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Aliases for TMSB15B Gene

Aliases for TMSB15B Gene

  • Thymosin Beta 15B 2 3 5
  • Thymosin Beta-15B 3
  • Tbeta15b 3

External Ids for TMSB15B Gene

Previous GeneCards Identifiers for TMSB15B Gene

  • GC0XP103104
  • GC0XP092867

Summaries for TMSB15B Gene

GeneCards Summary for TMSB15B Gene

TMSB15B (Thymosin Beta 15B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and actin monomer binding. An important paralog of this gene is TMSB15A.

UniProtKB/Swiss-Prot for TMSB15B Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration.

Gene Wiki entry for TMSB15B Gene

Additional gene information for TMSB15B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB15B Gene

Genomics for TMSB15B Gene

GeneHancer (GH) Regulatory Elements for TMSB15B Gene

Promoters and enhancers for TMSB15B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI103962 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.3 +44.0 44005 1.8 GTF2F1 ESRRA NFIB NEUROD1 RFX5 ZNF335 ZFHX2 POLR2A ZSCAN29 ZNF600 GC0XM103962 DPPA3P1 TMSB15B FAM199X SLC25A53 H2BFXP
GH0XI103917 Promoter/Enhancer 1.3 Ensembl ENCODE 550.8 +0.2 197 2.8 PKNOX1 SIN3A ZNF335 GLIS2 SCRT2 BCLAF1 EGR2 SMARCA5 SP3 ZNF654 TMSB15B LOC100128594 H2BFM ENSG00000235946 SLC25A53 FAM199X RAB9B
GH0XI103716 Enhancer 0.5 Ensembl ENCODE 5.5 -201.6 -201579 1.7 JUND BEX2 BEX4 TMSB15B TMEM31 GLRA4
GH0XI104334 Enhancer 0.5 ENCODE 5 +416.9 416884 1.9 SMARCE1 GATA3 FOSL2 DPF2 FOS FOXA1 TMSB15B GC0XM104365 ESX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMSB15B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMSB15B gene promoter:

Genomic Locations for TMSB15B Gene

Genomic Locations for TMSB15B Gene
47,817 bases
Plus strand

Genomic View for TMSB15B Gene

Genes around TMSB15B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMSB15B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMSB15B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB15B Gene

Proteins for TMSB15B Gene

  • Protein details for TMSB15B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thymosin beta-15B
    Protein Accession:
    Secondary Accessions:
    • A8K614
    • Q99406

    Protein attributes for TMSB15B Gene

    45 amino acids
    Molecular mass:
    5229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMSB15B Gene

Post-translational modifications for TMSB15B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMSB15B Gene

No data available for DME Specific Peptides for TMSB15B Gene

Domains & Families for TMSB15B Gene

Gene Families for TMSB15B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TMSB15B Gene


Suggested Antigen Peptide Sequences for TMSB15B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the thymosin beta family.
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB15B: view

Function for TMSB15B Gene

Molecular function for TMSB15B Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). May be involved in cell migration.

Gene Ontology (GO) - Molecular Function for TMSB15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0003785 actin monomer binding IEA --
genes like me logo Genes that share ontologies with TMSB15B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMSB15B Gene

Localization for TMSB15B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB15B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMSB15B gene
Compartment Confidence
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for TMSB15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TMSB15B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMSB15B Gene

Pathways & Interactions for TMSB15B Gene

SuperPathways for TMSB15B Gene

No Data Available

Interacting Proteins for TMSB15B Gene

Gene Ontology (GO) - Biological Process for TMSB15B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
GO:0030335 positive regulation of cell migration IMP 19296525
genes like me logo Genes that share ontologies with TMSB15B: view

No data available for Pathways by source and SIGNOR curated interactions for TMSB15B Gene

Drugs & Compounds for TMSB15B Gene

No Compound Related Data Available

Transcripts for TMSB15B Gene

Unigene Clusters for TMSB15B Gene

Thymosin beta 15B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB15B Gene

No ASD Table

Relevant External Links for TMSB15B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMSB15B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMSB15B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMSB15B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMSB15B Gene:


SOURCE GeneReport for Unigene cluster for TMSB15B Gene:


mRNA Expression by UniProt/SwissProt for TMSB15B Gene:

Tissue specificity: Expressed in colon and colon cancer tissue.

Evidence on tissue expression from TISSUES for TMSB15B Gene

  • Blood(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMSB15B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMSB15B Gene

Orthologs for TMSB15B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB15B Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Tmsb15b1 34
  • 80 (a)
Tmsb15b2 34
  • 46 (a)
Tmsb15l 34
  • 46 (a)
(Bos Taurus)
Mammalia TMSB4 34
  • 70 (a)
(Pan troglodytes)
Mammalia -- 34
  • 70 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
(Canis familiaris)
Mammalia -- 34
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 84 (a)
(Danio rerio)
Actinopterygii tmsb4x 34
  • 66 (a)
si:ch211-11c15.3 34
  • 62 (a)
tmsb 34
  • 53 (a)
Species where no ortholog for TMSB15B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB15B Gene

Gene Tree for TMSB15B (if available)
Gene Tree for TMSB15B (if available)

Paralogs for TMSB15B Gene

Variants for TMSB15B Gene

Sequence variations from dbSNP and Humsavar for TMSB15B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs111305533 -- 103,962,328(+) T/C upstream_transcript_variant
rs111506375 -- 103,964,185(+) TTTTTTT/TTTTTT intron_variant
rs111960701 -- 103,960,738(+) C/A upstream_transcript_variant
rs112168184 -- 103,965,242(+) C/T intron_variant
rs112601190 -- 103,960,641(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMSB15B Gene

Variant ID Type Subtype PubMed ID
dgv2355e212 CNV gain 25503493
dgv5n1 OTHER inversion 15895083
esv1007027 OTHER inversion 20482838
esv27035 CNV gain 19812545
esv2758880 CNV gain 17122850
esv3577011 CNV gain 25503493
esv3577013 CNV gain 25503493
esv3577035 CNV gain 25503493
nsv1119352 CNV duplication 24896259
nsv469772 CNV gain 16826518
nsv519626 CNV gain 19592680
nsv7453 OTHER inversion 18451855
nsv9961 CNV gain 18304495

Variation tolerance for TMSB15B Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMSB15B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMSB15B Gene

Disorders for TMSB15B Gene

Additional Disease Information for TMSB15B

No disorders were found for TMSB15B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMSB15B Gene

Publications for TMSB15B Gene

  1. Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. (PMID: 19296525) Banyard J … Zetter BR (Genes, chromosomes & cancer 2009) 3 4 58
  2. Thymosin beta-NB is the human isoform of rat thymosin beta15. (PMID: 17567946) Banyard J … Zetter BR (Annals of the New York Academy of Sciences 2007) 2 3 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58

Products for TMSB15B Gene

Sources for TMSB15B Gene

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