This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014] See more...

Aliases for TMIGD3 Gene

Aliases for TMIGD3 Gene

  • Transmembrane And Immunoglobulin Domain Containing 3 2 3 5
  • Transmembrane Domain-Containing Protein TMIGD3 3 4
  • AD026 Protein (AD026) 3
  • AD026 3

External Ids for TMIGD3 Gene

Summaries for TMIGD3 Gene

Entrez Gene Summary for TMIGD3 Gene

  • This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014]

GeneCards Summary for TMIGD3 Gene

TMIGD3 (Transmembrane And Immunoglobulin Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled adenosine receptor activity. An important paralog of this gene is CD300E.

UniProtKB/Swiss-Prot Summary for TMIGD3 Gene

  • Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).

Additional gene information for TMIGD3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMIGD3 Gene

Genomics for TMIGD3 Gene

GeneHancer (GH) Regulatory Elements for TMIGD3 Gene

Promoters and enhancers for TMIGD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J111489 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 758.1 +73.7 73702 2.6 HLF ZFX SP1 CEBPG ZNF639 ZNF644 CEBPA ZNF316 NFE2 MGA TMIGD3 RNU6-792P RF00026-062 lnc-ADORA3-5 DDX20 INKA2
GH01J111563 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 750.6 -1.1 -1098 3.4 SMARCE1 SP1 SMARCA4 ZNF644 IKZF1 DPF2 POLR2A RXRA SOX13 EGR1 TMIGD3 KRT18P57 RNU6-151P HSALNG0006060 RAP1A
GH01J111591 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 11.2 -29.3 -29259 3.2 ZBTB40 SP1 SMARCE1 ZNF362 CC2D1A ETV6 RELA DACH1 TEAD4 ZNF148 DENND2D DDX20 RAP1A TMIGD3 ADORA3 C1orf162 INKA2 OVGP1 HSALNG0006060 piR-49732-029
GH01J111534 Enhancer 1.2 FANTOM5 Ensembl ENCODE 12.2 +28.3 28253 2.5 RBPJ NR2F6 RAD21 ELF3 SP1 CEBPG PPARG ZNF644 KAT8 RXRA TMIGD3 ADORA3 KRT18P57 RNU6-151P ENSG00000231246 piR-31162-029 lnc-RAP1A-1
GH01J111541 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 12.2 +22.2 22202 2 ZBTB40 PRDM1 ZNF384 ZNF316 MCM7 RAP1A lnc-RAP1A-1 TMIGD3 ADORA3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMIGD3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMIGD3 Gene

Genomic Locations for TMIGD3 Gene
chr1:111,483,348-111,564,003
(GRCh38/hg38)
Size:
80,656 bases
Orientation:
Minus strand

Genomic View for TMIGD3 Gene

Genes around TMIGD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMIGD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMIGD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMIGD3 Gene

Proteins for TMIGD3 Gene

  • Protein details for TMIGD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMS9-TMIG3_HUMAN
    Recommended name:
    Transmembrane domain-containing protein TMIGD3
    Protein Accession:
    P0DMS9
    Secondary Accessions:
    • A2A3P4
    • P33765
    • Q5QNY7
    • Q6P2N6
    • Q6UWU0
    • Q9BYZ1

    Protein attributes for TMIGD3 Gene

    Size:
    266 amino acids
    Molecular mass:
    30327 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41707.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH64411.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW56500.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMIGD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMIGD3 Gene

Post-translational modifications for TMIGD3 Gene

  • Glycosylation at Asn192
  • Modification sites at PhosphoSitePlus

Other Protein References for TMIGD3 Gene

No data available for DME Specific Peptides for TMIGD3 Gene

Domains & Families for TMIGD3 Gene

Gene Families for TMIGD3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMIGD3 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TMIGD3: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMIGD3 Gene

Function for TMIGD3 Gene

Molecular function for TMIGD3 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).

Phenotypes From GWAS Catalog for TMIGD3 Gene

genes like me logo Genes that share phenotypes with TMIGD3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMIGD3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMIGD3 Gene

Localization for TMIGD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMIGD3 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8399349
GO:0016020 membrane IDA,IEA 27886186
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMIGD3: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMIGD3 Gene

Pathways & Interactions for TMIGD3 Gene

PathCards logo

SuperPathways for TMIGD3 Gene

No Data Available

Interacting Proteins for TMIGD3 Gene

Gene Ontology (GO) - Biological Process for TMIGD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 9164961
GO:0007165 signal transduction TAS 8399349
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007190 activation of adenylate cyclase activity TAS 9380026
GO:0008016 regulation of heart contraction TAS 9837869
genes like me logo Genes that share ontologies with TMIGD3: view

No data available for Pathways by source and SIGNOR curated interactions for TMIGD3 Gene

Drugs & Compounds for TMIGD3 Gene

No Compound Related Data Available

Transcripts for TMIGD3 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMIGD3

Alternative Splicing Database (ASD) splice patterns (SP) for TMIGD3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: -
SP7: - -
SP8: - - - - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 10c ^ 11a · 11b
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TMIGD3 Gene

GeneLoc Exon Structure for
TMIGD3
ECgene alternative splicing isoforms for
TMIGD3

Expression for TMIGD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMIGD3 Gene:

TMIGD3

mRNA Expression by UniProt/SwissProt for TMIGD3 Gene:

P0DMS9-TMIG3_HUMAN
Tissue specificity: Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMIGD3 Gene

Orthologs for TMIGD3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMIGD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADORA3 33
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADORA3 33
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADORA3 33
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adora3 33
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADORA3 33
  • 44 (a)
OneToOne
Species where no ortholog for TMIGD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMIGD3 Gene

ENSEMBL:
Gene Tree for TMIGD3 (if available)
TreeFam:
Gene Tree for TMIGD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMIGD3: view image

Paralogs for TMIGD3 Gene

genes like me logo Genes that share paralogs with TMIGD3: view

Variants for TMIGD3 Gene

Sequence variations from dbSNP and Humsavar for TMIGD3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000035687 -- 111,511,080(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000038056 -- 111,544,076(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000088595 -- 111,543,861(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000089426 -- 111,484,580(-) T/C/G intron_variant
rs1000159733 -- 111,490,581(-) G/A intron_variant

Additional Variant Information for TMIGD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMIGD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TMIGD3 Gene

Disorders for TMIGD3 Gene

Additional Disease Information for TMIGD3

No disorders were found for TMIGD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMIGD3 Gene

Publications for TMIGD3 Gene

  1. Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression. (PMID: 27886186) Iyer SV … Iwakuma T (Nature communications 2016) 3 4 56
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for TMIGD3 Gene

Sources for TMIGD3 Gene