRNA for TNFAIP3 Gene

miRTarBase miRNAs that target TNFAIP3

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for TNFAIP3 Gene

Localization for TNFAIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP3 Gene

Cytoplasm. Nucleus. Lysosome.
A20p50: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFAIP3 gene
Compartment Confidence
nucleus 5
cytosol 5
lysosome 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TNFAIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11463333
GO:0005737 cytoplasm IBA 21873635
GO:0005764 lysosome IEA --
GO:0005829 cytosol TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TNFAIP3: view

Pathways & Interactions for TNFAIP3 Gene

genes like me logo Genes that share pathways with TNFAIP3: view

Pathways by source for TNFAIP3 Gene

6 Qiagen pathways for TNFAIP3 Gene
  • 14-3-3 and Regulation of BAD Activity
  • 14-3-3 Induced Apoptosis
  • CD40 Signaling
  • NF-KappaB (p50-p65) Pathway
  • TNFR1 Pathway
2 Cell Signaling Technology pathways for TNFAIP3 Gene

SIGNOR curated interactions for TNFAIP3 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for TNFAIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001922 B-1 B cell homeostasis ISS --
GO:0002237 response to molecule of bacterial origin IEA,IDA 19912257
GO:0002634 regulation of germinal center formation ISS,IEA --
GO:0002677 negative regulation of chronic inflammatory response IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TNFAIP3: view

Drugs & Compounds for TNFAIP3 Gene

(7) Drugs for TNFAIP3 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1757
Ustekinumab Approved, Investigational Pharma 123
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0

(4) Additional Compounds for TNFAIP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFAIP3: view

Transcripts for TNFAIP3 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ·
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - - - - -
SP5: -
SP6: -
SP7: -
SP8: - -
SP9:

ExUns: 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TNFAIP3 Gene

GeneLoc Exon Structure for
TNFAIP3
ECgene alternative splicing isoforms for
TNFAIP3

Expression for TNFAIP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFAIP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFAIP3 Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for TNFAIP3 Gene

This gene is overexpressed in Testis (17.2), Lymph node (13.8), Placenta (13.0), Peripheral blood mononuclear cells (10.3), and CD8 Tcells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNFAIP3 Gene



Protein tissue co-expression partners for TNFAIP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFAIP3 Gene:

TNFAIP3

SOURCE GeneReport for Unigene cluster for TNFAIP3 Gene:

Hs.211600

Evidence on tissue expression from TISSUES for TNFAIP3 Gene

  • Liver(4.4)
  • Lung(3)
  • Blood(2.6)
  • Intestine(2.6)
  • Lymph node(2.4)
  • Nervous system(2.4)
  • Bone marrow(2.3)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with TNFAIP3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFAIP3 Gene

Orthologs for TNFAIP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFAIP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFAIP3 33 32
  • 99.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNFAIP3 33 32
  • 87.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TNFAIP3 33 32
  • 85.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfaip3 17 33 32
  • 85.08 (n)
rat
(Rattus norvegicus)
Mammalia Tnfaip3 32
  • 84.66 (n)
oppossum
(Monodelphis domestica)
Mammalia TNFAIP3 33
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFAIP3 33
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFAIP3 33 32
  • 69.64 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFAIP3 33
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tnfaip3 33 32
  • 58.08 (n)
OneToOne
Species where no ortholog for TNFAIP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFAIP3 Gene

ENSEMBL:
Gene Tree for TNFAIP3 (if available)
TreeFam:
Gene Tree for TNFAIP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFAIP3: view image

Paralogs for TNFAIP3 Gene

Paralogs for TNFAIP3 Gene

(1) SIMAP similar genes for TNFAIP3 Gene using alignment to 20 proteins:

  • TNAP3_HUMAN
  • D3TTY4_HUMAN
  • D3TTY5_HUMAN
  • D3TTY6_HUMAN
  • D3TTY7_HUMAN
  • D3TTY8_HUMAN
  • D3TTY9_HUMAN
  • D3TTZ0_HUMAN
  • D3TTZ1_HUMAN
  • D3TTZ2_HUMAN
  • D3TTZ3_HUMAN
  • D3TTZ4_HUMAN
  • D3TTZ5_HUMAN
  • D3TTZ6_HUMAN
  • D3TTZ7_HUMAN
  • D3TTZ8_HUMAN
  • F8K9X7_HUMAN
  • Q5VXQ8_HUMAN
  • Q5VXQ9_HUMAN
  • Q5VXR0_HUMAN
genes like me logo Genes that share paralogs with TNFAIP3: view

Variants for TNFAIP3 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP3 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs2230926 not-provided, not specified, - 137,874,929(+) T/C/G 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs5029941 uncertain-significance, not specified, - 137,874,923(+) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs864321625 pathogenic, Autoinflammatory syndrome, familial, Behcet-like 137,876,041(+) T/A coding_sequence_variant, stop_gained
rs864321626 pathogenic, Autoinflammatory syndrome, familial, Behcet-like, not provided 137,877,081(+) C/T coding_sequence_variant, stop_gained
rs864321682 pathogenic, Autoinflammatory syndrome, familial, Behcet-like 137,876,030(+) TTT/TT coding_sequence_variant, frameshift

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP3 Gene

Variant ID Type Subtype PubMed ID
nsv470863 CNV loss 18288195
nsv523826 CNV loss 19592680
nsv5493 CNV insertion 18451855
nsv830818 CNV gain 17160897
nsv830819 CNV loss 17160897

Variation tolerance for TNFAIP3 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.54; 77.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFAIP3 Gene

Human Gene Mutation Database (HGMD)
TNFAIP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFAIP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP3 Gene

Disorders for TNFAIP3 Gene

MalaCards: The human disease database

(11) MalaCards diseases for TNFAIP3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
autoinflammatory syndrome, familial, behcet-like
  • aisbl
iridocyclitis
  • primary iridocyclitis
autoinflammatory syndrome
primary mediastinal b-cell lymphoma
  • large cell lymphoma of the mediastinum
marginal zone b-cell lymphoma
  • marginal zone lymphoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TNAP3_HUMAN
  • Autoinflammatory syndrome, familial, Behcet-like (AISBL) [MIM:616744]: An autosomal dominant, autoinflammatory disorder with early onset, characterized by ulceration of mucosal surfaces, particularly in the oral and genital areas. Additional variable features include skin rash, uveitis, and polyarthritis. {ECO:0000269 PubMed:26642243, ECO:0000269 PubMed:27175295}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TNFAIP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFAIP3: view

No data available for Genatlas for TNFAIP3 Gene

Publications for TNFAIP3 Gene

  1. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. (PMID: 2118515) Opipari AW … Dixit VM (The Journal of biological chemistry 1990) 2 3 4 23 56
  2. Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis. (PMID: 19366996) Scherer HU … Toes RE (Annals of the rheumatic diseases 2010) 3 23 43 56
  3. Association of TNFAIP3 polymorphism with rheumatic heart disease in Chinese Han population. (PMID: 19902201) Hua R … Wang XF (Immunogenetics 2009) 3 23 43 56
  4. A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. (PMID: 19494296) Düwel M … Krappmann D (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4 23 56
  5. Polymorphisms in the tumour necrosis factor alpha-induced protein 3 (TNFAIP3) gene are associated with chronic rhinosinusitis. (PMID: 19344623) Cormier C … Desrosiers M (Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 2009) 3 23 43 56

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