This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [pro... See more...

Aliases for TNC Gene

Aliases for TNC Gene

  • Tenascin C 2 3 5
  • TN 2 3 4
  • Glioma-Associated-Extracellular Matrix Antigen 3 4
  • Deafness, Autosomal Dominant 56 2 3
  • Hexabrachion (Tenascin) 2 3
  • Myotendinous Antigen 3 4
  • Neuronectin 3 4
  • GP 150-225 3 4
  • Cytotactin 3 4
  • Tenascin 3 4
  • GMEM 3 4
  • TN-C 3 4
  • HXB 3 4
  • JI 3 4
  • Hexabrachion (Tenascin C, Cytotactin) 2
  • Tenascin-C Additional Domain 1 3
  • Hexabrachion 4
  • Tenascin-C 4
  • MGC167029 2
  • 150-225 3
  • DFNA56 3
  • TNC 5
  • GP 3

External Ids for TNC Gene

Previous HGNC Symbols for TNC Gene

  • HXB
  • DFNA56

Previous GeneCards Identifiers for TNC Gene

  • GC09M108581
  • GC09M109514
  • GC09M111236
  • GC09M113158
  • GC09M113135
  • GC09M114862
  • GC09M116822
  • GC09M117782
  • GC09M087387

Summaries for TNC Gene

Entrez Gene Summary for TNC Gene

  • This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

GeneCards Summary for TNC Gene

TNC (Tenascin C) is a Protein Coding gene. Diseases associated with TNC include Deafness, Autosomal Dominant 56 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are MET promotes cell motility and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include syndecan binding. An important paralog of this gene is TNR.

UniProtKB/Swiss-Prot Summary for TNC Gene

  • Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).

Gene Wiki entry for TNC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNC Gene

Genomics for TNC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TNC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J115114 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 263.9 +1.4 1441 5.6 ZNF600 JUND ZNF580 ZNF10 ZIC2 CEBPB FEZF1 ZNF639 ZNF341 ZEB1 TNC DELEC1 LOC101928748 FJ601676 TNFSF8
GH09J115202 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.4 -90.1 -90144 12.8 BCLAF1 ZNF600 JUND ATF2 POLR2A BCL11A CEBPB TRIM22 FEZF1 EP300 TNC DELEC1 TNFSF15 piR-57137-024 LOC105376233 PAPPA
GH09J115104 Enhancer 1 Ensembl ENCODE dbSUPER 15 +12.1 12056 4 JUND CEBPA YY1 FOXA2 MAFF RXRA ZNF316 ZBTB33 MAFK ZBTB40 TNC DELEC1 FJ601676 TNFSF8
GH09J115169 Enhancer 0.9 Ensembl ENCODE dbSUPER 15.5 -52.4 -52440 1.8 MAFF MAFK JUND TRIM28 POU5F1 NANOG FOS RFX5 DELEC1 TNC HSALNG0073940 piR-57137-024 PAPPA
GH09J115004 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +110.2 110157 7.4 JUND CEBPB RAD21 SMC3 STAT3 MAFK ZNF362 MAFF ZNF140 HLF lnc-DEC1-9 piR-50443-386 TNFSF8 TNFSF15 TNC ATP6V1G1 WHRN DELEC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNC

Top Transcription factor binding sites by QIAGEN in the TNC gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • NF-kappaB1
  • Sp1
  • STAT3

Genomic Locations for TNC Gene

Latest Assembly
chr9:115,019,575-115,118,257
(GRCh38/hg38)
Size:
98,683 bases
Orientation:
Minus strand

Previous Assembly
chr9:117,781,854-117,880,436
(GRCh37/hg19 by Entrez Gene)
Size:
98,583 bases
Orientation:
Minus strand

chr9:117,782,806-117,880,536
(GRCh37/hg19 by Ensembl)
Size:
97,731 bases
Orientation:
Minus strand

Genomic View for TNC Gene

Genes around TNC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNC Gene

Proteins for TNC Gene

  • Protein details for TNC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24821-TENA_HUMAN
    Recommended name:
    Tenascin
    Protein Accession:
    P24821
    Secondary Accessions:
    • C9IYT7
    • C9J575
    • C9J6D9
    • C9J848
    • Q14583
    • Q15567
    • Q5T7S3

    Protein attributes for TNC Gene

    Size:
    2201 amino acids
    Molecular mass:
    240853 Da
    Quaternary structure:
    • Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.

    Three dimensional structures from OCA and Proteopedia for TNC Gene

    Alternative splice isoforms for TNC Gene

neXtProt entry for TNC Gene

Post-translational modifications for TNC Gene

  • Glycosylation at Asn38, Asn166, Asn184, Asn327, Asn788, Asn1018, Asn1034, Asn1079, Asn1445, Asn1455, Asn1093, Asn1119, Asn1485, Asn1534, Asn1809, Asn1184, Asn1210, Asn1261, Asn1275, Asn1301, Asn1366, Asn1392, and Asn2162
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Antibodies for research

No data available for DME Specific Peptides for TNC Gene

Domains & Families for TNC Gene

Gene Families for TNC Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TNC Gene

InterPro:
Blocks:
  • Laminin-type EGF-like domain
  • Type I EGF
  • Fibrinogen, beta/gamma chain, C-terminal globular

Suggested Antigen Peptide Sequences for TNC Gene

GenScript: Design optimal peptide antigens:
  • TNC protein (A7MBN2_HUMAN)
  • Tenascin-C additional domain 1 (A9YUB8_HUMAN)
  • Tenascin-C (TENA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P24821

UniProtKB/Swiss-Prot:

TENA_HUMAN :
  • Belongs to the tenascin family.
Family:
  • Belongs to the tenascin family.
genes like me logo Genes that share domains with TNC: view

Function for TNC Gene

Molecular function for TNC Gene

UniProtKB/Swiss-Prot Function:
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
UniProtKB/Swiss-Prot Induction:
By TGFB1.

Phenotypes From GWAS Catalog for TNC Gene

Gene Ontology (GO) - Molecular Function for TNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent RCA 20551380
GO:0005515 protein binding IEA,IPI 20979576
GO:0045545 syndecan binding IDA 8769660
genes like me logo Genes that share ontologies with TNC: view
genes like me logo Genes that share phenotypes with TNC: view

Human Phenotype Ontology for TNC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TNC Gene

MGI Knock Outs for TNC:
  • Tnc Tnc<tm1Ref>
  • Tnc Tnc<tm1Sia>
  • Tnc Tnc<tm1Msch>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNC

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNC Gene

Localization for TNC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNC Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNC gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA,TAS --
GO:0005604 basement membrane IEA --
GO:0005614 interstitial matrix IEA --
GO:0005615 extracellular space HDA 16502470
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with TNC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNC Gene

Pathways & Interactions for TNC Gene

PathCards logo

SuperPathways for TNC Gene

SuperPathway Contained pathways
1 Integrin Pathway
.67
.67
.56
.56
.50
.38
2 ERK Signaling
.61
.61
.58
.51
.49
3 ECM-receptor interaction
4 Focal Adhesion
5 PI3K-Akt signaling pathway
genes like me logo Genes that share pathways with TNC: view

Pathways by source for TNC Gene

1 GeneGo (Thomson Reuters) pathway for TNC Gene
  • Cell adhesion_Cell-matrix glycoconjugates
13 Qiagen pathways for TNC Gene
  • ERK Signaling
  • FAK1 Signaling
  • GnRH Signaling
  • ILK Signaling
  • Inhibition of Angiogenesis by TSP1
2 Cell Signaling Technology pathways for TNC Gene

SIGNOR curated interactions for TNC Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TNC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation HDA 16210410
GO:0007155 cell adhesion IEA --
GO:0007162 negative regulation of cell adhesion IEA --
GO:0007528 neuromuscular junction development IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with TNC: view

Drugs & Compounds for TNC Gene

(20) Drugs for TNC Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Neuradiab Investigational Pharma 0

(22) Additional Compounds for TNC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNC: view

Transcripts for TNC Gene

mRNA/cDNA for TNC Gene

1 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNC

Alternative Splicing Database (ASD) splice patterns (SP) for TNC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ·
SP1: -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7:
SP8: -
SP9: - - - - - - - -

ExUns: 18c ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TNC Gene

GeneLoc Exon Structure for
TNC

Expression for TNC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNC Gene

This gene is overexpressed in Artery - Tibial (x11.4) and Colon - Sigmoid (x5.9).

Protein differential expression in normal tissues from HIPED for TNC Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (43.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNC Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNC

SOURCE GeneReport for Unigene cluster for TNC Gene:

Hs.143250

Evidence on tissue expression from TISSUES for TNC Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Bone marrow(4.2)
  • Intestine(3.9)
  • Lung(3.7)
  • Gall bladder(3.2)
  • Bone(3.2)
  • Kidney(3)
  • Adrenal gland(2.7)
  • Skin(2.6)
  • Heart(2.6)
  • Muscle(2.1)
  • Eye(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TNC Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • head
  • inner ear
  • middle ear
  • outer ear
Thorax:
  • heart
  • heart valve
Limb:
  • forearm
General:
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with TNC: view

Primer products for research

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TNC Gene

Orthologs for TNC Gene

This gene was present in the common ancestor of animals.

Orthologs for TNC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TNC 29 30
  • 99.21 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TNC 29 30
  • 87.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TNC 30
  • 85 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Tnc 29 16 30
  • 74.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tnc 29
  • 73.97 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TNC 30
  • 72 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TNC 30
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TNC 29 30
  • 62.98 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TNC 30
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tnc 29
  • 58.62 (n)
Str.15574 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.24480 29
Zebrafish
(Danio rerio)
Actinopterygii tnc 30
  • 55 (a)
OneToMany
LOC100149028 29
  • 54.7 (n)
CABZ01048373.1 30
  • 45 (a)
OneToMany
tenc 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4969 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG5550 31
  • 43 (a)
CG1791 31
  • 40 (a)
CG30280 31
  • 39 (a)
CG30281 31
  • 39 (a)
BG:DS00180.10 31
  • 31 (a)
BG:DS00180.14 31
  • 28 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 38 (a)
OneToMany
Species where no ortholog for TNC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TNC Gene

ENSEMBL:
Gene Tree for TNC (if available)
TreeFam:
Gene Tree for TNC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNC: view image
Alliance of Genome Resources:
Additional Orthologs for TNC

Paralogs for TNC Gene

(17) SIMAP similar genes for TNC Gene using alignment to 8 proteins:

  • TENA_HUMAN
  • A7MBN2_HUMAN
  • A9YUB8_HUMAN
  • E9PC84_HUMAN
  • F5H5D6_HUMAN
  • F5H7V9_HUMAN
  • H0YGZ3_HUMAN
  • J3QSU6_HUMAN

Pseudogenes.org Pseudogenes for TNC Gene

genes like me logo Genes that share paralogs with TNC: view

Variants for TNC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNC Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
1029564 Uncertain Significance: Deafness, autosomal dominant 56 115,086,151(-) C/G
NM_002160.4(TNC):c.1580G>C (p.Cys527Ser)
MISSENSE
1029565 Uncertain Significance: Deafness, autosomal dominant 56 115,082,700(-) G/A
NM_002160.4(TNC):c.2239C>T (p.Arg747Trp)
MISSENSE
1033486 Uncertain Significance: Deafness, autosomal dominant 56 115,076,455(-) C/G
NM_002160.4(TNC):c.2795G>C (p.Gly932Ala)
MISSENSE
930251 Uncertain Significance: Deafness, autosomal dominant 56 115,021,284(-) AG/A
NM_002160.4(TNC):c.6496-18del
INTRON
987789 Uncertain Significance: not specified 115,035,248(-) T/C
NM_002160.4(TNC):c.5743A>G (p.Thr1915Ala)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TNC Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TNC Gene

Variant ID Type Subtype PubMed ID
dgv4130n106 CNV deletion 24896259
esv1008522 CNV deletion 20482838
esv1713245 CNV deletion 17803354
esv21967 CNV gain 19812545
esv2422541 CNV deletion 19546169
esv2738965 CNV deletion 23290073
esv2738966 CNV deletion 23290073
esv2738967 CNV deletion 23290073
esv3545358 CNV deletion 23714750
esv3825 CNV loss 18987735
nsv1076200 CNV deletion 25765185
nsv1121699 CNV deletion 24896259
nsv1144289 CNV deletion 24896259
nsv1152680 CNV deletion 26484159
nsv519131 CNV loss 19592680
nsv615250 CNV loss 21841781
nsv7434 OTHER inversion 18451855
nsv831696 CNV gain 17160897
nsv831697 CNV loss 17160897
nsv957714 CNV deletion 24416366

Variation tolerance for TNC Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.84; 98.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNC Gene

Human Gene Mutation Database (HGMD)
TNC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNC
Leiden Open Variation Database (LOVD)
TNC

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNC Gene

Disorders for TNC Gene

MalaCards: The human disease database

(15) MalaCards diseases for TNC Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
deafness, autosomal dominant 56
  • dfna56
autosomal dominant non-syndromic sensorineural deafness type dfna
  • autosomal dominant isolated neurosensory deafness type dfna
bullous keratopathy
tarsal tunnel syndrome
  • neuropathy of the posterior tibial nerve and its branches
tibial neuropathy
  • posterior tibial neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search TNC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TENA_HUMAN
  • Deafness, autosomal dominant, 56 (DFNA56) [MIM:615629]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with post-lingual onset. {ECO:0000269 PubMed:23936043}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for TNC

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TNC: view

No data available for Genatlas for TNC Gene

Publications for TNC Gene

  1. Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss. (PMID: 23936043) Zhao Y … Wang Q (PloS one 2013) 2 3 4 72
  2. Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies. (PMID: 1707164) Siri A … Zardi L (Nucleic acids research 1991) 2 3 4 22
  3. Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls. (PMID: 18353721) Posthumus M … Collins M (Journal of science and medicine in sport 2009) 3 22 40
  4. Human tenascin gene. Structure of the 5'-region, identification, and characterization of the transcription regulatory sequences. (PMID: 7531707) Gherzi R … Zardi L (The Journal of biological chemistry 1995) 3 4 22
  5. The complete cDNA sequence of human hexabrachion (Tenascin). A multidomain protein containing unique epidermal growth factor repeats. (PMID: 1704365) Nies DE … Stefansson K (The Journal of biological chemistry 1991) 2 3 4

Products for TNC Gene

  • Addgene plasmids for TNC

Sources for TNC Gene