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Aliases for TMPRSS7 Gene

Aliases for TMPRSS7 Gene

  • Transmembrane Protease, Serine 7 2 3 5
  • Type II Transmembrane Serine Protease 7 2 3
  • Matriptase-3 3 4
  • Transmembrane Protease Serine 7 3
  • Transmembrane Serine Protease 7 3
  • EC 56
  • EC 56
  • EC 3.4.21.- 4
  • EC 3.4.21 56

External Ids for TMPRSS7 Gene

Previous GeneCards Identifiers for TMPRSS7 Gene

  • GC03P113034
  • GC03P113082
  • GC03P113241
  • GC03P111753
  • GC03P109133

Summaries for TMPRSS7 Gene

GeneCards Summary for TMPRSS7 Gene

TMPRSS7 (Transmembrane Protease, Serine 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ST14.

UniProtKB/Swiss-Prot for TMPRSS7 Gene

  • Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.

Additional gene information for TMPRSS7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS7 Gene

Genomics for TMPRSS7 Gene

GeneHancer (GH) Regulatory Elements for TMPRSS7 Gene

Promoters and enhancers for TMPRSS7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I112043 Enhancer 0.9 Ensembl ENCODE 8.3 +9.1 9058 0.6 CTCF ZNF654 TRIM22 RAD21 RFX5 YY1 CTBP1 PATZ1 SMC3 ZNF143 C3orf52 MIR567 ABHD10 TMPRSS7
GH03I112015 Enhancer 0.6 ENCODE 10.3 -20.8 -20834 0.2 CTCF ZC3H11A TRIM22 RAD21 KAT8 ZGPAT NBN THAP11 ABHD10 TMPRSS7 PLCXD2 TAGLN3 RFKP2
GH03I112014 Enhancer 0.7 ENCODE 6.1 -21.1 -21134 0.2 CTCF ETV1 RAD21 TEAD3 ZNF316 ZNF143 MAFK THAP11 NR2F1 TRIM22 ABHD10 TMPRSS7 TAGLN3 RFKP2
GH03I112031 Enhancer 0.3 ENCODE 12.5 -2.6 -2609 1.3 CTCF RFKP2 TMPRSS7
GH03I112426 Enhancer 0.5 FANTOM5 ENCODE 2.4 +391.8 391814 0.4 CD200 BTLA TMPRSS7 LOC105374041
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMPRSS7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMPRSS7 gene promoter:

Genomic Locations for TMPRSS7 Gene

Genomic Locations for TMPRSS7 Gene
46,427 bases
Plus strand

Genomic View for TMPRSS7 Gene

Genes around TMPRSS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS7 Gene

Proteins for TMPRSS7 Gene

  • Protein details for TMPRSS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 7
    Protein Accession:
    Secondary Accessions:
    • C9J8P7
    • E9PAS3
    • Q17RH4

    Protein attributes for TMPRSS7 Gene

    843 amino acids
    Molecular mass:
    94415 Da
    Quaternary structure:
    • Forms a heterodimer with SERPINA5.

    Alternative splice isoforms for TMPRSS7 Gene


neXtProt entry for TMPRSS7 Gene

Selected DME Specific Peptides for TMPRSS7 Gene


Post-translational modifications for TMPRSS7 Gene

Other Protein References for TMPRSS7 Gene

Domains & Families for TMPRSS7 Gene

Gene Families for TMPRSS7 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TMPRSS7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS7: view

Function for TMPRSS7 Gene

Molecular function for TMPRSS7 Gene

UniProtKB/Swiss-Prot Function:
Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.

Enzyme Numbers (IUBMB) for TMPRSS7 Gene

Phenotypes From GWAS Catalog for TMPRSS7 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity ISS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS7: view
genes like me logo Genes that share phenotypes with TMPRSS7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMPRSS7

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMPRSS7 Gene

Localization for TMPRSS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS7 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS7 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TMPRSS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMPRSS7 Gene

Pathways & Interactions for TMPRSS7 Gene

SuperPathways for TMPRSS7 Gene

No Data Available

Interacting Proteins for TMPRSS7 Gene

Gene Ontology (GO) - Biological Process for TMPRSS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis ISS --
genes like me logo Genes that share ontologies with TMPRSS7: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS7 Gene

Drugs & Compounds for TMPRSS7 Gene

No Compound Related Data Available

Transcripts for TMPRSS7 Gene

mRNA/cDNA for TMPRSS7 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS7 Gene

Transmembrane protease, serine 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS7 Gene

No ASD Table

Relevant External Links for TMPRSS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMPRSS7 Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS7 Gene

This gene is overexpressed in Testis (x19.4) and Pituitary (x4.2).

Protein differential expression in normal tissues from HIPED for TMPRSS7 Gene

This gene is overexpressed in Pancreatic juice (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS7 Gene

Protein tissue co-expression partners for TMPRSS7 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMPRSS7 Gene:


SOURCE GeneReport for Unigene cluster for TMPRSS7 Gene:


mRNA Expression by UniProt/SwissProt for TMPRSS7 Gene:

Tissue specificity: Expressed in brain, ovary, testis, salivary gland, trachea and lung.
genes like me logo Genes that share expression patterns with TMPRSS7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS7 Gene

Orthologs for TMPRSS7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS7 33 34
  • 99.54 (n)
(Bos Taurus)
Mammalia TMPRSS7 33 34
  • 90.66 (n)
(Canis familiaris)
Mammalia TMPRSS7 33 34
  • 90.14 (n)
(Rattus norvegicus)
Mammalia Tmprss7 33
  • 87.73 (n)
(Mus musculus)
Mammalia Tmprss7 33 16 34
  • 87.03 (n)
(Monodelphis domestica)
Mammalia TMPRSS7 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS7 34
  • 72 (a)
(Gallus gallus)
Aves TMPRSS7 33 34
  • 71.18 (n)
(Anolis carolinensis)
Reptilia TMPRSS7 34
  • 60 (a)
(Danio rerio)
Actinopterygii LOC798480 33
  • 56.1 (n)
  • 46 (a)
Species where no ortholog for TMPRSS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS7 Gene

Gene Tree for TMPRSS7 (if available)
Gene Tree for TMPRSS7 (if available)

Paralogs for TMPRSS7 Gene

Variants for TMPRSS7 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS7 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000007863 -- 112,081,694(+) G/T downstream_transcript_variant
rs1000065862 -- 112,059,933(+) C/T intron_variant
rs1000297756 -- 112,054,535(+) A/G intron_variant
rs1000356221 -- 112,080,077(+) A/C intron_variant
rs1000413375 -- 112,076,433(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS7 Gene

Variant ID Type Subtype PubMed ID
dgv919e214 CNV gain 21293372
esv3597404 CNV loss 21293372
esv3597408 CNV loss 21293372

Variation tolerance for TMPRSS7 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.36; 90.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPRSS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS7 Gene

Disorders for TMPRSS7 Gene

Additional Disease Information for TMPRSS7

No disorders were found for TMPRSS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS7 Gene

Publications for TMPRSS7 Gene

  1. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 2 3 4 58
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Type II transmembrane serine protease gene variants associate with breast cancer. (PMID: 25029565) Luostari K … Kosma VM (PloS one 2014) 3 58

Products for TMPRSS7 Gene

Sources for TMPRSS7 Gene

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