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Aliases for TMPRSS9 Gene

Aliases for TMPRSS9 Gene

  • Transmembrane Protease, Serine 9 2 3 5
  • Polyserine Protease 1 3 4
  • Polyserase-1 3 4
  • Polyserase-I 3 4
  • Transmembrane Protease Serine 9 3
  • Transmembrane Serine Protease 9 3
  • Polyserase 1 2
  • EC 3.4.21.4 56
  • EC 3.4.21.- 4
  • EC 3.4.21 56

External Ids for TMPRSS9 Gene

Previous GeneCards Identifiers for TMPRSS9 Gene

  • GC19P002341
  • GC19P002342
  • GC19P002161

Summaries for TMPRSS9 Gene

Entrez Gene Summary for TMPRSS9 Gene

  • The protein encoded by this gene is a membrane-bound type II serine polyprotease that is cleaved to release three different proteases. Two of the proteases are active and can be inhibited by serine protease inhibitors, and one is thought to be catalytically inactive. This gene enhances the invasive capability of pancreatic cancer cells and may be involved in cancer progression. [provided by RefSeq, Jul 2016]

GeneCards Summary for TMPRSS9 Gene

TMPRSS9 (Transmembrane Protease, Serine 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is PRSS36.

UniProtKB/Swiss-Prot for TMPRSS9 Gene

  • Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed.

Additional gene information for TMPRSS9 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS9 Gene

Genomics for TMPRSS9 Gene

GeneHancer (GH) Regulatory Elements for TMPRSS9 Gene

Promoters and enhancers for TMPRSS9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I002385 Enhancer 1.2 Ensembl ENCODE 550.8 +0.2 163 1.3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 FOS KLF13 TMPRSS9 ZNF554 SPPL2B PIR50739 GC19P002378
GH19I002384 Enhancer 0.9 Ensembl ENCODE 550.8 -1.0 -1035 0.4 MEIS2 KLF1 MAX EBF1 ZIC2 ZFHX2 GLIS2 EGR1 FOS ZNF600 TMPRSS9 SPPL2B GC19P002378
GH19I002422 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22 +40.9 40926 6.8 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 TIMM13 PIR39105 PIR60720 TMPRSS9 RPS15 SF3A2 SCAMP4 LMNB2
GH19I002454 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.2 +70.9 70852 3.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 SLC30A9 ZNF121 LMNB2 TMPRSS9 TIMM13 ENSG00000267214 GC19P002446
GH19I002586 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +202.7 202721 2.7 FOXA2 MLX ARID4B ZNF48 YY1 SLC30A9 RXRA SP5 REST PPARG TMPRSS9 GNG7 LINGO3 DIRAS1 RN7SL121P PIR44748
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMPRSS9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMPRSS9 gene promoter:

Genomic Locations for TMPRSS9 Gene

Genomic Locations for TMPRSS9 Gene
chr19:2,385,235-2,426,261
(GRCh38/hg38)
Size:
41,027 bases
Orientation:
Plus strand
chr19:2,389,769-2,426,237
(GRCh37/hg19)

Genomic View for TMPRSS9 Gene

Genes around TMPRSS9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS9 Gene

Proteins for TMPRSS9 Gene

  • Protein details for TMPRSS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z410-TMPS9_HUMAN
    Recommended name:
    Transmembrane protease serine 9
    Protein Accession:
    Q7Z410
    Secondary Accessions:
    • Q6ZND6
    • Q7Z411

    Protein attributes for TMPRSS9 Gene

    Size:
    1059 amino acids
    Molecular mass:
    114021 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18439.1; Type=Frameshift; Positions=776; Evidence={ECO:0000305}; Sequence=CAD35759.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for TMPRSS9 Gene

Selected DME Specific Peptides for TMPRSS9 Gene

Q7Z410:
  • GDSGGPL
  • CLISGWG
  • VSWGIGC
  • SGGPLVC
  • DSCQGDSGG
  • CQGDSGGP
  • WPWQVSL

Post-translational modifications for TMPRSS9 Gene

  • Proteolytically cleaved to generate 3 independent serine protease chains. The cleaved chains may remain attached to the membrane thanks to disufide bonds. It is unclear whether cleavage always takes place.
  • Glycosylation at isoforms=547, isoforms=638, isoforms=663, and isoforms=786
  • Modification sites at PhosphoSitePlus

Other Protein References for TMPRSS9 Gene

Domains & Families for TMPRSS9 Gene

Gene Families for TMPRSS9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TMPRSS9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z410

UniProtKB/Swiss-Prot:

TMPS9_HUMAN :
  • The serine protease 1 and 2 domains are catalytically active, whereas the serine protease 3 domain lacks the essential Ser residue of the catalytic triad at position 1009 and is predicted to be inactive.
  • Belongs to the peptidase S1 family.
Domain:
  • The serine protease 1 and 2 domains are catalytically active, whereas the serine protease 3 domain lacks the essential Ser residue of the catalytic triad at position 1009 and is predicted to be inactive.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS9: view

Function for TMPRSS9 Gene

Molecular function for TMPRSS9 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by serine protease inhibitors PMSF and 4-(2-aminoethyl)benzenesulfonyl fluoride, but not by EDTA.
UniProtKB/Swiss-Prot Function:
Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed.

Enzyme Numbers (IUBMB) for TMPRSS9 Gene

Phenotypes From GWAS Catalog for TMPRSS9 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS9: view
genes like me logo Genes that share phenotypes with TMPRSS9: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMPRSS9 Gene

Localization for TMPRSS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS9 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS9 gene
Compartment Confidence
plasma membrane 4
extracellular 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMPRSS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMPRSS9 Gene

Pathways & Interactions for TMPRSS9 Gene

SuperPathways for TMPRSS9 Gene

No Data Available

Interacting Proteins for TMPRSS9 Gene

Gene Ontology (GO) - Biological Process for TMPRSS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TMPRSS9: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS9 Gene

Drugs & Compounds for TMPRSS9 Gene

(1) Drugs for TMPRSS9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TMPRSS9: view

Transcripts for TMPRSS9 Gene

mRNA/cDNA for TMPRSS9 Gene

Unigene Clusters for TMPRSS9 Gene

Transmembrane protease, serine 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS9 Gene

No ASD Table

Relevant External Links for TMPRSS9 Gene

GeneLoc Exon Structure for
TMPRSS9
ECgene alternative splicing isoforms for
TMPRSS9

Expression for TMPRSS9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMPRSS9 Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS9 Gene

This gene is overexpressed in Testis (x8.1), Liver (x7.7), and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for TMPRSS9 Gene

This gene is overexpressed in Pancreatic juice (36.6) and Liver (30.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS9 Gene



Protein tissue co-expression partners for TMPRSS9 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMPRSS9 Gene:

TMPRSS9

SOURCE GeneReport for Unigene cluster for TMPRSS9 Gene:

Hs.465560

mRNA Expression by UniProt/SwissProt for TMPRSS9 Gene:

Q7Z410-TMPS9_HUMAN
Tissue specificity: Expressed in fetal human tissues, such as kidney, liver, lung and brain, and in a variety of tumor cell lines. Weakly expressed in adult tissues including skeletal muscle, liver, placenta and heart.

Evidence on tissue expression from TISSUES for TMPRSS9 Gene

  • Liver(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TMPRSS9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS9 Gene

Orthologs for TMPRSS9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPRSS9 33 34
  • 98.65 (n)
cow
(Bos Taurus)
Mammalia TMPRSS9 33 34
  • 84.32 (n)
dog
(Canis familiaris)
Mammalia TMPRSS9 33 34
  • 80.91 (n)
mouse
(Mus musculus)
Mammalia Tmprss9 33 16 34
  • 78.99 (n)
rat
(Rattus norvegicus)
Mammalia Tmprss9 33
  • 78.45 (n)
oppossum
(Monodelphis domestica)
Mammalia TMPRSS9 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS9 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMPRSS9 33 34
  • 67.03 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss9 33
  • 60.14 (n)
zebrafish
(Danio rerio)
Actinopterygii tmprss9 33 34
  • 50.98 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006869 33
  • 48.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13744 34
  • 26 (a)
OneToMany
CG8170 34
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea try-1 34
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToOne
Species where no ortholog for TMPRSS9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMPRSS9 Gene

ENSEMBL:
Gene Tree for TMPRSS9 (if available)
TreeFam:
Gene Tree for TMPRSS9 (if available)

Paralogs for TMPRSS9 Gene

Variants for TMPRSS9 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS9 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000059185 -- 2,391,827(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000097498 -- 2,417,779(+) G/A intron_variant
rs1000122432 -- 2,393,585(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000162023 -- 2,387,081(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000191486 -- 2,411,382(+) CTTCTT/CTT genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS9 Gene

Variant ID Type Subtype PubMed ID
dgv1014e212 CNV loss 25503493
dgv1687n106 CNV deletion 24896259
esv1399285 CNV deletion 17803354
esv1707583 CNV deletion 17803354
esv2664636 CNV deletion 23128226
esv2677064 CNV deletion 23128226
esv2763054 CNV loss 21179565
esv3583208 CNV loss 25503493
nsv1064930 CNV gain 25217958
nsv1071493 CNV deletion 25765185
nsv1071494 CNV deletion 25765185
nsv1160562 CNV deletion 26073780
nsv578386 CNV loss 21841781
nsv953944 CNV deletion 24416366

Variation tolerance for TMPRSS9 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.19; 97.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPRSS9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPRSS9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS9 Gene

Disorders for TMPRSS9 Gene

Additional Disease Information for TMPRSS9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMPRSS9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS9 Gene

Publications for TMPRSS9 Gene

  1. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. (PMID: 12886014) Cal S … Lopez-Otin C (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans. (PMID: 16872279) Okumura Y … Kido H (The Biochemical journal 2006) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Polyserase-1/TMPRSS9 induces pro-tumor effects in pancreatic cancer cells by activation of pro-uPA. (PMID: 24756697) Fontanil T … Cal S (Oncology reports 2014) 3 58

Products for TMPRSS9 Gene

Sources for TMPRSS9 Gene

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