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Aliases for TMSB4Y Gene

Aliases for TMSB4Y Gene

  • Thymosin Beta 4, Y-Linked 2 3 5
  • Thymosin, Beta 4, Y Chromosome 2 3
  • TB4Y 3 4
  • Thymosin Beta-4, Y-Chromosomal 3
  • Thymosin Beta-4, Y Isoform 3

External Ids for TMSB4Y Gene

Previous GeneCards Identifiers for TMSB4Y Gene

  • GC0YP015133
  • GC0YP014824
  • GC0YP014253
  • GC0YP015815
  • GC0YP010461

Summaries for TMSB4Y Gene

Entrez Gene Summary for TMSB4Y Gene

  • This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMSB4Y Gene

TMSB4Y (Thymosin Beta 4, Y-Linked) is a Protein Coding gene. Among its related pathways are ERK Signaling and Regulation of actin cytoskeleton. Gene Ontology (GO) annotations related to this gene include actin binding and actin monomer binding. An important paralog of this gene is TMSB4X.

UniProtKB/Swiss-Prot for TMSB4Y Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Wiki entry for TMSB4Y Gene

Additional gene information for TMSB4Y Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB4Y Gene

Genomics for TMSB4Y Gene

GeneHancer (GH) Regulatory Elements for TMSB4Y Gene

Promoters and enhancers for TMSB4Y Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0YI013703 Promoter/Enhancer 1 EPDnew ENCODE 550.8 +0.9 909 2.1 POLR2A ETV4 SIN3A ZNF384 ELF1 KAT8 TEAD3 TMSB4Y PSIP1P2
GH0YI013704 Enhancer 0.2 ENCODE 550.8 -0.5 -491 0 TMSB4Y GC0YM013490
GH0YI013435 Enhancer 0.7 FANTOM5 ENCODE 1.5 -267.3 -267344 1.8 CTCF HLF NR2F6 TMSB4Y UTY PIR33577
GH0YI013663 Enhancer 0.3 ENCODE 0.3 -39.7 -39658 1 POU5F1 TMSB4Y GC0YM013490
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMSB4Y on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMSB4Y gene promoter:

Genomic Locations for TMSB4Y Gene

Genomic Locations for TMSB4Y Gene
2,458 bases
Plus strand

Genomic View for TMSB4Y Gene

Genes around TMSB4Y on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMSB4Y Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMSB4Y Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB4Y Gene

Proteins for TMSB4Y Gene

  • Protein details for TMSB4Y Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thymosin beta-4, Y-chromosomal
    Protein Accession:
    Secondary Accessions:
    • Q0VDA2

    Protein attributes for TMSB4Y Gene

    44 amino acids
    Molecular mass:
    5013 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMSB4Y Gene

Post-translational modifications for TMSB4Y Gene

No Post-translational modifications

Other Protein References for TMSB4Y Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMSB4Y Gene

Domains & Families for TMSB4Y Gene

Gene Families for TMSB4Y Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TMSB4Y Gene


Suggested Antigen Peptide Sequences for TMSB4Y Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the thymosin beta family.
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB4Y: view

Function for TMSB4Y Gene

Molecular function for TMSB4Y Gene

GENATLAS Biochemistry:
thymosin-beta 4,identical to the interferon inducible gene 6-26 (4/26),potential actin sequestering protein,ubiquitous in a AZF deleted region
UniProtKB/Swiss-Prot Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Ontology (GO) - Molecular Function for TMSB4Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003785 actin monomer binding IEA --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with TMSB4Y: view
genes like me logo Genes that share phenotypes with TMSB4Y: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMSB4Y Gene

Localization for TMSB4Y Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB4Y Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMSB4Y gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TMSB4Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TMSB4Y: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMSB4Y Gene

Pathways & Interactions for TMSB4Y Gene

genes like me logo Genes that share pathways with TMSB4Y: view

Pathways by source for TMSB4Y Gene

1 KEGG pathway for TMSB4Y Gene
1 Qiagen pathway for TMSB4Y Gene

Gene Ontology (GO) - Biological Process for TMSB4Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
GO:0008064 regulation of actin polymerization or depolymerization TAS 8838802
GO:0042989 sequestering of actin monomers TAS 8838802
genes like me logo Genes that share ontologies with TMSB4Y: view

No data available for SIGNOR curated interactions for TMSB4Y Gene

Drugs & Compounds for TMSB4Y Gene

No Compound Related Data Available

Transcripts for TMSB4Y Gene

mRNA/cDNA for TMSB4Y Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMSB4Y Gene

Thymosin beta 4, Y-linked:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB4Y Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
SP1: - -

Relevant External Links for TMSB4Y Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMSB4Y Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMSB4Y Gene

NURSA nuclear receptor signaling pathways regulating expression of TMSB4Y Gene:


SOURCE GeneReport for Unigene cluster for TMSB4Y Gene:


mRNA Expression by UniProt/SwissProt for TMSB4Y Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TMSB4Y Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMSB4Y: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMSB4Y Gene

Orthologs for TMSB4Y Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB4Y Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMSB4Y 34
  • 95 (a)
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
(Mus musculus)
Mammalia Tmsb4x 34
  • 93 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia TMSB4Y 34
  • 91 (a)
(Bos Taurus)
Mammalia -- 34
  • 86 (a)
  • 80 (a)
TMSB4 34
  • 66 (a)
(Gallus gallus)
Aves TMSB4X 34
  • 93 (a)
(Anolis carolinensis)
Reptilia TMSB4Y 34
  • 93 (a)
(Danio rerio)
Actinopterygii tmsb4x 34
  • 77 (a)
tmsb 34
  • 69 (a)
si:ch211-11c15.3 34
  • 67 (a)
Species where no ortholog for TMSB4Y was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB4Y Gene

Gene Tree for TMSB4Y (if available)
Gene Tree for TMSB4Y (if available)

Paralogs for TMSB4Y Gene

Paralogs for TMSB4Y Gene

(5) SIMAP similar genes for TMSB4Y Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMSB4Y: view

Variants for TMSB4Y Gene

Sequence variations from dbSNP and Humsavar for TMSB4Y Gene

SNP ID Clin Chr 0Y pos Variation AA Info Type
rs1005517418 -- 13,704,249(+) G/A 5_prime_UTR_variant
rs1005842717 -- 13,702,167(+) C/T upstream_transcript_variant
rs1006983496 -- 13,703,443(+) C/T upstream_transcript_variant
rs1018505160 -- 13,702,234(+) C/G upstream_transcript_variant
rs1019329879 -- 13,703,447(+) T/A upstream_transcript_variant

Additional Variant Information for TMSB4Y Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TMSB4Y Gene

Disorders for TMSB4Y Gene

Additional Disease Information for TMSB4Y

No disorders were found for TMSB4Y Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMSB4Y Gene

Publications for TMSB4Y Gene

  1. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn BT … Page DC (Science (New York, N.Y.) 1997) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. (PMID: 15557202) Torikai H … Takahashi T (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 22 58
  4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H … Page DC (Nature 2003) 3 4 58
  5. TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer. (PMID: 26702755) Wong HY … Park BH (Oncotarget 2015) 3 58

Products for TMSB4Y Gene

Sources for TMSB4Y Gene

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