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Aliases for TMEM99 Gene

Aliases for TMEM99 Gene

  • Transmembrane Protein 99 2 3 5

External Ids for TMEM99 Gene

Previous GeneCards Identifiers for TMEM99 Gene

  • GC17P036229
  • GC17P038975
  • GC17P034769

Summaries for TMEM99 Gene

GeneCards Summary for TMEM99 Gene

TMEM99 (Transmembrane Protein 99) is a Protein Coding gene.

Additional gene information for TMEM99 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM99 Gene

Genomics for TMEM99 Gene

GeneHancer (GH) Regulatory Elements for TMEM99 Gene

Promoters and enhancers for TMEM99 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I040817 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 566.5 +0.4 430 3.4 PKNOX1 ATF1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF48 POLR2B GATA2 TMEM99 KRT34 MED24 KRT13 KRT10 GC17P040810
GH17I040306 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.7 -501.6 -501567 22.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RARA MED1 SMARCE1 SNORD124 CDK12 MED24 MSL1 TMEM99 CDC6 WIPF2
GH17I041687 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 19.4 +871.3 871307 6.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 GC17P041692 GC17P041691 EIF1 ENSG00000267758 ENSG00000259623 KLHL10 CNTNAP1 NT5C3B STAT5A CCR10
GH17I040848 Enhancer 1.2 Ensembl ENCODE 32.4 +33.0 32962 6.9 ATF1 PKNOX1 FOXA2 ZNF133 FEZF1 NCOA2 TCF12 ATF7 FOS KLF13 ENSG00000265359 GC17P040954 TMEM99 KRT20 KRT28 ENSG00000234477 KRT37 LOC100505782 KRT31 MED24
GH17I039859 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 15.2 -954.7 -954663 9.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IKZF3 ZPBP2 GSDMB ORMDL3 MED24 GSDMA TMEM99 LRRC3C MSL1 MED1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM99 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM99 gene promoter:

Genomic Locations for TMEM99 Gene

Genomic Locations for TMEM99 Gene
chr17:40,819,092-40,836,274
(GRCh38/hg38)
Size:
17,183 bases
Orientation:
Plus strand
chr17:38,975,344-38,992,526
(GRCh37/hg19)

Genomic View for TMEM99 Gene

Genes around TMEM99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM99 Gene

Proteins for TMEM99 Gene

  • Protein details for TMEM99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N816-TMM99_HUMAN
    Recommended name:
    Transmembrane protein 99
    Protein Accession:
    Q8N816
    Secondary Accessions:
    • B4DQ34
    • Q96BP9

    Protein attributes for TMEM99 Gene

    Size:
    258 amino acids
    Molecular mass:
    27975 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM99 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM99 Gene

Post-translational modifications for TMEM99 Gene

No Post-translational modifications

Other Protein References for TMEM99 Gene

No data available for DME Specific Peptides for TMEM99 Gene

Domains & Families for TMEM99 Gene

Gene Families for TMEM99 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM99 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM99 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM99: view

No data available for UniProtKB/Swiss-Prot for TMEM99 Gene

Function for TMEM99 Gene

Phenotypes From GWAS Catalog for TMEM99 Gene

Phenotypes for TMEM99 Gene

GenomeRNAi human phenotypes for TMEM99:
genes like me logo Genes that share phenotypes with TMEM99: view

Animal Model Products

CRISPR Products

miRNA for TMEM99 Gene

miRTarBase miRNAs that target TMEM99

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM99 Gene

Localization for TMEM99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM99 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM99 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM99: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM99 Gene

Pathways & Interactions for TMEM99 Gene

SuperPathways for TMEM99 Gene

No Data Available

Interacting Proteins for TMEM99 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000301665%0d%0a9606.ENSP00000276052%0d%0a
Selected Interacting proteins: ENSP00000301665 for TMEM99 Gene via STRING

Symbol External ID(s) Details
CDK16

Gene Ontology (GO) - Biological Process for TMEM99 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM99 Gene

Drugs & Compounds for TMEM99 Gene

No Compound Related Data Available

Transcripts for TMEM99 Gene

Unigene Clusters for TMEM99 Gene

Transmembrane protein 99:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM99 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for TMEM99 Gene

GeneLoc Exon Structure for
TMEM99
ECgene alternative splicing isoforms for
TMEM99

Expression for TMEM99 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM99 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM99 Gene

This gene is overexpressed in Testis (x6.6) and Skin - Sun Exposed (Lower leg) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of TMEM99 Gene:

TMEM99

SOURCE GeneReport for Unigene cluster for TMEM99 Gene:

Hs.744059

Evidence on tissue expression from TISSUES for TMEM99 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with TMEM99: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM99 Gene

Orthologs for TMEM99 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM99 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM99 33
  • 98.58 (n)
Species where no ortholog for TMEM99 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM99 Gene

ENSEMBL:
Gene Tree for TMEM99 (if available)
TreeFam:
Gene Tree for TMEM99 (if available)

Paralogs for TMEM99 Gene

No data available for Paralogs for TMEM99 Gene

Variants for TMEM99 Gene

Sequence variations from dbSNP and Humsavar for TMEM99 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs267607384 pathogenic, not-provided, Erythroderma, ichthyosiform, congenital reticular, not provided 40,818,974(+) CGC/C upstream_transcript_variant
rs387906640 pathogenic, Bullous ichthyosiform erythroderma 40,819,609(+) G/T intron_variant
rs57784225 pathogenic, not-provided, Bullous ichthyosiform erythroderma, not provided 40,822,126(+) T/G intron_variant
rs58026994 pathogenic, not-provided, Bullous ichthyosiform erythroderma, not provided 40,819,565(+) A/T intron_variant
rs58075662 not-provided, pathogenic, not provided, Bullous ichthyosiform erythroderma 40,822,119(+) C/A/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM99 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for TMEM99 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.01; 74.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM99 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM99

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM99 Gene

Disorders for TMEM99 Gene

Additional Disease Information for TMEM99

No disorders were found for TMEM99 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM99 Gene

Publications for TMEM99 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A … Carmell MA (Nature 2006) 3 58
  5. Decoding the fine-scale structure of a breast cancer genome and transcriptome. (PMID: 16461635) Volik S … Collins C (Genome research 2006) 3 58

Products for TMEM99 Gene

Sources for TMEM99 Gene

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