Aliases for TMTC3 Gene
External Ids for TMTC3 Gene
Previous GeneCards Identifiers for TMTC3 Gene
This gene encodes a protein that belongs to the transmembrane and tetratricopeptide repeat-containing protein family. [provided by RefSeq, May 2010]
GeneCards Summary for TMTC3 Gene
TMTC3 (Transmembrane O-Mannosyltransferase Targeting Cadherins 3) is a Protein Coding gene. Diseases associated with TMTC3 include Lissencephaly 8 and Periventricular Nodular Heterotopia. An important paralog of this gene is TMTC1.
UniProtKB/Swiss-Prot Summary for TMTC3 Gene
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3 (PubMed:28973932). Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.