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Aliases for TMPRSS12 Gene

Aliases for TMPRSS12 Gene

  • Transmembrane Protease, Serine 12 2 3 5
  • Transmembrane (C-Terminal) Protease, Serine 12 3
  • Testicular Tissue Protein Li 208 3
  • Transmembrane Protease Serine 12 3
  • EC 56
  • EC 3.4.21.- 4
  • EC 3.4.21 56
  • CT151 3

External Ids for TMPRSS12 Gene

Previous GeneCards Identifiers for TMPRSS12 Gene

  • GC12P049523
  • GC12P051236
  • GC12P048269

Summaries for TMPRSS12 Gene

GeneCards Summary for TMPRSS12 Gene

TMPRSS12 (Transmembrane Protease, Serine 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is ACR.

Additional gene information for TMPRSS12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS12 Gene

Genomics for TMPRSS12 Gene

GeneHancer (GH) Regulatory Elements for TMPRSS12 Gene

Promoters and enhancers for TMPRSS12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I050841 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 -0.1 -111 2.4 CTCF DPF2 RAD21 YY1 ZNF316 POLR2A FOXK2 ZBTB33 MAFK RN7SL519P TMPRSS12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMPRSS12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMPRSS12 gene promoter:

Genomic Locations for TMPRSS12 Gene

Genomic Locations for TMPRSS12 Gene
44,967 bases
Plus strand

Genomic View for TMPRSS12 Gene

Genes around TMPRSS12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS12 Gene

Proteins for TMPRSS12 Gene

  • Protein details for TMPRSS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 12
    Protein Accession:
    Secondary Accessions:
    • B9ZVX2

    Protein attributes for TMPRSS12 Gene

    348 amino acids
    Molecular mass:
    38605 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS12 Gene

Selected DME Specific Peptides for TMPRSS12 Gene


Post-translational modifications for TMPRSS12 Gene

  • Glycosylation at posLast=219219 and isoforms=249
  • Modification sites at PhosphoSitePlus

Other Protein References for TMPRSS12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TMPRSS12 Gene

Gene Families for TMPRSS12 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for TMPRSS12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS12: view

Function for TMPRSS12 Gene

Enzyme Numbers (IUBMB) for TMPRSS12 Gene

Gene Ontology (GO) - Molecular Function for TMPRSS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS12: view
genes like me logo Genes that share phenotypes with TMPRSS12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMPRSS12

miRNA for TMPRSS12 Gene

miRTarBase miRNAs that target TMPRSS12

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS12 Gene

Localization for TMPRSS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS12 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS12 gene
Compartment Confidence
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMPRSS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMPRSS12 Gene

Pathways & Interactions for TMPRSS12 Gene

SuperPathways for TMPRSS12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMPRSS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TMPRSS12: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS12 Gene

Drugs & Compounds for TMPRSS12 Gene

No Compound Related Data Available

Transcripts for TMPRSS12 Gene

mRNA/cDNA for TMPRSS12 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS12 Gene

Transmembrane (C-terminal) protease, serine 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS12 Gene

No ASD Table

Relevant External Links for TMPRSS12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMPRSS12 Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS12 Gene

This gene is overexpressed in Testis (x48.4).

Protein differential expression in normal tissues from HIPED for TMPRSS12 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS12 Gene

Protein tissue co-expression partners for TMPRSS12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMPRSS12 Gene:


SOURCE GeneReport for Unigene cluster for TMPRSS12 Gene:


mRNA Expression by UniProt/SwissProt for TMPRSS12 Gene:

Tissue specificity: In testis, expressed in spermatocytes and spermatids. Expressed in colorectal cancer (at protein level).
genes like me logo Genes that share expression patterns with TMPRSS12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS12 Gene

Orthologs for TMPRSS12 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS12 33 34
  • 99.04 (n)
(Bos Taurus)
Mammalia TMPRSS12 33
  • 81.65 (n)
(Canis familiaris)
Mammalia TMPRSS12 33 34
  • 79.77 (n)
(Mus musculus)
Mammalia Tmprss12 33 16 34
  • 72.44 (n)
(Rattus norvegicus)
Mammalia Tmprss12 33
  • 71.15 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
-- 34
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS12 34
  • 48 (a)
(Gallus gallus)
Aves TMPRSS12 33 34
  • 53.78 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
-- 34
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmprss12 33
  • 55.38 (n)
(Danio rerio)
Actinopterygii TMPRSS12 34
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11836 34
  • 30 (a)
CG6865 34
  • 29 (a)
CG3355 34
  • 25 (a)
CG11841 34
  • 24 (a)
CG11842 34
  • 23 (a)
CG11843 34
  • 23 (a)
CG4914 34
  • 23 (a)
CG14642 34
  • 21 (a)
CG18735 34
  • 21 (a)
CG3700 34
  • 21 (a)
CG4613 34
  • 21 (a)
CG4927 34
  • 21 (a)
CG9372 34
  • 21 (a)
CG4386 34
  • 20 (a)
CG9294 34
  • 20 (a)
psh 34
  • 20 (a)
snk 34
  • 20 (a)
CG11668 34
  • 19 (a)
CG14892 34
  • 19 (a)
spirit 34
  • 19 (a)
CG11670 34
  • 17 (a)
CG1299 34
  • 16 (a)
CG32260 34
  • 16 (a)
CG8172 34
  • 15 (a)
CG31728 34
  • 13 (a)
CG6361 34
  • 12 (a)
CG7432 34
  • 12 (a)
Sb 34
  • 11 (a)
CG34350 34
  • 9 (a)
CG8213 34
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10974 34
  • 17 (a)
Species where no ortholog for TMPRSS12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPRSS12 Gene

Gene Tree for TMPRSS12 (if available)
Gene Tree for TMPRSS12 (if available)

Paralogs for TMPRSS12 Gene

Variants for TMPRSS12 Gene

Sequence variations from dbSNP and Humsavar for TMPRSS12 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000120927 -- 50,871,486(+) T/C intron_variant
rs1000275469 -- 50,865,566(+) T/G intron_variant
rs1000327831 -- 50,851,319(+) T/C intron_variant
rs1000356291 -- 50,881,698(+) C/T intron_variant
rs1000417537 -- 50,874,810(+) AAAA/AAAAA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS12 Gene

Variant ID Type Subtype PubMed ID
esv1433992 CNV insertion 17803354
esv2669568 CNV deletion 23128226
esv3629492 CNV loss 21293372
esv3629493 CNV loss 21293372
nsv1076782 CNV insertion 25765185
nsv1116698 CNV tandem duplication 24896259
nsv1120260 CNV tandem duplication 24896259
nsv1125183 CNV insertion 24896259
nsv1125548 CNV tandem duplication 24896259
nsv1142808 CNV tandem duplication 24896259

Variation tolerance for TMPRSS12 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPRSS12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS12 Gene

Disorders for TMPRSS12 Gene

Additional Disease Information for TMPRSS12

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMPRSS12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS12 Gene

Publications for TMPRSS12 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill SJ … Livingston DM (Genes & development 2014) 3 58
  4. Scanning of novel cancer/testis proteins by human testis proteomic analysis. (PMID: 23436708) Liu M … Sha J (Proteomics 2013) 4 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for TMPRSS12 Gene

Sources for TMPRSS12 Gene

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