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Aliases for TMX2-CTNND1 Gene

Subcategory (RNA class) for TMX2-CTNND1 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for TMX2-CTNND1 Gene

  • TMX2-CTNND1 Readthrough (NMD Candidate) 2 3 5

External Ids for TMX2-CTNND1 Gene

Previous GeneCards Identifiers for TMX2-CTNND1 Gene

  • GC11U901785
  • GC11P057482
  • GC11P057486

Summaries for TMX2-CTNND1 Gene

Entrez Gene Summary for TMX2-CTNND1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring TMX2 (thioredoxin-related transmembrane protein 2) and CTNND1 (catenin, cadherin-associated protein, delta 1) genes on chromosome 11. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. [provided by RefSeq, Dec 2010]

GeneCards Summary for TMX2-CTNND1 Gene

TMX2-CTNND1 (TMX2-CTNND1 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. An important paralog of this gene is TMX2.

Additional gene information for TMX2-CTNND1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMX2-CTNND1 Gene

Genomics for TMX2-CTNND1 Gene

GeneHancer (GH) Regulatory Elements for TMX2-CTNND1 Gene

Promoters and enhancers for TMX2-CTNND1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I057710 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.0 36 3.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B MED19 TMX2 TMX2-CTNND1 PIR45741 SSRP1 ZFP91 ENSG00000269570 YPEL4 SELENOH ENSG00000254732
GH11I057740 Promoter/Enhancer 1.6 Ensembl ENCODE 0.3 +29.4 29366 2.7 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D GC11M057740 GC11P057750 PIR53867 SELENOH GC11P057749 ENSG00000254732 CLP1 MED19 ENSG00000269570 SSRP1
GH11I057774 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.2 +69.4 69418 16 PKNOX1 FOXA2 SMAD1 MLX SIN3A FEZF1 FOS SP5 NFYC JUNB CTNND1 YPEL4 TIMM10 MED19 SELENOH BTBD18 ENSG00000254732 CLP1 ENSG00000254602 SMTNL1
GH11I057760 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 0.2 +50.9 50937 5.3 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 CTNND1 MED19 YPEL4 ENSG00000254732 SELENOH UBE2L6 SMTNL1 BTBD18 PIR53177 TMX2-CTNND1
GH11I057751 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 0.3 +39.3 39293 0.7 SOX13 CTCF TEAD4 ARID4B ZNF48 RAD21 GATA3 ZNF143 SMC3 MIXL1 BTBD18 CTNND1 PIR32204 ENSG00000254732 TMX2-CTNND1 GC11P057680
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMX2-CTNND1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMX2-CTNND1 Gene

Genomic Locations for TMX2-CTNND1 Gene
chr11:57,712,523-57,819,180
(GRCh38/hg38)
Size:
106,658 bases
Orientation:
Plus strand
chr11:57,479,995-57,586,652
(GRCh37/hg19)

Genomic View for TMX2-CTNND1 Gene

Genes around TMX2-CTNND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMX2-CTNND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMX2-CTNND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMX2-CTNND1 Gene

Proteins for TMX2-CTNND1 Gene

  • Protein details for TMX2-CTNND1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BSU7
    Recommended name:
    TMX2-CTNND1 readthrough (NMD candidate)
    Protein Accession:
    H3BSU7

    Protein attributes for TMX2-CTNND1 Gene

    Size:
    103 amino acids
    Molecular mass:
    11615 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMX2-CTNND1 Gene

Post-translational modifications for TMX2-CTNND1 Gene

No Post-translational modifications

Other Protein References for TMX2-CTNND1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TMX2-CTNND1 Gene

Domains & Families for TMX2-CTNND1 Gene

Protein Domains for TMX2-CTNND1 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMX2-CTNND1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMX2-CTNND1 Gene

Function for TMX2-CTNND1 Gene

Phenotypes From GWAS Catalog for TMX2-CTNND1 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMX2-CTNND1 Gene

Localization for TMX2-CTNND1 Gene

Gene Ontology (GO) - Cellular Components for TMX2-CTNND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMX2-CTNND1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMX2-CTNND1 Gene

Pathways & Interactions for TMX2-CTNND1 Gene

SuperPathways for TMX2-CTNND1 Gene

No Data Available

Interacting Proteins for TMX2-CTNND1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000456881%0d%0a9606.ENSP00000356231%0d%0a
Selected Interacting proteins: ENSP00000456881 for TMX2-CTNND1 Gene via STRING

Symbol External ID(s) Details
RABIF

Gene Ontology (GO) - Biological Process for TMX2-CTNND1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMX2-CTNND1 Gene

Drugs & Compounds for TMX2-CTNND1 Gene

No Compound Related Data Available

Transcripts for TMX2-CTNND1 Gene

mRNA/cDNA for TMX2-CTNND1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMX2-CTNND1 Gene

No ASD Table

Relevant External Links for TMX2-CTNND1 Gene

GeneLoc Exon Structure for
TMX2-CTNND1
ECgene alternative splicing isoforms for
TMX2-CTNND1

Expression for TMX2-CTNND1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMX2-CTNND1 Gene

genes like me logo Genes that share expression patterns with TMX2-CTNND1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMX2-CTNND1 Gene

Orthologs for TMX2-CTNND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMX2-CTNND1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 28 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 13 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmx2b 34
  • 20 (a)
ManyToMany
tmx2a 34
  • 18 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11007 34
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35D10.10 34
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5859 34
  • 12 (a)
OneToMany
Species where no ortholog for TMX2-CTNND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMX2-CTNND1 Gene

ENSEMBL:
Gene Tree for TMX2-CTNND1 (if available)
TreeFam:
Gene Tree for TMX2-CTNND1 (if available)

Paralogs for TMX2-CTNND1 Gene

Paralogs for TMX2-CTNND1 Gene

(1) SIMAP similar genes for TMX2-CTNND1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMX2-CTNND1: view

Variants for TMX2-CTNND1 Gene

Sequence variations from dbSNP and Humsavar for TMX2-CTNND1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs750470937 uncertain-significance, Abnormality of neuronal migration 57,737,988(+) A/G intron_variant
rs759161110 uncertain-significance, Abnormality of neuronal migration 57,739,207(+) C/A/T intron_variant
rs1000033039 -- 57,722,793(+) G/A intron_variant
rs1000045935 -- 57,765,062(+) C/T intron_variant
rs1000050338 -- 57,795,807(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMX2-CTNND1 Gene

Variant ID Type Subtype PubMed ID
esv2668702 CNV deletion 23128226
esv3579728 CNV loss 25503493
esv3626507 CNV loss 21293372
nsv1070037 CNV deletion 25765185
nsv1070457 CNV deletion 25765185
nsv1136036 CNV deletion 24896259
nsv1138036 CNV deletion 24896259
nsv1153289 CNV deletion 26484159
nsv326 CNV insertion 18451855
nsv327 CNV deletion 18451855
nsv508633 CNV deletion 20534489
nsv832163 CNV gain 17160897
nsv832164 CNV loss 17160897
nsv952454 CNV deletion 24416366
nsv975188 CNV duplication 23825009
nsv975931 CNV duplication 23825009

Additional Variant Information for TMX2-CTNND1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMX2-CTNND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TMX2-CTNND1 Gene

Disorders for TMX2-CTNND1 Gene

Additional Disease Information for TMX2-CTNND1

No disorders were found for TMX2-CTNND1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMX2-CTNND1 Gene

Publications for TMX2-CTNND1 Gene

  1. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  3. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for TMX2-CTNND1 Gene

Sources for TMX2-CTNND1 Gene

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