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Aliases for TNFAIP1 Gene

Aliases for TNFAIP1 Gene

  • TNF Alpha Induced Protein 1 2 3 5
  • Tumor Necrosis Factor, Alpha-Induced Protein 1 (Endothelial) 2 3
  • BTB/POZ Domain-Containing Protein TNFAIP1 3 4
  • HBACURD2 3 4
  • EDP1 3 4
  • BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 2 3
  • Tumor Necrosis Factor, Alpha-Induced Protein 1, Endothelial 4
  • Tumor Necrosis Factor, Alpha Induced Protein 1 3
  • Protein B12 4
  • BACURD2 4
  • BTBD34 3
  • B61 3
  • B12 3

External Ids for TNFAIP1 Gene

Previous HGNC Symbols for TNFAIP1 Gene

  • EDP1

Previous GeneCards Identifiers for TNFAIP1 Gene

  • GC17P026517
  • GC17P028562
  • GC17P026808
  • GC17P023686
  • GC17P026662
  • GC17P022870

Summaries for TNFAIP1 Gene

Entrez Gene Summary for TNFAIP1 Gene

  • This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFAIP1 Gene

TNFAIP1 (TNF Alpha Induced Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and GTP-Rho binding. An important paralog of this gene is KCTD10.

UniProtKB/Swiss-Prot for TNFAIP1 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Gene Wiki entry for TNFAIP1 Gene

Additional gene information for TNFAIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP1 Gene

Genomics for TNFAIP1 Gene

GeneHancer (GH) Regulatory Elements for TNFAIP1 Gene

Promoters and enhancers for TNFAIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I028333 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.3 1344 5.9 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IFT20 TNFAIP1 SUPT6H ENSG00000264577 NUFIP2 ITM2BP1 RPL23A TMEM97 NEK8 POLDIP2
GH17I028380 Enhancer 0.9 ENCODE 11.2 +44.8 44825 0.2 PKNOX1 ATF1 FOXA2 NEUROD1 SIN3A FEZF1 BRCA1 ZNF207 FOS ATF7 ITM2BP1 ENSG00000264577 SUPT6H NUFIP2 ENSG00000265205 ENSG00000265908 PHF12 SLC46A1 RPL23A SDF2
GH17I028277 Enhancer 0.9 Ensembl ENCODE 10.9 -57.1 -57116 1.2 HDAC1 PKNOX1 FEZF1 FOSL1 ZFHX2 NCOR1 EGR1 CBFA2T2 ATF7 IKZF2 GC17M029101 PIR58208 TNFAIP1 IFT20 NOS2 PIRC93 KRT18P55
GH17I028393 Enhancer 0.8 ENCODE 11.3 +61.3 61344 5.7 ZFP64 RARA TCF12 DEK RXRA USF2 CEBPB REST PPARG NR2F2 POLDIP2 VTN SARM1 TMEM199 TNFAIP1 IFT20 FOXN1 UNC119 PIGS GC17M029117
GH17I027980 Enhancer 1.1 FANTOM5 Ensembl ENCODE 1.3 -354.4 -354433 2.2 BCOR FOXA2 JUN MAX ZMYM3 BRCA1 RFX5 ADNP RCOR1 FOSL2 ENSG00000251818 ENSG00000202389 NLK PYY2 TNFAIP1 LINC01992 GC17M027891 LYRM9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFAIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFAIP1 gene promoter:

Genomic Locations for TNFAIP1 Gene

Genomic Locations for TNFAIP1 Gene
chr17:28,335,522-28,347,009
(GRCh38/hg38)
Size:
11,488 bases
Orientation:
Plus strand
chr17:26,662,548-26,674,035
(GRCh37/hg19)

Genomic View for TNFAIP1 Gene

Genes around TNFAIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP1 Gene

Proteins for TNFAIP1 Gene

  • Protein details for TNFAIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13829-BACD2_HUMAN
    Recommended name:
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Protein Accession:
    Q13829
    Secondary Accessions:
    • B7Z6M4
    • Q5TZQ1

    Protein attributes for TNFAIP1 Gene

    Size:
    316 amino acids
    Molecular mass:
    36204 Da
    Quaternary structure:
    • Component of the BCR(TNFAIP1) E3 ubiquitin ligase complex, at least composed of CUL3, TNFAIP1/BACURD2 and RBX1. Interacts with RHOA; with a preference for RhoA-GDP. Interacts with RHOB. Interacts with PCNA. Interacts with CSNK2B.

    Alternative splice isoforms for TNFAIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFAIP1 Gene

Post-translational modifications for TNFAIP1 Gene

  • Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA.
  • Ubiquitination at posLast=2121

Other Protein References for TNFAIP1 Gene

No data available for DME Specific Peptides for TNFAIP1 Gene

Domains & Families for TNFAIP1 Gene

Gene Families for TNFAIP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNFAIP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13829

UniProtKB/Swiss-Prot:

BACD2_HUMAN :
  • Belongs to the BACURD family.
Family:
  • Belongs to the BACURD family.
genes like me logo Genes that share domains with TNFAIP1: view

Function for TNFAIP1 Gene

Molecular function for TNFAIP1 Gene

GENATLAS Biochemistry:
tumor necrosis factor alpha,inducible primary response,1 (endothelial)
UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
UniProtKB/Swiss-Prot Induction:
By TNF, IL1B/interleukin-1 beta and bacterial lipopolysaccharides (LPS).

Phenotypes From GWAS Catalog for TNFAIP1 Gene

Gene Ontology (GO) - Molecular Function for TNFAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 19782033
GO:0005515 protein binding IPI 19615732
GO:0017049 GTP-Rho binding IDA 19637314
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with TNFAIP1: view
genes like me logo Genes that share phenotypes with TNFAIP1: view

Animal Models for TNFAIP1 Gene

MGI Knock Outs for TNFAIP1:

Animal Model Products

miRNA for TNFAIP1 Gene

miRTarBase miRNAs that target TNFAIP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFAIP1 Gene

Localization for TNFAIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP1 Gene

Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFAIP1 gene
Compartment Confidence
nucleus 5
endosome 5
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TNFAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA,IEA 19637314
GO:0005768 endosome IDA,IEA 19637314
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 19782033
genes like me logo Genes that share ontologies with TNFAIP1: view

Pathways & Interactions for TNFAIP1 Gene

SuperPathways for TNFAIP1 Gene

No Data Available

UniProtKB/Swiss-Prot Q13829-BACD2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TNFAIP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TNFAIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA,ISS --
GO:0006915 apoptotic process TAS 19637314
GO:0006955 immune response IEP 1370465
GO:0009790 embryo development IEA,ISS --
GO:0016477 cell migration IMP 19782033
genes like me logo Genes that share ontologies with TNFAIP1: view

No data available for Pathways by source for TNFAIP1 Gene

Drugs & Compounds for TNFAIP1 Gene

No Compound Related Data Available

Transcripts for TNFAIP1 Gene

Unigene Clusters for TNFAIP1 Gene

Tumor necrosis factor, alpha-induced protein 1 (endothelial):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for TNFAIP1 Gene

GeneLoc Exon Structure for
TNFAIP1
ECgene alternative splicing isoforms for
TNFAIP1

Expression for TNFAIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFAIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNFAIP1 Gene

This gene is overexpressed in Heart (63.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFAIP1 Gene



Protein tissue co-expression partners for TNFAIP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFAIP1 Gene:

TNFAIP1

SOURCE GeneReport for Unigene cluster for TNFAIP1 Gene:

Hs.76090

Evidence on tissue expression from TISSUES for TNFAIP1 Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Heart(4.3)
  • Intestine(2.4)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with TNFAIP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFAIP1 Gene

Orthologs for TNFAIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFAIP1 33 34
  • 99.89 (n)
dog
(Canis familiaris)
Mammalia TNFAIP1 33 34
  • 93.35 (n)
oppossum
(Monodelphis domestica)
Mammalia TNFAIP1 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNFAIP1 33 34
  • 92.72 (n)
mouse
(Mus musculus)
Mammalia Tnfaip1 33 16 34
  • 91.35 (n)
rat
(Rattus norvegicus)
Mammalia Tnfaip1 33
  • 90.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves TNFAIP1 33 34
  • 77.42 (n)
lizard
(Anolis carolinensis)
Reptilia TNFAIP1 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfaip1 33
  • 76.9 (n)
Str.2336 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24189 33
zebrafish
(Danio rerio)
Actinopterygii tnfaip1 33 34
  • 71.32 (n)
wufi06b02 33
fruit fly
(Drosophila melanogaster)
Insecta CG10465 35 34
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea ZC239.13 34
  • 35 (a)
ManyToMany
ZC239.17 34
  • 35 (a)
ManyToMany
B0281.6 34
  • 32 (a)
ManyToMany
ZC239.16 34
  • 32 (a)
ManyToMany
D2045.8 34
  • 31 (a)
ManyToMany
C40A11.6 34
  • 30 (a)
ManyToMany
T08G3.13 34
  • 29 (a)
ManyToMany
B0281.5 34
  • 28 (a)
ManyToMany
C40A11.7 34
  • 28 (a)
ManyToMany
F22E5.6 34
  • 27 (a)
ManyToMany
ZC239.14 34
  • 27 (a)
ManyToMany
C17F4.8 34
  • 26 (a)
ManyToMany
C40A11.3 34
  • 26 (a)
ManyToMany
sdz-35 34
  • 26 (a)
ManyToMany
ZC239.4 34
  • 26 (a)
ManyToMany
C40A11.2 34
  • 25 (a)
ManyToMany
ZC239.15 34
  • 25 (a)
ManyToMany
ZC239.3 34
  • 25 (a)
ManyToMany
F22E5.12 34
  • 24 (a)
ManyToMany
K02F6.5 34
  • 24 (a)
ManyToMany
K02F6.8 34
  • 23 (a)
ManyToMany
T05E12.3 34
  • 23 (a)
ManyToMany
ZC239.6 34
  • 23 (a)
ManyToMany
F22E5.8 34
  • 22 (a)
ManyToMany
ZC239.2 34
  • 22 (a)
ManyToMany
ZC239.5 34
  • 22 (a)
ManyToMany
C40A11.4 34
  • 21 (a)
ManyToMany
F22E5.11 34
  • 19 (a)
ManyToMany
F22E5.13 34
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9320 34
  • 66 (a)
OneToMany
Species where no ortholog for TNFAIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNFAIP1 Gene

ENSEMBL:
Gene Tree for TNFAIP1 (if available)
TreeFam:
Gene Tree for TNFAIP1 (if available)

Paralogs for TNFAIP1 Gene

Paralogs for TNFAIP1 Gene

(5) SIMAP similar genes for TNFAIP1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TNFAIP1: view

Variants for TNFAIP1 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000930560 -- 28,342,312(+) G/A coding_sequence_variant, missense_variant
rs1001100615 -- 28,335,720(+) C/G 5_prime_UTR_variant
rs1001151565 -- 28,335,513(+) C/A upstream_transcript_variant
rs1001377599 -- 28,342,696(+) G/A intron_variant
rs1001382808 -- 28,342,094(+) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP1 Gene

Variant ID Type Subtype PubMed ID
nsv2017 CNV insertion 18451855
nsv519388 CNV loss 19592680
nsv574653 CNV gain 21841781

Variation tolerance for TNFAIP1 Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFAIP1 Gene

Human Gene Mutation Database (HGMD)
TNFAIP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFAIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP1 Gene

Disorders for TNFAIP1 Gene

Additional Disease Information for TNFAIP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TNFAIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFAIP1 Gene

Publications for TNFAIP1 Gene

  1. CK2 phosphorylates TNFAIP1 to affect its subcellular localization and interaction with PCNA. (PMID: 19851886) Yang L … Zhang J (Molecular biology reports 2010) 3 4 58
  2. Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. (PMID: 19782033) Chen Y … Shao F (Molecular cell 2009) 3 4 58
  3. RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. (PMID: 19637314) Kim DM … Seo YS (International journal of cancer 2009) 3 4 58
  4. Joint effect of obesity and TNFA variability on asthma: two international cohort studies. (PMID: 19196817) Castro-Giner F … Probst-Hensch NM (The European respiratory journal 2009) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TNFAIP1 Gene

Sources for TNFAIP1 Gene

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