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Aliases for TMEM92 Gene

Aliases for TMEM92 Gene

  • Transmembrane Protein 92 2 3 5

External Ids for TMEM92 Gene

Previous GeneCards Identifiers for TMEM92 Gene

  • GC17P045707
  • GC17P048352
  • GC17P043718

Summaries for TMEM92 Gene

GeneCards Summary for TMEM92 Gene

TMEM92 (Transmembrane Protein 92) is a Protein Coding gene.

Additional gene information for TMEM92 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM92 Gene

Genomics for TMEM92 Gene

GeneHancer (GH) Regulatory Elements for TMEM92 Gene

Promoters and enhancers for TMEM92 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I050262 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 568 -2.2 -2226 13.4 HDGF PKNOX1 SIN3A ZBTB7B ZNF143 ZNF263 MCM3 SP3 MXD4 REST TMEM92 LUC7L3 MBTD1 ENSG00000262837 COL1A1 LOC105371824 MYCBPAP SPATA20 FAM117A FLJ45513
GH17I050171 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.3 -78.9 -78884 42 CLOCK DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D COL1A1 SGCA ENSG00000262837 LUC7L3 TMEM92-AS1 TMEM92 XYLT2 ZNF652 PPP1R9B FLJ45513
GH17I050278 Enhancer 1.1 Ensembl ENCODE dbSUPER 26.4 +8.8 8831 3.6 KLF1 BATF ZIC2 ZFHX2 HNF4G FOSL2 PRDM10 RUNX3 EGR2 RXRA TMEM92 EME1 TMEM92-AS1
GH17I050216 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.9 -51.6 -51576 6.9 FOXA2 ARID4B YY1 SCRT2 ATF7 FOS IKZF2 RXRA USF2 CEBPB TMEM92 TMEM92-AS1 HILS1 SGCA ENSG00000253730 SAMD14 PDK2 ENSG00000250282 ACSF2 CHAD
GH17I050317 Enhancer 1 ENCODE dbSUPER 11.6 +47.3 47306 2.9 PKNOX1 CLOCK ATF1 SIN3A ZNF766 FOS CAVIN1 ZBTB11 USF2 HDAC8 ACSF2 LUC7L3 MBTD1 TMEM92-AS1 XYLT2 COL1A1 TMEM92 ENSG00000262837 ENSG00000253102 ENSG00000250282
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM92 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM92 gene promoter:

Genomic Locations for TMEM92 Gene

Genomic Locations for TMEM92 Gene
chr17:50,271,406-50,281,485
(GRCh38/hg38)
Size:
10,080 bases
Orientation:
Plus strand
chr17:48,348,767-48,358,846
(GRCh37/hg19)

Genomic View for TMEM92 Gene

Genes around TMEM92 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM92 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM92 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM92 Gene

Proteins for TMEM92 Gene

  • Protein details for TMEM92 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXU6-TMM92_HUMAN
    Recommended name:
    Transmembrane protein 92
    Protein Accession:
    Q6UXU6
    Secondary Accessions:
    • Q8NBF0

    Protein attributes for TMEM92 Gene

    Size:
    159 amino acids
    Molecular mass:
    17229 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM92 Gene

Post-translational modifications for TMEM92 Gene

No Post-translational modifications

Other Protein References for TMEM92 Gene

No data available for DME Specific Peptides for TMEM92 Gene

Domains & Families for TMEM92 Gene

Gene Families for TMEM92 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM92 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM92 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM92: view

No data available for UniProtKB/Swiss-Prot for TMEM92 Gene

Function for TMEM92 Gene

Phenotypes From GWAS Catalog for TMEM92 Gene

genes like me logo Genes that share phenotypes with TMEM92: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM92 Gene

Localization for TMEM92 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM92 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM92 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM92: view

Pathways & Interactions for TMEM92 Gene

SuperPathways for TMEM92 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM92 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM92 Gene

Drugs & Compounds for TMEM92 Gene

No Compound Related Data Available

Transcripts for TMEM92 Gene

Unigene Clusters for TMEM92 Gene

Transmembrane protein 92:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM92 Gene

No ASD Table

Relevant External Links for TMEM92 Gene

GeneLoc Exon Structure for
TMEM92
ECgene alternative splicing isoforms for
TMEM92

Expression for TMEM92 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM92 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM92 Gene

This gene is overexpressed in Stomach (x13.6), Small Intestine - Terminal Ileum (x9.8), and Liver (x6.6).

NURSA nuclear receptor signaling pathways regulating expression of TMEM92 Gene:

TMEM92

SOURCE GeneReport for Unigene cluster for TMEM92 Gene:

Hs.224630

Evidence on tissue expression from TISSUES for TMEM92 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with TMEM92: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM92 Gene

Orthologs for TMEM92 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM92 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM92 34
  • 98 (a)
OneToOne
LOC747062 33
  • 96.99 (n)
dog
(Canis familiaris)
Mammalia TMEM92 33 34
  • 76.65 (n)
cow
(Bos Taurus)
Mammalia TMEM92 34
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM92 34
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem92 34
  • 41 (a)
OneToOne
Species where no ortholog for TMEM92 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM92 Gene

ENSEMBL:
Gene Tree for TMEM92 (if available)
TreeFam:
Gene Tree for TMEM92 (if available)

Paralogs for TMEM92 Gene

Pseudogenes.org Pseudogenes for TMEM92 Gene

genes like me logo Genes that share paralogs with TMEM92: view

No data available for Paralogs for TMEM92 Gene

Variants for TMEM92 Gene

Sequence variations from dbSNP and Humsavar for TMEM92 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs730882247 likely-pathogenic, Bilateral squint, Cerebellar atrophy, Global developmental delay, Hydrocephalus 50,277,743(+) A/G intron_variant
rs1000003484 -- 50,278,210(+) C/G intron_variant
rs1000244385 -- 50,276,281(+) C/T intron_variant
rs1000546016 -- 50,278,426(+) C/T intron_variant
rs1000632762 -- 50,270,531(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM92 Gene

Variant ID Type Subtype PubMed ID
nsv509661 CNV insertion 20534489
nsv833475 CNV loss 17160897

Variation tolerance for TMEM92 Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM92 Gene

Human Gene Mutation Database (HGMD)
TMEM92
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM92

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM92 Gene

Disorders for TMEM92 Gene

Additional Disease Information for TMEM92

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM92 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM92 Gene

Publications for TMEM92 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. (PMID: 22120523) Pei J … Grishin NV (Cellular signalling 2012) 2 3 58
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TMEM92 Gene

Sources for TMEM92 Gene

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