Aliases for TMEM99 Gene

Subcategory (RNA class) for TMEM99 Gene

lncRNA

Number of RNA Genes sources:

1 / 14

Aliases for TMEM99 Gene

  • Transmembrane Protein 99 (Putative) 2 3 5
  • Transmembrane Protein 99 2 4
  • HSALNG0116399 167

External Ids for TMEM99 Gene

Previous GeneCards Identifiers for TMEM99 Gene

  • GC17P036229
  • GC17P038975
  • GC17P034769

Summaries for TMEM99 Gene

GeneCards Summary for TMEM99 Gene

TMEM99 (Transmembrane Protein 99 (Putative)) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with TMEM99 include Erythroderma, Ichthyosiform, Congenital Reticular and Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis.

Additional gene information for TMEM99 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM99 Gene

Genomics for TMEM99 Gene

GeneHancer (GH) Regulatory Elements for TMEM99 Gene

Promoters and enhancers for TMEM99 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM99 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM99

Top Transcription factor binding sites by QIAGEN in the TMEM99 gene promoter:
  • Bach1
  • C/EBPbeta
  • LUN-1
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for TMEM99 Gene

Genomic Locations for TMEM99 Gene
chr17:40,819,092-40,836,274
(GRCh38/hg38)
Size:
17,183 bases
Orientation:
Plus strand
chr17:38,975,344-38,992,526
(GRCh37/hg19)
Size:
17,183 bases
Orientation:
Plus strand

Genomic View for TMEM99 Gene

Genes around TMEM99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM99 Gene

Proteins for TMEM99 Gene

  • Protein details for TMEM99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N816-TMM99_HUMAN
    Recommended name:
    Transmembrane protein 99
    Protein Accession:
    Q8N816
    Secondary Accessions:
    • B4DQ34
    • Q96BP9

    Protein attributes for TMEM99 Gene

    Size:
    258 amino acids
    Molecular mass:
    27975 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM99 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM99 Gene

Post-translational modifications for TMEM99 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM99 Gene

Domains & Families for TMEM99 Gene

Gene Families for TMEM99 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM99 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM99 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 99 (TMM99_HUMAN)
genes like me logo Genes that share domains with TMEM99: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM99 Gene

Function for TMEM99 Gene

Phenotypes From GWAS Catalog for TMEM99 Gene

genes like me logo Genes that share phenotypes with TMEM99: view

Animal Model Products

CRISPR Products

miRNA for TMEM99 Gene

miRTarBase miRNAs that target TMEM99

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM99

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM99 Gene

Localization for TMEM99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM99 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM99 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM99: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM99 Gene

Pathways & Interactions for TMEM99 Gene

PathCards logo

SuperPathways for TMEM99 Gene

No Data Available

Interacting Proteins for TMEM99 Gene

Selected Interacting proteins: Q8N816-TMM99_HUMAN for TMEM99 Gene via IID

Symbol External ID(s) Details
CDK16
;

Gene Ontology (GO) - Biological Process for TMEM99 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM99 Gene

Drugs & Compounds for TMEM99 Gene

No Compound Related Data Available

Transcripts for TMEM99 Gene

mRNA/cDNA for TMEM99 Gene

12 RNACentral transcripts :
6 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
1 LncBook transcripts :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM99

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM99 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for TMEM99 Gene

GeneLoc Exon Structure for
TMEM99

Expression for TMEM99 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM99 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM99 Gene

This gene is overexpressed in Testis (x6.6) and Skin - Sun Exposed (Lower leg) (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM99

SOURCE GeneReport for Unigene cluster for TMEM99 Gene:

Hs.744059

Evidence on tissue expression from TISSUES for TMEM99 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with TMEM99: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM99 Gene

Orthologs for TMEM99 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM99 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM99 30
  • 98.58 (n)
Species where no ortholog for TMEM99 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM99 Gene

ENSEMBL:
Gene Tree for TMEM99 (if available)
TreeFam:
Gene Tree for TMEM99 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM99: view image

Paralogs for TMEM99 Gene

No data available for Paralogs for TMEM99 Gene

Variants for TMEM99 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM99 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
681454 Likely Benign: not provided 40,822,248(+) C/T MISSENSE_VARIANT
rs146835683 Uncertain Significance: not provided 40,822,428(+) C/T MISSENSE_VARIANT
rs1555548670 Pathogenic: not provided 40,819,515(+) A/G SPLICE_DONOR_VARIANT
rs267607377 Not Provided: not provided 40,819,608(+) GG/TT NONSENSE
rs267607378 Not Provided: not provided 40,819,550(+) T/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TMEM99 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM99 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for TMEM99 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.01; 74.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM99 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM99

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM99 Gene

Disorders for TMEM99 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TMEM99 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM99

genes like me logo Genes that share disorders with TMEM99: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM99 Gene

Publications for TMEM99 Gene

  1. Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex. (PMID: 29561261) Florio M … Hiller M (eLife 2018) 2 3 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A … Carmell MA (Nature 2006) 3 54
  5. Decoding the fine-scale structure of a breast cancer genome and transcriptome. (PMID: 16461635) Volik S … Collins C (Genome research 2006) 3 54

Products for TMEM99 Gene

Sources for TMEM99 Gene