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Aliases for TMEM91 Gene

Aliases for TMEM91 Gene

  • Transmembrane Protein 91 2 3 5
  • Interferon Induced Transmembrane Protein Domain Containing 6 2 3
  • Dispanin Subfamily C Member 3 3 4
  • DSPC3 3 4
  • IFITMD6 3

External Ids for TMEM91 Gene

Previous GeneCards Identifiers for TMEM91 Gene

  • GC19U900569
  • GC19P046549
  • GC19P041869
  • GC19P038301
  • GC19P041856

Summaries for TMEM91 Gene

GeneCards Summary for TMEM91 Gene

TMEM91 (Transmembrane Protein 91) is a Protein Coding gene. An important paralog of this gene is SYNDIG1L.

Additional gene information for TMEM91 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM91 Gene

Genomics for TMEM91 Gene

GeneHancer (GH) Regulatory Elements for TMEM91 Gene

Promoters and enhancers for TMEM91 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I041348 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563.6 +0.7 702 6.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 DMAP1 IRF4 ZNF213 ZNF207 TMEM91 ENSG00000255730 TGFB1 ZNF526 SNRPA ZNF574 HNRNPUL1 ENSG00000269843 CCDC97 COQ8B
GH19I041362 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.4 +12.9 12920 3 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B B9D2 TMEM91 ZNF574 ZNF526 CCDC97 CYP2F2P CIC HNRNPUL1 CYP2G1P NUMBL
GH19I041376 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 561.7 +25.8 25786 1.1 ELF3 ZSCAN4 ARID4B ZNF76 SIN3A FEZF1 DMAP1 ZNF2 ZNF335 POLR2B TMEM91 TGFB1 CCDC97 ERICH4 DMAC2 EXOSC5 ENSG00000277744 BCKDHA ENSG00000255730
GH19I041424 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 31.3 +76.1 76101 5 HDGF FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF766 GLIS2 ENSG00000268475 B3GNT8 TMEM91 EXOSC5 DMAC2 ZNF574 SPTBN4 BCKDHA TGFB1 MEGF8
GH19I041294 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.5 -47.6 -47614 16.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 CCDC97 ZNF526 HNRNPUL1 SNRPA ZNF574 ENSG00000269843 COQ8B TGFB1 AXL ITPKC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM91 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM91 gene promoter:

Genomic Locations for TMEM91 Gene

Genomic Locations for TMEM91 Gene
33,173 bases
Plus strand

Genomic View for TMEM91 Gene

Genes around TMEM91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM91 Gene

Proteins for TMEM91 Gene

  • Protein details for TMEM91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 91
    Protein Accession:
    Secondary Accessions:
    • C9J9D1
    • C9JZ62
    • C9K046
    • Q6P434

    Protein attributes for TMEM91 Gene

    172 amino acids
    Molecular mass:
    18162 Da
    Quaternary structure:
    No Data Available
    • Sequence=BM931402; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM91 Gene


neXtProt entry for TMEM91 Gene

Post-translational modifications for TMEM91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM91 Gene

Domains & Families for TMEM91 Gene

Gene Families for TMEM91 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM91 Gene


Suggested Antigen Peptide Sequences for TMEM91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD225/Dispanin family.
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with TMEM91: view

Function for TMEM91 Gene

Phenotypes From GWAS Catalog for TMEM91 Gene

Gene Ontology (GO) - Molecular Function for TMEM91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM91: view
genes like me logo Genes that share phenotypes with TMEM91: view

Animal Model Products

miRNA for TMEM91 Gene

miRTarBase miRNAs that target TMEM91

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM91 Gene

Localization for TMEM91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM91 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM91 gene
Compartment Confidence
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for TMEM91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM91: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM91 Gene

Pathways & Interactions for TMEM91 Gene

SuperPathways for TMEM91 Gene

No Data Available

Interacting Proteins for TMEM91 Gene

Gene Ontology (GO) - Biological Process for TMEM91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0008150 biological_process ND --
GO:0009607 response to biotic stimulus IEA --
genes like me logo Genes that share ontologies with TMEM91: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM91 Gene

Drugs & Compounds for TMEM91 Gene

No Compound Related Data Available

Transcripts for TMEM91 Gene

mRNA/cDNA for TMEM91 Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM91 Gene

Transmembrane protein 91:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM91 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for TMEM91 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM91 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM91 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM91 Gene

This gene is overexpressed in Whole Blood (x8.0).

Protein differential expression in normal tissues from HIPED for TMEM91 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM91 Gene

Protein tissue co-expression partners for TMEM91 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM91 Gene:


SOURCE GeneReport for Unigene cluster for TMEM91 Gene:


Evidence on tissue expression from TISSUES for TMEM91 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with TMEM91: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM91 Gene

Orthologs for TMEM91 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM91 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM91 33 34
  • 99.42 (n)
(Canis familiaris)
Mammalia TMEM91 33
  • 85.08 (n)
(Bos Taurus)
Mammalia TMEM91 33 34
  • 84.12 (n)
(Mus musculus)
Mammalia Tmem91 33 16 34
  • 79.26 (n)
(Rattus norvegicus)
Mammalia Tmem91 33
  • 78.49 (n)
(Anolis carolinensis)
Reptilia TMEM91 34
  • 30 (a)
(Danio rerio)
Actinopterygii tmem91 34
  • 30 (a)
Species where no ortholog for TMEM91 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM91 Gene

Gene Tree for TMEM91 (if available)
Gene Tree for TMEM91 (if available)

Paralogs for TMEM91 Gene

Paralogs for TMEM91 Gene

(2) SIMAP similar genes for TMEM91 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TMEM91: view

Variants for TMEM91 Gene

Sequence variations from dbSNP and Humsavar for TMEM91 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1005277420 uncertain-significance, Meckel-Gruber syndrome 41,364,144(+) G/A genic_upstream_transcript_variant, intron_variant
rs116599193 uncertain-significance, Meckel-Gruber syndrome 41,364,033(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs143639901 uncertain-significance, Meckel-Gruber syndrome 41,364,080(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs199601180 uncertain-significance, Meckel-Gruber syndrome 41,363,536(+) A/G upstream_transcript_variant
rs2241714 benign, not specified, Meckel-Gruber syndrome 41,363,487(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM91 Gene

Variant ID Type Subtype PubMed ID
esv2587471 CNV insertion 19546169
esv996035 CNV deletion 20482838
nsv475050 CNV novel sequence insertion 20440878
nsv521311 CNV gain 19592680

Variation tolerance for TMEM91 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM91 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM91 Gene

Disorders for TMEM91 Gene

Additional Disease Information for TMEM91

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM91 Gene

Publications for TMEM91 Gene

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sällman Almén M … Schiöth HB (PloS one 2012) 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 4 58

Products for TMEM91 Gene

Sources for TMEM91 Gene

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