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Aliases for TNFAIP2 Gene

Aliases for TNFAIP2 Gene

  • TNF Alpha Induced Protein 2 2 3 5
  • Exocyst Complex Component 3-Like 3 2 3
  • Primary Response Gene B94 Protein 3 4
  • Tumor Necrosis Factor, Alpha Induced Protein 2 3
  • Tumor Necrosis Factor, Alpha-Induced Protein 2 2
  • Tumor Necrosis Factor Alpha-Induced Protein 2 3
  • TNF Alpha-Induced Protein 2 4
  • EXOC3L3 3
  • B94 3

External Ids for TNFAIP2 Gene

Previous GeneCards Identifiers for TNFAIP2 Gene

  • GC14P100983
  • GC14P097408
  • GC14P101579
  • GC14P101582
  • GC14P102662
  • GC14P103592
  • GC14P083771
  • GC14P103123
  • GC14P103204

Summaries for TNFAIP2 Gene

Entrez Gene Summary for TNFAIP2 Gene

  • This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFAIP2 Gene

TNFAIP2 (TNF Alpha Induced Protein 2) is a Protein Coding gene. Diseases associated with TNFAIP2 include Acute Promyelocytic Leukemia. Gene Ontology (GO) annotations related to this gene include SNARE binding. An important paralog of this gene is EXOC3L4.

UniProtKB/Swiss-Prot for TNFAIP2 Gene

  • May play a role as a mediator of inflammation and angiogenesis.

Additional gene information for TNFAIP2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP2 Gene

Genomics for TNFAIP2 Gene

GeneHancer (GH) Regulatory Elements for TNFAIP2 Gene

Promoters and enhancers for TNFAIP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J103117 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 664.7 +3.6 3635 14.2 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF766 ZNF143 SP3 SP5 REST TNFAIP2 LINC00677 RCOR1 XRCC3 WDR20 NDUFB4P11 ENSG00000259444 TRAF3 EIF5 MARK3
GH14J103185 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 17.9 +66.7 66743 4.9 PKNOX1 INSM2 ARID4B ZNF48 RAD21 YY1 ZNF335 ZNF614 ZNF143 RCOR1 LINC00605 TNFAIP2 EXOC3L4 GCSHP2 GC14M103156
GH14J103107 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -10.7 -10674 6.7 HDGF PKNOX1 ATF1 SIN3A IRF4 GLIS2 ZNF143 FOS ATF7 RUNX3 XRCC3 TNFAIP2 ENSG00000259444 RCOR1 WDR20 TRAF3 RD3L EIF5 MARK3 BAG5
GH14J103416 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +296.8 296820 2.7 HDAC1 EGR1 SCRT2 FOS IKZF2 RUNX3 PHF21A NCOA1 CEBPB SREBF1 MARK3 TNFAIP2 RNU7-160P CKB EIF5 RPL10AP1 GC14P103445 GC14M103376
GH14J103361 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.2 +241.0 240953 1.8 PKNOX1 ARNT DMAP1 BRCA1 ZNF280A ZNF143 ATF7 FOS KLF13 NFKBIZ CKB TNFAIP2 MARK3 XRCC3 EIF5 GC14M103366 GC14M103345
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFAIP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFAIP2 gene promoter:
  • Lmo2
  • c-Myb
  • HSF1short
  • HSF1 (long)
  • ITF-2
  • Tal-1beta
  • GR
  • GR-alpha
  • SRF
  • CRE-BP1

Genomic Locations for TNFAIP2 Gene

Genomic Locations for TNFAIP2 Gene
chr14:103,121,147-103,137,439
(GRCh38/hg38)
Size:
16,293 bases
Orientation:
Plus strand
chr14:103,589,779-103,603,776
(GRCh37/hg19)
Size:
13,998 bases
Orientation:
Plus strand

Genomic View for TNFAIP2 Gene

Genes around TNFAIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP2 Gene

Proteins for TNFAIP2 Gene

  • Protein details for TNFAIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03169-TNAP2_HUMAN
    Recommended name:
    Tumor necrosis factor alpha-induced protein 2
    Protein Accession:
    Q03169
    Secondary Accessions:
    • Q86VI0

    Protein attributes for TNFAIP2 Gene

    Size:
    654 amino acids
    Molecular mass:
    72661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNFAIP2 Gene

Post-translational modifications for TNFAIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TNFAIP2 Gene

Domains & Families for TNFAIP2 Gene

Gene Families for TNFAIP2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for TNFAIP2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNFAIP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q03169

UniProtKB/Swiss-Prot:

TNAP2_HUMAN :
  • Belongs to the SEC6 family.
Family:
  • Belongs to the SEC6 family.
genes like me logo Genes that share domains with TNFAIP2: view

Function for TNFAIP2 Gene

Molecular function for TNFAIP2 Gene

UniProtKB/Swiss-Prot Function:
May play a role as a mediator of inflammation and angiogenesis.
UniProtKB/Swiss-Prot Induction:
By TNF and other proinflammatory factors.
GENATLAS Biochemistry:
tumor necrosis factor alpha,inducible primary response,2

Phenotypes From GWAS Catalog for TNFAIP2 Gene

Gene Ontology (GO) - Molecular Function for TNFAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
genes like me logo Genes that share ontologies with TNFAIP2: view
genes like me logo Genes that share phenotypes with TNFAIP2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFAIP2 Gene

Localization for TNFAIP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFAIP2 gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IBA --
GO:0005615 extracellular space TAS 1374453
genes like me logo Genes that share ontologies with TNFAIP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP2 Gene

Pathways & Interactions for TNFAIP2 Gene

SuperPathways for TNFAIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNFAIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006887 exocytosis IBA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0051601 exocyst localization IBA --
genes like me logo Genes that share ontologies with TNFAIP2: view

No data available for Pathways by source and SIGNOR curated interactions for TNFAIP2 Gene

Drugs & Compounds for TNFAIP2 Gene

(2) Additional Compounds for TNFAIP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFAIP2: view

Transcripts for TNFAIP2 Gene

Unigene Clusters for TNFAIP2 Gene

Tumor necrosis factor, alpha-induced protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1:
SP2:
SP3: -

Relevant External Links for TNFAIP2 Gene

GeneLoc Exon Structure for
TNFAIP2
ECgene alternative splicing isoforms for
TNFAIP2

Expression for TNFAIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFAIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFAIP2 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for TNFAIP2 Gene

This gene is overexpressed in Lymph node (8.1), Spleen (7.9), and Bone (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNFAIP2 Gene



Protein tissue co-expression partners for TNFAIP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFAIP2 Gene:

TNFAIP2

SOURCE GeneReport for Unigene cluster for TNFAIP2 Gene:

Hs.525607

Evidence on tissue expression from TISSUES for TNFAIP2 Gene

  • Heart(4.3)
  • Lung(3.2)
  • Spleen(2.4)
  • Bone marrow(2.1)
  • Blood(2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with TNFAIP2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFAIP2 Gene

Orthologs for TNFAIP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFAIP2 34 33
  • 93.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNFAIP2 34 33
  • 85.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TNFAIP2 34 33
  • 84.15 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfaip2 16 34 33
  • 80.21 (n)
rat
(Rattus norvegicus)
Mammalia Tnfaip2 33
  • 79.67 (n)
oppossum
(Monodelphis domestica)
Mammalia TNFAIP2 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFAIP2 34
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFAIP2 34 33
  • 51.2 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFAIP2 34
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfaip2 33
  • 45.29 (n)
zebrafish
(Danio rerio)
Actinopterygii tnfaip2b 34 34 33
  • 44.47 (n)
OneToMany
tnfaip2a 34
  • 23 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sec6 34
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-6 34
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
OneToMany
Species where no ortholog for TNFAIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNFAIP2 Gene

ENSEMBL:
Gene Tree for TNFAIP2 (if available)
TreeFam:
Gene Tree for TNFAIP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFAIP2: view image

Paralogs for TNFAIP2 Gene

Paralogs for TNFAIP2 Gene

genes like me logo Genes that share paralogs with TNFAIP2: view

Variants for TNFAIP2 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000115504 -- 103,137,541(+) A/G downstream_transcript_variant
rs1000257035 -- 103,122,720(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000500933 -- 103,121,096(+) T/G upstream_transcript_variant
rs1000607872 -- 103,133,648(+) C/A/T genic_downstream_transcript_variant, intron_variant
rs1000687594 -- 103,122,443(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP2 Gene

Variant ID Type Subtype PubMed ID
nsv952257 CNV deletion 24416366
nsv9168 CNV loss 18304495
nsv84629 CNV deletion 16902084
nsv84480 CNV deletion 16902084
nsv832882 CNV loss 17160897
nsv565972 CNV loss 21841781
nsv565971 CNV loss 21841781
nsv565970 CNV loss 21841781
esv995383 CNV deletion 20482838
esv3187495 CNV deletion 24192839
esv2749162 CNV deletion 23290073
esv2387988 CNV deletion 18987734
esv1662663 CNV deletion 17803354
dgv3937n54 CNV loss 21841781
dgv3936n54 CNV loss 21841781
dgv3935n54 CNV loss 21841781
dgv141e215 CNV deletion 23714750

Variation tolerance for TNFAIP2 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFAIP2 Gene

Human Gene Mutation Database (HGMD)
TNFAIP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFAIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP2 Gene

Disorders for TNFAIP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNFAIP2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
acute promyelocytic leukemia
  • apl
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFAIP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFAIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFAIP2 Gene

Publications for TNFAIP2 Gene

  1. Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro. (PMID: 1374453) Sarma V … Dixit VM (Journal of immunology (Baltimore, Md. : 1950) 1992) 2 3 4 22 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  4. SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance. (PMID: 20157331) Edvardsen H … Kristensen VN (The pharmacogenomics journal 2010) 3 44 58
  5. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PMID: 19339270) Canova C … Brennan P (Cancer research 2009) 3 44 58

Products for TNFAIP2 Gene

Sources for TNFAIP2 Gene

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