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Aliases for TMEM91 Gene

Aliases for TMEM91 Gene

  • Transmembrane Protein 91 2 3 4 5
  • Dispanin Subfamily C Member 3 2 3 4
  • Interferon Induced Transmembrane Protein Domain Containing 6 2 3
  • DSPC3 3 4
  • IFITMD6 3

External Ids for TMEM91 Gene

Previous GeneCards Identifiers for TMEM91 Gene

  • GC19U900569
  • GC19P046549
  • GC19P041869
  • GC19P038301
  • GC19P041856

Summaries for TMEM91 Gene

GeneCards Summary for TMEM91 Gene

TMEM91 (Transmembrane Protein 91) is a Protein Coding gene. Diseases associated with TMEM91 include Meckel Syndrome, Type 10. An important paralog of this gene is SYNDIG1L.

Additional gene information for TMEM91 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM91 Gene

Genomics for TMEM91 Gene

GeneHancer (GH) Regulatory Elements for TMEM91 Gene

Promoters and enhancers for TMEM91 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J041348 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 613.5 +0.7 702 6.9 SP1 ZFX CC2D1A CTCF CBFA2T2 ZNF148 NKRF MLLT1 POLR2A GTF2F1 TMEM91 ENSG00000255730 TGFB1 ZNF526 SNRPA ZNF574 HNRNPUL1 CCDC97 ENSG00000269843 COQ8B
GH19J041362 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.4 +12.9 12920 3 SP1 CC2D1A ELF3 SIX5 ZNF148 POLR2A ZNF121 CSDE1 ZNF687 NFRKB B9D2 TMEM91 ZNF574 ZNF526 CCDC97 CYP2F2P CIC HNRNPUL1 CYP2G1P NUMBL
GH19J041376 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 622.3 +27.4 27415 4.7 ZNF473 ELF3 MLLT1 ZNF121 CEBPG ZNF687 ZSCAN21 SP7 SP5 KLF14 TMEM91 MEGF8 CYP2G1P EXOSC5 SPTBN4 ZNF574 GRIK5 TGFB1 NUMBL CCDC97
GH19J041382 Promoter 0.5 EPDnew 611.4 +32.0 31993 0.1 TMEM91 TGFB1 CCDC97 ENSG00000277744 EXOSC5 ENSG00000255730
GH19J041424 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 31.3 +76.1 76101 5 ZFX ELF3 ZNF148 MLLT1 CEBPG GTF2F1 AHR SP7 PPARG SP5 ENSG00000268475 B3GNT8 TMEM91 EXOSC5 DMAC2 ZNF574 SPTBN4 BCKDHA TGFB1 MEGF8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM91 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM91 gene promoter:
  • ATF-2
  • c-Jun
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for TMEM91 Gene

Genomic Locations for TMEM91 Gene
33,173 bases
Plus strand
33,173 bases
Plus strand

Genomic View for TMEM91 Gene

Genes around TMEM91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM91 Gene

Proteins for TMEM91 Gene

  • Protein details for TMEM91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 91
    Protein Accession:
    Secondary Accessions:
    • C9J9D1
    • C9JZ62
    • C9K046
    • Q6P434

    Protein attributes for TMEM91 Gene

    172 amino acids
    Molecular mass:
    18162 Da
    Quaternary structure:
    No Data Available
    • Sequence=BM931402; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM91 Gene


neXtProt entry for TMEM91 Gene

Post-translational modifications for TMEM91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM91 Gene

Domains & Families for TMEM91 Gene

Gene Families for TMEM91 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM91 Gene


Suggested Antigen Peptide Sequences for TMEM91 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 91 (TMM91_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD225/Dispanin family.
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with TMEM91: view

Function for TMEM91 Gene

Phenotypes From GWAS Catalog for TMEM91 Gene

Gene Ontology (GO) - Molecular Function for TMEM91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM91: view
genes like me logo Genes that share phenotypes with TMEM91: view

Animal Model Products

CRISPR Products

miRNA for TMEM91 Gene

miRTarBase miRNAs that target TMEM91

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM91 - Now 50% OFF >
  • * TMEM91 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM91 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM91 Gene

Localization for TMEM91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM91 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM91 gene
Compartment Confidence
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for TMEM91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM91: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM91 Gene

Pathways & Interactions for TMEM91 Gene

PathCards logo

SuperPathways for TMEM91 Gene

No Data Available

Interacting Proteins for TMEM91 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
Selected Interacting proteins: ENSP00000375859 for TMEM91 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM91: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM91 Gene

Drugs & Compounds for TMEM91 Gene

No Compound Related Data Available

Transcripts for TMEM91 Gene

mRNA/cDNA for TMEM91 Gene

(8) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for TMEM91 Gene

Transmembrane protein 91:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM91 - Now 50% OFF >
  • * TMEM91 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM91 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM91 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for TMEM91 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM91 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM91 Gene

This gene is overexpressed in Whole Blood (x8.0).

Protein differential expression in normal tissues from HIPED for TMEM91 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM91 Gene

Protein tissue co-expression partners for TMEM91 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM91 Gene:


SOURCE GeneReport for Unigene cluster for TMEM91 Gene:


Evidence on tissue expression from TISSUES for TMEM91 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with TMEM91: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM91 Gene

Orthologs for TMEM91 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM91 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM91 34 35
  • 99.42 (n)
(Canis familiaris)
Mammalia TMEM91 34
  • 85.08 (n)
(Bos Taurus)
Mammalia TMEM91 35 34
  • 84.12 (n)
(Mus musculus)
Mammalia Tmem91 17 35 34
  • 79.26 (n)
(Rattus norvegicus)
Mammalia Tmem91 34
  • 78.49 (n)
(Anolis carolinensis)
Reptilia TMEM91 35
  • 30 (a)
(Danio rerio)
Actinopterygii tmem91 35
  • 30 (a)
Species where no ortholog for TMEM91 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM91 Gene

Gene Tree for TMEM91 (if available)
Gene Tree for TMEM91 (if available)
Evolutionary constrained regions (ECRs) for TMEM91: view image

Paralogs for TMEM91 Gene

Paralogs for TMEM91 Gene

(2) SIMAP similar genes for TMEM91 Gene using alignment to 8 proteins:

  • F5H665_HUMAN
  • F8W6Q6_HUMAN
  • H0YG43_HUMAN
  • S4R3Y8_HUMAN
genes like me logo Genes that share paralogs with TMEM91: view

Variants for TMEM91 Gene

Sequence variations from dbSNP and Humsavar for TMEM91 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs116599193 uncertain-significance, Meckel-Gruber syndrome 41,364,033(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs143639901 uncertain-significance, Meckel-Gruber syndrome 41,364,080(+) C/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs199601180 uncertain-significance, Meckel-Gruber syndrome 41,363,536(+) A/G upstream_transcript_variant
rs2241714 benign, not specified, Meckel-Gruber syndrome, Meckel syndrome, type 10 41,363,487(+) T/A/C upstream_transcript_variant
rs370117663 uncertain-significance, Meckel-Gruber syndrome 41,364,077(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM91 Gene

Variant ID Type Subtype PubMed ID
esv2587471 CNV insertion 19546169
esv996035 CNV deletion 20482838
nsv475050 CNV novel sequence insertion 20440878
nsv521311 CNV gain 19592680

Variation tolerance for TMEM91 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM91 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM91 Gene

Disorders for TMEM91 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM91 Gene - From: GeneCards

Disorder Aliases PubMed IDs
meckel syndrome, type 10
  • mks10
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM91

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TMEM91: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM91 Gene

Publications for TMEM91 Gene

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sällman Almén M … Schiöth HB (PloS one 2012) 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 4 58

Products for TMEM91 Gene

Sources for TMEM91 Gene

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