This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014] See more...

Aliases for TMIGD3 Gene

Aliases for TMIGD3 Gene

  • Transmembrane And Immunoglobulin Domain Containing 3 2 3 5
  • Transmembrane Domain-Containing Protein TMIGD3 3 4
  • AD026 2 3
  • AD026 Protein (AD026) 3
  • TMIGD3 5

External Ids for TMIGD3 Gene

Summaries for TMIGD3 Gene

Entrez Gene Summary for TMIGD3 Gene

  • This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014]

GeneCards Summary for TMIGD3 Gene

TMIGD3 (Transmembrane And Immunoglobulin Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled adenosine receptor activity. An important paralog of this gene is CD300LG.

UniProtKB/Swiss-Prot Summary for TMIGD3 Gene

  • [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).

Additional gene information for TMIGD3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMIGD3 Gene

Genomics for TMIGD3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMIGD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J111489 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 608.1 +73.7 73702 2.6 SP1 CEBPA CEBPB MGA ZNF766 NFE2 ZNF316 YY1 MAFG EHMT2 TMIGD3 RF00026-062 RNU6-792P lnc-ADORA3-5 DDX20 INKA2 ADORA3 C1orf162
GH01J111563 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 600.7 -1.1 -1098 3.4 IKZF1 JUND SP1 DPF2 SOX13 EGR1 CEBPB FOS YY1 FOSL1 TMIGD3 KRT18P57 RNU6-151P RAP1A HSALNG0006060 DDX20
GH01J111591 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 11.2 -29.3 -29259 3.2 ARHGAP35 SP1 PRDM10 ZNF629 ZNF512 LEF1 IKZF1 ZNF692 BACH1 TARDBP DDX20 RAP1A DENND2D TMIGD3 ADORA3 C1orf162 INKA2 OVGP1 HSALNG0006060 piR-49732-029
GH01J111534 Enhancer 1.2 FANTOM5 Ensembl ENCODE 12.2 +28.3 28253 2.5 GATAD2A SOX13 RBFOX2 RXRB SP1 FOXK2 ETS1 ZBTB26 FOXA2 YY1 TMIGD3 ADORA3 RNU6-151P KRT18P57 LINC02884 RAP1A piR-31162-029 lnc-RAP1A-1
GH01J111541 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 12.2 +22.2 22202 2 PRDM1 MCM7 ZNF316 ZBTB40 JUND ZNF384 RAP1A lnc-RAP1A-1 TMIGD3 ADORA3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMIGD3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMIGD3

Genomic Locations for TMIGD3 Gene

Genomic Locations for TMIGD3 Gene
chr1:111,483,348-111,564,003
(GRCh38/hg38)
Size:
80,656 bases
Orientation:
Minus strand

Genomic View for TMIGD3 Gene

Genes around TMIGD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMIGD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMIGD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMIGD3 Gene

Proteins for TMIGD3 Gene

  • Protein details for TMIGD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMS9-TMIG3_HUMAN
    Recommended name:
    Transmembrane domain-containing protein TMIGD3
    Protein Accession:
    P0DMS9
    Secondary Accessions:
    • A2A3P4
    • P33765
    • Q5QNY7
    • Q6P2N6
    • Q6UWU0
    • Q9BYZ1

    Protein attributes for TMIGD3 Gene

    Size:
    266 amino acids
    Molecular mass:
    30327 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41707.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH64411.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=EAW56500.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 1]: The first exon of TMIGD3 isoform 1 (i1) is shared with the first exon of ADORA3 isoform 2 (A3AR i2, commonly known as A3AR), resulting in a fusion protein.

    Alternative splice isoforms for TMIGD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMIGD3 Gene

Post-translational modifications for TMIGD3 Gene

  • Glycosylation at Asn192
  • Modification sites at PhosphoSitePlus

Other Protein References for TMIGD3 Gene

No data available for DME Specific Peptides for TMIGD3 Gene

Domains & Families for TMIGD3 Gene

Gene Families for TMIGD3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMIGD3 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TMIGD3: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMIGD3 Gene

Function for TMIGD3 Gene

Molecular function for TMIGD3 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).

Phenotypes From GWAS Catalog for TMIGD3 Gene

Gene Ontology (GO) - Molecular Function for TMIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
genes like me logo Genes that share ontologies with TMIGD3: view
genes like me logo Genes that share phenotypes with TMIGD3: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMIGD3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMIGD3 Gene

Localization for TMIGD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMIGD3 Gene

Membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8399349
GO:0016020 membrane IEA,IDA 27886186
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMIGD3: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMIGD3 Gene

Pathways & Interactions for TMIGD3 Gene

PathCards logo

SuperPathways for TMIGD3 Gene

No Data Available

Interacting Proteins for TMIGD3 Gene

Gene Ontology (GO) - Biological Process for TMIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 9164961
GO:0007165 signal transduction TAS 8399349
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007190 activation of adenylate cyclase activity TAS 9380026
GO:0008016 regulation of heart contraction TAS 9837869
genes like me logo Genes that share ontologies with TMIGD3: view

No data available for Pathways by source and SIGNOR curated interactions for TMIGD3 Gene

Drugs & Compounds for TMIGD3 Gene

No Compound Related Data Available

Transcripts for TMIGD3 Gene

mRNA/cDNA for TMIGD3 Gene

3 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMIGD3

Alternative Splicing Database (ASD) splice patterns (SP) for TMIGD3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: -
SP7: - -
SP8: - - - - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 10c ^ 11a · 11b
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TMIGD3 Gene

GeneLoc Exon Structure for
TMIGD3

Expression for TMIGD3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMIGD3

mRNA Expression by UniProt/SwissProt for TMIGD3 Gene:

P0DMS9-TMIG3_HUMAN
Tissue specificity: Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMIGD3 Gene

Orthologs for TMIGD3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMIGD3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ADORA3 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ADORA3 31
  • 76 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ADORA3 31
  • 68 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Adora3 31
  • 65 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ADORA3 31
  • 44 (a)
OneToOne
Species where no ortholog for TMIGD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TMIGD3 Gene

ENSEMBL:
Gene Tree for TMIGD3 (if available)
TreeFam:
Gene Tree for TMIGD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMIGD3: view image

Paralogs for TMIGD3 Gene

genes like me logo Genes that share paralogs with TMIGD3: view

Variants for TMIGD3 Gene

Additional dbSNP identifiers (rs#s) for TMIGD3 Gene

Additional Variant Information for TMIGD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMIGD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TMIGD3 Gene

Disorders for TMIGD3 Gene

No disorders were found for TMIGD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMIGD3 Gene

Publications for TMIGD3 Gene

  1. Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression. (PMID: 27886186) Iyer SV … Iwakuma T (Nature communications 2016) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for TMIGD3 Gene

Sources for TMIGD3 Gene