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This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014] See more...
Aliases for TMIGD3 Gene
Aliases for TMIGD3 Gene
External Ids for TMIGD3 Gene
- HGNC: 51375
- Entrez Gene: 57413
- Ensembl: ENSG00000121933
- UniProtKB: P0DMS9
Summaries for TMIGD3 Gene
-
This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014]
GeneCards Summary for TMIGD3 Gene
TMIGD3 (Transmembrane And Immunoglobulin Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled adenosine receptor activity. An important paralog of this gene is CD300LG.
UniProtKB/Swiss-Prot Summary for TMIGD3 Gene
-
[Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).
Additional gene information for TMIGD3 Gene
- HGNC(51375)
- Entrez Gene(57413)
- Ensembl(ENSG00000121933)
- UniProtKB(P0DMS9)
- Open Targets Platform(ENSG00000121933)
- Search for TMIGD3 at DataMed
- Search for TMIGD3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMIGD3 Gene
Genomics for TMIGD3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TMIGD3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TMIGD3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMIGD3
Genomic Locations for TMIGD3 Gene
Genomic Locations for TMIGD3 Gene
- chr1:111,483,348-111,564,003
- (GRCh38/hg38)
- Size:
- 80,656 bases
- Orientation:
- Minus strand
Genomic View for TMIGD3 Gene
Genes around TMIGD3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by HGNC
- 1p13.2 by Entrez Gene
- 1p13.2 by Ensembl
TMIGD3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMIGD3 Gene
Proteins for TMIGD3 Gene
-
Protein details for TMIGD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0DMS9-TMIG3_HUMAN
- Recommended name:
- Transmembrane domain-containing protein TMIGD3
- Protein Accession:
- P0DMS9
- A2A3P4
- P33765
- Q5QNY7
- Q6P2N6
- Q6UWU0
- Q9BYZ1
Protein attributes for TMIGD3 Gene
- Size:
- 266 amino acids
- Molecular mass:
- 30327 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH41707.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH64411.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=EAW56500.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 1]: The first exon of TMIGD3 isoform 1 (i1) is shared with the first exon of ADORA3 isoform 2 (A3AR i2, commonly known as A3AR), resulting in a fusion protein.
Post-translational modifications for TMIGD3 Gene
Other Protein References for TMIGD3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMIGD3
- Origene Custom Protein Services for TMIGD3
No data available for DME Specific Peptides for TMIGD3 Gene
Domains & Families for TMIGD3 Gene
Gene Families for TMIGD3 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for TMIGD3 Gene
- InterPro:
- ProtoNet:
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMIGD3 Gene
Function for TMIGD3 Gene
Molecular function for TMIGD3 Gene
- UniProtKB/Swiss-Prot Function:
- [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity (PubMed:27886186).
Phenotypes From GWAS Catalog for TMIGD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IEA | -- |
Phenotypes for TMIGD3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for TMIGD3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMIGD3
miRNA Products
Inhibitory RNA Products
- Origene RNAi products in human, mouse, rat for TMIGD3
- Browse OriGene Inhibitory RNA Products For TMIGD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMIGD3
Clone Products
- Sino Biological Human cDNA Clone for TMIGD3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMIGD3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMIGD3 Gene
Localization for TMIGD3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMIGD3 Gene
- Membrane. Multi-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005887 | integral component of plasma membrane | TAS | 8399349 |
| GO:0016020 | membrane | IEA,IDA | 27886186 |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMIGD3 Gene
Pathways & Interactions for TMIGD3 Gene
Interacting Proteins for TMIGD3 Gene
GPS-Prot Interaction Network for TMIGD3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006954 | inflammatory response | TAS | 9164961 |
| GO:0007165 | signal transduction | TAS | 8399349 |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
| GO:0007190 | activation of adenylate cyclase activity | TAS | 9380026 |
| GO:0008016 | regulation of heart contraction | TAS | 9837869 |
No data available for Pathways by source and SIGNOR curated interactions for TMIGD3 Gene
Transcripts for TMIGD3 Gene
mRNA/cDNA for TMIGD3 Gene
- 3 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000369716 1662 nts (view in UCSC)
- ENST00000369717 1150 nts (view in UCSC)
- ENST00000442484 962 nts (view in UCSC)
- ENST00000443498 637 nts (view in UCSC)
- ENST00000463993 586 nts (view in UCSC)
CRISPR Products
-
OriGene CRISPR knockouts for TMIGD3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMIGD3
miRNA Products
Inhibitory RNA Products
- Origene RNAi products in human, mouse, rat for TMIGD3
- Browse OriGene Inhibitory RNA Products For TMIGD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMIGD3
Clone Products
- Sino Biological Human cDNA Clone for TMIGD3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMIGD3
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 10c | ^ | 11a | · | 11b |
|---|---|---|---|---|---|
| SP1: | - | ||||
| SP2: | - | ||||
| SP3: | - | ||||
| SP4: | - | ||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: |
Relevant External Links for TMIGD3 Gene
- GeneLoc Exon Structure for
- TMIGD3
Expression for TMIGD3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMIGD3
mRNA Expression by UniProt/SwissProt for TMIGD3 Gene:
P0DMS9-TMIG3_HUMAN
Tissue specificity:
Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).
Primer Products
-
OriGene qPCR primer pairs for TMIGD3
Gene Expression Assay Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMIGD3 Gene
Orthologs for TMIGD3 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ADORA3 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ADORA3 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ADORA3 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Adora3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ADORA3 31 |
|
OneToOne |
- Species where no ortholog for TMIGD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for TMIGD3 Gene
- ENSEMBL:
- Gene Tree for TMIGD3 (if available)
- TreeFam:
- Gene Tree for TMIGD3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TMIGD3: view image
Paralogs for TMIGD3 Gene
Variants for TMIGD3 Gene
Additional Variant Information for TMIGD3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TMIGD3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TMIGD3 Gene
Disorders for TMIGD3 Gene
Additional Disease Information for TMIGD3
No disorders were found for TMIGD3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMIGD3 Gene
Publications for TMIGD3 Gene
- Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression. (PMID: 27886186) Iyer SV … Iwakuma T (Nature communications 2016) 3 4
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
ExternalLinks
Products for TMIGD3 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMIGD3
- Origene Custom Protein Services for TMIGD3
- Origene RNAi products in human, mouse, rat for TMIGD3
- Browse OriGene Inhibitory RNA Products For TMIGD3
- OriGene qPCR primer pairs for TMIGD3
- OriGene CRISPR knockouts for TMIGD3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TMIGD3
- Sino Biological Human cDNA Clone for TMIGD3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for TMIGD3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TMIGD3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TMIGD3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TMIGD3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TMIGD3
- antibodies-online: Search results for available TMIGD3 related products ranked by validation data
- antibodies-online: Search results for available TMIGD3 related products ranked by validation data
- antibodies-online: Search results for available TMIGD3 related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TMIGD3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TMIGD3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TMIGD3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMIGD3
Sources for TMIGD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
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- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
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- (115) NCBI Bookshelf
- (116) ClinVar
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
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- (156) Mastermind
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- (159) GeneImprint
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- (163) LncBase
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- (178) MirGeneDB