This gene encodes a member of the type II transmembrane serine protease family. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] See more...

Aliases for TMPRSS13 Gene

Aliases for TMPRSS13 Gene

  • Transmembrane Serine Protease 13 2 3 5
  • Membrane-Type Mosaic Serine Protease 2 3 4
  • Transmembrane Protease, Serine 11 2 3
  • Transmembrane Protease, Serine 13 2 3
  • Transmembrane Protease Serine 13 3 4
  • TMPRSS11 3 4
  • MSPL 2 3
  • MSPS 2 3
  • MSP 3 4
  • Mosaic Serine Protease 4
  • EC 3.4.21.109 50
  • EC 3.4.21.- 4
  • EC 3.4.21 50
  • TMPRSS13 5

External Ids for TMPRSS13 Gene

Previous HGNC Symbols for TMPRSS13 Gene

  • TMPRSS11

Previous GeneCards Identifiers for TMPRSS13 Gene

  • GC11M117277
  • GC11M117771
  • GC11M113705

Summaries for TMPRSS13 Gene

Entrez Gene Summary for TMPRSS13 Gene

  • This gene encodes a member of the type II transmembrane serine protease family. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TMPRSS13 Gene

TMPRSS13 (Transmembrane Serine Protease 13) is a Protein Coding gene. Diseases associated with TMPRSS13 include Avian Influenza and Variegate Porphyria. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type exopeptidase activity. An important paralog of this gene is TMPRSS3.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMPRSS13 Gene

Genomics for TMPRSS13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMPRSS13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMPRSS13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMPRSS13

Top Transcription factor binding sites by QIAGEN in the TMPRSS13 gene promoter:
  • AML1a
  • AP-4
  • ATF-2
  • CP2
  • E2F
  • E2F-1
  • GATA-2
  • NF-E2
  • NF-E2 p45

Genomic Locations for TMPRSS13 Gene

Latest Assembly
chr11:117,900,641-117,929,459
(GRCh38/hg38)
Size:
28,819 bases
Orientation:
Minus strand

Previous Assembly
chr11:117,771,356-117,800,117
(GRCh37/hg19 by Entrez Gene)
Size:
28,762 bases
Orientation:
Minus strand

chr11:117,771,358-117,800,174
(GRCh37/hg19 by Ensembl)
Size:
28,817 bases
Orientation:
Minus strand

Genomic View for TMPRSS13 Gene

Genes around TMPRSS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS13 Gene

Proteins for TMPRSS13 Gene

  • Protein details for TMPRSS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYE2-TMPSD_HUMAN
    Recommended name:
    Transmembrane protease serine 13
    Protein Accession:
    Q9BYE2
    Secondary Accessions:
    • B4DTM9
    • E9PIJ5
    • E9PRA0
    • F8WAJ3
    • J3KQC6
    • Q1RMF8
    • Q86YM4
    • Q96JY8
    • Q9BYE1

    Protein attributes for TMPRSS13 Gene

    Size:
    586 amino acids
    Molecular mass:
    63167 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMPRSS13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPRSS13 Gene

Selected DME Specific Peptides for TMPRSS13 Gene

Q9BYE2:
  • VLTAAHC
  • GDSGGPL
  • WPWQVSLH
  • SGGPLVC
  • PGVYTKV
  • DSCQGDSGG
  • CQGDSGGP
  • LTAAHCF
  • WVLTAAH
  • WPWQVSL

Post-translational modifications for TMPRSS13 Gene

  • Glycosylation at Asn255, Asn292, Asn405, and Asn445
  • Modification sites at PhosphoSitePlus

Domains & Families for TMPRSS13 Gene

Gene Families for TMPRSS13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMPRSS13 Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
  • Low density lipoprotein-receptor, class A
  • Speract/scavenger receptor

Suggested Antigen Peptide Sequences for TMPRSS13 Gene

GenScript: Design optimal peptide antigens:
  • TMPRSS13 protein (Q1RMF8_HUMAN)
  • Membrane-type mosaic serine protease (TMPSD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BYE2

UniProtKB/Swiss-Prot:

TMPSD_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS13: view

Function for TMPRSS13 Gene

Enzyme Numbers (IUBMB) for TMPRSS13 Gene

Phenotypes From GWAS Catalog for TMPRSS13 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 11267681
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS13: view
genes like me logo Genes that share phenotypes with TMPRSS13: view

Animal Models for TMPRSS13 Gene

MGI Knock Outs for TMPRSS13:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS13

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMPRSS13 Gene

Localization for TMPRSS13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS13 Gene

Membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS13 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for TMPRSS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11267681
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with TMPRSS13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMPRSS13 Gene

Pathways & Interactions for TMPRSS13 Gene

PathCards logo

SuperPathways for TMPRSS13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMPRSS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006897 endocytosis IEA --
genes like me logo Genes that share ontologies with TMPRSS13: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS13 Gene

Drugs & Compounds for TMPRSS13 Gene

(2) Drugs for TMPRSS13 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PMSF Pharma Serine proteinases inhibitor, irreversible 0

(1) Additional Compounds for TMPRSS13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for TMPRSS13 Gene

Compound Action Cas Number
PMSF Serine proteinases inhibitor, irreversible 329-98-6
genes like me logo Genes that share compounds with TMPRSS13: view

Drug products for research

Transcripts for TMPRSS13 Gene

mRNA/cDNA for TMPRSS13 Gene

5 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS13

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5:
SP6: - - - - -

Relevant External Links for TMPRSS13 Gene

GeneLoc Exon Structure for
TMPRSS13

Expression for TMPRSS13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPRSS13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS13 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.5), Skin - Not Sun Exposed (Suprapubic) (x11.6), and Esophagus - Mucosa (x5.9).

Protein differential expression in normal tissues from HIPED for TMPRSS13 Gene

This gene is overexpressed in Cervix (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMPRSS13 Gene



Protein tissue co-expression partners for TMPRSS13 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMPRSS13

SOURCE GeneReport for Unigene cluster for TMPRSS13 Gene:

Hs.266308

mRNA Expression by UniProt/SwissProt for TMPRSS13 Gene:

Q9BYE2-TMPSD_HUMAN
Tissue specificity: Isoform 1 and isoform 3 are predominantly expressed in lung, placenta, pancreas, and prostate. Isoform 3 is weakly expressed in testis and peripheral blood lymphocytes.

Evidence on tissue expression from TISSUES for TMPRSS13 Gene

  • Lung(4.4)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with TMPRSS13: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS13 Gene

Orthologs for TMPRSS13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMPRSS13 29 30
  • 97.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMPRSS13 29 30
  • 87.07 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmprss13 29 16 30
  • 85.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmprss13 29
  • 84.67 (n)
Cow
(Bos Taurus)
Mammalia TMPRSS13 29 30
  • 83.47 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMPRSS13 30
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS13 30
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100859131 29
  • 68.84 (n)
TMPRSS13 30
  • 61 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMPRSS13 30
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmprss13 29
  • 52.59 (n)
Zebrafish
(Danio rerio)
Actinopterygii tmprss13b 29 30
  • 50.63 (n)
OneToMany
tmprss13a 30
  • 34 (a)
OneToMany
Species where no ortholog for TMPRSS13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMPRSS13 Gene

ENSEMBL:
Gene Tree for TMPRSS13 (if available)
TreeFam:
Gene Tree for TMPRSS13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMPRSS13: view image
Alliance of Genome Resources:
Additional Orthologs for TMPRSS13

Paralogs for TMPRSS13 Gene

genes like me logo Genes that share paralogs with TMPRSS13: view

Variants for TMPRSS13 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS13 Gene

TMPSD_HUMAN-Q9BYE2
The repeat A-S-P-A-[GLQR] is polymorphic and the number of copies varies between 12 to 14.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMPRSS13 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
993528 Uncertain Significance: none provided 117,908,620(-) G/T
NM_001077263.3(TMPRSS13):c.1274C>A (p.Thr425Asn)
MISSENSE
993968 Uncertain Significance: none provided 117,904,080(-) C/T
NM_001077263.3(TMPRSS13):c.1403G>A (p.Arg468Gln)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMPRSS13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS13 Gene

Variant ID Type Subtype PubMed ID
esv2745121 CNV deletion 23290073

Variation tolerance for TMPRSS13 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPRSS13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPRSS13
Leiden Open Variation Database (LOVD)
TMPRSS13

SNP Genotyping and Copy Number Assays for research

Disorders for TMPRSS13 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMPRSS13 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
avian influenza
  • avian flu
variegate porphyria
  • vp
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMPRSS13

genes like me logo Genes that share disorders with TMPRSS13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPRSS13 Gene

Publications for TMPRSS13 Gene

  1. Cloning and expression of novel mosaic serine proteases with and without a transmembrane domain from human lung. (PMID: 11267681) Kim DR … Kido H (Biochimica et biophysica acta 2001) 2 3 4
  2. Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication. (PMID: 20219906) Okumura Y … Kido H (Journal of virology 2010) 3 22
  3. MSPL/TMPRSS13. (PMID: 17981585) Kido H … Okumura Y (Frontiers in bioscience : a journal and virtual library 2008) 3 22
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for TMPRSS13 Gene

Sources for TMPRSS13 Gene