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Aliases for TMUB2 Gene

Aliases for TMUB2 Gene

  • Transmembrane And Ubiquitin Like Domain Containing 2 2 3 5
  • Transmembrane And Ubiquitin-Like Domain-Containing Protein 2 3
  • Transmembrane And Ubiquitin-Like Domain Containing 2 2
  • FP2653 3

External Ids for TMUB2 Gene

Previous GeneCards Identifiers for TMUB2 Gene

  • GC17P039620
  • GC17P042264
  • GC17P038028

Summaries for TMUB2 Gene

GeneCards Summary for TMUB2 Gene

TMUB2 (Transmembrane And Ubiquitin Like Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is TMUB1.

Gene Wiki entry for TMUB2 Gene

Additional gene information for TMUB2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMUB2 Gene

Genomics for TMUB2 Gene

GeneHancer (GH) Regulatory Elements for TMUB2 Gene

Promoters and enhancers for TMUB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J044185 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 681 +0.0 34 3.7 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A ZNF2 IRF4 YY1 ASB16-AS1 TMUB2 PIR42921 LSM12 DHX8 EFTUD2 UBTF ASB16 GPATCH8 ENSG00000224505
GH17J045143 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 139.5 +961.0 960978 9.6 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 HEXIM1 GC17M045149 ENSG00000276728 ENSG00000262372 ASB16-AS1 UBTF TMUB2 ENSG00000224505 LINC02210 EFTUD2
GH17J043322 Enhancer 1.5 Ensembl ENCODE dbSUPER 152.9 -863.8 -863806 1.6 CLOCK MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 UBTF ASB16-AS1 ENSG00000267340 DHX8 ENSG00000267002 HMGN1P29 TMUB2 NBR2 LINC00910 PLEKHH3
GH17J044707 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 67.7 +521.7 521698 2.3 FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 SSRP1 ZNF610 NBN NR2C1 DBF4B TMUB2 ASB16-AS1 UBTF ENSG00000224505 EFTUD2 C17orf53 HEXIM1 MAP3K14-AS1 MAP3K14
GH17J043366 Enhancer 1.5 Ensembl ENCODE dbSUPER 69.4 -818.3 -818255 4 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC LOC105371785 DHX8 NBR2 HMGN1P29 ASB16-AS1 LINC00910 TMUB2 UBTF PSME3 ENSG00000267340
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMUB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMUB2 gene promoter:
  • E2F
  • Sp1
  • RSRFC4
  • Pax-5
  • E2F-1
  • E2F-2

Genomic Locations for TMUB2 Gene

Genomic Locations for TMUB2 Gene
4,763 bases
Plus strand
4,762 bases
Plus strand

Genomic View for TMUB2 Gene

Genes around TMUB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMUB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMUB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMUB2 Gene

Proteins for TMUB2 Gene

  • Protein details for TMUB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane and ubiquitin-like domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B3KU81
    • Q8NDI2
    • Q9BPZ5
    • Q9HAG3

    Protein attributes for TMUB2 Gene

    321 amino acids
    Molecular mass:
    33788 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMUB2 Gene


neXtProt entry for TMUB2 Gene

Post-translational modifications for TMUB2 Gene

  • Ubiquitination at posLast=212212, isoforms=2, 3179, and posLast=145145
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMUB2 Gene

Domains & Families for TMUB2 Gene

Gene Families for TMUB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMUB2 Gene

Suggested Antigen Peptide Sequences for TMUB2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMUB2: view

No data available for UniProtKB/Swiss-Prot for TMUB2 Gene

Function for TMUB2 Gene

Phenotypes From GWAS Catalog for TMUB2 Gene

Gene Ontology (GO) - Molecular Function for TMUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMUB2: view
genes like me logo Genes that share phenotypes with TMUB2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMUB2

miRNA for TMUB2 Gene

miRTarBase miRNAs that target TMUB2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMUB2 Gene

Localization for TMUB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMUB2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMUB2 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMUB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMUB2: view

Pathways & Interactions for TMUB2 Gene

SuperPathways for TMUB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMUB2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMUB2 Gene

Drugs & Compounds for TMUB2 Gene

No Compound Related Data Available

Transcripts for TMUB2 Gene

Unigene Clusters for TMUB2 Gene

Transmembrane and ubiquitin-like domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMUB2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - -
SP7: -
SP9: - -
SP10: -
SP12: - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - -
SP15: -
SP16: - -
SP17: - - - - -
SP18: - - -

Relevant External Links for TMUB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMUB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMUB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMUB2 Gene

This gene is overexpressed in Breast (41.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMUB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMUB2 Gene:


SOURCE GeneReport for Unigene cluster for TMUB2 Gene:


Evidence on tissue expression from TISSUES for TMUB2 Gene

  • Nervous system(4.6)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with TMUB2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMUB2 Gene

Orthologs for TMUB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMUB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMUB2 34 33
  • 99.58 (n)
(Canis familiaris)
Mammalia TMUB2 34 33
  • 93.04 (n)
(Bos Taurus)
Mammalia TMUB2 34 33
  • 91.81 (n)
(Rattus norvegicus)
Mammalia Tmub2 33
  • 87.46 (n)
(Mus musculus)
Mammalia Tmub2 16 34 33
  • 86.83 (n)
(Monodelphis domestica)
Mammalia TMUB2 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia TMUB2 34
  • 68 (a)
(Anolis carolinensis)
Reptilia TMUB2 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmub2 33
  • 57.67 (n)
(Danio rerio)
Actinopterygii tmub2 34 33
  • 59.13 (n)
(Caenorhabditis elegans)
Secernentea B0303.4 34
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5389 34
  • 22 (a)
Species where no ortholog for TMUB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMUB2 Gene

Gene Tree for TMUB2 (if available)
Gene Tree for TMUB2 (if available)
Evolutionary constrained regions (ECRs) for TMUB2: view image

Paralogs for TMUB2 Gene

Paralogs for TMUB2 Gene

(1) SIMAP similar genes for TMUB2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMUB2: view

Variants for TMUB2 Gene

Sequence variations from dbSNP and Humsavar for TMUB2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000341675 -- 44,187,027(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000545036 -- 44,186,787(+) G/T upstream_transcript_variant
rs1000945378 -- 44,186,035(+) T/C upstream_transcript_variant
rs1001002248 -- 44,187,043(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001614406 -- 44,188,239(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMUB2 Gene

Variant ID Type Subtype PubMed ID
dgv529n67 CNV gain 20364138
nsv1146669 OTHER inversion 26484159
nsv833455 CNV loss 17160897

Variation tolerance for TMUB2 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMUB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMUB2 Gene

Disorders for TMUB2 Gene

Additional Disease Information for TMUB2

No disorders were found for TMUB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMUB2 Gene

Publications for TMUB2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58

Products for TMUB2 Gene

Sources for TMUB2 Gene

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