Aliases for TMSB15A Gene

Aliases for TMSB15A Gene

  • Thymosin Beta 15a 2 3 5
  • TMSNB 2 3 4
  • Thymosin-Like Protein 8 3 4
  • Thymosin Beta-15A 3 4
  • NB Thymosin Beta 3 4
  • Thymosin-Like 8 2 3
  • TMSL8 3 4
  • Thymosin, Beta, Identified In Neuroblastoma Cells 3
  • Thymosin Beta-15B 3
  • TMSB15B 3
  • TMSB15A 5
  • TMSB15 3
  • Tb15 3
  • TbNB 3

External Ids for TMSB15A Gene

Previous HGNC Symbols for TMSB15A Gene

  • TMSL8

Previous GeneCards Identifiers for TMSB15A Gene

  • GC0XM101657
  • GC0XM101768
  • GC0XM091433

Summaries for TMSB15A Gene

GeneCards Summary for TMSB15A Gene

TMSB15A (Thymosin Beta 15a) is a Protein Coding gene. Diseases associated with TMSB15A include Retinitis Pigmentosa 10 and Purine-Pyrimidine Metabolic Disorder. Gene Ontology (GO) annotations related to this gene include actin binding and actin monomer binding. An important paralog of this gene is ENSG00000269226.

UniProtKB/Swiss-Prot Summary for TMSB15A Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Wiki entry for TMSB15A Gene

Additional gene information for TMSB15A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMSB15A Gene

Genomics for TMSB15A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMSB15A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ102516 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.3 338 2 PRDM10 POLR2A ZNF740 CTCF ZNF600 MGA ZBTB20 SP2 CEBPB ZBTB48 TMSB15A BEX5 TCP11X2
GH0XJ102471 Promoter 0.3 Ensembl 0.3 +44.8 44838 0.6 ENSG00000284800 TCP11X2 TMSB15A
GH0XJ102549 Enhancer 0.2 Ensembl 0.3 -33.2 -33162 0.2 FOXN3P1 LOC100420162 NXF4 lnc-ARMCX5-2 NXF2 TMSB15A ARMCX5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMSB15A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMSB15A

Top Transcription factor binding sites by QIAGEN in the TMSB15A gene promoter:
  • AML1a
  • Chx10
  • CUTL1
  • FOXI1
  • HFH-3
  • POU3F2
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3

Genomic Locations for TMSB15A Gene

Genomic Locations for TMSB15A Gene
chrX:102,513,682-102,516,739
(GRCh38/hg38)
Size:
3,058 bases
Orientation:
Minus strand
chrX:101,768,604-101,771,712
(GRCh37/hg19)
Size:
3,109 bases
Orientation:
Minus strand

Genomic View for TMSB15A Gene

Genes around TMSB15A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMSB15A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMSB15A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB15A Gene

Proteins for TMSB15A Gene

  • Protein details for TMSB15A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG34-TB15A_HUMAN
    Recommended name:
    Thymosin beta-15A
    Protein Accession:
    P0CG34
    Secondary Accessions:
    • A8K614
    • Q99406

    Protein attributes for TMSB15A Gene

    Size:
    45 amino acids
    Molecular mass:
    5229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMSB15A Gene

Post-translational modifications for TMSB15A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMSB15A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMSB15A Gene

Domains & Families for TMSB15A Gene

Gene Families for TMSB15A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TMSB15A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMSB15A Gene

GenScript: Design optimal peptide antigens:
  • Thymosin-like protein 8 (TB15A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CG34

UniProtKB/Swiss-Prot:

TB15A_HUMAN :
  • Belongs to the thymosin beta family.
Family:
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB15A: view

Function for TMSB15A Gene

Molecular function for TMSB15A Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by TGFB1.

Gene Ontology (GO) - Molecular Function for TMSB15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0003785 actin monomer binding IBA 21873635
genes like me logo Genes that share ontologies with TMSB15A: view
genes like me logo Genes that share phenotypes with TMSB15A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMSB15A

CRISPR Products

miRNA for TMSB15A Gene

miRTarBase miRNAs that target TMSB15A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMSB15A

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMSB15A Gene

Localization for TMSB15A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB15A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMSB15A gene
Compartment Confidence
cytoskeleton 3
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMSB15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TMSB15A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMSB15A Gene

Pathways & Interactions for TMSB15A Gene

PathCards logo

SuperPathways for TMSB15A Gene

No Data Available

Interacting Proteins for TMSB15A Gene

Gene Ontology (GO) - Biological Process for TMSB15A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
GO:0030334 regulation of cell migration IBA 21873635
GO:0042989 sequestering of actin monomers IBA 21873635
genes like me logo Genes that share ontologies with TMSB15A: view

No data available for Pathways by source and SIGNOR curated interactions for TMSB15A Gene

Drugs & Compounds for TMSB15A Gene

No Compound Related Data Available

Transcripts for TMSB15A Gene

mRNA/cDNA for TMSB15A Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMSB15A

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB15A Gene

No ASD Table

Relevant External Links for TMSB15A Gene

GeneLoc Exon Structure for
TMSB15A

Expression for TMSB15A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMSB15A Gene

mRNA differential expression in normal tissues according to GTEx for TMSB15A Gene

This gene is overexpressed in Prostate (x5.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMSB15A

SOURCE GeneReport for Unigene cluster for TMSB15A Gene:

Hs.56145

mRNA Expression by UniProt/SwissProt for TMSB15A Gene:

P0CG34-TB15A_HUMAN
Tissue specificity: Neuroblastoma-specific.

Evidence on tissue expression from TISSUES for TMSB15A Gene

  • Nervous system(4.3)
  • Blood(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with TMSB15A: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMSB15A Gene

Orthologs for TMSB15A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB15A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMSB15A 31
  • 100 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmsb15b1 31
  • 80 (a)
ManyToMany
Tmsb15b2 31
  • 46 (a)
ManyToMany
Tmsb15l 31
  • 46 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 70 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 58 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 84 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii tmsb4x 31
  • 66 (a)
ManyToMany
si:ch211-11c15.3 31
  • 62 (a)
ManyToMany
tmsb 31
  • 53 (a)
ManyToMany
Species where no ortholog for TMSB15A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMSB15A Gene

ENSEMBL:
Gene Tree for TMSB15A (if available)
TreeFam:
Gene Tree for TMSB15A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMSB15A: view image

Paralogs for TMSB15A Gene

Paralogs for TMSB15A Gene

(5) SIMAP similar genes for TMSB15A Gene using alignment to 1 proteins:

  • TB15A_HUMAN
genes like me logo Genes that share paralogs with TMSB15A: view

Variants for TMSB15A Gene

Additional dbSNP identifiers (rs#s) for TMSB15A Gene

Structural Variations from Database of Genomic Variants (DGV) for TMSB15A Gene

Variant ID Type Subtype PubMed ID
esv3577000 CNV gain 25503493

Variation tolerance for TMSB15A Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMSB15A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMSB15A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMSB15A Gene

Disorders for TMSB15A Gene

MalaCards: The human disease database

(23) MalaCards diseases for TMSB15A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 10
  • rp10
purine-pyrimidine metabolic disorder
  • inborn errors of purine-pyrimidine metabolism
ankyloglossia with or without tooth anomalies
  • ankg
rectosigmoid cancer
  • rectosigmoid junction cancer
endobronchial lipoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TMSB15A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMSB15A Gene

Publications for TMSB15A Gene

  1. Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. (PMID: 19296525) Banyard J … Zetter BR (Genes, chromosomes & cancer 2009) 3 4 23
  2. Thymosin beta-NB is the human isoform of rat thymosin beta15. (PMID: 17567946) Banyard J … Zetter BR (Annals of the New York Academy of Sciences 2007) 2 3 23
  3. Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles. (PMID: 9039501) Yokoyama M … Matsubara K (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for TMSB15A Gene

  • Signalway ELISA kits for TMSB15A

Sources for TMSB15A Gene