Aliases for TMPRSS4 Gene
External Ids for TMPRSS4 Gene
Previous GeneCards Identifiers for TMPRSS4 Gene
This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TMPRSS4 Gene
TMPRSS4 (Transmembrane Serine Protease 4) is a Protein Coding gene. Diseases associated with TMPRSS4 include Autosomal Recessive Cerebral Atrophy and Deafness, Autosomal Recessive 8. Among its related pathways are Measles. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is KLK2.
UniProtKB/Swiss-Prot Summary for TMPRSS4 Gene
Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity).
(Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry.