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Aliases for TMEM98 Gene

Aliases for TMEM98 Gene

  • Transmembrane Protein 98 2 3 3 5
  • Protein TADA1 4
  • TADA1 3

External Ids for TMEM98 Gene

Previous GeneCards Identifiers for TMEM98 Gene

  • GC17P028280
  • GC17P031254
  • GC17P027440

Summaries for TMEM98 Gene

Entrez Gene Summary for TMEM98 Gene

  • This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for TMEM98 Gene

TMEM98 (Transmembrane Protein 98) is a Protein Coding gene. Diseases associated with TMEM98 include Nanophthalmos 4 and Microphthalmia.

Gene Wiki entry for TMEM98 Gene

Additional gene information for TMEM98 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM98 Gene

Genomics for TMEM98 Gene

GeneHancer (GH) Regulatory Elements for TMEM98 Gene

Promoters and enhancers for TMEM98 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J032927 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 671.4 +0.6 575 3 HDGF FOXA2 MLX ARNT ZFP64 ARID4B YBX1 DMAP1 ZNF766 NFYC TMEM98 ZNF207 SUZ12 SH3GL1P1 LRRC37B PIR43668
GH17J032875 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 25.4 -50.1 -50107 4.5 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZNF766 E2F8 ZNF207 ZNF143 KLF13 MYO1D ENSG00000226377 LOC102724715 GC17P032879 TMEM98 UTP6 SUZ12 SH3GL1P1 ZNF207
GH17J032893 Enhancer 1.1 ENCODE dbSUPER 28.1 -33.3 -33250 2 PKNOX1 SMAD1 ATF1 ARNT TCF12 GATA2 ATF7 NCOA1 ZNF592 MBD2 TMEM98 MYO1D ENSG00000236377 LOC102724715 GC17P032879
GH17J032896 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 17.4 -29.5 -29494 3.4 HDGF PKNOX1 SMAD1 ATF1 ARNT TCF12 POLR2B ZNF766 GATA2 ATF7 TMEM98 ENSG00000236377 GC17P032879 LOC102724715
GH17J032443 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 -482.4 -482447 3.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B PSMD11 GC17P032446 ENSG00000279762 ZNF207 UTP6 SUZ12 ENSG00000265139 CDK5R1 TMEM98 RHBDL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM98 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM98 gene promoter:
  • C/EBPalpha
  • AML1a
  • YY1
  • GCNF-2
  • GCNF-1
  • GCNF
  • RFX1
  • HNF-4alpha1
  • ATF6
  • Pax-4a

Genomic Locations for TMEM98 Gene

Genomic Locations for TMEM98 Gene
chr17:32,927,910-32,945,106
(GRCh38/hg38)
Size:
17,197 bases
Orientation:
Plus strand
chr17:31,254,928-31,272,124
(GRCh37/hg19)
Size:
17,197 bases
Orientation:
Plus strand

Genomic View for TMEM98 Gene

Genes around TMEM98 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM98 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM98 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM98 Gene

Proteins for TMEM98 Gene

  • Protein details for TMEM98 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Y6-TMM98_HUMAN
    Recommended name:
    Transmembrane protein 98
    Protein Accession:
    Q9Y2Y6
    Secondary Accessions:
    • E1P631
    • Q9UFK2

    Protein attributes for TMEM98 Gene

    Size:
    226 amino acids
    Molecular mass:
    24611 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM98 Gene

Post-translational modifications for TMEM98 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM98 Gene

Domains & Families for TMEM98 Gene

Gene Families for TMEM98 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted membrane proteins

Protein Domains for TMEM98 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM98 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2Y6

UniProtKB/Swiss-Prot:

TMM98_HUMAN :
  • Belongs to the TMEM98 family.
Family:
  • Belongs to the TMEM98 family.
genes like me logo Genes that share domains with TMEM98: view

Function for TMEM98 Gene

Phenotypes From GWAS Catalog for TMEM98 Gene

genes like me logo Genes that share phenotypes with TMEM98: view

Human Phenotype Ontology for TMEM98 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TMEM98 Gene

MGI Knock Outs for TMEM98:
  • Tmem98 Tmem98<tm1a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM98

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TMEM98 Gene

Localization for TMEM98 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM98 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM98 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
nucleus 3
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM98 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM98: view

Pathways & Interactions for TMEM98 Gene

SuperPathways for TMEM98 Gene

No Data Available

Interacting Proteins for TMEM98 Gene

Selected Interacting proteins: Q9Y2Y6-TMM98_HUMAN for TMEM98 Gene via MINT IID

Gene Ontology (GO) - Biological Process for TMEM98 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM98 Gene

Drugs & Compounds for TMEM98 Gene

No Compound Related Data Available

Transcripts for TMEM98 Gene

mRNA/cDNA for TMEM98 Gene

Unigene Clusters for TMEM98 Gene

Transmembrane protein 98:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM98 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for TMEM98 Gene

GeneLoc Exon Structure for
TMEM98
ECgene alternative splicing isoforms for
TMEM98

Expression for TMEM98 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM98 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM98 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM98 Gene



Protein tissue co-expression partners for TMEM98 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM98 Gene:

TMEM98

SOURCE GeneReport for Unigene cluster for TMEM98 Gene:

Hs.3447

mRNA Expression by UniProt/SwissProt for TMEM98 Gene:

Q9Y2Y6-TMM98_HUMAN
Tissue specificity: Expressed in the eye, particularly in corneal endothelium, iris, ciliary body, sclera, optic nerve, optic nerve head, and retina.

Evidence on tissue expression from TISSUES for TMEM98 Gene

  • Nervous system(4.7)
  • Muscle(4.2)
  • Eye(2.5)
  • Heart(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM98 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with TMEM98: view

No data available for mRNA differential expression in normal tissues for TMEM98 Gene

Orthologs for TMEM98 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM98 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM98 34 33
  • 99.85 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM98 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM98 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM98 34 33
  • 90.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM98 34 33
  • 90.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem98 33
  • 89.23 (n)
mouse
(Mus musculus)
Mammalia Tmem98 16 34 33
  • 88.5 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM98 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem98 33
  • 74.48 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem98 34 33
  • 74.5 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K10C3.4 34
  • 15 (a)
OneToOne
Species where no ortholog for TMEM98 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM98 Gene

ENSEMBL:
Gene Tree for TMEM98 (if available)
TreeFam:
Gene Tree for TMEM98 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM98: view image

Paralogs for TMEM98 Gene

Pseudogenes.org Pseudogenes for TMEM98 Gene

genes like me logo Genes that share paralogs with TMEM98: view

No data available for Paralogs for TMEM98 Gene

Variants for TMEM98 Gene

Sequence variations from dbSNP and Humsavar for TMEM98 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs587777690 pathogenic, Nanophthalmos 4, Nanophthalmos 4 (NNO4) [MIM:615972] 32,940,889(+) G/C/T coding_sequence_variant, missense_variant
rs869312733 pathogenic, Nanophthalmos 4 32,940,899(+) A/C coding_sequence_variant, missense_variant
rs869312734 pathogenic, Nanophthalmos 4 32,933,276(+) GGAGAATGAAGACTGGATCGAAGATGCCTCGTAAGG/GG coding_sequence_variant, intron_variant, splice_donor_variant
rs1000161412 -- 32,930,578(+) C/A/T intron_variant
rs1000300782 -- 32,942,065(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM98 Gene

Variant ID Type Subtype PubMed ID
esv24161 CNV loss 19812545
esv2667652 CNV deletion 23128226
nsv510705 CNV deletion 20534489
nsv833417 CNV gain 17160897

Variation tolerance for TMEM98 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM98 Gene

Human Gene Mutation Database (HGMD)
TMEM98
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM98

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM98 Gene

Disorders for TMEM98 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM98 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nanophthalmos 4
  • nno4
microphthalmia
  • microphthalmos
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TMM98_HUMAN
  • Nanophthalmos 4 (NNO4) [MIM:615972]: A rare disorder of eye development characterized by extreme hyperopia (farsightedness) and small functional eyes. The cornea and lens are normal in size and shape. Hyperopia occurs because insufficient growth along the visual axis places these lensing components too close to the retina. Nanophthalmic eyes show considerable thickening of both the choroidal vascular bed and scleral coat, which provide nutritive and structural support for the retina. {ECO:0000269 PubMed:24852644}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TMEM98

genes like me logo Genes that share disorders with TMEM98: view

No data available for Genatlas for TMEM98 Gene

Publications for TMEM98 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Mutation in TMEM98 in a large white kindred with autosomal dominant nanophthalmos linked to 17p12-q12. (PMID: 24852644) Awadalla MS … Craig JE (JAMA ophthalmology 2014) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. siRNA-TMEM98 inhibits the invasion and migration of lung cancer cells. (PMID: 26884835) Mao M … Wu Z (International journal of clinical and experimental pathology 2015) 3 58

Products for TMEM98 Gene

Sources for TMEM98 Gene

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