This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may pla... See more...

Aliases for TMPRSS11D Gene

Aliases for TMPRSS11D Gene

  • Transmembrane Serine Protease 11D 2 3 5
  • HAT 2 3 4
  • Transmembrane Protease, Serine 11D 2 3
  • Adrenal Secretory Serine Protease 2 3
  • Transmembrane Protease Serine 11D 3 4
  • Airway Trypsin-Like Protease 3 4
  • ASP 2 3
  • Airway Trypsin Like Protease 2
  • EC 3.4.21.- 4
  • TMPRSS11D 5
  • EC 3.4.21 50

External Ids for TMPRSS11D Gene

Previous GeneCards Identifiers for TMPRSS11D Gene

  • GC04M068518
  • GC04M068369
  • GC04M068686
  • GC04M064599

Summaries for TMPRSS11D Gene

Entrez Gene Summary for TMPRSS11D Gene

  • This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMPRSS11D Gene

TMPRSS11D (Transmembrane Serine Protease 11D) is a Protein Coding gene. Diseases associated with TMPRSS11D include Deafness, Autosomal Recessive 27 and Deafness, Autosomal Dominant 27. Among its related pathways are Measles. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is TMPRSS11F.

UniProtKB/Swiss-Prot Summary for TMPRSS11D Gene

  • May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.

Gene Wiki entry for TMPRSS11D Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMPRSS11D Gene

Genomics for TMPRSS11D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMPRSS11D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J067880 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 250.7 +1.8 1763 8.6 JUND NFE2 SPI1 MAFK BHLHE40 NFE2L2 EP300 FOS TMPRSS11D lnc-TMPRSS11A-5 TMPRSS11GP ENSG00000227725 UGT2B15 piR-32810-081 GNRHR UBA6-AS1
GH04J067697 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 +184.5 184505 4.1 SP1 MYC IKZF1 ZNF580 ZNF592 KLF9 POLR2A CEBPA ATF3 YY1 UBA6 UBA6-AS1 lnc-GNRHR-4 CENPC YTHDC1 ENSG00000270257 STAP1 TMPRSS11D
GH04J067725 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.8 +158.5 158512 4.4 YY1 MAFF FOXA2 RXRA ZNF316 NFE2 MAFK CBX1 JUND CTCF ENSG00000270292 LOC100419046 lnc-GNRHR-1 UBA6 GNRHR TMPRSS11D lnc-STAP1-15 UBA6-AS1
GH04J067928 Enhancer 0.8 Ensembl ENCODE 10.8 -43.7 -43738 0.4 ZNF217 CTBP1 CUX1 GATA3 FOXA1 DPF2 NFIB NCOA3 EP300 ATF7 TMPRSS11D HSALNG0034899 piR-39098-174 TMPRSS11A UBA6-AS1
GH04J067861 Enhancer 0.7 Ensembl ENCODE 11.7 +23.3 23342 1 EBF1 BATF JUNB IKZF1 IKZF2 MTA2 RELB TMPRSS11D GNRHR lnc-TMPRSS11A-5 piR-32810-081 UBA6-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMPRSS11D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMPRSS11D

Top Transcription factor binding sites by QIAGEN in the TMPRSS11D gene promoter:
  • Bach1
  • CREB
  • CUTL1
  • deltaCREB
  • FOXO4
  • p53
  • Sox9

Genomic Locations for TMPRSS11D Gene

Latest Assembly
chr4:67,820,876-67,885,063
(GRCh38/hg38)
Size:
64,188 bases
Orientation:
Minus strand

Previous Assembly
chr4:68,686,594-68,749,720
(GRCh37/hg19 by Entrez Gene)
Size:
63,127 bases
Orientation:
Minus strand

chr4:68,686,594-68,749,750
(GRCh37/hg19 by Ensembl)
Size:
63,157 bases
Orientation:
Minus strand

Genomic View for TMPRSS11D Gene

Genes around TMPRSS11D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11D Gene

Proteins for TMPRSS11D Gene

  • Protein details for TMPRSS11D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60235-TM11D_HUMAN
    Recommended name:
    Transmembrane protease serine 11D
    Protein Accession:
    O60235
    Secondary Accessions:
    • Q08AF6

    Protein attributes for TMPRSS11D Gene

    Size:
    418 amino acids
    Molecular mass:
    46263 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for TMPRSS11D Gene

Selected DME Specific Peptides for TMPRSS11D Gene

O60235:
  • DACQGDSGG
  • GDSGGPL
  • DIALVRL
  • CQGDSGGP
  • WILTAAHC
  • LTAAHCF
  • WPWQVSL

Post-translational modifications for TMPRSS11D Gene

  • Glycosylation at Asn144

Other Protein References for TMPRSS11D Gene

Domains & Families for TMPRSS11D Gene

Gene Families for TMPRSS11D Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMPRSS11D Gene

InterPro:
Blocks:
  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
  • SEA domain

Suggested Antigen Peptide Sequences for TMPRSS11D Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57391, highly similar to Transmembrane protease, serine 11D (EC 3.4.21.-) (B4DL57_HUMAN)
  • Airway trypsin-like protease (TM11D_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60235

UniProtKB/Swiss-Prot:

TM11D_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11D: view

Function for TMPRSS11D Gene

Molecular function for TMPRSS11D Gene

UniProtKB/Swiss-Prot Function:
May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by diisopropyl fluorophosphate, leupeptin, antipain, aprotinin, and soybean trypsin inhibitor, but hardly inhibited by secretory leukocyte protease inhibitor at 10 microM.

Enzyme Numbers (IUBMB) for TMPRSS11D Gene

Phenotypes From GWAS Catalog for TMPRSS11D Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 32296183
GO:0008233 peptidase activity TAS 9565616
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS11D: view
genes like me logo Genes that share phenotypes with TMPRSS11D: view

miRNA for TMPRSS11D Gene

miRTarBase miRNAs that target TMPRSS11D

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS11D

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11D Gene

Localization for TMPRSS11D Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11D Gene

Cell membrane. Single-pass type II membrane protein. Note=Activated by cleavage and secreted.
[Transmembrane protease serine 11D catalytic chain]: Secreted. Note=Activated by cleavage and secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS11D gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9565616
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMPRSS11D Gene

Pathways & Interactions for TMPRSS11D Gene

PathCards logo

SuperPathways for TMPRSS11D Gene

SuperPathway Contained pathways
1 Measles
genes like me logo Genes that share pathways with TMPRSS11D: view

Pathways by source for TMPRSS11D Gene

1 KEGG pathway for TMPRSS11D Gene

Gene Ontology (GO) - Biological Process for TMPRSS11D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 24227843
GO:0007585 respiratory gaseous exchange TAS 9565616
genes like me logo Genes that share ontologies with TMPRSS11D: view

No data available for SIGNOR curated interactions for TMPRSS11D Gene

Drugs & Compounds for TMPRSS11D Gene

(5) Drugs for TMPRSS11D Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TMPRSS11D Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMPRSS11D: view

Transcripts for TMPRSS11D Gene

mRNA/cDNA for TMPRSS11D Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS11D

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11D Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2:
SP3: - - - - -
SP4:

Relevant External Links for TMPRSS11D Gene

GeneLoc Exon Structure for
TMPRSS11D

Expression for TMPRSS11D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPRSS11D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS11D Gene

This gene is overexpressed in Esophagus - Mucosa (x17.9), Vagina (x16.7), Cervix - Ectocervix (x12.3), and Minor Salivary Gland (x5.7).

Protein differential expression in normal tissues from HIPED for TMPRSS11D Gene

This gene is overexpressed in Nasal epithelium (35.7) and Cervix (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMPRSS11D Gene



Protein tissue co-expression partners for TMPRSS11D Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMPRSS11D

SOURCE GeneReport for Unigene cluster for TMPRSS11D Gene:

Hs.132195

mRNA Expression by UniProt/SwissProt for TMPRSS11D Gene:

O60235-TM11D_HUMAN
Tissue specificity: Located in the cells of the submucosal serous glands of the bronchi and trachea.

Evidence on tissue expression from TISSUES for TMPRSS11D Gene

  • Kidney(2.2)
genes like me logo Genes that share expression patterns with TMPRSS11D: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS11D Gene

Orthologs for TMPRSS11D Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS11D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMPRSS11D 29 30
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMPRSS11D 29 30
  • 85.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMPRSS11D 29 30
  • 81.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmprss11d 29
  • 75.94 (n)
Mouse
(Mus musculus)
Mammalia Tmprss11d 29 16 30
  • 75.86 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMPRSS11D 30
  • 58 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMPRSS11D 30
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 30
  • 52 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 48 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012842 29
  • 47.17 (n)
Species where no ortholog for TMPRSS11D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TMPRSS11D Gene

ENSEMBL:
Gene Tree for TMPRSS11D (if available)
TreeFam:
Gene Tree for TMPRSS11D (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMPRSS11D: view image
Alliance of Genome Resources:
Additional Orthologs for TMPRSS11D

Paralogs for TMPRSS11D Gene

genes like me logo Genes that share paralogs with TMPRSS11D: view

Variants for TMPRSS11D Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMPRSS11D Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11D Gene

Variant ID Type Subtype PubMed ID
esv3600854 CNV loss 21293372
esv3600855 CNV loss 21293372
nsv1007376 CNV gain 25217958
nsv829960 CNV loss 17160897

Variation tolerance for TMPRSS11D Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPRSS11D Gene

Human Gene Mutation Database (HGMD)
TMPRSS11D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPRSS11D
Leiden Open Variation Database (LOVD)
TMPRSS11D

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMPRSS11D Gene

Disorders for TMPRSS11D Gene

MalaCards: The human disease database

(4) MalaCards diseases for TMPRSS11D Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMPRSS11D

genes like me logo Genes that share disorders with TMPRSS11D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPRSS11D Gene

Publications for TMPRSS11D Gene

  1. Cloning and characterization of the cDNA for human airway trypsin-like protease. (PMID: 9565616) Yamaoka K … Yasuoka S (The Journal of biological chemistry 1998) 2 3 4
  2. Purification, characterization, and localization of a novel trypsin-like protease found in the human airway. (PMID: 9070615) Yasuoka S … Sano T (American journal of respiratory cell and molecular biology 1997) 2 3 4
  3. TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. (PMID: 24227843) Heurich A … Pöhlmann S (Journal of virology 2014) 3 4
  4. Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. (PMID: 16973594) Böttcher E … Matrosovich M (Journal of virology 2006) 3 22
  5. Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway. (PMID: 16199437) Matsushima R … Yasuoka S (American journal of physiology. Lung cellular and molecular physiology 2006) 3 22

Products for TMPRSS11D Gene

Sources for TMPRSS11D Gene