Aliases for TMPRSS11E Gene

Aliases for TMPRSS11E Gene

  • Transmembrane Serine Protease 11E 2 3 5
  • DESC1 2 3 4
  • Transmembrane Protease, Serine 11E 2 3
  • Transmembrane Protease Serine 11E2 3 4
  • Transmembrane Protease Serine 11E 3 4
  • Serine Protease DESC1 3 4
  • TMPRSS11E2 3 4
  • Transmembrane Protease, Serine 11E2 2
  • EC 51
  • EC 3.4.21.- 4
  • TMPRSS11E 5
  • EC 3.4.21 51

External Ids for TMPRSS11E Gene

Previous HGNC Symbols for TMPRSS11E Gene

  • TMPRSS11E2

Previous GeneCards Identifiers for TMPRSS11E Gene

  • GC04P069142
  • GC04P068995
  • GC04P069313
  • GC04P065226

Summaries for TMPRSS11E Gene

GeneCards Summary for TMPRSS11E Gene

TMPRSS11E (Transmembrane Serine Protease 11E) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TMPRSS11F.

UniProtKB/Swiss-Prot Summary for TMPRSS11E Gene

  • Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.

Additional gene information for TMPRSS11E Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMPRSS11E Gene

Genomics for TMPRSS11E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMPRSS11E Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J068403 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 612 -41.7 -41740 4.8 TEAD4 KDM1A POLR2A FOXA2 YY1 CEBPB CHD1 TAF1 NANOG TBP TMPRSS11E piR-32559-314 TMPRSS11GP RF00004-087 YTHDC1
GH04J068447 Promoter/Enhancer 0.7 EPDnew Ensembl 600.7 +0.2 238 1 ZHX2 DPF2 SMARCE1 TMPRSS11E piR-33432-380 UGT2B17
GH04J068446 Enhancer 0.2 Ensembl 600.7 -0.7 -662 0.4 TMPRSS11E piR-55194-258 YTHDC1
GH04J068731 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.2 +286.8 286801 5.9 GATAD2A REST TFE3 SOX13 NFKBIZ RCOR2 RBFOX2 RXRB IRF2 IKZF2 ENSG00000250376 TMPRSS11E UGT2A3 UGT2B7 ENSG00000272626 UGT2B10 UGT2B11 UGT2B15 lnc-UGT2B15-1 LOC728811
GH04J068408 Enhancer 0.8 Ensembl ENCODE dbSUPER 11.3 -37.2 -37236 3.5 POLR2A ETS1 FOS NANOG HLF TMPRSS11E piR-32559-314 piR-55194-258 YTHDC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMPRSS11E on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMPRSS11E

Genomic Locations for TMPRSS11E Gene

Genomic Locations for TMPRSS11E Gene
50,142 bases
Plus strand
50,156 bases
Plus strand

Genomic View for TMPRSS11E Gene

Genes around TMPRSS11E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11E Gene

Proteins for TMPRSS11E Gene

  • Protein details for TMPRSS11E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 11E
    Protein Accession:
    Secondary Accessions:
    • A6NL71
    • Q14DC8
    • Q6UW31

    Protein attributes for TMPRSS11E Gene

    423 amino acids
    Molecular mass:
    47696 Da
    Quaternary structure:
    • Forms a heterodimer with SERPINA5 and SERPINE1.

    Three dimensional structures from OCA and Proteopedia for TMPRSS11E Gene

neXtProt entry for TMPRSS11E Gene

Selected DME Specific Peptides for TMPRSS11E Gene


Post-translational modifications for TMPRSS11E Gene

Other Protein References for TMPRSS11E Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TMPRSS11E Gene

Gene Families for TMPRSS11E Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for TMPRSS11E Gene

  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
  • SEA domain

Suggested Antigen Peptide Sequences for TMPRSS11E Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protease serine 11E2 (TM11E_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11E: view

Function for TMPRSS11E Gene

Molecular function for TMPRSS11E Gene

UniProtKB/Swiss-Prot Function:
Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by SERPINA5.

Enzyme Numbers (IUBMB) for TMPRSS11E Gene

Phenotypes From GWAS Catalog for TMPRSS11E Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity ISS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS11E: view
genes like me logo Genes that share phenotypes with TMPRSS11E: view

Animal Model Products

CRISPR Products

miRNA for TMPRSS11E Gene

miRTarBase miRNAs that target TMPRSS11E

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS11E

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11E Gene

Localization for TMPRSS11E Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11E Gene

Cell membrane. Single-pass type II membrane protein.
[Transmembrane protease serine 11E catalytic chain]: Secreted. Note=Activated by cleavage and secreted. {ECO:0000250 UniProtKB:Q5S248}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS11E gene
Compartment Confidence
plasma membrane 4
extracellular 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMPRSS11E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IBA 21873635
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11E: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMPRSS11E Gene

Pathways & Interactions for TMPRSS11E Gene

PathCards logo

SuperPathways for TMPRSS11E Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMPRSS11E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis ISS --
GO:0050890 cognition IMP 23227193
genes like me logo Genes that share ontologies with TMPRSS11E: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11E Gene

Drugs & Compounds for TMPRSS11E Gene

No Compound Related Data Available

Transcripts for TMPRSS11E Gene

mRNA/cDNA for TMPRSS11E Gene

7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS11E

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11E Gene

No ASD Table

Relevant External Links for TMPRSS11E Gene

GeneLoc Exon Structure for

Expression for TMPRSS11E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPRSS11E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS11E Gene

This gene is overexpressed in Esophagus - Mucosa (x22.7), Vagina (x14.8), Cervix - Ectocervix (x8.8), and Minor Salivary Gland (x4.8).

Protein differential expression in normal tissues from HIPED for TMPRSS11E Gene

This gene is overexpressed in Saliva (32.3) and Cervix (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMPRSS11E Gene

Protein tissue co-expression partners for TMPRSS11E Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMPRSS11E

SOURCE GeneReport for Unigene cluster for TMPRSS11E Gene:


mRNA Expression by UniProt/SwissProt for TMPRSS11E Gene:

Tissue specificity: Expression can only be detected in tissues derived from the head and neck, and in skin, prostate and testis.

Evidence on tissue expression from TISSUES for TMPRSS11E Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TMPRSS11E: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS11E Gene

Orthologs for TMPRSS11E Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPRSS11E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS11E 30 31
  • 99.37 (n)
(Canis familiaris)
Mammalia TMPRSS11E 30 31
  • 87.6 (n)
(Bos Taurus)
Mammalia TMPRSS11E 30
  • 86.65 (n)
-- 31
  • 42 (a)
(Mus musculus)
Mammalia Tmprss11e 30 17 31
  • 80.96 (n)
(Rattus norvegicus)
Mammalia Tmprss11e 30
  • 80.96 (n)
(Monodelphis domestica)
Mammalia TMPRSS11E 31
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS11E 31
  • 63 (a)
(Gallus gallus)
Aves TMPRSS11F 30
  • 58.44 (n)
-- 31
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 46 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101732637 30
  • 56.09 (n)
Species where no ortholog for TMPRSS11E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TMPRSS11E Gene

Gene Tree for TMPRSS11E (if available)
Gene Tree for TMPRSS11E (if available)
Evolutionary constrained regions (ECRs) for TMPRSS11E: view image

Paralogs for TMPRSS11E Gene Pseudogenes for TMPRSS11E Gene

genes like me logo Genes that share paralogs with TMPRSS11E: view

Variants for TMPRSS11E Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMPRSS11E Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs976002 - p.Tyr303Cys

Additional dbSNP identifiers (rs#s) for TMPRSS11E Gene

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11E Gene

Variant ID Type Subtype PubMed ID
dgv1490e212 CNV gain 25503493
dgv49e213 CNV gain 24956385
dgv5242n100 CNV gain 25217958
dgv5243n100 CNV gain 25217958
dgv5246n100 CNV loss 25217958
dgv5247n100 CNV loss 25217958
dgv5248n100 CNV gain 25217958
dgv5249n100 CNV gain 25217958
dgv5250n100 CNV gain+loss 25217958
dgv5251n100 CNV gain 25217958
dgv5253n100 CNV gain 25217958
dgv5254n100 CNV gain 25217958
dgv88n17 CNV loss 16327808
dgv9102n54 CNV gain 21841781
esv2759258 CNV gain+loss 17122850
esv2763805 CNV loss 21179565
esv3584514 CNV gain 24956385
esv3584804 CNV loss 24956385
esv3584805 CNV loss 24956385
esv3893944 CNV gain+loss 25118596
nsv1004012 CNV gain 25217958
nsv10515 CNV gain 18304495
nsv1073769 CNV deletion 25765185
nsv1119002 CNV deletion 24896259
nsv1119003 CNV deletion 24896259
nsv1119004 CNV deletion 24896259
nsv1122086 CNV deletion 24896259
nsv1161106 CNV deletion 26073780
nsv442910 CNV loss 18776908

Variation tolerance for TMPRSS11E Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPRSS11E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11E Gene

Disorders for TMPRSS11E Gene

No disorders were found for TMPRSS11E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS11E Gene

Publications for TMPRSS11E Gene

  1. Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family. (PMID: 17388811) Kyrieleis OJ … Jacob U (The FEBS journal 2007) 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. (PMID: 15328353) Hobson JP … Bugge TH (The Journal of biological chemistry 2004) 2 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for TMPRSS11E Gene

  • Signalway Proteins for TMPRSS11E

Sources for TMPRSS11E Gene