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This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in ... See more...
Aliases for TNFAIP3 Gene
Aliases for TNFAIP3 Gene
External Ids for TNFAIP3 Gene
- HGNC: 11896
- NCBI Entrez Gene: 7128
- Ensembl: ENSG00000118503
- OMIM®: 191163
- UniProtKB/Swiss-Prot: P21580
Previous GeneCards Identifiers for TNFAIP3 Gene
- GC06P137811
- GC06P138035
- GC06P138123
- GC06P138169
- GC06P138230
- GC06P135750
- GC06P138188
Summaries for TNFAIP3 Gene
-
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for TNFAIP3 Gene
TNFAIP3 (TNF Alpha Induced Protein 3) is a Protein Coding gene. Diseases associated with TNFAIP3 include Autoinflammatory Syndrome, Familial, Behcet-Like and Primary Mediastinal B-Cell Lymphoma. Among its related pathways are Signaling by GPCR and TNF signaling. Gene Ontology (GO) annotations related to this gene include ligase activity and thiol-dependent ubiquitin-specific protease activity. An important paralog of this gene is OTUD7A.
UniProtKB/Swiss-Prot Summary for TNFAIP3 Gene
-
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.
Additional gene information for TNFAIP3 Gene
- HGNC (11896)
- NCBI Entrez Gene (7128)
- Ensembl (ENSG00000118503)
- OMIM® (191163)
- UniProtKB/Swiss-Prot (P21580)
- Open Targets Platform(ENSG00000118503)
- Monarch Initiative
- Alliance of Genome Resources
- Search for TNFAIP3 at DataMed
- Search for TNFAIP3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFAIP3 Gene
Genomics for TNFAIP3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TNFAIP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TNFAIP3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFAIP3
Genomic Locations for TNFAIP3 Gene
Latest Assembly
- chr6:137,866,317-137,883,312
- (GRCh38/hg38)
- Size:
- 16,996 bases
- Orientation:
- Plus strand
Previous Assembly
- chr6:138,188,396-138,204,449
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 16,054 bases
- Orientation:
- Plus strand
Genomic View for TNFAIP3 Gene
Genes around TNFAIP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q23.3 by HGNC
- 6q23.3 by Entrez Gene
- 6q23.3 by Ensembl
TNFAIP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNFAIP3 Gene
Proteins for TNFAIP3 Gene
-
Protein details for TNFAIP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P21580-TNAP3_HUMAN
- Recommended name:
- Tumor necrosis factor alpha-induced protein 3
- Protein Accession:
- P21580
- B2R767
- E1P588
- Q2HIX9
- Q5VXQ7
- Q9NSR6
Protein attributes for TNFAIP3 Gene
- Size:
- 790 amino acids
- Molecular mass:
- 89614 Da
- Quaternary structure:
-
- Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6; the interaction is inhibited by HTLV-1 protein Tax.
Protein Expression for TNFAIP3 Gene
Post-translational modifications for TNFAIP3 Gene
- Proteolytically cleaved by MALT1 upon TCR stimulation; disrupts NF-kappa-B inhibitory function and results in increased IL-2 production. It is proposed that only a fraction of TNFAIP3 colocalized with TCR and CBM complex is cleaved, leaving the main TNFAIP3 pool intact.
-
Ubiquitination at Lys541, Lys621, Lys643, Lys676, and Lys722
- NX_P21580 (NX_P21580-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TNFAIP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences TNFAIP3 / A20 Antibody (LS-B3849) and TNFAIP3 / A20 Antibody (LS-B4603)
- G Biosciences Immunotag™ TNFAIP3 Antibody
- GeneTex Anti-TNFAIP3 antibody and Anti-TNFAIP3 antibody [SN07-31]
-
Custom Antibody ServicesOriGene Antibodies for TNFAIP3
- Novus Biologicals Antibodies for TNFAIP3
-
Abcam antibodies for TNFAIP3
- Invitrogen Antibodies for TNFAIP3 (AFLGC-TNFAIP3)
- antibodies-online: Show 79 available TNFAIP3 Antibodies ranked by validation data
- Compare Top TNFAIP3 Antibodies
-
Recommended
- 81 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 55 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 52 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TNFAIP3
- Sino Biological Antibodies for TNFAIP3
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for TNFAIP3
- Origene Custom Protein Services for TNFAIP3
-
Abcam proteins for TNFAIP3
Assay products for research
No data available for DME Specific Peptides for TNFAIP3 Gene
Domains & Families for TNFAIP3 Gene
Gene Families for TNFAIP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for TNFAIP3 Gene
Suggested Antigen Peptide Sequences for TNFAIP3 Gene
- GenScript: Design optimal peptide antigens:
-
- Truncated tumor necrosis factor alpha-induced protein 3 (D3TTY4_HUMAN)
- Truncated tumor necrosis factor alpha-induced protein 3 (D3TTY6_HUMAN)
- Truncated tumor necrosis factor alpha-induced protein 3 (D3TTY8_HUMAN)
- Truncated tumor necrosis factor alpha-induced protein 3 (D3TTY9_HUMAN)
- Truncated tumor necrosis factor alpha-induced protein 3 (D3TTZ0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P21580UniProtKB/Swiss-Prot:
TNAP3_HUMAN :- The A20-type zinc fingers mediate the ubiquitin ligase activity. The A20-type zinc finger 4 selectively recognizes 'Lys-63'-linked polyubiquitin. The A20-type zinc finger 4-7 are sufficient to bind polyubiquitin.
- Belongs to the peptidase C64 family.
- Domain:
-
- The A20-type zinc fingers mediate the ubiquitin ligase activity. The A20-type zinc finger 4 selectively recognizes 'Lys-63'-linked polyubiquitin. The A20-type zinc finger 4-7 are sufficient to bind polyubiquitin.
- The OTU domain mediates the deubiquitinase activity.
- Family:
-
- Belongs to the peptidase C64 family.
Function for TNFAIP3 Gene
Molecular function for TNFAIP3 Gene
- UniProtKB/Swiss-Prot Function:
- Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000269|PubMed:14748687, ECO:0000269|PubMed:17961127, ECO:0000269|PubMed:18164316, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:27732584};.
- UniProtKB/Swiss-Prot Induction:
- By TNF.
- GENATLAS Biochemistry:
- tumor necrosis factor,alpha-induced protein 3
Enzyme Numbers (IUBMB) for TNFAIP3 Gene
Phenotypes From GWAS Catalog for TNFAIP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IPI | 18223652 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 15258597 |
| GO:0004843 | thiol-dependent ubiquitin-specific protease activity | IEA,TAS | 20392859 |
Phenotypes for TNFAIP3 Gene
- MGI mutant phenotypes for TNFAIP3:
-
inferred from 9 alleles
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- renal/urinary system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- skeleton phenotype
- integument phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for TNFAIP3:
-
- Decreased viability
- shRNA abundance <= 25%
- no effect
- Increased S DNA content
- Decreased vaccinia virus (VACV) infection
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Actin fiber cells
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased cell number in G2M, increased number of polyploid cells, increased number of cells with high perimeter-to-area ratio nuclei
Animal Models for TNFAIP3 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TNFAIP3 - Starting at $85 >
- * TNFAIP3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TNFAIP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNFAIP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFAIP3
miRNA for TNFAIP3 Gene
- miRTarBase miRNAs that target TNFAIP3
-
- hsa-miR-21-5p (MIRT005955)
- hsa-miR-29a-3p (MIRT006380)
- hsa-miR-125a-5p (MIRT006471)
- hsa-miR-125b-5p (MIRT006472)
- mmu-miR-136-5p (MIRT015075)
- hsa-miR-26b-5p (MIRT029863)
- hsa-miR-24-3p (MIRT030581)
- mmu-miR-29b-3p (MIRT054480)
- mmu-miR-873a-5p (MIRT438380)
- hsa-miR-374a-5p (MIRT439414)
- hsa-miR-4709-3p (MIRT448403)
- hsa-miR-3185 (MIRT448405)
- hsa-miR-4635 (MIRT448406)
- hsa-miR-4729 (MIRT448407)
- hsa-miR-5582-3p (MIRT448408)
- hsa-miR-548x-3p (MIRT448409)
- hsa-miR-548j-3p (MIRT448410)
- hsa-miR-548aq-3p (MIRT448411)
- hsa-miR-548am-3p (MIRT448412)
- hsa-miR-548aj-3p (MIRT448413)
- hsa-miR-548ah-3p (MIRT448414)
- hsa-miR-548ae-3p (MIRT448415)
- hsa-miR-573 (MIRT448416)
- hsa-miR-3616-5p (MIRT448417)
- hsa-miR-4670-3p (MIRT448418)
- hsa-miR-6837-3p (MIRT448419)
- hsa-miR-6754-3p (MIRT448420)
- hsa-miR-412-3p (MIRT448421)
- hsa-miR-5692a (MIRT448422)
- hsa-miR-141-5p (MIRT450585)
- hsa-miR-335-3p (MIRT553481)
- hsa-miR-5096 (MIRT553482)
- hsa-miR-3658 (MIRT553483)
- hsa-miR-505-3p (MIRT553484)
- hsa-miR-3653-3p (MIRT553485)
- hsa-miR-5093 (MIRT553486)
- hsa-miR-3688-3p (MIRT553487)
- hsa-miR-580-5p (MIRT553488)
- hsa-miR-6507-5p (MIRT553489)
- hsa-miR-23a-3p (MIRT553490)
- hsa-miR-130a-5p (MIRT553491)
- hsa-miR-23b-3p (MIRT553492)
- hsa-miR-23c (MIRT553493)
- hsa-miR-4659b-3p (MIRT621748)
- hsa-miR-4659a-3p (MIRT621749)
- hsa-miR-6875-3p (MIRT621750)
- hsa-miR-3679-3p (MIRT621751)
- hsa-miR-4777-5p (MIRT621752)
- hsa-miR-526a (MIRT621753)
- hsa-miR-523-5p (MIRT621754)
- hsa-miR-522-5p (MIRT621755)
- hsa-miR-520c-5p (MIRT621756)
- hsa-miR-519c-5p (MIRT621757)
- hsa-miR-519b-5p (MIRT621758)
- hsa-miR-519a-5p (MIRT621759)
- hsa-miR-518f-5p (MIRT621760)
- hsa-miR-518e-5p (MIRT621761)
- hsa-miR-518d-5p (MIRT621762)
- hsa-miR-6826-3p (MIRT621763)
- hsa-miR-520g-5p (MIRT621764)
- hsa-miR-4667-3p (MIRT621765)
- hsa-miR-6795-3p (MIRT621766)
- hsa-miR-6887-3p (MIRT621767)
- hsa-miR-586 (MIRT621768)
- hsa-miR-2278 (MIRT621769)
- hsa-miR-5700 (MIRT621770)
- hsa-miR-19b-3p (MIRT726265)
- hsa-miR-19a-3p (MIRT726266)
- mmu-miR-23a-3p (MIRT732601)
- mmu-miR-23a-3p (MIRT733678)
- hsa-miR-19a-5p (MIRT733865)
- hsa-miR-18a-5p (MIRT733998)
- hsa-miR-29b-3p (MIRT734056)
- hsa-let-7a-5p (MIRT735327)
- hsa-let-7e-5p (MIRT735328)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNFAIP3
- Browse OriGene Inhibitory RNA Products For TNFAIP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFAIP3
Clone products for research
- Applied Biological Materials (abm): Clones for TNFAIP3 - Starting at $45 >
- * TNFAIP3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TNFAIP3
- Addgene plasmids for TNFAIP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNFAIP3
Cell Lines for research
-
Horizon Cell Lines for TNFAIP3
No data available for Transcription Factor Targets and HOMER Transcription for TNFAIP3 Gene
Localization for TNFAIP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP3 Gene
- Cytoplasm. Nucleus. Lysosome.
- [A20p50]: Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| lysosome | 5 |
| extracellular | 4 |
| cytoskeleton | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Centrosome (2)
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 11463333 |
| GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 20458337 |
Pathways & Interactions for TNFAIP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TNF signaling |
.86
|
|
| 2 | Measles |
.35
|
|
| 3 | 4-1BB Pathway |
CD40 Signaling
.54
|
TNFR2 Pathway
.37
|
| 4 | TNFR1 Pathway |
TNFR1 Pathway
.56
|
|
| 5 | Innate Immune System |
.61
|
|
Pathways by source for TNFAIP3 Gene
5 BioSystems pathways for TNFAIP3 Gene
16 Reactome pathways for TNFAIP3 Gene
7 KEGG pathways for TNFAIP3 Gene
6 Qiagen pathways for TNFAIP3 Gene
- 14-3-3 and Regulation of BAD Activity
- 14-3-3 Induced Apoptosis
- CD40 Signaling
- NF-KappaB (p50-p65) Pathway
- TNFR1 Pathway
2 Cell Signaling Technology pathways for TNFAIP3 Gene
Interacting Proteins for TNFAIP3 Gene
Selected Interacting proteins:
P21580-TNAP3_HUMAN
ENSP00000481570
for TNFAIP3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TNFAIP3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001922 | B-1 B cell homeostasis | IEA,ISS | -- |
| GO:0002237 | response to molecule of bacterial origin | IEA,IDA | 19912257 |
| GO:0002634 | regulation of germinal center formation | IEA,ISS | -- |
| GO:0002677 | negative regulation of chronic inflammatory response | IEA | -- |
| GO:0006508 | proteolysis | IEA | -- |
Drugs & Compounds for TNFAIP3 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for TNFAIP3 Gene
mRNA/cDNA for TNFAIP3 Gene
- 3 REFSEQ mRNAs :
- 29 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000237289 4432 nts (view in UCSC)
- ENST00000420009 698 nts (view in UCSC)
- ENST00000421450 421 nts (view in UCSC)
- ENST00000433680 465 nts (view in UCSC)
- ENST00000485192 604 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TNFAIP3 - Starting at $85 >
- * TNFAIP3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TNFAIP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNFAIP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFAIP3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNFAIP3
- Browse OriGene Inhibitory RNA Products For TNFAIP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFAIP3
Clone products for research
- Applied Biological Materials (abm): Clones for TNFAIP3 - Starting at $45 >
- * TNFAIP3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TNFAIP3
- Addgene plasmids for TNFAIP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNFAIP3
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | · | 3f | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 13c |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: |
Relevant External Links for TNFAIP3 Gene
- GeneLoc Exon Structure for
- TNFAIP3
Expression for TNFAIP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
-
Epithelial Cells
- Duct Cells Pancreatic Ducts
- Bone (Muscoskeletal System)
- Epidermis (Integumentary System)
- Hair
-
Spleen (Hematopoietic System)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for TNFAIP3 Gene
This gene is overexpressed in Whole Blood (x4.3).
This gene is overexpressed in Testis (17.2), Lymph node (13.8), Placenta (13.0), Peripheral blood mononuclear cells (10.3), and CD8 Tcells (8.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNFAIP3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFAIP3
SOURCE GeneReport for Unigene cluster for TNFAIP3 Gene:
Hs.211600Evidence on tissue expression from TISSUES for TNFAIP3 Gene
- Liver(4.5)
- Lung(3.3)
- Bone marrow(3.3)
- Lymph node(3.1)
- Intestine(3.1)
- Spleen(3.1)
- Nervous system(2.9)
- Blood(2.9)
- Skin(2.5)
- Heart(2.4)
- Kidney(2.3)
- Muscle(2.3)
- Stomach(2.2)
Primer products for research
-
OriGene qPCR primer pairs for TNFAIP3
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFAIP3 Gene
Orthologs for TNFAIP3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TNFAIP3 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TNFAIP3 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TNFAIP3 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tnfaip3 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tnfaip3 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | TNFAIP3 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TNFAIP3 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TNFAIP3 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TNFAIP3 30 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | tnfaip3 29 30 |
|
OneToOne |
- Species where no ortholog for TNFAIP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TNFAIP3 Gene
- ENSEMBL:
- Gene Tree for TNFAIP3 (if available)
- TreeFam:
- Gene Tree for TNFAIP3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TNFAIP3: view image
- Alliance of Genome Resources:
- Additional Orthologs for TNFAIP3
Paralogs for TNFAIP3 Gene
(1) SIMAP similar genes for TNFAIP3 Gene using alignment to 20 proteins:
- TNAP3_HUMAN
- D3TTY4_HUMAN
- D3TTY5_HUMAN
- D3TTY6_HUMAN
- D3TTY7_HUMAN
- D3TTY8_HUMAN
- D3TTY9_HUMAN
- D3TTZ0_HUMAN
- D3TTZ1_HUMAN
- D3TTZ2_HUMAN
- D3TTZ3_HUMAN
- D3TTZ4_HUMAN
- D3TTZ5_HUMAN
- D3TTZ6_HUMAN
- D3TTZ7_HUMAN
- D3TTZ8_HUMAN
- F8K9X7_HUMAN
- Q5VXQ8_HUMAN
- Q5VXQ9_HUMAN
- Q5VXR0_HUMAN
Variants for TNFAIP3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFAIP3 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1003848 | Uncertain Significance: not provided | 137,876,171(+) |
G/A NM_001270508.2(TNFAIP3):c.805+5G>A |
INTRON | |
| 1012787 | Likely Pathogenic: not provided | 137,871,390(+) |
C/T NM_001270508.2(TNFAIP3):c.163C>T (p.Gln55Ter) |
NONSENSE | |
| 1012788 | Uncertain Significance: not provided | 137,879,309(+) |
G/A NM_001270508.2(TNFAIP3):c.1864G>A (p.Gly622Ser) |
MISSENSE | |
| 1027062 | Uncertain Significance: not provided | 137,877,180(+) |
A/G NM_001270508.2(TNFAIP3):c.910A>G (p.Lys304Glu) |
MISSENSE | |
| 1028499 | Likely Pathogenic: Autoinflammatory syndrome, familial, Behcet-like | 137,871,249(+) |
C/T NM_001270508.2(TNFAIP3):c.22C>T (p.Gln8Ter) |
NONSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.54;
77.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TNFAIP3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP3 Gene
Disorders for TNFAIP3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| autoinflammatory syndrome, familial, behcet-like |
|
|
| primary mediastinal b-cell lymphoma |
|
|
| iridocyclitis |
|
|
| marginal zone b-cell lymphoma |
|
|
| systemic lupus erythematosus |
|
Search TNFAIP3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TNAP3_HUMAN- Autoinflammatory syndrome, familial, Behcet-like (AISBL) [MIM:616744]: An autosomal dominant, autoinflammatory disorder with early onset, characterized by ulceration of mucosal surfaces, particularly in the oral and genital areas. Additional variable features include skin rash, uveitis, and polyarthritis. {ECO:0000269 PubMed:26642243, ECO:0000269 PubMed:27175295}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for TNFAIP3
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for TNFAIP3 Gene
Publications for TNFAIP3 Gene
- The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. (PMID: 2118515) Opipari AW … Dixit VM (The Journal of biological chemistry 1990) 2 3 4 22
- Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. (PMID: 26642243) Zhou Q … Aksentijevich I (Nature genetics 2016) 3 4 72
- Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population. (PMID: 20617138) Kawasaki A … Tsuchiya N (Journal of biomedicine & biotechnology 2010) 3 40 72
- Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis. (PMID: 19366996) Scherer HU … Toes RE (Annals of the rheumatic diseases 2010) 3 22 40
- Polymorphisms in the tumour necrosis factor alpha-induced protein 3 (TNFAIP3) gene are associated with chronic rhinosinusitis. (PMID: 19344623) Cormier C … Desrosiers M (Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 2009) 3 22 40
ExternalLinks
Products for TNFAIP3 Gene
- Custom Antibody ServicesOriGene Antibodies for TNFAIP3
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- VectorBuilder Viral vectors for TNFAIP3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TNFAIP3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TNFAIP3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TNFAIP3
- Addgene plasmids for TNFAIP3
- antibodies-online: Show 79 available TNFAIP3 Antibodies ranked by validation data
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- 81 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 2 FACS Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 55 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 52 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 12 available TNFAIP3 Elisa Kits ranked by validation data
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- antibodies-online: Show 8 available TNFAIP3 Proteins ranked by validation data
- Compare Top TNFAIP3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TNFAIP3
- Search Santa Cruz Biotechnology (SCBT) for TNFAIP3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TNFAIP3
- Custom Antibody ServicesProSci Antibodies for TNFAIP3
- Search for TNFAIP3 Proteins at ProSci
- Horizon Cell Lines for TNFAIP3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNFAIP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNFAIP3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TNFAIP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFAIP3
Sources for TNFAIP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
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- (16) MGI
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- (26) ASD
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- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
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- (43) Atlas
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- (65) Reactome
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- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
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