Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nu... See more...

Aliases for TMPO Gene

Aliases for TMPO Gene

  • Thymopoietin 2 3 5
  • LAP2 2 3 4
  • LEM Domain Containing 4 2 3
  • LEMD4 2 3
  • TP 2 3
  • Lamina-Associated Polypeptide 2, Isoforms Beta/Gamma 4
  • Thymopoietin-Related Peptide Isoforms Beta/Gamma 4
  • Lamina-Associated Polypeptide 2, Isoform Alpha 4
  • Thymopoietin-Related Peptide Isoform Alpha 4
  • Thymopoietin, Isoforms Beta/Gamma 4
  • Lamina-Associated Polypeptide 2 3
  • Thymopoietin Isoform Alpha 4
  • TPRP Isoforms Beta/Gamma 4
  • TPRP Isoform Alpha 4
  • TP Beta/Gamma 4
  • TP Alpha 4
  • PRO0868 3
  • CMD1T 3
  • TMPO 5

External Ids for TMPO Gene

Previous GeneCards Identifiers for TMPO Gene

  • GC12M098312
  • GC12P099412
  • GC12P098842
  • GC12P097411
  • GC12P098909
  • GC12P095970

Summaries for TMPO Gene

Entrez Gene Summary for TMPO Gene

  • Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]

GeneCards Summary for TMPO Gene

TMPO (Thymopoietin) is a Protein Coding gene. Diseases associated with TMPO include Familial Isolated Dilated Cardiomyopathy and Dilated Cardiomyopathy. Among its related pathways are Nuclear Envelope Reassembly and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include lamin binding. An important paralog of this gene is LEMD1.

UniProtKB/Swiss-Prot Summary for TMPO Gene

  • May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.
  • TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
  • May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.
  • Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Gene Wiki entry for TMPO Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMPO Gene

Genomics for TMPO Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMPO Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMPO on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMPO

Top Transcription factor binding sites by QIAGEN in the TMPO gene promoter:
  • AP-4
  • GATA-1
  • HEN1
  • Pax-5
  • SRY

Genomic Locations for TMPO Gene

Latest Assembly
chr12:98,515,573-98,550,351
(GRCh38/hg38)
Size:
34,779 bases
Orientation:
Plus strand

Previous Assembly
chr12:98,909,351-98,944,129
(GRCh37/hg19 by Entrez Gene)
Size:
34,779 bases
Orientation:
Plus strand

chr12:98,909,290-98,944,157
(GRCh37/hg19 by Ensembl)
Size:
34,868 bases
Orientation:
Plus strand

Genomic View for TMPO Gene

Genes around TMPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPO Gene

Proteins for TMPO Gene

  • Protein details for TMPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42166-LAP2A_HUMAN
    Recommended name:
    Lamina-associated polypeptide 2, isoform alpha
    Protein Accession:
    P42166
    Secondary Accessions:
    • P08918
    • P08919
    • Q14860
    • Q16295

    Protein attributes for TMPO Gene

    Size:
    694 amino acids
    Molecular mass:
    75492 Da
    Quaternary structure:
    • Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages. Interacts with CMTM6 (PubMed:28813417).

    Three dimensional structures from OCA and Proteopedia for TMPO Gene

    Alternative splice isoforms for TMPO Gene

    UniProtKB/Swiss-Prot:
  • Protein details for TMPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42167-LAP2B_HUMAN
    Recommended name:
    Lamina-associated polypeptide 2, isoforms beta/gamma
    Protein Accession:
    P42167
    Secondary Accessions:
    • A2T926
    • Q14861

    Protein attributes for TMPO Gene

    Size:
    454 amino acids
    Molecular mass:
    50670 Da
    Quaternary structure:
    • Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes (By similarity). Isoform Zeta interacts with BANF1/BAF and may sequester it in the cytoplasm.
    Miscellaneous:
    • [Isoform Zeta]: Inhibits LAP2beta-mediated repression.

    Alternative splice isoforms for TMPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPO Gene

Post-translational modifications for TMPO Gene

  • Phosphorylated in a mitose-specific manner.
  • Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes.
  • Citrullinated by PADI4.
  • Ubiquitination at Lys213, Lys346, Lys389, Lys393, Lys401, and Lys303
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMPO Gene

Domains & Families for TMPO Gene

Gene Families for TMPO Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMPO Gene

InterPro:
Blocks:
  • LEM-like fold
  • Lamino-associated polypeptide 2/emerin

Suggested Antigen Peptide Sequences for TMPO Gene

GenScript: Design optimal peptide antigens:
  • Thymopoietin zeta isoform (A2T926_HUMAN)
  • Thymopoietin-related peptide isoform alpha (LAP2A_HUMAN)
  • Thymopoietin-related peptide isoforms beta/gamma (LAP2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42166

UniProtKB/Swiss-Prot:

LAP2B_HUMAN :
  • The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
  • Belongs to the LEM family.
Domain:
  • The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
  • The C-terminal domain forms a four-stranded coiled coil.
  • Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
Family:
  • Belongs to the LEM family.
genes like me logo Genes that share domains with TMPO: view

Function for TMPO Gene

Molecular function for TMPO Gene

UniProtKB/Swiss-Prot Function:
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.
UniProtKB/Swiss-Prot Function:
TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
UniProtKB/Swiss-Prot Function:
May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.
UniProtKB/Swiss-Prot Function:
Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
GENATLAS Biochemistry:
thymopoietin,nuclear precursor of subunits alpha (75kDa),beta (51kDa),gamma (39kDa),LAP2 (lamina-associated protein 2) family

Phenotypes From GWAS Catalog for TMPO Gene

Gene Ontology (GO) - Molecular Function for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16247757
GO:0005521 lamin binding TAS 8530026
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with TMPO: view
genes like me logo Genes that share phenotypes with TMPO: view

Human Phenotype Ontology for TMPO Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TMPO Gene

MGI Knock Outs for TMPO:
  • Tmpo Tmpo<tm1.1Foi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPO

Clone products for research

  • Addgene plasmids for TMPO

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TMPO Gene

Localization for TMPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPO Gene

Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus.
Nucleus inner membrane. Single-pass type II membrane protein. Note=Tightly associated with the nuclear lamina.
[Isoform Zeta]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPO gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 17284516
GO:0005634 nucleus TAS,IDA 17284516
GO:0005635 nuclear envelope IDA,IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with TMPO: view

Pathways & Interactions for TMPO Gene

genes like me logo Genes that share pathways with TMPO: view

Gene Ontology (GO) - Biological Process for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TMPO: view

No data available for SIGNOR curated interactions for TMPO Gene

Drugs & Compounds for TMPO Gene

(17) Drugs for TMPO Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(17) Additional Compounds for TMPO Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMPO: view

Transcripts for TMPO Gene

mRNA/cDNA for TMPO Gene

4 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMPO

Clone products for research

  • Addgene plasmids for TMPO

Alternative Splicing Database (ASD) splice patterns (SP) for TMPO Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for TMPO Gene

GeneLoc Exon Structure for
TMPO

Expression for TMPO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMPO Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMPO Gene



Protein tissue co-expression partners for TMPO Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMPO

SOURCE GeneReport for Unigene cluster for TMPO Gene:

Hs.11355

mRNA Expression by UniProt/SwissProt for TMPO Gene:

P42166-LAP2A_HUMAN
Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver.

Evidence on tissue expression from TISSUES for TMPO Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Liver(4.4)
  • Eye(4.3)
  • Spleen(2.6)
  • Bone marrow(2.5)
  • Lymph node(2.4)
  • Muscle(2.1)
  • Intestine(2.1)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPO Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • nervous
  • respiratory
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • ear
  • head
Thorax:
  • heart
  • heart valve
  • lung
Limb:
  • lower limb
  • upper limb
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • spinal cord
genes like me logo Genes that share expression patterns with TMPO: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for TMPO Gene

Orthologs for TMPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPO Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMPO 29 30
  • 99.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMPO 29 30
  • 94.78 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmpo 29 16 30
  • 89.75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmpo 29
  • 89.75 (n)
Cow
(Bos Taurus)
Mammalia TMPO 29 30
  • 75.45 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TMPO 30
  • 42 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMPO 30
  • 38 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMPO 29 30
  • 80.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMPO 30
  • 37 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmpo 29
  • 69.58 (n)
MGC75950 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.464 29
Zebrafish
(Danio rerio)
Actinopterygii tmpoa 29 30
  • 59.21 (n)
OneToMany
tmpob 30
  • 30 (a)
OneToMany
TMPO (3 of 3) 30
  • 28 (a)
OneToMany
tmpo 29
Species where no ortholog for TMPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMPO Gene

ENSEMBL:
Gene Tree for TMPO (if available)
TreeFam:
Gene Tree for TMPO (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMPO: view image
Alliance of Genome Resources:
Additional Orthologs for TMPO

Paralogs for TMPO Gene

Paralogs for TMPO Gene

genes like me logo Genes that share paralogs with TMPO: view

Variants for TMPO Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMPO Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
1003800 Uncertain Significance: Loeys-Dietz syndrome 2 98,516,146(+) G/A
NM_001032283.3(TMPO):c.279G>A (p.Arg93=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
1007527 Uncertain Significance: Loeys-Dietz syndrome 2 98,534,178(+) C/G
NM_001032283.3(TMPO):c.565+2340C>G
MISSENSE_VARIANT,INTRON
1008195 Uncertain Significance: Loeys-Dietz syndrome 2 98,532,871(+) C/T
NM_001032283.3(TMPO):c.565+1033C>T
MISSENSE_VARIANT,INTRON
1011482 Uncertain Significance: Loeys-Dietz syndrome 2 98,516,123(+) C/G
NM_001032283.3(TMPO):c.256C>G (p.Arg86Gly)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
1013677 Uncertain Significance: Loeys-Dietz syndrome 2 98,533,222(+) A/G
NM_001032283.3(TMPO):c.565+1384A>G
MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMPO Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMPO Gene

Variant ID Type Subtype PubMed ID
esv2601754 CNV deletion 19546169
esv2761763 CNV loss 21179565
nsv1040329 CNV gain 25217958
nsv1138163 CNV deletion 24896259
nsv7234 OTHER inversion 18451855
nsv975655 CNV duplication 23825009

Variation tolerance for TMPO Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPO Gene

Human Gene Mutation Database (HGMD)
TMPO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPO
Leiden Open Variation Database (LOVD)
TMPO

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPO Gene

Disorders for TMPO Gene

MalaCards: The human disease database

(17) MalaCards diseases for TMPO Gene - From: GTR, ORP, COP, and GCD

Disorder Aliases PubMed IDs
familial isolated dilated cardiomyopathy
  • familial or idiopathic dilated cardiomyopathy
dilated cardiomyopathy
  • congestive cardiomyopathy
emery-dreifuss muscular dystrophy
  • edmd
dilated cardiomyopathy 1t
  • cmd1t
loeys-dietz syndrome 2
  • lds2
- elite association - COSMIC cancer census association via MalaCards
Search TMPO in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TMPO

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TMPO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPO Gene

Publications for TMPO Gene

  1. Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. (PMID: 16247757) Taylor MR … Familial Cardiomyopathy Registry Research Group (Human mutation 2005) 3 4 22 72
  2. Three distinct human thymopoietins are derived from alternatively spliced mRNAs. (PMID: 7517549) Harris CA … Goldstein G (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 22
  3. Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics. (PMID: 10806084) Dechat T … Foisner R (Journal of structural biology 2000) 3 4 22
  4. Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2. (PMID: 8530026) Harris CA … Goldstein G (Genomics 1995) 3 4 22
  5. A new thymopoietin precursor gene from human thymus. (PMID: 7703909) Hara H … Ohta M (Biochemistry and molecular biology international 1994) 3 4 22

Products for TMPO Gene

Sources for TMPO Gene