Aliases for TMPRSS11F Gene

Aliases for TMPRSS11F Gene

  • Transmembrane Serine Protease 11F 2 3 5
  • Airway Trypsin-Like Protease 4 2 3 4
  • HATL4 2 3 4
  • Transmembrane Protease, Serine 11F 2 3
  • Transmembrane Protease Serine 11F 3 4
  • EC 50
  • EC 3.4.21.- 4
  • TMPRSS11F 5
  • EC 3.4.21 50
  • FLJ16046 2

External Ids for TMPRSS11F Gene

Previous GeneCards Identifiers for TMPRSS11F Gene

  • GC04M068748
  • GC04M068601
  • GC04M068918
  • GC04M064834

Summaries for TMPRSS11F Gene

GeneCards Summary for TMPRSS11F Gene

TMPRSS11F (Transmembrane Serine Protease 11F) is a Protein Coding gene. Diseases associated with TMPRSS11F include Ichthyosis, Congenital, Autosomal Recessive 11 and Autosomal Recessive Congenital Ichthyosis. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is TMPRSS11E.

UniProtKB/Swiss-Prot Summary for TMPRSS11F Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMPRSS11F Gene

Genomics for TMPRSS11F Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMPRSS11F Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J068129 Enhancer 0.9 Ensembl ENCODE 250.7 -0.1 -126 0.8 NCOR1 ZNF217 CTBP1 CUX1 TAL1 NFE2 STAT5A SMARCA4 SMARCE1 PKNOX1 TMPRSS11F TMPRSS11GP piR-50886-006 TMPRSS11B
GH04J068151 Enhancer 0.7 Ensembl ENCODE 12.1 -22.6 -22597 1.3 JUND MAFG ZMYM3 ATF3 FOS SOX6 SMARCA4 ENSG00000227725 TMPRSS11GP TMPRSS11F TMPRSS11BNL TMPRSS11D piR-50886-006 TMPRSS11B
GH04J067988 Enhancer 0.5 Ensembl 11.1 +141.2 141168 0.2 ZNF654 CEBPB REST CTCF RAD21 ZBTB40 SMC3 CEBPG TMPRSS11F TMPRSS11D RF00026-763 RNU6-95P HSALNG0034900 TMPRSS11A UBA6-AS1
GH04J068074 Enhancer 0.5 ENCODE 10.9 +55.2 55211 0.2 CEBPB EP300 USF2 JUND ATF2 ATF3 ATF7 TMPRSS11GP TMPRSS11F RNU6-95P LOC100420693 SYT14P1 lnc-TMPRSS11A-2 TMPRSS11A UBA6-AS1
GH04J068079 Enhancer 0.3 Ensembl 11.2 +49.7 49668 0.8 CTCF RAD21 ENSG00000227725 TMPRSS11F LOC100420693 L13714-338 TMPRSS11A UBA6-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMPRSS11F on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMPRSS11F

Top Transcription factor binding sites by QIAGEN in the TMPRSS11F gene promoter:
  • Brachyury
  • Cart-1
  • CUTL1
  • FOXF2
  • FOXO1
  • FOXO1a
  • Gfi-1
  • Lhx3a
  • LHX3b
  • STAT5A

Genomic Locations for TMPRSS11F Gene

Latest Assembly
76,672 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
76,672 bases
Minus strand

(GRCh37/hg19 by Ensembl)
76,683 bases
Minus strand

Genomic View for TMPRSS11F Gene

Genes around TMPRSS11F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11F Gene

Proteins for TMPRSS11F Gene

  • Protein details for TMPRSS11F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 11F
    Protein Accession:
    Secondary Accessions:
    • A8MXX2

    Protein attributes for TMPRSS11F Gene

    438 amino acids
    Molecular mass:
    49410 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS11F Gene

Selected DME Specific Peptides for TMPRSS11F Gene


Post-translational modifications for TMPRSS11F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMPRSS11F Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TMPRSS11F Gene

Gene Families for TMPRSS11F Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for TMPRSS11F Gene

  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
  • SEA domain

Suggested Antigen Peptide Sequences for TMPRSS11F Gene

GenScript: Design optimal peptide antigens:
  • Airway trypsin-like protease 4 (TM11F_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11F: view

Function for TMPRSS11F Gene

Molecular function for TMPRSS11F Gene

UniProtKB/Swiss-Prot Function:
Probable serine protease.

Enzyme Numbers (IUBMB) for TMPRSS11F Gene

Phenotypes From GWAS Catalog for TMPRSS11F Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS11F: view
genes like me logo Genes that share phenotypes with TMPRSS11F: view

miRNA for TMPRSS11F Gene

miRTarBase miRNAs that target TMPRSS11F

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS11F

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11F Gene

Localization for TMPRSS11F Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11F Gene

Membrane. Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS11F gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
mitochondrion 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for TMPRSS11F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0009986 cell surface IDA 28338078
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11F: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMPRSS11F Gene

Pathways & Interactions for TMPRSS11F Gene

PathCards logo

SuperPathways for TMPRSS11F Gene

No Data Available

Interacting Proteins for TMPRSS11F Gene

Gene Ontology (GO) - Biological Process for TMPRSS11F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TMPRSS11F: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11F Gene

Drugs & Compounds for TMPRSS11F Gene

No Compound Related Data Available

Transcripts for TMPRSS11F Gene

mRNA/cDNA for TMPRSS11F Gene

2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS11F

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11F Gene

No ASD Table

Relevant External Links for TMPRSS11F Gene

GeneLoc Exon Structure for

Expression for TMPRSS11F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPRSS11F Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS11F Gene

This gene is overexpressed in Esophagus - Mucosa (x19.3), Vagina (x9.0), Skin - Sun Exposed (Lower leg) (x6.3), Skin - Not Sun Exposed (Suprapubic) (x6.0), Minor Salivary Gland (x5.4), and Cervix - Ectocervix (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMPRSS11F

SOURCE GeneReport for Unigene cluster for TMPRSS11F Gene:

genes like me logo Genes that share expression patterns with TMPRSS11F: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS11F Gene

Orthologs for TMPRSS11F Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS11F Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS11F 29 30
  • 99.47 (n)
(Canis familiaris)
Mammalia TMPRSS11F 29 30
  • 90.72 (n)
(Bos Taurus)
Mammalia TMPRSS11F 29 30
  • 87.76 (n)
(Mus musculus)
Mammalia Tmprss11f 29 16 30
  • 85.84 (n)
(Rattus norvegicus)
Mammalia Tmprss11f 29
  • 85.1 (n)
(Ornithorhynchus anatinus)
Mammalia TMPRSS11F 30
  • 69 (a)
(Monodelphis domestica)
Mammalia TMPRSS11F 30
  • 66 (a)
(Gallus gallus)
Aves -- 30
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 47 (a)
Species where no ortholog for TMPRSS11F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TMPRSS11F Gene

Gene Tree for TMPRSS11F (if available)
Gene Tree for TMPRSS11F (if available)
Evolutionary constrained regions (ECRs) for TMPRSS11F: view image
Alliance of Genome Resources:
Additional Orthologs for TMPRSS11F

Paralogs for TMPRSS11F Gene

genes like me logo Genes that share paralogs with TMPRSS11F: view

Variants for TMPRSS11F Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMPRSS11F Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs10030708 -- p.Ala4Thr
rs1438391 -- p.Asp124Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMPRSS11F Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11F Gene

Variant ID Type Subtype PubMed ID
esv22957 CNV gain 19812545
esv2759257 CNV gain 17122850
esv3304224 CNV mobile element insertion 20981092
esv3309520 CNV mobile element insertion 20981092
esv3397062 CNV insertion 20981092
esv3427684 CNV insertion 20981092
esv3437728 CNV insertion 20981092
esv35010 CNV gain 17911159
esv3600857 CNV gain 21293372
nsv1007376 CNV gain 25217958
nsv10514 CNV gain 18304495
nsv433367 CNV gain 18776910
nsv469718 CNV gain 16826518
nsv472528 CNV novel sequence insertion 20440878
nsv477505 CNV novel sequence insertion 20440878
nsv515010 CNV loss 21397061
nsv818242 CNV gain 17921354

Variation tolerance for TMPRSS11F Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.56; 86.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPRSS11F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11F Gene

Disorders for TMPRSS11F Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMPRSS11F Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMPRSS11F

genes like me logo Genes that share disorders with TMPRSS11F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPRSS11F Gene

Publications for TMPRSS11F Gene

  1. Ectopic expression of human airway trypsin-like protease 4 in acute myeloid leukemia promotes cancer cell invasion and tumor growth. (PMID: 30843660) Yan R … Wu Q (Cancer medicine 2019) 3
  2. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  3. The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss. (PMID: 28338078) Zhang Z … Wu Q (Scientific reports 2017) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4

Products for TMPRSS11F Gene

Sources for TMPRSS11F Gene