Aliases for TMPRSS11B Gene

Aliases for TMPRSS11B Gene

  • Transmembrane Serine Protease 11B 2 3 5
  • Airway Trypsin-Like Protease 5 2 3 4
  • HATL5 2 3 4
  • Transmembrane Protease, Serine 11B 2 3
  • Transmembrane Protease Serine 11B 3 4
  • EC 3.4.21.- 4
  • TMPRSS11B 5

External Ids for TMPRSS11B Gene

Previous GeneCards Identifiers for TMPRSS11B Gene

  • GC04M068923
  • GC04M068774
  • GC04M069092
  • GC04M065004

Summaries for TMPRSS11B Gene

GeneCards Summary for TMPRSS11B Gene

TMPRSS11B (Transmembrane Serine Protease 11B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TMPRSS11A.

UniProtKB/Swiss-Prot Summary for TMPRSS11B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMPRSS11B Gene

Genomics for TMPRSS11B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMPRSS11B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J068245 Promoter 0.5 EPDnew 250.7 0.0 -20 0.1 CREB1 HMBOX1 HSALNG0034908 TMPRSS11B HSALNG0034909 YTHDC1
GH04J068266 Enhancer 0.8 Ensembl ENCODE 11.4 -22.1 -22064 1.6 ZNF592 NFIC ZNF316 NFE2 PRDM10 ETV1 MAFG DPF2 ARID1B SMARCE1 TMPRSS11B YTHDC1 ENSG00000227725 HSALNG0034909 piR-41245-191
GH04J068267 Enhancer 0.4 ENCODE 11.4 -20.9 -20854 0.4 MEIS2 CEBPB PKNOX1 MEF2D TMPRSS11B YTHDC1 ENSG00000227725 HSALNG0034909 piR-41245-191
GH04J068346 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.2 -103.1 -103100 5.2 BCLAF1 SP1 NCOR1 IKZF1 MYC JUND ATF2 KLF9 POLR2A CEBPA YTHDC1 HSALNG0034917 HSALNG0034918 lnc-TMPRSS11E-5 CENPC UBA6 ENSG00000270257 UGT2B29P TMPRSS11BNL HSALNG0034916
GH04J068256 Enhancer 0.6 ENCODE 0.4 -10.8 -10814 0.1 TAL1 TCF12 TEAD4 ARID1B CBFA2T2 RNF2 SOX6 CHAMP1 NCOR1 GATAD2A TMPRSS11BNL HSALNG0034909 TMPRSS11B YTHDC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMPRSS11B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMPRSS11B

Top Transcription factor binding sites by QIAGEN in the TMPRSS11B gene promoter:
  • C/EBPalpha
  • FOXD3
  • HTF
  • Lhx3a
  • LHX3b
  • Pbx1a
  • S8

Genomic Locations for TMPRSS11B Gene

Latest Assembly
19,042 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
19,042 bases
Minus strand

(GRCh37/hg19 by Ensembl)
19,068 bases
Minus strand

Genomic View for TMPRSS11B Gene

Genes around TMPRSS11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11B Gene

Proteins for TMPRSS11B Gene

  • Protein details for TMPRSS11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 11B
    Protein Accession:
    Secondary Accessions:
    • A8K4D9

    Protein attributes for TMPRSS11B Gene

    416 amino acids
    Molecular mass:
    46337 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS11B Gene

Post-translational modifications for TMPRSS11B Gene

  • Glycosylation at Asn72, Asn107, and Asn315
  • Modification sites at PhosphoSitePlus

Other Protein References for TMPRSS11B Gene

Protein products for research

No data available for DME Specific Peptides for TMPRSS11B Gene

Domains & Families for TMPRSS11B Gene

Gene Families for TMPRSS11B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for TMPRSS11B Gene

  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
  • SEA domain

Suggested Antigen Peptide Sequences for TMPRSS11B Gene

GenScript: Design optimal peptide antigens:
  • Airway trypsin-like protease 5 (TM11B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11B: view

Function for TMPRSS11B Gene

Molecular function for TMPRSS11B Gene

UniProtKB/Swiss-Prot Function:
Serine protease.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by aprotinin, leupeptin, benzamidine, SERPINA1, SPINT1 and SPINT2.

Enzyme Numbers (IUBMB) for TMPRSS11B Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA,IDA 24498351
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS11B: view
genes like me logo Genes that share phenotypes with TMPRSS11B: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS11B

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11B Gene

Localization for TMPRSS11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11B Gene

Cell membrane. Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS11B gene
Compartment Confidence
plasma membrane 5
extracellular 4
golgi apparatus 1
endoplasmic reticulum 0
lysosome 0

Gene Ontology (GO) - Cellular Components for TMPRSS11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IBA,IDA 24498351
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMPRSS11B Gene

Pathways & Interactions for TMPRSS11B Gene

PathCards logo

SuperPathways for TMPRSS11B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMPRSS11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMPRSS11B: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11B Gene

Drugs & Compounds for TMPRSS11B Gene

No Compound Related Data Available

Transcripts for TMPRSS11B Gene

mRNA/cDNA for TMPRSS11B Gene

5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPRSS11B

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11B Gene

No ASD Table

Relevant External Links for TMPRSS11B Gene

GeneLoc Exon Structure for

Expression for TMPRSS11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPRSS11B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMPRSS11B Gene

This gene is overexpressed in Esophagus - Mucosa (x34.0), Vagina (x9.2), Cervix - Ectocervix (x4.8), and Minor Salivary Gland (x4.6).

Protein differential expression in normal tissues from HIPED for TMPRSS11B Gene

This gene is overexpressed in Cervix (52.9) and Saliva (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMPRSS11B Gene

Protein tissue co-expression partners for TMPRSS11B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMPRSS11B

SOURCE GeneReport for Unigene cluster for TMPRSS11B Gene:

genes like me logo Genes that share expression patterns with TMPRSS11B: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS11B Gene

Orthologs for TMPRSS11B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS11B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS11B 29 30
  • 99.36 (n)
(Canis familiaris)
Mammalia TMPRSS11B 29 30
  • 84.15 (n)
(Monodelphis domestica)
Mammalia TMPRSS11B 30
  • 53 (a)
(Mus musculus)
Mammalia Tmprss11bnl 30
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS11B 30
  • 50 (a)
(Bos Taurus)
Mammalia -- 30
  • 41 (a)
(Gallus gallus)
Aves -- 30
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004567 29
  • 47.77 (n)
Species where no ortholog for TMPRSS11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TMPRSS11B Gene

Gene Tree for TMPRSS11B (if available)
Gene Tree for TMPRSS11B (if available)
Evolutionary constrained regions (ECRs) for TMPRSS11B: view image
Alliance of Genome Resources:
Additional Orthologs for TMPRSS11B

Paralogs for TMPRSS11B Gene Pseudogenes for TMPRSS11B Gene

genes like me logo Genes that share paralogs with TMPRSS11B: view

Variants for TMPRSS11B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMPRSS11B Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs12331141 -- p.Ile242Val
rs2319796 -- p.Asp325Ala
rs2319797 -- p.Thr348Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMPRSS11B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11B Gene

Variant ID Type Subtype PubMed ID
nsv520487 CNV loss 19592680
nsv594506 CNV loss 21841781

Variation tolerance for TMPRSS11B Gene

Residual Variation Intolerance Score: 71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPRSS11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11B Gene

Disorders for TMPRSS11B Gene

Additional Disease Information for TMPRSS11B

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TMPRSS11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS11B Gene

Publications for TMPRSS11B Gene

  1. HATL5: a cell surface serine protease differentially expressed in epithelial cancers. (PMID: 24498351) Miller GS … List K (PloS one 2014) 3 4
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 40
  3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 40
  4. Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism. (PMID: 30463017) Updegraff BL … O'Donnell KA (Cell reports 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for TMPRSS11B Gene

  • Biorbyt antibodies for TMPRSS11B

Sources for TMPRSS11B Gene