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This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [pro... See more...
Aliases for TNC Gene
Aliases for TNC Gene
External Ids for TNC Gene
- HGNC: 5318
- Entrez Gene: 3371
- Ensembl: ENSG00000041982
- OMIM: 187380
- UniProtKB: P24821
Previous HGNC Symbols for TNC Gene
- HXB
- DFNA56
Previous GeneCards Identifiers for TNC Gene
- GC09M108581
- GC09M109514
- GC09M111236
- GC09M113158
- GC09M113135
- GC09M114862
- GC09M116822
- GC09M117782
- GC09M087387
Summaries for TNC Gene
-
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
GeneCards Summary for TNC Gene
TNC (Tenascin C) is a Protein Coding gene. Diseases associated with TNC include Deafness, Autosomal Dominant 56 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are Neuroscience and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include syndecan binding. An important paralog of this gene is TNR.
UniProtKB/Swiss-Prot Summary for TNC Gene
-
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
Additional gene information for TNC Gene
- HGNC(5318)
- Entrez Gene(3371)
- Ensembl(ENSG00000041982)
- OMIM(187380)
- UniProtKB(P24821)
- Open Targets Platform(ENSG00000041982)
- Monarch Initiative
- Search for TNC at DataMed
- Search for TNC at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNC Gene
Genomics for TNC Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TNC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TNC on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNC
- Top Transcription factor binding sites by QIAGEN in the TNC gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- NF-kappaB1
- Sp1
- STAT3
Genomic Locations for TNC Gene
Genomic Locations for TNC Gene
- chr9:115,019,575-115,118,257
- (GRCh38/hg38)
- Size:
- 98,683 bases
- Orientation:
- Minus strand
- chr9:117,782,805-117,880,536
- (GRCh37/hg19)
- Size:
- 97,732 bases
- Orientation:
- Minus strand
Genomic View for TNC Gene
Genes around TNC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q33.1 by HGNC
- 9q33.1 by Entrez Gene
- 9q33.1 by Ensembl
TNC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNC Gene
Proteins for TNC Gene
-
Protein details for TNC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24821-TENA_HUMAN
- Recommended name:
- Tenascin
- Protein Accession:
- P24821
- C9IYT7
- C9J575
- C9J6D9
- C9J848
- Q14583
- Q15567
- Q5T7S3
Protein attributes for TNC Gene
- Size:
- 2201 amino acids
- Molecular mass:
- 240853 Da
- Quaternary structure:
-
- Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.
Three dimensional structures from OCA and Proteopedia for TNC Gene
Protein Expression for TNC Gene
Post-translational modifications for TNC Gene
-
Glycosylation at Asn38, Asn166, Asn184, Asn327, Asn788, Asn1018, Asn1034, Asn1079, Asn1445, Asn1455, Asn1093, Asn1119, Asn1485, Asn1534, Asn1809, Asn1184, Asn1210, Asn1261, Asn1275, Asn1301, Asn1366, Asn1392, and Asn2162
- NX_P24821 (NX_P24821-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- TENA_HUMAN (1792)
Other Protein References for TNC Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences TNC / Tenascin C Monoclonal Antibody and TNC / Tenascin C Antibody
- G Biosciences Immunotag™ TNC Antibody
- NSJ Bioreagents Tenascin C Antibody (Mouse Monoclonal)
- Creative Diagnostics Rabbit Anti-Human TNC monoclonal antibody, clone TV47-12
-
Creative Biolabs
- Recombinant Anti-Human TNC Antibody
- Anti-Human Tenascin C/TNC Therapeutic Antibody (Tenatumomab)
- Hi-Affi™ Recombinant Rabbit Anti-TNC Monoclonal Antibody (DS3601AB)
- Anti-Human Tenascin C Therapeutic Antibody Fab Fragment (4Al-Fl6)
- Anti-Human Tenascin C Therapeutic Antibody (B12)
- Mouse Anti-TNC Recombinant Antibody (CBYJT-3596)
- Mouse Anti-TNC Recombinant Antibody (DB7)
- Afuco™ Anti-TNC ADCC Theraputic Antibody (Tenatumomab), ADCC Enhanced
- Anti-Human Tenascin C Therapeutic Antibody scFv Fragment (D8)
- Recombinant Human Anti-TNC Antibody scFv Fragment (E10)
-
Custom Antibody ServicesOriGene Antibodies for TNC
- Novus Biologicals Antibodies for TNC
-
Abcam antibodies for TNC
- Invitrogen Antibodies for TNC (AFLGC-TNC)
- antibodies-online: Show 98 available TNC Antibodies ranked by validation data
- Compare Top TNC Antibodies
-
Recommended
- 124 WB Antibodies (anti-human)
- 66 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 21 IHC (f) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 5 EIA Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 35 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 7 IHC (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 47 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 7 IHC (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TNC
- Sino Biological Antibodies for TNC
Protein Products
- Creative Biomart Recombinant Human TNC
- Search Origene for MassSpec and Protein Over-expression Lysates for TNC
- Origene Custom Protein Services for TNC
- Novus Biologicals proteins for TNC
- antibodies-online: Show 15 available TNC Proteins ranked by validation data
- Compare Top TNC Proteins
-
Abcam proteins for TNC
Assay Products
- G Biosciences Immunotag™ Human TNC (Tenascin) ELISA and Immunotag™ Tenascin ELISA Kit
- RayBiotech Human Tenascin C ELISA
- Creative Diagnostics Tenascin-C Large (FNIII-C) ELISA Kit
-
Custom Assay ServicesOriGene ELISA Kits for TNC
- Novus Biologicals ELISA Kits for TNC
- antibodies-online: Show 84 available TNC Elisa Kits ranked by validation data
- Compare Top TNC Elisa Kits
-
Quality Products:
- ABIN415118
- ABIN1117366
- ABIN457079
- ABIN2859318
- ABIN5521693
- ABIN456536
- ABIN1029905
- ABIN5592702
- ABIN510595
- ABIN626598
- ABIN824973
- ABIN1117368
- ABIN773876
- ABIN6254454
- ABIN6208089
- ABIN6208090
- ABIN628239
- ABIN1161152
- ABIN6730987
- ABIN1117367
- ABIN431614
- ABIN5521694
- ABIN457268
- ABIN5670563
- ABIN1572780
- ABIN772542
- ABIN5659115
- ABIN2539415
- ABIN1567211
- ABIN6208080
- ABIN6208081
- ABIN6208082
- ABIN1059034
- ABIN1161151
-
Boster Bio ELISA Kits for TNC
-
Abcam assays for TNC
No data available for DME Specific Peptides for TNC Gene
Domains & Families for TNC Gene
Gene Families for TNC Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for TNC Gene
- InterPro:
- Blocks:
-
- Laminin-type EGF-like domain
- Type I EGF
- Fibrinogen, beta/gamma chain, C-terminal globular
- ProtoNet:
Suggested Antigen Peptide Sequences for TNC Gene
- GenScript: Design optimal peptide antigens:
-
- TNC protein (A7MBN2_HUMAN)
- Tenascin-C additional domain 1 (A9YUB8_HUMAN)
- Tenascin-C (TENA_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P24821- Family:
-
- Belongs to the tenascin family.
Function for TNC Gene
Molecular function for TNC Gene
- UniProtKB/Swiss-Prot Function:
- Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
- UniProtKB/Swiss-Prot Induction:
- By TGFB1.
Phenotypes From GWAS Catalog for TNC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005201 | extracellular matrix structural constituent | RCA | 20551380 |
| GO:0005515 | protein binding | IEA,IPI | 20979576 |
| GO:0045545 | syndecan binding | IDA | 8769660 |
Phenotypes for TNC Gene
- MGI mutant phenotypes for TNC:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TNC:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Increased cell death HMECs cells
- Decreased vaccinia virus (VACV) infection
- Increased viability (proliferation)
- Decreased shRNA abundance
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased transferrin (TF) endocytosis
- Decreased influenza A/WSN/33 replication
- Decreased IL-8 secretion
- Decreased ionizing radiation sensitivity
- Increased mitotic delay (prometaphase or metaphase alignment problems, MAP), dynamic nuclei (hole, folded or small irregular)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TNC - Select products 50% OFF >
- * TNC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TNC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNC
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNC
miRNA for TNC Gene
- miRTarBase miRNAs that target TNC
-
- hsa-miR-335-5p (MIRT000666)
- mmu-miR-758-3p (MIRT007596)
- mmu-miR-425-5p (MIRT008593)
- hsa-miR-20b-3p (MIRT784184)
- hsa-miR-3137 (MIRT784630)
- hsa-miR-3606-3p (MIRT784938)
- hsa-miR-3686 (MIRT785232)
- hsa-miR-4652-3p (MIRT786316)
- hsa-miR-4732-5p (MIRT786565)
- hsa-miR-4743-3p (MIRT786594)
- hsa-miR-513a-3p (MIRT787144)
- hsa-miR-513c-3p (MIRT787155)
- hsa-miR-6832-5p (MIRT789009)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNC
- Browse OriGene Inhibitory RNA Products For TNC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNC
Clone Products
- Applied Biological Materials (abm): Clones for TNC - Select products 50% OFF >
- * TNC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TNC
- Addgene plasmids for TNC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNC
Cell Line Products
-
Horizon Cell Lines for TNC
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNC Gene
Localization for TNC Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNC Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 4 |
| plasma membrane | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA,TAS | -- |
| GO:0005604 | basement membrane | IEA | -- |
| GO:0005614 | interstitial matrix | IEA | -- |
| GO:0005615 | extracellular space | HDA | 16502470 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNC Gene
Pathways & Interactions for TNC Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Integrin Pathway |
FAK1 Signaling
.67
Integrin Pathway
.67
GnRH Signaling
.56
|
UPA-UPAR Pathway
.56
Inhibition of Angiogenesis by TSP1
.50
Transendothelial Migration of Leukocytes
.38
|
| 2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 3 | ECM-receptor interaction | ||
| 4 | Focal Adhesion |
.61
|
.61
|
| 5 | PI3K-Akt signaling pathway | ||
Pathways by source for TNC Gene
5 BioSystems pathways for TNC Gene
5 Reactome pathways for TNC Gene
5 KEGG pathways for TNC Gene
1 GeneGo (Thomson Reuters) pathway for TNC Gene
- Cell adhesion_Cell-matrix glycoconjugates
13 Qiagen pathways for TNC Gene
- ERK Signaling
- FAK1 Signaling
- GnRH Signaling
- ILK Signaling
- Inhibition of Angiogenesis by TSP1
2 Cell Signaling Technology pathways for TNC Gene
Interacting Proteins for TNC Gene
Selected Interacting proteins:
P24821-TENA_HUMAN
ENSP00000265131
for TNC Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TNC
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001649 | osteoblast differentiation | HDA | 16210410 |
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007162 | negative regulation of cell adhesion | IEA | -- |
| GO:0007528 | neuromuscular junction development | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
No data available for SIGNOR curated interactions for TNC Gene
Drugs & Compounds for TNC Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| NEURADIAB | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Creative Biomart Recombinant Human TNC
Transcripts for TNC Gene
mRNA/cDNA for TNC Gene
- 1 REFSEQ mRNAs :
- 22 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000341037 6786 nts (view in UCSC)
- ENST00000350763 8500 nts (view in UCSC)
- ENST00000423613 6281 nts (view in UCSC)
- ENST00000460345 651 nts (view in UCSC)
- ENST00000473855 386 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TNC - Select products 50% OFF >
- * TNC CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TNC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNC
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNC
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNC
- Browse OriGene Inhibitory RNA Products For TNC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNC
Clone Products
- Applied Biological Materials (abm): Clones for TNC - Select products 50% OFF >
- * TNC as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TNC
- Addgene plasmids for TNC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNC
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - |
| ExUns: | 18c | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||
| SP9: |
Relevant External Links for TNC Gene
- GeneLoc Exon Structure for
- TNC
Expression for TNC Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Prechondrocytes Stylopod Epiphyseal End
- Intramembranous Preosteoblasts Membranous Facial Bones
- Prechondrocytes Rostral Synchondroses
- Intramembranous Osteoblasts Rostral Skull Membranous Bones
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Articular Cartilage Cells Zeugopod Articular Cartilage
- Articular Cartilage Cells Stylopod Articular Cartilage
- Prechondrocytes Stylopod Epiphyseal End
- Prechondrocytes Rostral Synchondroses
-
Neural Tube (Nervous System)
- Astrocyte Precursor Cells pV2 Neural Domain
- Astrocyte Precursor Cells Cortical Sub Ventricular Zone
- Adult Neural Stem Cells Cortical Sub Ventricular Zone
- Astrocyte Precursor Cells pV1 Neural Domain
- Bergmann Glia Precursor Cells Cerebellar Ventricular Zone
-
Brain (Nervous System)
- Bergmann Glia Purkinje Cell Layer
- Adult Neural Stem Cells Cortical Sub Ventricular Zone
- Neocortical Radial Glia Cells Cortical Sub Ventricular Zone
- Protoplasmic Astrocyte Cells Neocortex
- Cerebellum
-
Fibroblasts
- Dermal Fibroblasts Ventral Dermis
- Mature Cardiac Fibroblasts Myocardium
- Dermal Fibroblasts Cranial Dermis
- Cardiac Fibroblasts Myocardium
- Dermal Fibroblasts Dorsal Dermis
-
Heart (Cardiovascular System)
- Semilunar Valve Cells Semilunar Valves
- Mature Cardiac Fibroblasts Myocardium
- Cardiac Fibroblasts Myocardium
- Heart Tube
- Outflow Tract
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Autopod
- Mesenchymal Condensate Cells Stylopod
- Mesenchymal Condensate Cells Zeugopod
- Autopod
-
Dermis (Integumentary System)
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
- Detroit 551
-
Tendon & Ligament (Muscoskeletal System)
- Tenocytes Limb Tendons and Ligaments
- Early Tenocyte Cells Axial Tendon Primordia
- Tenocytes Axial Tendons and Ligamnets
- Early Tenocyte Cells Limb Tendon Primordia
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Dental Mesenchymal Cells Branchial Arch 1
- Stellate Reticulum Cells Dental Core
- Dentin
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Basal Keratinocytes Embryonic Epidermis
- Immortalized hair follicle stem cells
-
Glial Cells
- Bergmann Glia Purkinje Cell Layer
- Protoplasmic Astrocyte Cells Neocortex
- Oligodendrocyte-like cells(Najm FJ et. al. 2011)
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Basal Keratinocytes Embryonic Epidermis
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
- Schwann Precursor Cells Peripheral Nerve Domain
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
- Prechondrocytes Branchial Arch 2
- Inner Cell Mass (Early Embryonic Tissues)
- NULL (Uncategorized)
- Spinal Cord (Nervous System)
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
- Thymus (Hematopoietic System)
- Mesenchymal Stem Cells
- Mesoderm (Gastrulation Derivatives)
- Neural Crest (Gastrulation Derivatives)
- Oligodendrocytes (Nervous System)
- Endoderm (Gastrulation Derivatives)
- Adipose (Muscoskeletal System)
- Primitive Streak (Early Embryonic Tissues)
-
Uterus (Reproductive System)
-
Larynx (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for TNC Gene
This gene is overexpressed in Artery - Tibial (x11.4) and Colon - Sigmoid (x5.9).
This gene is overexpressed in Bone marrow mesenchymal stem cell (43.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNC Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNC
SOURCE GeneReport for Unigene cluster for TNC Gene:
Hs.143250Evidence on tissue expression from TISSUES for TNC Gene
- Nervous system(4.9)
- Liver(4.6)
- Bone marrow(4.2)
- Intestine(4)
- Lung(4)
- Kidney(3.5)
- Bone(3.4)
- Gall bladder(3.2)
- Skin(3)
- Heart(2.8)
- Adrenal gland(2.7)
- Eye(2.4)
- Muscle(2.3)
- Blood(2.3)
- Spleen(2.3)
- Lymph node(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TNC Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
Regions:
Head and neck:
- brain
- cerebellum
- cranial nerve
- ear
- head
- inner ear
- middle ear
- outer ear
Thorax:
- heart
- heart valve
Limb:
- forearm
General:
- peripheral nerve
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for TNC
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TNC Gene
Orthologs for TNC Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TNC 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TNC 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TNC 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tnc 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tnc 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TNC 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TNC 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TNC 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TNC 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tnc 30 |
|
||
| Str.15574 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24480 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tnc 31 |
|
OneToMany | |
| LOC100149028 30 |
|
||||
| CABZ01048373.1 31 |
|
OneToMany | |||
| tenc 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4969 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG5550 32 |
|
|
|
| CG1791 32 |
|
|
|||
| CG30280 32 |
|
|
|||
| CG30281 32 |
|
|
|||
| BG:DS00180.10 32 |
|
|
|||
| BG:DS00180.14 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for TNC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TNC Gene
- ENSEMBL:
- Gene Tree for TNC (if available)
- TreeFam:
- Gene Tree for TNC (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TNC: view image
Paralogs for TNC Gene
Paralogs for TNC Gene
(17) SIMAP similar genes for TNC Gene using alignment to 8 proteins:
- TENA_HUMAN
- A7MBN2_HUMAN
- A9YUB8_HUMAN
- E9PC84_HUMAN
- F5H5D6_HUMAN
- F5H7V9_HUMAN
- H0YGZ3_HUMAN
- J3QSU6_HUMAN
Pseudogenes.org Pseudogenes for TNC Gene
Variants for TNC Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNC Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 637026 | Uncertain Significance: Deafness, autosomal dominant 56 | 115,023,974(-) | T/C | MISSENSE_VARIANT | |
| 689600 | Likely Benign: Deafness, autosomal dominant 56 | 115,081,836(-) | C/A | MISSENSE_VARIANT | |
| 709861 | Benign: not provided | 115,063,845(-) | C/T | SYNONYMOUS_VARIANT | |
| 716393 | Benign: not provided | 115,064,848(-) | C/T | MISSENSE_VARIANT | |
| 719962 | Likely Benign: not provided | 115,090,931(-) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4130n106 | CNV | deletion | 24896259 |
| esv1008522 | CNV | deletion | 20482838 |
| esv1713245 | CNV | deletion | 17803354 |
| esv21967 | CNV | gain | 19812545 |
| esv2422541 | CNV | deletion | 19546169 |
| esv2738965 | CNV | deletion | 23290073 |
| esv2738966 | CNV | deletion | 23290073 |
| esv2738967 | CNV | deletion | 23290073 |
| esv3545358 | CNV | deletion | 23714750 |
| esv3825 | CNV | loss | 18987735 |
| nsv1076200 | CNV | deletion | 25765185 |
| nsv1121699 | CNV | deletion | 24896259 |
| nsv1144289 | CNV | deletion | 24896259 |
| nsv1152680 | CNV | deletion | 26484159 |
| nsv519131 | CNV | loss | 19592680 |
| nsv615250 | CNV | loss | 21841781 |
| nsv7434 | OTHER | inversion | 18451855 |
| nsv831696 | CNV | gain | 17160897 |
| nsv831697 | CNV | loss | 17160897 |
| nsv957714 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
19.84;
98.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TNC Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNC Gene
Disorders for TNC Gene
(17) MalaCards diseases for TNC Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal dominant 56 |
|
|
| autosomal dominant non-syndromic sensorineural deafness type dfna |
|
|
| bullous keratopathy |
|
|
| acute myocarditis |
|
|
| juvenile pilocytic astrocytoma |
|
Search TNC in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TENA_HUMAN- Deafness, autosomal dominant, 56 (DFNA56) [MIM:615629]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with post-lingual onset. {ECO:0000269 PubMed:23936043}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for TNC
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for TNC Gene
Publications for TNC Gene
- Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies. (PMID: 1707164) Siri A … Zardi L (Nucleic acids research 1991) 2 3 4 23
- Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss. (PMID: 23936043) Zhao Y … Wang Q (PloS one 2013) 2 3 4
- Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls. (PMID: 18353721) Posthumus M … Collins M (Journal of science and medicine in sport 2009) 3 23 41
- Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences. (PMID: 7531707) Gherzi R … Zardi L (The Journal of biological chemistry 1995) 3 4 23
- The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats. (PMID: 1704365) Nies DE … Stefansson K (The Journal of biological chemistry 1991) 2 3 4
ExternalLinks
Products for TNC Gene
- View all 9 R&D Systems TNC (Tenascin C) Products
- View all R&D Systems TNC (Tenascin C) Proteins and Enzymes
- View all 5 R&D Systems TNC (Tenascin C) Primary Antibodies
- View all R&D Systems TNC (Tenascin C) Luminex Assays
- View all R&D Systems TNC (Tenascin C) Proteome Profiler Antibody Arrays
- View all R&D Systems TNC (Tenascin C) cDNA Clones
- Learn more about R&D Systems custom TNC antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for TNC
- Custom Assay ServicesOriGene ELISA Kits for TNC
- Search Origene for MassSpec and Protein Over-expression Lysates for TNC
- Origene Custom Protein Services for TNC
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNC
- Browse OriGene Inhibitory RNA Products For TNC
- OriGene qPCR primer pairs for TNC
- OriGene CRISPR knockouts for TNC
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TNC
- Sino Biological Human cDNA Clone for TNC
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for TNC
- Browse Sino Biological Assays
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TNC
- Novus Biologicals proteins for TNC
- Novus Biologicals ELISA Kits for TNC
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TNC
- Abcam proteins for TNC
- Abcam assays for TNC
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- Browse Primary Antibodies
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- Browse Proteins and Peptides
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- VectorBuilder Custom and pre-made DNA vectors for TNC (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TNC (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TNC (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TNC CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TNC
- Addgene plasmids for TNC
- antibodies-online: Show 98 available TNC Antibodies ranked by validation data
- Compare Top TNC Antibodies
- Recommended
- 124 WB Antibodies (anti-human)
- 66 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 21 IHC (f) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 5 EIA Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 35 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 7 IHC (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 47 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 7 IHC (p) Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- antibodies-online: Show 84 available TNC Elisa Kits ranked by validation data
- Compare Top TNC Elisa Kits
- Quality Products:
- ABIN415118
- ABIN1117366
- ABIN457079
- ABIN2859318
- ABIN5521693
- ABIN456536
- ABIN1029905
- ABIN5592702
- ABIN510595
- ABIN626598
- ABIN824973
- ABIN1117368
- ABIN773876
- ABIN6254454
- ABIN6208089
- ABIN6208090
- ABIN628239
- ABIN1161152
- ABIN6730987
- ABIN1117367
- ABIN431614
- ABIN5521694
- ABIN457268
- ABIN5670563
- ABIN1572780
- ABIN772542
- ABIN5659115
- ABIN2539415
- ABIN1567211
- ABIN6208080
- ABIN6208081
- ABIN6208082
- ABIN1059034
- ABIN1161151
- antibodies-online: Show 15 available TNC Proteins ranked by validation data
- Compare Top TNC Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TNC
- Search Santa Cruz Biotechnology (SCBT) for TNC siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TNC
- Horizon Cell Lines for TNC
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNC
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TNC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNC
Sources for TNC Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB