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Aliases for TMPRSS11B Gene

Aliases for TMPRSS11B Gene

  • Transmembrane Protease, Serine 11B 2 3 5
  • Airway Trypsin-Like Protease 5 4
  • EC 3.4.21.- 4
  • HATL5 4

External Ids for TMPRSS11B Gene

Previous GeneCards Identifiers for TMPRSS11B Gene

  • GC04M068923
  • GC04M068774
  • GC04M069092
  • GC04M065004

Summaries for TMPRSS11B Gene

GeneCards Summary for TMPRSS11B Gene

TMPRSS11B (Transmembrane Protease, Serine 11B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TMPRSS11F.

UniProtKB/Swiss-Prot for TMPRSS11B Gene

  • Serine protease.

Additional gene information for TMPRSS11B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPRSS11B Gene

Genomics for TMPRSS11B Gene

GeneHancer (GH) Regulatory Elements for TMPRSS11B Gene

Promoters and enhancers for TMPRSS11B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I068245 Promoter 0.7 EPDnew 550.8 +0.0 6 0.1 CREB1 HMBOX1 TMPRSS11B TMPRSS11BNL
GH04I068266 Enhancer 0.9 Ensembl ENCODE 11.4 -22.0 -22038 1.6 ETV1 JUN BACH1 ZNF644 ZBTB40 FOSL1 ZNF316 NFE2 PRDM10 SMARCE1 TMPRSS11B YTHDC1 GCOM2 ENSG00000250642
GH04I068271 Enhancer 0.8 Ensembl ENCODE 11.3 -27.5 -27461 2.8 CTCF PKNOX1 ZNF654 TRIM22 SIN3A REST BATF RAD21 SMC3 ZNF143 TMPRSS11B YTHDC1 GCOM2 ENSG00000250642
GH04I068267 Enhancer 0.5 ENCODE 11.4 -20.8 -20828 0.4 MEF2D MEIS2 ZNF639 PKNOX1 TMPRSS11B YTHDC1 GCOM2 ENSG00000250642
GH04I068256 Enhancer 0.6 ENCODE 0.4 -10.8 -10788 0.1 GATAD2A SOX6 TEAD4 TAL1 CBFA2T3 ZEB2 CHAMP1 TCF12 NCOR1 ADNP TMPRSS11BNL TMPRSS11B ENSG00000250642
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMPRSS11B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMPRSS11B gene promoter:

Genomic Locations for TMPRSS11B Gene

Genomic Locations for TMPRSS11B Gene
19,068 bases
Minus strand

Genomic View for TMPRSS11B Gene

Genes around TMPRSS11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPRSS11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPRSS11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPRSS11B Gene

Proteins for TMPRSS11B Gene

  • Protein details for TMPRSS11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protease serine 11B
    Protein Accession:
    Secondary Accessions:
    • A8K4D9

    Protein attributes for TMPRSS11B Gene

    416 amino acids
    Molecular mass:
    46337 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMPRSS11B Gene

Post-translational modifications for TMPRSS11B Gene

  • Glycosylation at isoforms=72, posLast=107107, and posLast=315315

Other Protein References for TMPRSS11B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMPRSS11B Gene

Domains & Families for TMPRSS11B Gene

Gene Families for TMPRSS11B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TMPRSS11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with TMPRSS11B: view

Function for TMPRSS11B Gene

Molecular function for TMPRSS11B Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by aprotinin, leupeptin, benzamidine, SERPINA1, SPINT1 and SPINT2.
UniProtKB/Swiss-Prot Function:
Serine protease.

Enzyme Numbers (IUBMB) for TMPRSS11B Gene

Phenotypes From GWAS Catalog for TMPRSS11B Gene

Gene Ontology (GO) - Molecular Function for TMPRSS11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA,IDA 24498351
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMPRSS11B: view
genes like me logo Genes that share phenotypes with TMPRSS11B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMPRSS11B Gene

Localization for TMPRSS11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPRSS11B Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPRSS11B gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMPRSS11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA,IDA 24498351
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMPRSS11B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMPRSS11B Gene

Pathways & Interactions for TMPRSS11B Gene

SuperPathways for TMPRSS11B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMPRSS11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMPRSS11B: view

No data available for Pathways by source and SIGNOR curated interactions for TMPRSS11B Gene

Drugs & Compounds for TMPRSS11B Gene

No Compound Related Data Available

Transcripts for TMPRSS11B Gene

mRNA/cDNA for TMPRSS11B Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMPRSS11B Gene

Transmembrane protease, serine 11B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMPRSS11B Gene

No ASD Table

Relevant External Links for TMPRSS11B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMPRSS11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMPRSS11B Gene

mRNA differential expression in normal tissues according to GTEx for TMPRSS11B Gene

This gene is overexpressed in Esophagus - Mucosa (x34.0), Vagina (x9.2), Cervix - Ectocervix (x4.8), and Minor Salivary Gland (x4.6).

Protein differential expression in normal tissues from HIPED for TMPRSS11B Gene

This gene is overexpressed in Cervix (52.9) and Saliva (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMPRSS11B Gene

Protein tissue co-expression partners for TMPRSS11B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMPRSS11B Gene:


SOURCE GeneReport for Unigene cluster for TMPRSS11B Gene:

genes like me logo Genes that share expression patterns with TMPRSS11B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPRSS11B Gene

Orthologs for TMPRSS11B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMPRSS11B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMPRSS11B 33 34
  • 99.36 (n)
(Canis familiaris)
Mammalia TMPRSS11B 33 34
  • 84.15 (n)
(Monodelphis domestica)
Mammalia TMPRSS11B 34
  • 53 (a)
(Mus musculus)
Mammalia Tmprss11bnl 34
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia TMPRSS11B 34
  • 50 (a)
(Bos Taurus)
Mammalia -- 34
  • 41 (a)
(Gallus gallus)
Aves -- 34
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004567 33
  • 47.77 (n)
Species where no ortholog for TMPRSS11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMPRSS11B Gene

Gene Tree for TMPRSS11B (if available)
Gene Tree for TMPRSS11B (if available)

Paralogs for TMPRSS11B Gene Pseudogenes for TMPRSS11B Gene

genes like me logo Genes that share paralogs with TMPRSS11B: view

Variants for TMPRSS11B Gene

Sequence variations from dbSNP and Humsavar for TMPRSS11B Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000045419 -- 68,243,220(-) C/A intron_variant
rs1000073285 -- 68,238,540(-) T/C intron_variant
rs1000100470 -- 68,238,624(-) G/A intron_variant
rs10001898 -- 68,230,676(-) T/C intron_variant
rs1000351397 -- 68,245,207(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMPRSS11B Gene

Variant ID Type Subtype PubMed ID
nsv594506 CNV loss 21841781
nsv520487 CNV loss 19592680

Variation tolerance for TMPRSS11B Gene

Residual Variation Intolerance Score: 71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPRSS11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPRSS11B Gene

Disorders for TMPRSS11B Gene

Additional Disease Information for TMPRSS11B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMPRSS11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMPRSS11B Gene

Publications for TMPRSS11B Gene

  1. HATL5: a cell surface serine protease differentially expressed in epithelial cancers. (PMID: 24498351) Miller GS … List K (PloS one 2014) 3 4 58
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 44 58
  3. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 44 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M … Yates JR (Journal of proteome research 2009) 3 58

Products for TMPRSS11B Gene

Sources for TMPRSS11B Gene

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