TMPRSS2 Gene (Protein Coding)

Transmembrane Serine Protease 2

GC21M041464
GIFtS:
44
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hor... See more...

Aliases for TMPRSS2 Gene

Aliases for TMPRSS2 Gene

  • Transmembrane Serine Protease 2 2 3 5
  • PRSS10 2 3 4
  • Transmembrane Protease, Serine 2 2 3
  • Transmembrane Protease Serine 2 3 4
  • Serine Protease 10 3 4
  • EC 3.4.21.109 51
  • Epitheliasin 3
  • EC 3.4.21.- 4
  • EC 3.4.21 51
  • TMPRSS2 5

External Ids for TMPRSS2 Gene

Previous GeneCards Identifiers for TMPRSS2 Gene

  • GC21M039410
  • GC21M041757
  • GC21M041756
  • GC21M041750
  • GC21M042836
  • GC21M028305

Summaries for TMPRSS2 Gene

Entrez Gene Summary for TMPRSS2 Gene

  • This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]

CIViC Summary for TMPRSS2 Gene

GeneCards Summary for TMPRSS2 Gene

TMPRSS2 (Transmembrane Serine Protease 2) is a Protein Coding gene. Diseases associated with TMPRSS2 include Covid-19 and Influenza. Among its related pathways are Transcriptional misregulation in cancer and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is TMPRSS3.

UniProtKB/Swiss-Prot Summary for TMPRSS2 Gene

  • Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).
  • (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

Gene Wiki entry for TMPRSS2 Gene

Additional gene information for TMPRSS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMPRSS2 Gene

Genomics for TMPRSS2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TMPRSS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH21J041496 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 614.1 +27.3 27323 14.6 REST ZIC2 SP1 EZH2 GTF2F1 SOX13 ZFX SP2 TCF7 CTCF TMPRSS2 MX2 ENSG00000207503 FAM3B ABCG1 lnc-RIPK4-5 lnc-RIPK4-6 MX1
GH21J041529 Enhancer 0.4 Ensembl dbSUPER 600.7 +1.5 1515 1.2 KLF1 TMPRSS2 lnc-RIPK4-4 piR-49097-064 LINC00479 lnc-TMPRSS2-6 lnc-RIPK4-5 MX1
GH21J041530 Enhancer 0.3 dbSUPER 605.2 +0.2 156 0.9 GATA3 ATF2 TMPRSS2 lnc-RIPK4-4 piR-49097-064 lnc-TMPRSS2-6 lnc-RIPK4-5 MX1
GH21J041557 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.2 -28.9 -28947 5.9 GATAD2A BACH1 RELA IKZF2 SP1 EED SOX13 ZBTB20 ARID3A ZNF184 ENSG00000207503 TMPRSS2 PRDM15 LINC00112 LINC00479 ENSG00000232806 HSALNG0133214 LOC105372809 RIPK4
GH21J041611 Enhancer 1.1 ENCODE CraniofacialAtlas dbSUPER 11.1 -83.5 -83462 5.6 CTCF TEAD4 PATZ1 REST RAD21 ZNF740 TRIM22 ZNF600 ZNF561 CEBPB TMPRSS2 LINC00112 LINC00479 ENSG00000207503 HSALNG0133223 piR-48759-192 RIPK4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMPRSS2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMPRSS2

Top Transcription factor binding sites by QIAGEN in the TMPRSS2 gene promoter:
  • Bach1
  • CBF(2)
  • Ik-1
  • Ik-2
  • NF-Y
  • RelA
  • SREBP-1b
  • SREBP-1c
  • STAT3

Genomic Locations for TMPRSS2 Gene

Genomic Locations for TMPRSS2 Gene
chr21:41,464,305-41,531,116
(GRCh38/hg38)
Size:
66,812 bases
Orientation:
Minus strand
chr21:42,836,478-42,903,043
(GRCh37/hg19)
Size:
66,566 bases
Orientation:
Minus strand

Genomic View for TMPRSS2 Gene

Genes around TMPRSS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TMPRSS2 Gene

Proteins for TMPRSS2 Gene

Products:

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  • Protein details for TMPRSS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15393-TMPS2_HUMAN
    Recommended name:
    Transmembrane protease serine 2
    Protein Accession:
    O15393
    Secondary Accessions:
    • A8K6Z8
    • B2R8E5
    • B7Z459
    • D3DSJ2
    • F8WES1
    • Q6GTK7
    • Q9BXX1

    Protein attributes for TMPRSS2 Gene

    Size:
    492 amino acids
    Molecular mass:
    53859 Da
    Quaternary structure:
    • The catalytically active form interacts with ACE2.

    Alternative splice isoforms for TMPRSS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPRSS2 Gene

Protein Expression for TMPRSS2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for TMPRSS2 Gene

O15393:
  • DSCQGDSGG
  • CWISGWG
  • GDSGGPL
  • WPWQVSLH
  • CQGDSGGP
  • WPWQVSL

Post-translational modifications for TMPRSS2 Gene

  • Proteolytically processed; by an autocatalytic mechanism.
  • Glycosylation at Asn213 and Asn249
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TMPS2_HUMAN (1848)

Other Protein References for TMPRSS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TMPRSS2
  • Boster Bio Antibodies for TMPRSS2

Domains & Families for TMPRSS2 Gene

Gene Families for TMPRSS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMPRSS2 Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
  • Low density lipoprotein-receptor, class A
  • Speract/scavenger receptor
ProtoNet:

Suggested Antigen Peptide Sequences for TMPRSS2 Gene

GenScript: Design optimal peptide antigens:
  • Epitheliasin (Q96T73_HUMAN)
  • Serine protease 10 (TMPS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15393

UniProtKB/Swiss-Prot:

TMPS2_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS2: view

Function for TMPRSS2 Gene

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Molecular function for TMPRSS2 Gene

UniProtKB/Swiss-Prot Function:
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
UniProtKB/Swiss-Prot Induction:
By androgenic hormones in vivo.
GENATLAS Biochemistry:
transmembrane protein,type II,strongly expressed in small intestine and in normal or carcinoid cells of epithelial prostate,homologous to the enteropeptidase gene,potentially involved in prostate carcinogenesis

Enzyme Numbers (IUBMB) for TMPRSS2 Gene

Phenotypes From GWAS Catalog for TMPRSS2 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IPI 21068237
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 9325052
genes like me logo Genes that share ontologies with TMPRSS2: view
genes like me logo Genes that share phenotypes with TMPRSS2: view

Animal Models for TMPRSS2 Gene

MGI Knock Outs for TMPRSS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMPRSS2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS2

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TMPRSS2 Gene

Localization for TMPRSS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS2 Gene

Cell membrane. Single-pass type II membrane protein.
[Transmembrane protease serine 2 catalytic chain]: Secreted. Note=Activated by cleavage and secreted. {ECO:0000269 PubMed:11245484, ECO:0000269 PubMed:20382709}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 3
cytoskeleton 2
mitochondrion 2
endosome 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMPRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA,IDA 21068237
GO:0005887 integral component of plasma membrane TAS 9325052
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS2: view

Pathways & Interactions for TMPRSS2 Gene

genes like me logo Genes that share pathways with TMPRSS2: view

Pathways by source for TMPRSS2 Gene

SIGNOR curated interactions for TMPRSS2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TMPRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 21068237
GO:0006897 endocytosis IEA --
GO:0016540 protein autoprocessing IBA,IMP 21068237
GO:0046598 positive regulation of viral entry into host cell IDA 21068237
genes like me logo Genes that share ontologies with TMPRSS2: view

Drugs & Compounds for TMPRSS2 Gene

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(17) Drugs for TMPRSS2 Gene - From: DrugBank, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Camostat Experimental Pharma Target, inhibitor 6
Serine Investigational Nutra Agonist, Full agonist Weak endogenous glycine receptor agonist 1156
Nafamostat Investigational Pharma Channel blocker 7
Analgesics Pharma 13606
Analgesics, Non-Narcotic Pharma 7345

(1) Additional Compounds for TMPRSS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMPRSS2: view

Transcripts for TMPRSS2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TMPRSS2 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a ·
SP1: - - - - - - - -
SP2: - - - -
SP3:
SP4: - -
SP5: - - - - - - - -
SP6: - -
SP7: - - - - -
SP8: -
SP9: -
SP10: -
SP11:

ExUns: 17b · 17c ^ 18a · 18b · 18c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11: -

Relevant External Links for TMPRSS2 Gene

GeneLoc Exon Structure for
TMPRSS2

Expression for TMPRSS2 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPRSS2 Gene

mRNA expression in normal human tissues for TMPRSS2 Gene
mRNA expression by BioGPS for TMPRSS2 GenemRNA expression by GTEx for TMPRSS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS2 Gene

This gene is overexpressed in Prostate (x10.6), Colon - Transverse (x8.8), Stomach (x7.1), and Pancreas (x6.5).

Protein differential expression in normal tissues from HIPED for TMPRSS2 Gene

This gene is overexpressed in Amniocyte (60.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMPRSS2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMPRSS2

SOURCE GeneReport for Unigene cluster for TMPRSS2 Gene:

Hs.439309

mRNA Expression by UniProt/SwissProt for TMPRSS2 Gene:

O15393-TMPS2_HUMAN
Tissue specificity: Expressed in several tissues that comprise large populations of epithelial cells with the highest level of transcripts measured in the prostate gland. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland.

Evidence on tissue expression from TISSUES for TMPRSS2 Gene

  • Liver(4.5)
  • Nervous system(4.4)
  • Intestine(3.5)
  • Kidney(2.9)
  • Lung(2.8)
  • Stomach(2.8)
  • Urine(2.6)
  • Pancreas(2.6)
  • Blood(2.3)
  • Skin(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with TMPRSS2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS2 Gene

Orthologs for TMPRSS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TMPRSS2 30 31
  • 99.12 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TMPRSS2 30 31
  • 82.21 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TMPRSS2 30 31
  • 80.78 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Tmprss2 30
  • 77.85 (n)
Mouse
(Mus musculus)
 Mammalia Tmprss2 30 17 31
  • 77.64 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia TMPRSS2 31
  • 70 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TMPRSS2 31
  • 70 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves TMPRSS2 30 31
  • 65.46 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TMPRSS2 31
  • 58 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC101731874 30
  • 56.72 (n)
Str.13039 30
African clawed frog
(Xenopus laevis)
 Amphibia Xesp-2 30
Zebrafish
(Danio rerio)
 Actinopterygii tmprss2 30 31
  • 53.72 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG18065 32
  • 39 (a)
CG11192 32
  • 38 (a)
CG10405 32
  • 38 (a)
CG5197 32
  • 35 (a)
CG10663 32
  • 35 (a)
CG5246 32
  • 35 (a)
CG1299 32
  • 32 (a)
Worm
(Caenorhabditis elegans)
 Secernentea svh-1 30
  • 41.88 (n)
ZK546.15 32
  • 32 (a)
Species where no ortholog for TMPRSS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TMPRSS2 Gene

ENSEMBL:
Gene Tree for TMPRSS2 (if available)
TreeFam:
Gene Tree for TMPRSS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMPRSS2: view image

Paralogs for TMPRSS2 Gene

Paralogs for TMPRSS2 Gene

(73) SIMAP similar genes for TMPRSS2 Gene using alignment to 5 proteins:

  • TMPS2_HUMAN
  • C9J5Y1_HUMAN
  • C9JB05_HUMAN
  • C9JKZ3_HUMAN
  • Q96T73_HUMAN
genes like me logo Genes that share paralogs with TMPRSS2: view

Variants for TMPRSS2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMPRSS2 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
727567 Benign: not provided 41,494,541(-) T/C MISSENSE_VARIANT
746279 Benign: not provided 41,494,461(-) A/C MISSENSE_VARIANT
747838 Benign: not provided 41,473,432(-) C/T SYNONYMOUS_VARIANT
771222 Benign: not provided 41,480,508(-) G/A SYNONYMOUS_VARIANT
773614 Benign: not provided 41,494,370(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TMPRSS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS2 Gene

Variant ID Type Subtype PubMed ID
dgv7835n54 CNV loss 21841781
dgv7836n54 CNV gain 21841781
dgv7837n54 CNV gain 21841781
dgv7838n54 CNV gain 21841781
dgv7839n54 CNV gain+loss 21841781
dgv7840n54 CNV loss 21841781
dgv7841n54 CNV loss 21841781
dgv7842n54 CNV gain+loss 21841781
dgv7843n54 CNV loss 21841781
esv26806 CNV gain 19812545
esv2723487 CNV deletion 23290073
esv2723488 CNV deletion 23290073
esv2723489 CNV deletion 23290073
esv275165 CNV loss 21479260
esv3647063 CNV gain 21293372
esv3647064 CNV gain 21293372
esv3893416 CNV gain 25118596
nsv1071755 CNV deletion 25765185
nsv1112801 CNV deletion 24896259
nsv1144003 CNV deletion 24896259
nsv459261 CNV loss 19166990
nsv511631 CNV gain 21212237
nsv587496 CNV loss 21841781
nsv587503 CNV loss 21841781
nsv587506 CNV gain+loss 21841781
nsv587509 CNV gain+loss 21841781
nsv587517 CNV gain 21841781
nsv587523 CNV gain+loss 21841781
nsv587528 CNV loss 21841781
nsv587539 CNV loss 21841781
nsv587540 CNV loss 21841781
nsv834102 CNV loss 17160897
nsv953628 CNV deletion 24416366

Variation tolerance for TMPRSS2 Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.13; 95.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPRSS2 Gene

Human Gene Mutation Database (HGMD)
TMPRSS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPRSS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS2 Gene

Disorders for TMPRSS2 Gene

MalaCards: The human disease database

(13) MalaCards diseases for TMPRSS2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
covid-19
  • 2019 novel coronavirus
influenza
  • flu
prostate cancer
  • prostate cancer, somatic
middle east respiratory syndrome
  • mers
severe acute respiratory syndrome
  • sars
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMPRSS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TMPRSS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPRSS2 Gene

Publications for TMPRSS2 Gene

  1. Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. (PMID: 9325052) Paoloni-Giacobino A … Antonarakis SE (Genomics 1997) 2 3 4 23
  2. TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells. (PMID: 20382709) Chen YW … Lin CY (The American journal of pathology 2010) 3 4 23
  3. Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study. (PMID: 15065083) Lubieniecka JM … Ostrander EA (The Prostate 2004) 3 23 41
  4. Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues. (PMID: 11169526) Vaarala MH … Vihko PT (The Journal of pathology 2001) 3 4 23
  5. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. (PMID: 32142651) Hoffmann M … Pöhlmann S (Cell 2020) 3 4

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