Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]
TMPRSS2 (Transmembrane Serine Protease 2) is a Protein Coding gene. Diseases associated with TMPRSS2 include Covid-19 and Influenza. Among its related pathways are Transcriptional misregulation in cancer and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and scavenger receptor activity. An important paralog of this gene is TMPRSS3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004252 | serine-type endopeptidase activity | IEA | -- |
GO:0005044 | scavenger receptor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 21068237 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008236 | serine-type peptidase activity | TAS | 9325052 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | IEA,IDA | 21068237 |
GO:0005887 | integral component of plasma membrane | TAS | 9325052 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Measles |
.33
|
|
2 | Endometrial cancer |
.32
|
|
3 | Transcriptional misregulation in cancer | ||
4 | Coregulation of Androgen receptor activity | ||
5 | Regulation of Androgen receptor activity |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IDA | 21068237 |
GO:0006897 | endocytosis | IEA | -- |
GO:0016540 | protein autoprocessing | IBA,IMP | 21068237 |
GO:0046598 | positive regulation of viral entry into host cell | IDA | 21068237 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Camostat | Experimental | Pharma | Target, inhibitor | 6 | ||
Serine | Investigational | Nutra | Agonist, Full agonist | Weak endogenous glycine receptor agonist | 1156 | |
Nafamostat | Investigational | Pharma | Channel blocker | 7 | ||
Analgesics | Pharma | 13606 | ||||
Analgesics, Non-Narcotic | Pharma | 7345 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: |
ExUns: | 17b | · | 17c | ^ | 18a | · | 18b | · | 18c |
---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||
SP2: | |||||||||
SP3: | |||||||||
SP4: | |||||||||
SP5: | |||||||||
SP6: | |||||||||
SP7: | |||||||||
SP8: | - | ||||||||
SP9: | |||||||||
SP10: | |||||||||
SP11: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TMPRSS2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TMPRSS2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TMPRSS2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tmprss2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tmprss2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TMPRSS2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TMPRSS2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TMPRSS2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TMPRSS2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101731874 30 |
|
||
Str.13039 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xesp-2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tmprss2 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG18065 32 |
|
|
|
CG11192 32 |
|
|
|||
CG10405 32 |
|
|
|||
CG5197 32 |
|
|
|||
CG10663 32 |
|
|
|||
CG5246 32 |
|
|
|||
CG1299 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | svh-1 30 |
|
||
ZK546.15 32 |
|
|
SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
727567 | Benign: not provided | 41,494,541(-) | T/C | MISSENSE_VARIANT | |
746279 | Benign: not provided | 41,494,461(-) | A/C | MISSENSE_VARIANT | |
747838 | Benign: not provided | 41,473,432(-) | C/T | SYNONYMOUS_VARIANT | |
771222 | Benign: not provided | 41,480,508(-) | G/A | SYNONYMOUS_VARIANT | |
773614 | Benign: not provided | 41,494,370(-) | G/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
covid-19 |
|
|
influenza |
|
|
prostate cancer |
|
|
middle east respiratory syndrome |
|
|
severe acute respiratory syndrome |
|
|