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This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]
TNFAIP2 (TNF Alpha Induced Protein 2) is a Protein Coding gene. Diseases associated with TNFAIP2 include Acute Promyelocytic Leukemia. Gene Ontology (GO) annotations related to this gene include SNARE binding. An important paralog of this gene is EXOC3L2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000149 | SNARE binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000145 | exocyst | IBA | 21873635 |
GO:0005615 | extracellular space | TAS | 1374453 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | IEA | -- |
GO:0006887 | exocytosis | IBA | 21873635 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0030154 | cell differentiation | IEA | -- |
GO:0051601 | exocyst localization | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||
SP3: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TNFAIP2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TNFAIP2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TNFAIP2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tnfaip2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tnfaip2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | TNFAIP2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TNFAIP2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TNFAIP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TNFAIP2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tnfaip2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tnfaip2b 30 31 31 |
|
OneToMany | |
tnfaip2a 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | sec6 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | sec-6 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
715671 | Benign: not provided | 103,126,556(+) | G/A | SYNONYMOUS_VARIANT | |
734189 | Benign: not provided | 103,133,719(+) | C/T | MISSENSE_VARIANT | |
773855 | Benign: not provided | 103,126,688(+) | C/A | SYNONYMOUS_VARIANT | |
773856 | Benign: not provided | 103,132,800(+) | C/G | SYNONYMOUS_VARIANT | |
rs1132339 | - | p.Gln282Glu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv141e215 | CNV | deletion | 23714750 |
dgv3935n54 | CNV | loss | 21841781 |
dgv3936n54 | CNV | loss | 21841781 |
dgv3937n54 | CNV | loss | 21841781 |
esv1662663 | CNV | deletion | 17803354 |
esv2387988 | CNV | deletion | 18987734 |
esv2749162 | CNV | deletion | 23290073 |
esv3187495 | CNV | deletion | 24192839 |
esv995383 | CNV | deletion | 20482838 |
nsv565970 | CNV | loss | 21841781 |
nsv565971 | CNV | loss | 21841781 |
nsv565972 | CNV | loss | 21841781 |
nsv832882 | CNV | loss | 17160897 |
nsv84480 | CNV | deletion | 16902084 |
nsv84629 | CNV | deletion | 16902084 |
nsv9168 | CNV | loss | 18304495 |
nsv952257 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
acute promyelocytic leukemia |
|
|