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This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hor... See more...
Aliases for TMPRSS2 Gene
Aliases for TMPRSS2 Gene
External Ids for TMPRSS2 Gene
- HGNC: 11876
- Entrez Gene: 7113
- Ensembl: ENSG00000184012
- OMIM: 602060
- UniProtKB: O15393
Previous GeneCards Identifiers for TMPRSS2 Gene
- GC21M039410
- GC21M041757
- GC21M041756
- GC21M041750
- GC21M042836
- GC21M028305
Summaries for TMPRSS2 Gene
-
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]
GeneCards Summary for TMPRSS2 Gene
TMPRSS2 (Transmembrane Serine Protease 2) is a Protein Coding gene. Diseases associated with TMPRSS2 include Covid-19 and Influenza. Among its related pathways are Transcriptional misregulation in cancer and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is TMPRSS3.
UniProtKB/Swiss-Prot Summary for TMPRSS2 Gene
-
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).
-
(Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
Additional gene information for TMPRSS2 Gene
- HGNC(11876)
- Entrez Gene(7113)
- Ensembl(ENSG00000184012)
- OMIM(602060)
- UniProtKB(O15393)
- Open Targets Platform(ENSG00000184012)
- Search for TMPRSS2 at DataMed
- Search for TMPRSS2 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMPRSS2 Gene
Genomics for TMPRSS2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TMPRSS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TMPRSS2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMPRSS2
- Top Transcription factor binding sites by QIAGEN in the TMPRSS2 gene promoter:
-
- Bach1
- CBF(2)
- Ik-1
- Ik-2
- NF-Y
- RelA
- SREBP-1b
- SREBP-1c
- STAT3
Genomic Locations for TMPRSS2 Gene
Genomic Locations for TMPRSS2 Gene
- chr21:41,464,305-41,531,116
- (GRCh38/hg38)
- Size:
- 66,812 bases
- Orientation:
- Minus strand
- chr21:42,836,478-42,903,043
- (GRCh37/hg19)
- Size:
- 66,566 bases
- Orientation:
- Minus strand
Genomic View for TMPRSS2 Gene
Genes around TMPRSS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by HGNC
- 21q22.3 by Entrez Gene
- 21q22.3 by Ensembl
TMPRSS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMPRSS2 Gene
Proteins for TMPRSS2 Gene
-
Protein details for TMPRSS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15393-TMPS2_HUMAN
- Recommended name:
- Transmembrane protease serine 2
- Protein Accession:
- O15393
- A8K6Z8
- B2R8E5
- B7Z459
- D3DSJ2
- F8WES1
- Q6GTK7
- Q9BXX1
Protein attributes for TMPRSS2 Gene
- Size:
- 492 amino acids
- Molecular mass:
- 53859 Da
- Quaternary structure:
-
- The catalytically active form interacts with ACE2.
Protein Expression for TMPRSS2 Gene
Selected DME Specific Peptides for TMPRSS2 Gene
- O15393:
-
- DSCQGDSGG
- CWISGWG
- GDSGGPL
- WPWQVSLH
- CQGDSGGP
- WPWQVSL
Post-translational modifications for TMPRSS2 Gene
Other Protein References for TMPRSS2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences TMPRSS2 / Epitheliasin Antibody (LS-B14093) and TMPRSS2 / Epitheliasin Antibody (LS-B14876)
- G Biosciences Immunotag™ TMPRSS2 Antibody
- Creative Diagnostics Anti-TMPRSS2 monoclonal antibody, clone FQS4972
- Creative Biolabs Anti-Human TMPRSS2 Therapeutic Antibody and Anti-Human PRO115 Therapeutic Antibody (A107.1)
-
Custom Antibody ServicesOriGene Antibodies for TMPRSS2
- Novus Biologicals Antibodies for TMPRSS2
-
Abcam antibodies for TMPRSS2
- Invitrogen Antibodies for TMPRSS2 (AFLGC-TMPRSS2)
-
Boster Bio Antibodies for TMPRSS2
-
Santa Cruz Biotechnology (SCBT) Antibodies for TMPRSS2
- Sino Biological Antibodies for TMPRSS2
Protein Products
- Creative Biomart Recombinant Human TMPRSS2
-
OriGene Purified Proteins for TMPRSS2
- Search Origene for MassSpec and Protein Over-expression Lysates for TMPRSS2
- Origene Custom Protein Services for TMPRSS2
- antibodies-online: Show 12 available TMPRSS2 Proteins ranked by validation data
- Compare Top TMPRSS2 Proteins
-
Quality Products:
-
Abcam proteins for TMPRSS2
Assay Products
- Aviva Systems Biology TMPRSS2 ELISA Kit (Human) (OKDD00567) and TMPRSS2 ELISA Kit (Human) (OKCD08255)
- Novus Biologicals ELISA Kits for TMPRSS2
- antibodies-online: Show 26 available TMPRSS2 Elisa Kits ranked by validation data
- Compare Top TMPRSS2 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for TMPRSS2
Domains & Families for TMPRSS2 Gene
Gene Families for TMPRSS2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for TMPRSS2 Gene
- InterPro:
- Blocks:
-
- Serine protease, trypsin family
- Chymotrypsin serine protease family (S1) signature
- Low density lipoprotein-receptor, class A
- Speract/scavenger receptor
- ProtoNet:
Suggested Antigen Peptide Sequences for TMPRSS2 Gene
- GenScript: Design optimal peptide antigens:
-
- Epitheliasin (Q96T73_HUMAN)
- Serine protease 10 (TMPS2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O15393- Family:
-
- Belongs to the peptidase S1 family.
Function for TMPRSS2 Gene
Molecular function for TMPRSS2 Gene
- UniProtKB/Swiss-Prot Function:
- Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
- UniProtKB/Swiss-Prot Induction:
- By androgenic hormones in vivo.
- GENATLAS Biochemistry:
- transmembrane protein,type II,strongly expressed in small intestine and in normal or carcinoid cells of epithelial prostate,homologous to the enteropeptidase gene,potentially involved in prostate carcinogenesis
Enzyme Numbers (IUBMB) for TMPRSS2 Gene
Phenotypes From GWAS Catalog for TMPRSS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004252 | serine-type endopeptidase activity | IEA | -- |
| GO:0005044 | scavenger receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 21068237 |
| GO:0008233 | peptidase activity | IEA | -- |
| GO:0008236 | serine-type peptidase activity | TAS | 9325052 |
Phenotypes for TMPRSS2 Gene
- MGI mutant phenotypes for TMPRSS2:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for TMPRSS2:
Animal Models for TMPRSS2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for TMPRSS2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TMPRSS2 - Select products 50% OFF >
- * TMPRSS2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TMPRSS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMPRSS2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMPRSS2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMPRSS2
- Browse OriGene Inhibitory RNA Products For TMPRSS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS2
Clone Products
- Applied Biological Materials (abm): Clones for TMPRSS2 - Select products 50% OFF >
- * TMPRSS2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207852
- MR207852
- MR207852L3
- MR207852L4
- RC208677
- RC208677L1
- RC208677L2
- RC208677L3
- RC208677L4
- RC228432
- RC228432L1
- RC228432L2
- RC228432L3
- RC228432L4
- RG208677
- RG228432
- RR214298
- RR214298L3
- RR214298L4
- MR207852L3V
- MR207852L4V
- RC208677L1V
- RC208677L2V
- RC208677L3V
- RC208677L4V
- RC228432L1V
- RC228432L2V
- RC228432L3V
- RC228432L4V
- RR214298L3V
- RR214298L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TMPRSS2
- Addgene plasmids for TMPRSS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMPRSS2
Cell Line Products
-
Horizon Cell Lines for TMPRSS2
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TMPRSS2 Gene
Localization for TMPRSS2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS2 Gene
- Cell membrane. Single-pass type II membrane protein.
- [Transmembrane protease serine 2 catalytic chain]: Secreted. Note=Activated by cleavage and secreted. {ECO:0000269 PubMed:11245484, ECO:0000269 PubMed:20382709}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endosome | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cell Junctions (3)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005886 | plasma membrane | IEA,IDA | 21068237 |
| GO:0005887 | integral component of plasma membrane | TAS | 9325052 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TMPRSS2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Measles |
.33
|
|
| 2 | Endometrial cancer |
.32
|
|
| 3 | Transcriptional misregulation in cancer | ||
| 4 | Coregulation of Androgen receptor activity | ||
| 5 | Regulation of Androgen receptor activity | ||
Pathways by source for TMPRSS2 Gene
2 BioSystems pathways for TMPRSS2 Gene
3 KEGG pathways for TMPRSS2 Gene
Interacting Proteins for TMPRSS2 Gene
Selected Interacting proteins:
O15393-TMPS2_HUMAN
ENSP00000381588
for TMPRSS2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TMPRSS2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IDA | 21068237 |
| GO:0006897 | endocytosis | IEA | -- |
| GO:0016540 | protein autoprocessing | IBA,IMP | 21068237 |
| GO:0046598 | positive regulation of viral entry into host cell | IDA | 21068237 |
Drugs & Compounds for TMPRSS2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Camostat | Experimental | Pharma | Target, inhibitor | 6 | ||
| Serine | Investigational | Nutra | Agonist, Full agonist | Weak endogenous glycine receptor agonist | 1156 | |
| Nafamostat | Investigational | Pharma | Channel blocker | 7 | ||
| Analgesics | Pharma | 13606 | ||||
| Analgesics, Non-Narcotic | Pharma | 7345 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Creative Biomart Recombinant Human TMPRSS2
Transcripts for TMPRSS2 Gene
mRNA/cDNA for TMPRSS2 Gene
- 3 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000332149 3450 nts (view in UCSC)
- ENST00000398585 3240 nts (view in UCSC)
- ENST00000424093 726 nts (view in UCSC)
- ENST00000454499 1901 nts (view in UCSC)
- ENST00000455813 454 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TMPRSS2 - Select products 50% OFF >
- * TMPRSS2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TMPRSS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMPRSS2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMPRSS2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TMPRSS2
- Browse OriGene Inhibitory RNA Products For TMPRSS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS2
Clone Products
- Applied Biological Materials (abm): Clones for TMPRSS2 - Select products 50% OFF >
- * TMPRSS2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207852
- MR207852
- MR207852L3
- MR207852L4
- RC208677
- RC208677L1
- RC208677L2
- RC208677L3
- RC208677L4
- RC228432
- RC228432L1
- RC228432L2
- RC228432L3
- RC228432L4
- RG208677
- RG228432
- RR214298
- RR214298L3
- RR214298L4
- MR207852L3V
- MR207852L4V
- RC208677L1V
- RC208677L2V
- RC208677L3V
- RC208677L4V
- RC228432L1V
- RC228432L2V
- RC228432L3V
- RC228432L4V
- RR214298L3V
- RR214298L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TMPRSS2
- Addgene plasmids for TMPRSS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMPRSS2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 17b | · | 17c | ^ | 18a | · | 18b | · | 18c |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | - | ||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: | - |
Relevant External Links for TMPRSS2 Gene
- GeneLoc Exon Structure for
- TMPRSS2
Expression for TMPRSS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
- Renal Collecting Duct System
- Ureteric Bud
- S-shaped Body
- Testis (Reproductive System)
- Eye (Sensory Organs)
- Lung (Respiratory System)
- Epithelial Cells (Uncategorized)
- Liver (Hepatobiliary System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for TMPRSS2 Gene
This gene is overexpressed in Prostate (x10.6), Colon - Transverse (x8.8), Stomach (x7.1), and Pancreas (x6.5).
This gene is overexpressed in Amniocyte (60.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMPRSS2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMPRSS2
SOURCE GeneReport for Unigene cluster for TMPRSS2 Gene:
Hs.439309mRNA Expression by UniProt/SwissProt for TMPRSS2 Gene:
O15393-TMPS2_HUMAN
Tissue specificity:
Expressed in several tissues that comprise large populations of epithelial cells with the highest level of transcripts measured in the prostate gland. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland.
Evidence on tissue expression from TISSUES for TMPRSS2 Gene
- Liver(4.5)
- Nervous system(4.4)
- Intestine(3.5)
- Kidney(2.9)
- Lung(2.8)
- Stomach(2.8)
- Urine(2.6)
- Pancreas(2.6)
- Blood(2.3)
- Skin(2.2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for TMPRSS2
-
OriGene qPCR primer pairs and template standards for TMPRSS2
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS2 Gene
Orthologs for TMPRSS2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TMPRSS2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TMPRSS2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TMPRSS2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tmprss2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tmprss2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TMPRSS2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TMPRSS2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TMPRSS2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TMPRSS2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101731874 30 |
|
||
| Str.13039 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xesp-2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tmprss2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG18065 32 |
|
|
|
| CG11192 32 |
|
|
|||
| CG10405 32 |
|
|
|||
| CG5197 32 |
|
|
|||
| CG10663 32 |
|
|
|||
| CG5246 32 |
|
|
|||
| CG1299 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | svh-1 30 |
|
||
| ZK546.15 32 |
|
|
- Species where no ortholog for TMPRSS2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TMPRSS2 Gene
- ENSEMBL:
- Gene Tree for TMPRSS2 (if available)
- TreeFam:
- Gene Tree for TMPRSS2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TMPRSS2: view image
Paralogs for TMPRSS2 Gene
Paralogs for TMPRSS2 Gene
(73) SIMAP similar genes for TMPRSS2 Gene using alignment to 5 proteins:
- TMPS2_HUMAN
- C9J5Y1_HUMAN
- C9JB05_HUMAN
- C9JKZ3_HUMAN
- Q96T73_HUMAN
- MGC52282
- TMPRSS11E
- TMPRSS11B
- PRSS46
- DESC1
- TMPRSS11F
- TMPRSS11A
- PROC1
- PROC
- CELA2B
- TMPRSS3
- TMPRSS11D
- PRSS42
- DKFZp586F0824
- TMPRSS12
- KLKB1
- PRSS22
- PRSS1
- TMPRSS15
- F11
- PRSS45
- DKFZp779M0222
- F9
- ACR
- PRSS8
- KLK8
- TMPRSS4
- TPSD1
- PRSS33
- PRSS27
- ELA2A
- CTRL
- CELA2A
- KLK13
- TPSB2
- TPSAB1
- TRY8
- CELA3A
- tryptaseB
- PRSS48
- PRSS41
- PRSS21
- KLK9
- CTRB2
- CTRB1
- PRSS2
- CORIN
- PRSS38
- tryptaseC
- PRSS29P
- GZMM
- TMPRSS13
- TMPRSS5
- PRSS55
- PRSS3
- KLK11
- ELA3A
- ELA2B
- CTRC
- CELA1
- UNQ9391
- KLK6
- KLK5
- KLK14
- HPN
- GZMA
- CFD
- CELA3B
- KLK15
- KLK4
- ST14
- TMPRSS7
- DF
Variants for TMPRSS2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMPRSS2 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 727567 | Benign: not provided | 41,494,541(-) | T/C | MISSENSE_VARIANT | |
| 746279 | Benign: not provided | 41,494,461(-) | A/C | MISSENSE_VARIANT | |
| 747838 | Benign: not provided | 41,473,432(-) | C/T | SYNONYMOUS_VARIANT | |
| 771222 | Benign: not provided | 41,480,508(-) | G/A | SYNONYMOUS_VARIANT | |
| 773614 | Benign: not provided | 41,494,370(-) | G/A | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.13;
95.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TMPRSS2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS2 Gene
Disorders for TMPRSS2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| covid-19 |
|
|
| influenza |
|
|
| prostate cancer |
|
|
| middle east respiratory syndrome |
|
|
| severe acute respiratory syndrome |
|
|
Search TMPRSS2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TMPRSS2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TMPRSS2 Gene
Publications for TMPRSS2 Gene
- Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3. (PMID: 9325052) Paoloni-Giacobino A … Antonarakis SE (Genomics 1997) 2 3 4 23
- TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells. (PMID: 20382709) Chen YW … Lin CY (The American journal of pathology 2010) 3 4 23
- Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study. (PMID: 15065083) Lubieniecka JM … Ostrander EA (The Prostate 2004) 3 23 41
- Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues. (PMID: 11169526) Vaarala MH … Vihko PT (The Journal of pathology 2001) 3 4 23
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. (PMID: 32142651) Hoffmann M … Pöhlmann S (Cell 2020) 3 4
ExternalLinks
Products for TMPRSS2 Gene
- Custom Antibody ServicesOriGene Antibodies for TMPRSS2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TMPRSS2
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- OriGene CRISPR knockouts for TMPRSS2
- MG207852
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- RC228432L4
- RG208677
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- RR214298
- RR214298L3
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- RC228432L1V
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- RC228432L3V
- RC228432L4V
- RR214298L3V
- RR214298L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Browse Sino Biological Assays
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Browse Antibodies
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- Abcam antibodies for TMPRSS2
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- Browse Primary Antibodies
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- Taconic Biosciences Mouse Models for TMPRSS2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for TMPRSS2 (AFLGC-TMPRSS2)
- VectorBuilder Custom and pre-made DNA vectors for TMPRSS2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TMPRSS2 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for TMPRSS2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TMPRSS2
- Addgene plasmids for TMPRSS2
- antibodies-online: Show 14 available TMPRSS2 Antibodies ranked by validation data
- Compare Top TMPRSS2 Antibodies
- Quality Products:
- antibodies-online: Show 26 available TMPRSS2 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 12 available TMPRSS2 Proteins ranked by validation data
- Compare Top TMPRSS2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for TMPRSS2
- Search Santa Cruz Biotechnology (SCBT) for TMPRSS2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TMPRSS2
- Horizon Cell Lines for TMPRSS2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMPRSS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMPRSS2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TMPRSS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS2
- Boster Bio Antibodies for TMPRSS2
- Browse Boster Bio ELISA Kits
Sources for TMPRSS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB