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Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]
TMPO (Thymopoietin) is a Protein Coding gene. Diseases associated with TMPO include Familial Isolated Dilated Cardiomyopathy and Dilated Cardiomyopathy. Among its related pathways are Mitotic Prophase and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include lamin binding. An important paralog of this gene is LEMD1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16247757 |
GO:0005521 | lamin binding | TAS | 8530026 |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000785 | chromatin | IDA | 17284516 |
GO:0005634 | nucleus | TAS,IDA | 17284516 |
GO:0005635 | nuclear envelope | IDA,IEA | -- |
GO:0005637 | nuclear inner membrane | IEA | -- |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Initiation of Nuclear Envelope Reformation | ||
3 | Transport of the SLBP independent Mature mRNA | ||
4 | Mitotic Metaphase and Anaphase |
.94
|
|
5 | Apoptosis and Autophagy |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||
SP3: | - | ||||||||||||||||||||||
SP4: | |||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TMPO 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TMPO 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tmpo 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tmpo 30 |
|
||
Cow (Bos Taurus) |
Mammalia | TMPO 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TMPO 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TMPO 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TMPO 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TMPO 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tmpo 30 |
|
||
MGC75950 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.464 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tmpoa 30 31 |
|
OneToMany | |
tmpob 31 |
|
OneToMany | |||
TMPO (3 of 3) 31 |
|
OneToMany | |||
tmpo 30 |
|
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
649916 | Uncertain Significance: Loeys-Dietz syndrome 2 | 98,533,158(+) | A/C | MISSENSE_VARIANT,INTRON_VARIANT | |
652204 | Uncertain Significance: Loeys-Dietz syndrome 2 | 98,532,952(+) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
656773 | Uncertain Significance: Loeys-Dietz syndrome 2 | 98,532,891(+) | A/G | MISSENSE_VARIANT,INTRON_VARIANT | |
658170 | Uncertain Significance: Loeys-Dietz syndrome 2 | 98,534,191(+) | A/G | MISSENSE_VARIANT,INTRON_VARIANT | |
658454 | Uncertain Significance: Loeys-Dietz syndrome 2 | 98,533,148(+) | G/C | MISSENSE_VARIANT,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2601754 | CNV | deletion | 19546169 |
esv2761763 | CNV | loss | 21179565 |
nsv1040329 | CNV | gain | 25217958 |
nsv1138163 | CNV | deletion | 24896259 |
nsv7234 | OTHER | inversion | 18451855 |
nsv975655 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
familial isolated dilated cardiomyopathy |
|
|
dilated cardiomyopathy |
|
|
dilated cardiomyopathy 1t |
|
|
emery-dreifuss muscular dystrophy |
|
|
loeys-dietz syndrome 2 |
|
|