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Aliases for TMPRSS13 Gene

Aliases for TMPRSS13 Gene

  • Transmembrane Serine Protease 13 2 3 5
  • Membrane-Type Mosaic Serine Protease 3 4
  • Transmembrane Protease, Serine 11 2 3
  • Transmembrane Protease, Serine 13 2 3
  • TMPRSS11 3 4
  • MSP 3 4
  • Transmembrane Protease Serine 13 3
  • Mosaic Serine Protease 4
  • EC 3.4.21.- 4
  • MSPL 3
  • MSPS 3

External Ids for TMPRSS13 Gene

Previous HGNC Symbols for TMPRSS13 Gene

  • TMPRSS11

Previous GeneCards Identifiers for TMPRSS13 Gene

  • GC11M117277
  • GC11M117771
  • GC11M113705

Summaries for TMPRSS13 Gene

Entrez Gene Summary for TMPRSS13 Gene

  • This gene encodes a member of the type II transmembrane serine protease family. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TMPRSS13 Gene

TMPRSS13 (Transmembrane Serine Protease 13) is a Protein Coding gene. Among its related pathways are Influenza A. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type exopeptidase activity. An important paralog of this gene is TMPRSS2.

Additional gene information for TMPRSS13 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS13 Gene

Genomics for TMPRSS13 Gene

GeneHancer (GH) Regulatory Elements for TMPRSS13 Gene

Promoters and enhancers for TMPRSS13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J117985 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.2 -58.3 -58345 5.2 HDGF PKNOX1 CLOCK ARNT SIN3A YBX1 ZNF2 ZBTB7B IRF4 POLR2B IL10RA TMPRSS13 GC11P118003
GH11J117928 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 676.2 -0.4 -400 2.8 BCOR CTCF NEUROD1 SIN3A ZMYM3 CEBPG CTBP1 GATA3 RCOR1 ETV6 TMPRSS13 GC11M117924
GH11J117949 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16.6 -22.3 -22333 5.4 HDGF HDAC1 FOXA2 PKNOX1 NFIB RAD21 ZNF766 GATA2 ATF7 RUNX3 GC11P117950 IL10RA TMPRSS13 CD3E CD3G ENSG00000254844 DSCAML1 FXYD6 FXYD6-FXYD2 ENSG00000254528
GH11J117814 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +112.1 112057 6.7 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A YBX1 ZNF2 DSCAML1 FXYD2 ENSG00000254844 IL10RA FXYD6-FXYD2 FXYD6 LOC653303 RNF214 TMPRSS13 CEP164
GH11J117822 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +105.2 105170 2.9 DRAP1 CTCF TFAP4 JUN ARID4B CEBPG ZIC2 RAD21 POLR2A ZNF143 FXYD2 IL10RA FXYD6-FXYD2 FXYD6 TMPRSS13 DSCAML1 ENSG00000254528 ENSG00000254844
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMPRSS13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMPRSS13 gene promoter:
  • E2F
  • E2F-1
  • NF-E2
  • AML1a
  • NF-E2 p45
  • CP2
  • AP-4
  • ATF-2
  • GATA-2

Genomic Locations for TMPRSS13 Gene

Genomic Locations for TMPRSS13 Gene
28,819 bases
Minus strand
28,819 bases
Minus strand

Genomic View for TMPRSS13 Gene

Genes around TMPRSS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS13 Gene

Proteins for TMPRSS13 Gene

  • Protein details for TMPRSS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 13
    Protein Accession:
    Secondary Accessions:
    • B4DTM9
    • E9PIJ5
    • F8WAJ3
    • Q86YM4
    • Q96JY8
    • Q9BYE1

    Protein attributes for TMPRSS13 Gene

    586 amino acids
    Molecular mass:
    63153 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMPRSS13 Gene


neXtProt entry for TMPRSS13 Gene

Post-translational modifications for TMPRSS13 Gene

  • Glycosylation at posLast=445445, posLast=405405, posLast=292292, and isoforms=2, 3, 4, 5255
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMPRSS13 Gene

Domains & Families for TMPRSS13 Gene

Gene Families for TMPRSS13 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TMPRSS13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS13: view

Function for TMPRSS13 Gene

Enzyme Numbers (IUBMB) for TMPRSS13 Gene

Phenotypes From GWAS Catalog for TMPRSS13 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 11267681
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS13: view
genes like me logo Genes that share phenotypes with TMPRSS13: view

Animal Models for TMPRSS13 Gene

MGI Knock Outs for TMPRSS13:

Animal Model Products

miRNA for TMPRSS13 Gene

miRTarBase miRNAs that target TMPRSS13

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMPRSS13 Gene

Localization for TMPRSS13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS13 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS13 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMPRSS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11267681
GO:0072562 blood microparticle HDA 22516433
genes like me logo Genes that share ontologies with TMPRSS13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMPRSS13 Gene

Pathways & Interactions for TMPRSS13 Gene

SuperPathways for TMPRSS13 Gene

SuperPathway Contained pathways
1 Influenza A
genes like me logo Genes that share pathways with TMPRSS13: view

Pathways by source for TMPRSS13 Gene

1 KEGG pathway for TMPRSS13 Gene

Gene Ontology (GO) - Biological Process for TMPRSS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
genes like me logo Genes that share ontologies with TMPRSS13: view

No data available for SIGNOR curated interactions for TMPRSS13 Gene

Drugs & Compounds for TMPRSS13 Gene

(2) Drugs for TMPRSS13 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PMSF Pharma Serine proteinases inhibitor, irreversible 0

(1) Additional Compounds for TMPRSS13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for TMPRSS13 Gene

Compound Action Cas Number
PMSF Serine proteinases inhibitor, irreversible 329-98-6
genes like me logo Genes that share compounds with TMPRSS13: view

Drug Products

Transcripts for TMPRSS13 Gene

Unigene Clusters for TMPRSS13 Gene

Transmembrane protease, serine 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - - - - -
SP2: -
SP3: -
SP4: - - - -
SP6: - - - - -

Relevant External Links for TMPRSS13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMPRSS13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS13 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.5), Skin - Not Sun Exposed (Suprapubic) (x11.6), and Esophagus - Mucosa (x5.9).

Protein differential expression in normal tissues from HIPED for TMPRSS13 Gene

This gene is overexpressed in Cervix (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMPRSS13 Gene

Protein tissue co-expression partners for TMPRSS13 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMPRSS13 Gene:


SOURCE GeneReport for Unigene cluster for TMPRSS13 Gene:


mRNA Expression by UniProt/SwissProt for TMPRSS13 Gene:

Tissue specificity: Isoform 1 and isoform 3 are predominantly expressed in lung, placenta, pancreas, and prostate. Isoform 3 is weakly expressed in testis and peripheral blood lymphocytes.

Evidence on tissue expression from TISSUES for TMPRSS13 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with TMPRSS13: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS13 Gene

Orthologs for TMPRSS13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS13 34 33
  • 97.93 (n)
(Canis familiaris)
Mammalia TMPRSS13 34 33
  • 87.07 (n)
(Mus musculus)
Mammalia Tmprss13 16 34 33
  • 85.4 (n)
(Rattus norvegicus)
Mammalia Tmprss13 33
  • 84.67 (n)
(Bos Taurus)
Mammalia TMPRSS13 34 33
  • 83.47 (n)
(Ornithorhynchus anatinus)
Mammalia TMPRSS13 34
  • 67 (a)
(Monodelphis domestica)
Mammalia TMPRSS13 34
  • 67 (a)
(Gallus gallus)
Aves LOC100859131 33
  • 68.84 (n)
  • 61 (a)
(Anolis carolinensis)
Reptilia TMPRSS13 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss13 33
  • 52.59 (n)
(Danio rerio)
Actinopterygii tmprss13b 34 33
  • 50.63 (n)
tmprss13a 34
  • 34 (a)
Species where no ortholog for TMPRSS13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS13 Gene

Gene Tree for TMPRSS13 (if available)
Gene Tree for TMPRSS13 (if available)
Evolutionary constrained regions (ECRs) for TMPRSS13: view image

Paralogs for TMPRSS13 Gene

genes like me logo Genes that share paralogs with TMPRSS13: view

Variants for TMPRSS13 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS13 Gene

The repeat A-S-P-A-[GLQR] is polymorphic and the number of copies varies between 12 to 14.

Sequence variations from dbSNP and Humsavar for TMPRSS13 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000011196 -- 117,906,119(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000074568 -- 117,927,208(-) A/G intron_variant
rs1000201177 -- 117,915,408(-) G/A intron_variant
rs1000337372 -- 117,905,649(-) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000382200 -- 117,909,271(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS13 Gene

Variant ID Type Subtype PubMed ID
esv2745121 CNV deletion 23290073

Variation tolerance for TMPRSS13 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPRSS13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for TMPRSS13 Gene

Additional Disease Information for TMPRSS13

No disorders were found for TMPRSS13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS13 Gene

Publications for TMPRSS13 Gene

  1. Cloning and expression of novel mosaic serine proteases with and without a transmembrane domain from human lung. (PMID: 11267681) Kim DR … Kido H (Biochimica et biophysica acta 2001) 2 3 4 58
  2. Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication. (PMID: 20219906) Okumura Y … Kido H (Journal of virology 2010) 3 22 58
  3. MSPL/TMPRSS13. (PMID: 17981585) Kido H … Okumura Y (Frontiers in bioscience : a journal and virtual library 2008) 3 22 58
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TMPRSS13 Gene

Sources for TMPRSS13 Gene

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