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Aliases for TMOD2 Gene

Aliases for TMOD2 Gene

  • Tropomodulin 2 2 3 5
  • Neuronal Tropomodulin 2 3 4
  • N-TMOD 3 4
  • NTMOD 3 4
  • Tropomodulin 2 (Neuronal) 3
  • Tropomodulin-2 3

External Ids for TMOD2 Gene

Previous GeneCards Identifiers for TMOD2 Gene

  • GC15P047601
  • GC15P045089
  • GC15P049622
  • GC15P049759
  • GC15P049831
  • GC15P052043
  • GC15P028878

Summaries for TMOD2 Gene

Entrez Gene Summary for TMOD2 Gene

  • This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]

GeneCards Summary for TMOD2 Gene

TMOD2 (Tropomodulin 2) is a Protein Coding gene. Diseases associated with TMOD2 include Amyotrophic Lateral Sclerosis 1. Among its related pathways are Cardiac conduction and Striated Muscle Contraction. Gene Ontology (GO) annotations related to this gene include actin binding and tropomyosin binding. An important paralog of this gene is TMOD3.

UniProtKB/Swiss-Prot for TMOD2 Gene

  • Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

Gene Wiki entry for TMOD2 Gene

Additional gene information for TMOD2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMOD2 Gene

Genomics for TMOD2 Gene

GeneHancer (GH) Regulatory Elements for TMOD2 Gene

Promoters and enhancers for TMOD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I051751 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 145 1.4 HDAC1 PKNOX1 RB1 SIN3A ETS1 ZNF335 ZNF766 GLIS2 EGR1 SCRT2 LYSMD2 TMOD2 ENSG00000259377
GH15I051750 Enhancer 0.6 FANTOM5 dbSUPER 550.8 -1.2 -1187 0.4 POLR2A EZH2 LYSMD2 TMOD2 TMOD3 ENSG00000259296
GH15I051841 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +93.1 93077 6.9 PKNOX1 SMAD1 ATF1 SIN3A FEZF1 BRCA1 ZNF766 ATF7 FOS RUNX3 LYSMD2 TMOD2 TMOD3 DMXL2 MAPK6 ENSG00000259178 MYO5C ENSG00000274954 ENSG00000277677
GH15I051620 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -129.1 -129109 4.4 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B POLR2B ZNF766 E2F8 ZNF416 DMXL2 SCG3 LYSMD2 TRPM7 ENSG00000260618 MAPK6 AP4E1 TMOD2 TMOD3 ENSG00000259678
GH15I051728 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.5 -17.7 -17685 9.9 PKNOX1 ATF1 SIN3A IRF4 YY1 ZNF766 GLIS2 ELK1 ZNF207 ZNF143 LYSMD2 DMXL2 SCG3 TMOD3 MAPK6 TMOD2 ENSG00000259296
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMOD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMOD2 gene promoter:

Genomic Locations for TMOD2 Gene

Genomic Locations for TMOD2 Gene
chr15:51,751,561-51,816,368
(GRCh38/hg38)
Size:
64,808 bases
Orientation:
Plus strand
chr15:52,043,758-52,108,565
(GRCh37/hg19)

Genomic View for TMOD2 Gene

Genes around TMOD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMOD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMOD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMOD2 Gene

Proteins for TMOD2 Gene

  • Protein details for TMOD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZR1-TMOD2_HUMAN
    Recommended name:
    Tropomodulin-2
    Protein Accession:
    Q9NZR1
    Secondary Accessions:
    • B4DEW6

    Protein attributes for TMOD2 Gene

    Size:
    351 amino acids
    Molecular mass:
    39595 Da
    Quaternary structure:
    • Binds to the N-terminus of tropomyosin and to actin.

    Alternative splice isoforms for TMOD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMOD2 Gene

Post-translational modifications for TMOD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMOD2 Gene

No data available for DME Specific Peptides for TMOD2 Gene

Domains & Families for TMOD2 Gene

Gene Families for TMOD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TMOD2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TMOD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZR1

UniProtKB/Swiss-Prot:

TMOD2_HUMAN :
  • Belongs to the tropomodulin family.
Family:
  • Belongs to the tropomodulin family.
genes like me logo Genes that share domains with TMOD2: view

Function for TMOD2 Gene

Molecular function for TMOD2 Gene

GENATLAS Biochemistry:
tropomodulin 2,neuronal
UniProtKB/Swiss-Prot Function:
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).

Gene Ontology (GO) - Molecular Function for TMOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005523 tropomyosin binding IEA,IBA --
genes like me logo Genes that share ontologies with TMOD2: view
genes like me logo Genes that share phenotypes with TMOD2: view

Animal Models for TMOD2 Gene

MGI Knock Outs for TMOD2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMOD2 Gene

Localization for TMOD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMOD2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMOD2 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005865 striated muscle thin filament IBA --
GO:0030426 growth cone IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with TMOD2: view

Pathways & Interactions for TMOD2 Gene

genes like me logo Genes that share pathways with TMOD2: view

Pathways by source for TMOD2 Gene

1 Sino Biological pathway for TMOD2 Gene
2 Reactome pathways for TMOD2 Gene

Gene Ontology (GO) - Biological Process for TMOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction IBA --
GO:0007015 actin filament organization IBA --
GO:0007270 neuron-neuron synaptic transmission IEA --
GO:0007399 nervous system development TAS 10662549
GO:0007611 learning or memory IEA --
genes like me logo Genes that share ontologies with TMOD2: view

No data available for SIGNOR curated interactions for TMOD2 Gene

Drugs & Compounds for TMOD2 Gene

No Compound Related Data Available

Transcripts for TMOD2 Gene

Unigene Clusters for TMOD2 Gene

Tropomodulin 2 (neuronal):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMOD2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3:

Relevant External Links for TMOD2 Gene

GeneLoc Exon Structure for
TMOD2
ECgene alternative splicing isoforms for
TMOD2

Expression for TMOD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMOD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMOD2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.1), Brain - Anterior cingulate cortex (BA24) (x4.6), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for TMOD2 Gene

This gene is overexpressed in Brain (44.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMOD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMOD2 Gene:

TMOD2

SOURCE GeneReport for Unigene cluster for TMOD2 Gene:

Hs.513734

mRNA Expression by UniProt/SwissProt for TMOD2 Gene:

Q9NZR1-TMOD2_HUMAN
Tissue specificity: Neuronal-tissue specific.

Evidence on tissue expression from TISSUES for TMOD2 Gene

  • Nervous system(4.9)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with TMOD2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMOD2 Gene

Orthologs for TMOD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMOD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMOD2 33 34
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia TMOD2 33 34
  • 93.16 (n)
dog
(Canis familiaris)
Mammalia TMOD2 33 34
  • 92.12 (n)
mouse
(Mus musculus)
Mammalia Tmod2 33 16 34
  • 90.03 (n)
rat
(Rattus norvegicus)
Mammalia Tmod2 33
  • 88.79 (n)
oppossum
(Monodelphis domestica)
Mammalia TMOD2 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMOD2 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMOD2 33 34
  • 78.82 (n)
lizard
(Anolis carolinensis)
Reptilia TMOD2 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmod2 33
  • 73.12 (n)
zebrafish
(Danio rerio)
Actinopterygii tmod2 33 34
  • 71.33 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.683 33
fruit fly
(Drosophila melanogaster)
Insecta spdo 35
  • 34 (a)
Species where no ortholog for TMOD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMOD2 Gene

ENSEMBL:
Gene Tree for TMOD2 (if available)
TreeFam:
Gene Tree for TMOD2 (if available)

Paralogs for TMOD2 Gene

Paralogs for TMOD2 Gene

(8) SIMAP similar genes for TMOD2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMOD2: view

Variants for TMOD2 Gene

Sequence variations from dbSNP and Humsavar for TMOD2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000026838 -- 51,776,101(+) C/A intron_variant
rs1000032685 -- 51,792,182(+) C/T intron_variant
rs1000101765 -- 51,752,420(+) T/A intron_variant
rs1000137078 -- 51,808,114(+) A/G intron_variant
rs1000162958 -- 51,793,347(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMOD2 Gene

Variant ID Type Subtype PubMed ID
nsv569409 CNV loss 21841781

Variation tolerance for TMOD2 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMOD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMOD2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMOD2 Gene

Disorders for TMOD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMOD2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
Search TMOD2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TMOD2

genes like me logo Genes that share disorders with TMOD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMOD2 Gene

Publications for TMOD2 Gene

  1. Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. (PMID: 10662549) Cox PR … Zoghbi HY (Genomics 2000) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N … Wilson SA (Nucleic acids research 2015) 3 58

Products for TMOD2 Gene

Sources for TMOD2 Gene

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