Aliases for TMTC1 Gene
External Ids for TMTC1 Gene
Previous GeneCards Identifiers for TMTC1 Gene
GeneCards Summary for TMTC1 Gene
TMTC1 (Transmembrane O-Mannosyltransferase Targeting Cadherins 1) is a Protein Coding gene. Diseases associated with TMTC1 include Ossification Of The Posterior Longitudinal Ligament Of Spine and Diffuse Idiopathic Skeletal Hyperostosis. An important paralog of this gene is TMTC2.
UniProtKB/Swiss-Prot Summary for TMTC1 Gene
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.