Aliases for TMPO Gene
- Thymopoietin 2 3 5
- LEM Domain Containing 4 2 3
- LAP2 3 4
- Lamina-Associated Polypeptide 2, Isoforms Beta/Gamma 4
- Thymopoietin-Related Peptide Isoforms Beta/Gamma 4
- Lamina-Associated Polypeptide 2, Isoform Alpha 4
- Thymopoietin-Related Peptide Isoform Alpha 4
- Thymopoietin, Isoforms Beta/Gamma 4
- Lamina-Associated Polypeptide 2 3
External Ids for TMPO Gene
Previous GeneCards Identifiers for TMPO Gene
Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]
GeneCards Summary for TMPO Gene
TMPO (Thymopoietin) is a Protein Coding gene. Diseases associated with TMPO include Familial Isolated Dilated Cardiomyopathy and Dilated Cardiomyopathy. Among its related pathways are Nuclear Envelope Reassembly and DNA Damage. Gene Ontology (GO) annotations related to this gene include lamin binding. An important paralog of this gene is LEMD1.
UniProtKB/Swiss-Prot Summary for TMPO Gene
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.
TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.
Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.