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This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
TMSB4X (Thymosin Beta 4 X-Linked) is a Protein Coding gene. Diseases associated with TMSB4X include Osteoarthritis and Nephronophthisis 3. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include actin monomer binding. An important paralog of this gene is TMSB4Y.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003779 | actin binding | IEA | -- |
GO:0003785 | actin monomer binding | IDA | 1447300 |
GO:0005515 | protein binding | IPI | 17967441 |
GO:0019899 | enzyme binding | IPI | 21106936 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | HDA,TAS | -- |
GO:0005634 | nucleus | IDA | 21343177 |
GO:0005737 | cytoplasm | IDA | 21343177 |
GO:0005829 | cytosol | IDA | 1447300 |
GO:0005856 | cytoskeleton | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Response to elevated platelet cytosolic Ca2+ |
.44
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2 | Regulation of actin cytoskeleton | ||
3 | ERK Signaling |
ILK Signaling
.49
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4 | Association Between Physico-Chemical Features and Toxicity Associated Pathways | ||
5 | TarBasePathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002576 | platelet degranulation | TAS | -- |
GO:0007015 | actin filament organization | IEA | -- |
GO:0007253 | cytoplasmic sequestering of NF-kappaB | IMP | 21343177 |
GO:0030334 | regulation of cell migration | IBA | 21873635 |
GO:0032088 | negative regulation of NF-kappaB transcription factor activity | IMP | 21343177 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | TMSB4X 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
Cow (Bos Taurus) |
Mammalia | TMSB4X 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
ManyToMany | |
Mouse (Mus musculus) |
Mammalia | Tmsb15a 31 |
|
ManyToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | tmsb4x 31 |
|
ManyToMany | |
si:ch211-11c15.3 31 |
|
ManyToMany | |||
tmsb 31 |
|
ManyToMany | |||
Dr.12559 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1002384 | CNV | gain | 20482838 |
Disorder | Aliases | PubMed IDs |
---|---|---|
osteoarthritis |
|
|
nephronophthisis 3 |
|
|
pulmonary systemic sclerosis |
|
|
invasive malignant thymoma |
|
|
thymoma |
|
|