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TMIGD2 Gene(Protein Coding)

Transmembrane And Immunoglobulin Domain Containing 2

GCID:
GC19M004292
GIFtS:
40
Genes Participants
UDN Logo

Aliases for TMIGD2 Gene

Aliases for TMIGD2 Gene

  • Transmembrane And Immunoglobulin Domain Containing 2 2 3 5
  • Immunoglobulin And Proline-Rich Receptor 1 3 4
  • CD28 Homologue 2 3
  • CD28 Homolog 3 4
  • IGPR-1 3 4
  • CD28H 3 4
  • IGPR1 3 4
  • Transmembrane And Immunoglobulin Domain-Containing Protein 2 Variant 2 3
  • Transmembrane And Immunoglobulin Domain-Containing Protein 2 Variant 3 3
  • Transmembrane And Immunoglobulin Domain-Containing Protein 2 3
  • Immunoglobulin-Containing And Proline-Rich Receptor-1 2
  • Immunoglobulin-Containing And Proline-Rich Receptor 1 3

External Ids for TMIGD2 Gene

Previous GeneCards Identifiers for TMIGD2 Gene

  • GC19M004244
  • GC19M004055

Summaries for TMIGD2 Gene

GeneCards Summary for TMIGD2 Gene

TMIGD2 (Transmembrane And Immunoglobulin Domain Containing 2) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Gene Ontology (GO) annotations related to this gene include coreceptor activity.

UniProtKB/Swiss-Prot for TMIGD2 Gene

  • Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

Additional gene information for TMIGD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMIGD2 Gene

Genomics for TMIGD2 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for TMIGD2 Gene

Promoters and enhancers for TMIGD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I004300 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.3 -292 4.5 RB1 ZNF493 ZNF76 SIN3A ETS1 ZNF335 ZNF121 ZNF143 CREM THAP11 FSD1 TMIGD2 ENSG00000267205 STAP2
GH19I004340 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.4 -39.9 -39861 3.5 HDGF FOXA2 PKNOX1 CLOCK MLX ARID4B NEUROD1 SIN3A DMAP1 YY1 STAP2 MPND SH3GL1 ENSG00000267255 TMIGD2 FSD1 SHD CHAF1A CCDC94 ENSG00000269425
GH19I003719 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 9.9 +581.5 581489 4.8 HDGF PKNOX1 ARNT NEUROD1 SIN3A ZNF2 YY1 ZNF766 E2F8 ZNF207 GC19P003720 TJP3 ZNF77 CACTIN ZNF555 TLE2 MRPL54 GNA11 ZNF554 HDGFL2
GH19I004367 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -72.2 -72238 14.8 MLX DMAP1 IRF4 E2F8 ZNF143 MEF2D SSRP1 GLIS1 RCOR2 NBN ENSG00000267769 SEMA6B CHAF1A CACTIN SH3GL1 UBXN6 CCDC94 CACTIN-AS1 ENSG00000267030 FSD1
GH19I004142 Enhancer 1.5 Ensembl ENCODE dbSUPER 10.7 +156.0 156008 8 PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 CACTIN APBA3 ENSG00000267769 CCDC94 ENSG00000267030 ENSG00000269807 CHAF1A SIRT6 ANKRD24 DPP9-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMIGD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMIGD2 gene promoter:

Genomic Locations for TMIGD2 Gene

Genomic Locations for TMIGD2 Gene
chr19:4,292,227-4,302,582
(GRCh38/hg38)
Size:
10,356 bases
Orientation:
Minus strand
chr19:4,292,224-4,302,428
(GRCh37/hg19)

Genomic View for TMIGD2 Gene

Genes around TMIGD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMIGD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMIGD2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TMIGD2 Gene

Proteins for TMIGD2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TMIGD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BF3-TMIG2_HUMAN
    Recommended name:
    Transmembrane and immunoglobulin domain-containing protein 2
    Protein Accession:
    Q96BF3
    Secondary Accessions:
    • Q6UW59

    Protein attributes for TMIGD2 Gene

    Size:
    282 amino acids
    Molecular mass:
    30675 Da
    Quaternary structure:
    • May form homophilic interactions that could regulate cell-cell interaction. Interacts with CACNB2, DST, MIA and NCKIPSD. Interacts with HHLA2.

    Alternative splice isoforms for TMIGD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMIGD2 Gene

Protein Expression for TMIGD2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TMIGD2 Gene

Other Protein References for TMIGD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TMIGD2 (TMIGD2/CD28H)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TMIGD2

No data available for DME Specific Peptides for TMIGD2 Gene

Domains & Families for TMIGD2 Gene

Gene Families for TMIGD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMIGD2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMIGD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMIGD2: view

No data available for UniProtKB/Swiss-Prot for TMIGD2 Gene

Function for TMIGD2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TMIGD2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

Gene Ontology (GO) - Molecular Function for TMIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23784006
GO:0015026 coreceptor activity IDA 23784006
genes like me logo Genes that share ontologies with TMIGD2: view
genes like me logo Genes that share phenotypes with TMIGD2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMIGD2 Gene

Localization for TMIGD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMIGD2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMIGD2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMIGD2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMIGD2 Gene

Pathways & Interactions for TMIGD2 Gene

genes like me logo Genes that share pathways with TMIGD2: view

Pathways by source for TMIGD2 Gene

1 R&D Systems pathway for TMIGD2 Gene

Interacting Proteins for TMIGD2 Gene

Selected Interacting proteins: Q96BF3-TMIG2_HUMAN for TMIGD2 Gene via IID

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
ADRB2

Gene Ontology (GO) - Biological Process for TMIGD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 23784006
GO:0002377 immunoglobulin production IBA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction IEA --
GO:0031295 T cell costimulation IDA 23784006
genes like me logo Genes that share ontologies with TMIGD2: view

No data available for SIGNOR curated interactions for TMIGD2 Gene

Drugs & Compounds for TMIGD2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TMIGD2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TMIGD2 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMIGD2 Gene

Transmembrane and immunoglobulin domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMIGD2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: -

Relevant External Links for TMIGD2 Gene

GeneLoc Exon Structure for
TMIGD2
ECgene alternative splicing isoforms for
TMIGD2

Expression for TMIGD2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMIGD2 Gene

mRNA expression in normal human tissues for TMIGD2 Gene
mRNA expression by BioGPS for TMIGD2 GenemRNA expression by GTEx for TMIGD2 Gene

mRNA differential expression in normal tissues according to GTEx for TMIGD2 Gene

This gene is overexpressed in Whole Blood (x24.9) and Spleen (x5.4).

Protein differential expression in normal tissues from HIPED for TMIGD2 Gene

This gene is overexpressed in CD8 Tcells (51.9) and NK cells (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMIGD2 Gene



Protein tissue co-expression partners for TMIGD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMIGD2 Gene:

TMIGD2

SOURCE GeneReport for Unigene cluster for TMIGD2 Gene:

Hs.263928

mRNA Expression by UniProt/SwissProt for TMIGD2 Gene:

Q96BF3-TMIG2_HUMAN
Tissue specificity: Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at protein level). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level). Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double-negative cells (at protein level). In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cells and CD3+ T-cells(at protein level). Not detected on B-cells(at protein level). Expressed in tonsils (at protein level).
genes like me logo Genes that share expression patterns with TMIGD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMIGD2 Gene

Orthologs for TMIGD2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMIGD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TMIGD2 33 34
  • 98.7 (n)
cow
(Bos Taurus)
 Mammalia TMIGD2 33 34
  • 71.93 (n)
oppossum
(Monodelphis domestica)
 Mammalia TMIGD2 34
  • 33 (a)
 OneToOne
Species where no ortholog for TMIGD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMIGD2 Gene

ENSEMBL:
Gene Tree for TMIGD2 (if available)
TreeFam:
Gene Tree for TMIGD2 (if available)

Paralogs for TMIGD2 Gene

No data available for Paralogs for TMIGD2 Gene

Variants for TMIGD2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for TMIGD2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000216130 -- 4,295,134(-) G/A intron_variant
rs1000393430 -- 4,300,284(-) T/G intron_variant
rs1000463355 -- 4,298,651(-) G/A intron_variant
rs1000700299 -- 4,301,728(-) G/A intron_variant
rs1000764193 -- 4,299,685(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMIGD2 Gene

Variant ID Type Subtype PubMed ID
esv2677475 CNV deletion 23128226
esv2718004 CNV deletion 23290073
esv3643495 CNV loss 21293372
esv3643497 CNV gain 21293372
nsv1109161 CNV deletion 24896259
nsv578442 CNV loss 21841781
nsv833717 CNV loss 17160897
nsv833718 CNV loss 17160897

Variation tolerance for TMIGD2 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMIGD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMIGD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMIGD2 Gene

Disorders for TMIGD2 Gene

Additional Disease Information for TMIGD2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMIGD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMIGD2 Gene

Publications for TMIGD2 Gene

  1. B7-H5 costimulates human T cells via CD28H. (PMID: 23784006) Zhu Y … Chen L (Nature communications 2013) 2 3 4 58
  2. Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis. (PMID: 22419821) Rahimi N … Meyer RD (Molecular biology of the cell 2012) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function. (PMID: 27838321) Wang YHW … Rahimi N (Journal of molecular biology 2016) 3 58

Products for TMIGD2 Gene

Sources for TMIGD2 Gene

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