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Aliases for TMSB10 Gene

Aliases for TMSB10 Gene

  • Thymosin Beta 10 2 3 5
  • Migration-Inducing Protein 12 3
  • Migration-Inducing Gene 12 3
  • Thymosin Beta-10 3
  • PTMB10 4
  • THYB10 4
  • MIG12 3
  • TB10 3

External Ids for TMSB10 Gene

Previous GeneCards Identifiers for TMSB10 Gene

  • GC02P085114
  • GC02P085426
  • GC02P085090
  • GC02P085107
  • GC02P085044
  • GC02P084986
  • GC02P085132

Summaries for TMSB10 Gene

GeneCards Summary for TMSB10 Gene

TMSB10 (Thymosin Beta 10) is a Protein Coding gene. Diseases associated with TMSB10 include Primary Bacterial Infectious Disease. Gene Ontology (GO) annotations related to this gene include actin binding and actin monomer binding. An important paralog of this gene is TMSB4X.

UniProtKB/Swiss-Prot for TMSB10 Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Wiki entry for TMSB10 Gene

Additional gene information for TMSB10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB10 Gene

Genomics for TMSB10 Gene

GeneHancer (GH) Regulatory Elements for TMSB10 Gene

Promoters and enhancers for TMSB10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I084904 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.4 1375 5.6 HDGF SMAD1 FOXA2 MLX ARID4B SIN3A YBX1 DMAP1 SLC30A9 POLR2B TRABD2A TMSB10 LOC105374836 USP39 TCF7L1 ELMOD3 C2orf68 LOC100996506 VAMP8 GC02P084898
GH02I085536 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.7 +634.1 634135 6.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MAT2A PIR39955 PARTICL PIR40998 GC02M085541 SNORD94 USP39 C2orf68 LOC100996506 ELMOD3
GH02I085548 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.7 +644.9 644866 4 HDGF FOXA2 ARID4B SIN3A IRF4 ZNF48 ARID2 ZNF143 ATF7 FOS USP39 GGCX VAMP8 CAPG SH2D6 TGOLN2 TMEM150A RN7SL251P RNU7-64P ELMOD3
GH02I085545 Enhancer 1 ENCODE dbSUPER 4.7 +640.9 640928 1.2 FOXA2 MZF1 SIN3A DNMT3B THRB ZNF48 ZNF121 POLR2B E2F8 DEK GC02P085546 GC02P085544 USP39 GGCX SNORD94 KDM3A SH2D6 CAPG TMEM150A RN7SL251P
GH02I084918 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.5 +14.2 14217 3.3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 FOS MAT2A TCF7L1 ELMOD3 KCMF1 TMSB10 RPS2P17 LOC105374838
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMSB10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMSB10 gene promoter:

Genomic Locations for TMSB10 Gene

Genomic Locations for TMSB10 Gene
chr2:84,905,625-84,906,675
(GRCh38/hg38)
Size:
1,051 bases
Orientation:
Plus strand
chr2:85,132,749-85,133,799
(GRCh37/hg19)

Genomic View for TMSB10 Gene

Genes around TMSB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMSB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMSB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB10 Gene

Proteins for TMSB10 Gene

  • Protein details for TMSB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63313-TYB10_HUMAN
    Recommended name:
    Thymosin beta-10
    Protein Accession:
    P63313
    Secondary Accessions:
    • P13472
    • Q596K9

    Protein attributes for TMSB10 Gene

    Size:
    44 amino acids
    Molecular mass:
    5026 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36746.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC41691.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMSB10 Gene

Post-translational modifications for TMSB10 Gene

  • Ubiquitination at posLast=3232
  • Modification sites at PhosphoSitePlus

Other Protein References for TMSB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMSB10 Gene

Domains & Families for TMSB10 Gene

Gene Families for TMSB10 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TMSB10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMSB10 Gene

Graphical View of Domain Structure for InterPro Entry

P63313

UniProtKB/Swiss-Prot:

TYB10_HUMAN :
  • Belongs to the thymosin beta family.
Family:
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB10: view

Function for TMSB10 Gene

Molecular function for TMSB10 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Ontology (GO) - Molecular Function for TMSB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003785 actin monomer binding IEA --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with TMSB10: view
genes like me logo Genes that share phenotypes with TMSB10: view

miRNA for TMSB10 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMSB10 Gene

Localization for TMSB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB10 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMSB10 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TMSB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TMSB10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMSB10 Gene

Pathways & Interactions for TMSB10 Gene

SuperPathways for TMSB10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMSB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
genes like me logo Genes that share ontologies with TMSB10: view

No data available for Pathways by source and SIGNOR curated interactions for TMSB10 Gene

Drugs & Compounds for TMSB10 Gene

(2) Additional Compounds for TMSB10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMSB10: view

Transcripts for TMSB10 Gene

mRNA/cDNA for TMSB10 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1350) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMSB10 Gene

Thymosin beta 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2:
SP3: -

Relevant External Links for TMSB10 Gene

GeneLoc Exon Structure for
TMSB10
ECgene alternative splicing isoforms for
TMSB10

Expression for TMSB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMSB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMSB10 Gene

This gene is overexpressed in CD4 Tcells (8.1) and Amniocyte (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMSB10 Gene



Protein tissue co-expression partners for TMSB10 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMSB10 Gene:

TMSB10

SOURCE GeneReport for Unigene cluster for TMSB10 Gene:

Hs.446574

Evidence on tissue expression from TISSUES for TMSB10 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(4.6)
  • Kidney(4.5)
  • Intestine(4)
  • Skin(3.5)
  • Blood(3.3)
  • Lymph node(3.3)
  • Spleen(3.2)
  • Heart(3)
  • Pancreas(3)
  • Stomach(2.9)
  • Thyroid gland(2.9)
  • Gall bladder(2.8)
  • Eye(2.7)
  • Bone marrow(2.6)
  • Muscle(2.5)
  • Adrenal gland(2.4)
genes like me logo Genes that share expression patterns with TMSB10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMSB10 Gene

Orthologs for TMSB10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMSB10 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMSB10 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9844 34
  • 100 (a)
OneToMany
Tmsb10 34
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TMSB10 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMSB10 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMSB10 34
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmsb 34
  • 73 (a)
ManyToMany
tmsb4x 34
  • 70 (a)
ManyToMany
si:ch211-11c15.3 34
  • 69 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4131 33
Species where no ortholog for TMSB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB10 Gene

ENSEMBL:
Gene Tree for TMSB10 (if available)
TreeFam:
Gene Tree for TMSB10 (if available)

Paralogs for TMSB10 Gene

Paralogs for TMSB10 Gene

(5) SIMAP similar genes for TMSB10 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMSB10 Gene

genes like me logo Genes that share paralogs with TMSB10: view

Variants for TMSB10 Gene

Sequence variations from dbSNP and Humsavar for TMSB10 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000954437 -- 84,905,058(+) C/T upstream_transcript_variant
rs1001028099 -- 84,905,340(+) G/A upstream_transcript_variant
rs1001561956 -- 84,904,471(+) T/C upstream_transcript_variant
rs1001846706 -- 84,904,438(+) A/C upstream_transcript_variant
rs1001908104 -- 84,905,788(+) C/G intron_variant

Variation tolerance for TMSB10 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMSB10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMSB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMSB10 Gene

Disorders for TMSB10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMSB10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary bacterial infectious disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMSB10

genes like me logo Genes that share disorders with TMSB10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMSB10 Gene

Publications for TMSB10 Gene

  1. Thymosin beta-10 gene overexpression is a general event in human carcinogenesis. (PMID: 10487837) Santelli G … Fusco A (The American journal of pathology 1999) 2 3 22 58
  2. Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma. (PMID: 8425765) Weterman MA … Bloemers HP (International journal of cancer 1993) 3 4 22 58
  3. Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma. (PMID: 2169566) Hall AK … Morgan JI (Brain research. Molecular brain research 1990) 3 4 22 58
  4. Sequence of a human kidney cDNA clone encoding thymosin beta 10. (PMID: 3365256) McCreary V … Toback FG (Biochemical and biophysical research communications 1988) 2 3 4 58
  5. Expression of thymosin beta10 and its role in non-small cell lung cancer. (PMID: 18789485) Gu Y … Wang E (Human pathology 2009) 3 22 58

Products for TMSB10 Gene

Sources for TMSB10 Gene

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