This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008] See more...

Aliases for TMSB4X Gene

Aliases for TMSB4X Gene

  • Thymosin Beta 4 X-Linked 2 3 5
  • TB4X 2 3 4
  • Thymosin, Beta 4, X Chromosome 2 3
  • Thymosin Beta-4 3 4
  • T Beta-4 3 4
  • TMSB4 3 4
  • Prothymosin Beta-4 3
  • TMSB4X 5
  • PTMB4 3
  • THYB4 4
  • FX 3
  • Fx 4

External Ids for TMSB4X Gene

Previous HGNC Symbols for TMSB4X Gene

  • TMSB4

Previous GeneCards Identifiers for TMSB4X Gene

  • GC04M091917
  • GC04M092061
  • GC0XP012354
  • GC0XP012752
  • GC0XP012903
  • GC0XP010756
  • GC0XP012993

Summaries for TMSB4X Gene

Entrez Gene Summary for TMSB4X Gene

  • This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMSB4X Gene

TMSB4X (Thymosin Beta 4 X-Linked) is a Protein Coding gene. Diseases associated with TMSB4X include Osteoarthritis and Pulmonary Systemic Sclerosis. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include actin monomer binding. An important paralog of this gene is TMSB4Y.

UniProtKB/Swiss-Prot Summary for TMSB4X Gene

  • Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
  • Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.

Gene Wiki entry for TMSB4X Gene

Additional gene information for TMSB4X Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMSB4X Gene

Genomics for TMSB4X Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMSB4X Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMSB4X on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMSB4X

Top Transcription factor binding sites by QIAGEN in the TMSB4X gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • NF-kappaB
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for TMSB4X Gene

Genomic Locations for TMSB4X Gene
chrX:12,975,110-12,977,227
(GRCh38/hg38)
Size:
2,118 bases
Orientation:
Plus strand
chrX:12,993,226-12,995,346
(GRCh37/hg19)
Size:
2,121 bases
Orientation:
Plus strand

Genomic View for TMSB4X Gene

Genes around TMSB4X on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMSB4X Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMSB4X Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB4X Gene

Proteins for TMSB4X Gene

  • Protein details for TMSB4X Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62328-TYB4_HUMAN
    Recommended name:
    Thymosin beta-4
    Protein Accession:
    P62328
    Secondary Accessions:
    • P01253
    • P01254
    • Q546P5
    • Q63576
    • Q9UE55

    Protein attributes for TMSB4X Gene

    Size:
    44 amino acids
    Molecular mass:
    5053 Da
    Quaternary structure:
    • Interacts with SERPINB1 (By similarity). Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.

    Three dimensional structures from OCA and Proteopedia for TMSB4X Gene

neXtProt entry for TMSB4X Gene

Post-translational modifications for TMSB4X Gene

  • Ubiquitination at Lys4, Lys12, Lys26, Lys32, and Lys39
  • Modification sites at PhosphoSitePlus

Other Protein References for TMSB4X Gene

No data available for DME Specific Peptides for TMSB4X Gene

Domains & Families for TMSB4X Gene

Gene Families for TMSB4X Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TMSB4X Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMSB4X Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92006, Homo sapiens thymosin, beta 4, X chromosome (TMSB4X), mRNA (A2VCK8_HUMAN)
  • TMSB4X protein (Q0P5N8_HUMAN)
  • TMSB4X protein (Q0P5P4_HUMAN)
  • TMSB4X protein (Q0P5Q0_HUMAN)
  • TMSB4X protein (Q0P5T0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62328

UniProtKB/Swiss-Prot:

TYB4_HUMAN :
  • Belongs to the thymosin beta family.
Family:
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB4X: view

Function for TMSB4X Gene

Molecular function for TMSB4X Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
UniProtKB/Swiss-Prot Function:
Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.
UniProtKB/Swiss-Prot Induction:
By alpha interferons. Decreased levels in THP-1 cells after treatment with recombinant interferon-lambda.
GENATLAS Biochemistry:
thymosin beta 4,identical to the interferon inducible gene 6-26 (4/6-26)-like 7,potential actin sequestering protein,escaping inactivation,ubiquitous

Phenotypes From GWAS Catalog for TMSB4X Gene

Gene Ontology (GO) - Molecular Function for TMSB4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003779 actin binding IEA --
GO:0003785 actin monomer binding IDA 1447300
GO:0005515 protein binding IPI 17967441
GO:0019899 enzyme binding IPI 21106936
genes like me logo Genes that share ontologies with TMSB4X: view
genes like me logo Genes that share phenotypes with TMSB4X: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMSB4X

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMSB4X

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMSB4X Gene

Localization for TMSB4X Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB4X Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMSB4X gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4
plasma membrane 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMSB4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA,TAS --
GO:0005623 cell IEA --
GO:0005634 nucleus IDA 21343177
GO:0005737 cytoplasm IDA 21343177
GO:0005829 cytosol IDA 1447300
genes like me logo Genes that share ontologies with TMSB4X: view

Pathways & Interactions for TMSB4X Gene

genes like me logo Genes that share pathways with TMSB4X: view

Pathways by source for TMSB4X Gene

Gene Ontology (GO) - Biological Process for TMSB4X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007015 actin filament organization IEA --
GO:0007253 cytoplasmic sequestering of NF-kappaB IMP 21343177
GO:0030334 regulation of cell migration IBA 21873635
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP 21343177
genes like me logo Genes that share ontologies with TMSB4X: view

No data available for SIGNOR curated interactions for TMSB4X Gene

Drugs & Compounds for TMSB4X Gene

(10) Drugs for TMSB4X Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for TMSB4X Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMSB4X: view

Transcripts for TMSB4X Gene

mRNA/cDNA for TMSB4X Gene

1 REFSEQ mRNAs :
30 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMSB4X

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB4X Gene

No ASD Table

Relevant External Links for TMSB4X Gene

GeneLoc Exon Structure for
TMSB4X

Expression for TMSB4X Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMSB4X Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMSB4X Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for TMSB4X Gene

This gene is overexpressed in Amniocyte (15.8), Monocytes (10.6), and Urine (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMSB4X Gene



Protein tissue co-expression partners for TMSB4X Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMSB4X

SOURCE GeneReport for Unigene cluster for TMSB4X Gene:

Hs.437277

mRNA Expression by UniProt/SwissProt for TMSB4X Gene:

P62328-TYB4_HUMAN
Tissue specificity: Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.

Evidence on tissue expression from TISSUES for TMSB4X Gene

  • Blood(5)
  • Nervous system(5)
  • Lung(4.9)
  • Heart(4.9)
  • Liver(4.9)
  • Pancreas(4.8)
  • Intestine(4.8)
  • Skin(4.7)
  • Eye(4.7)
  • Stomach(4.6)
  • Spleen(4.5)
  • Kidney(4.2)
  • Muscle(3.7)
  • Bone marrow(3.7)
  • Lymph node(3.7)
  • Bone(3.6)
  • Adrenal gland(3.4)
  • Thyroid gland(3)
  • Gall bladder(2.9)
genes like me logo Genes that share expression patterns with TMSB4X: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TMSB4X Gene

Orthologs for TMSB4X Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB4X Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia TMSB4X 31
  • 98 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 91 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia TMSB4X 31
  • 86 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 64 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Tmsb15a 31
  • 64 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii tmsb4x 31
  • 82 (a)
ManyToMany
si:ch211-11c15.3 31
  • 69 (a)
ManyToMany
tmsb 31
  • 69 (a)
ManyToMany
Dr.12559 30
Species where no ortholog for TMSB4X was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMSB4X Gene

ENSEMBL:
Gene Tree for TMSB4X (if available)
TreeFam:
Gene Tree for TMSB4X (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMSB4X: view image

Paralogs for TMSB4X Gene

Paralogs for TMSB4X Gene

(5) SIMAP similar genes for TMSB4X Gene using alignment to 7 proteins:

  • TYB4_HUMAN
  • A2VCK8_HUMAN
  • Q0P5N8_HUMAN
  • Q0P5P4_HUMAN
  • Q0P5Q0_HUMAN
  • Q0P5T0_HUMAN
  • Q0P5U7_HUMAN

Pseudogenes.org Pseudogenes for TMSB4X Gene

genes like me logo Genes that share paralogs with TMSB4X: view

Variants for TMSB4X Gene

Additional dbSNP identifiers (rs#s) for TMSB4X Gene

Structural Variations from Database of Genomic Variants (DGV) for TMSB4X Gene

Variant ID Type Subtype PubMed ID
esv1002384 CNV gain 20482838

Variation tolerance for TMSB4X Gene

Residual Variation Intolerance Score: 50.7% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMSB4X Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMSB4X

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMSB4X Gene

Disorders for TMSB4X Gene

MalaCards: The human disease database

(8) MalaCards diseases for TMSB4X Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
osteoarthritis
  • kashin-beck disease
pulmonary systemic sclerosis
  • lung disease with systemic sclerosis
invasive malignant thymoma
  • infiltrating thymoma
thymoma
  • thymus neoplasms
fibrosarcoma
  • fibrocytic tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMSB4X

genes like me logo Genes that share disorders with TMSB4X: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMSB4X Gene

Publications for TMSB4X Gene

  1. Structural requirements for thymosin beta4 in its contact with actin. An NMR-analysis of thymosin beta4 mutants in solution and correlation with their biological activity. (PMID: 10848969) Simenel C … Delepierre M (European journal of biochemistry 2000) 3 4 23
  2. Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. (PMID: 1999398) Safer D … Nachmias VT (The Journal of biological chemistry 1991) 3 4 23
  3. Different thymosin Beta 4 immunoreactivity in foetal and adult gastrointestinal tract. (PMID: 20161756) Nemolato S … Faa G (PloS one 2010) 3 23
  4. Serum thymosin beta4 levels in patients with hepatitis B virus-related liver failure. (PMID: 20128033) Han T … Zhao ZG (World journal of gastroenterology 2010) 3 23
  5. Thymosin beta4 is involved in stabilin-2-mediated apoptotic cell engulfment. (PMID: 18519035) Lee SJ … Kim IS (FEBS letters 2008) 3 23

Products for TMSB4X Gene

Sources for TMSB4X Gene