Aliases for TMEM97 Gene
External Ids for TMEM97 Gene
Previous GeneCards Identifiers for TMEM97 Gene
TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]
GeneCards Summary for TMEM97 Gene
TMEM97 (Transmembrane Protein 97) is a Protein Coding gene. Diseases associated with TMEM97 include Meningioma, Familial.
UniProtKB/Swiss-Prot Summary for TMEM97 Gene
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337). Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588).