Aliases for TMEM9 Gene

Aliases for TMEM9 Gene

  • Transmembrane Protein 9 2 3 4 5
  • Dermal Papilla-Derived Protein 4 3 4
  • TMEM9A 3 4
  • DERM4 3
  • DERP4 4

External Ids for TMEM9 Gene

Previous GeneCards Identifiers for TMEM9 Gene

  • GC00U991238
  • GC01M196562
  • GC01M197570
  • GC01M198392
  • GC01M197835
  • GC01M199370
  • GC01M201103
  • GC01M172270

Summaries for TMEM9 Gene

GeneCards Summary for TMEM9 Gene

TMEM9 (Transmembrane Protein 9) is a Protein Coding gene. An important paralog of this gene is TMEM9B.

UniProtKB/Swiss-Prot Summary for TMEM9 Gene

Gene Wiki entry for TMEM9 Gene

Additional gene information for TMEM9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM9 Gene

Genomics for TMEM9 Gene

GeneHancer (GH) Regulatory Elements for TMEM9 Gene

Promoters and enhancers for TMEM9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J201169 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 765.6 +0.2 237 4 ZBTB40 CTCF ZBTB6 MLX RBPJ POLR2A CTBP1 NR2F1 NR2F6 ATF1 TMEM9 IPO9-AS1 RNPEP ENSG00000229821 IGFN1 DDX59 IPO9 CAMSAP2 ELF3-AS1 ASCL5
GH01J201153 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 807.4 +17.6 17612 2.6 ZBTB40 SP1 ZBTB6 SMARCE1 RUNX1 CC2D1A NFYC HLF L3MBTL2 RBM39 TMEM9 DDX59 RNPEP LMOD1 ELF3-AS1 IPO9 IGFN1 ASCL5 CACNA1S ENSG00000234132
GH01J201173 Enhancer 0.5 ENCODE 750.6 -1.9 -1906 0.2 CREB1 CEBPA CEBPB SCRT2 OSR2 RARA TMEM9 lnc-TMEM9-3
GH01J200668 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 +501.6 501615 3.5 FOXK2 ZNF785 SIN3A ZNF24 ZBTB40 SP1 LCORL ZBTB6 RBPJ SMARCE1 DDX59-AS1 DDX59 piR-46343-001 piR-48348-002 KIF14 CAMSAP2 ENSG00000224818 TMEM9
GH01J201136 Enhancer 0.7 Ensembl ENCODE dbSUPER 37.4 +33.7 33681 2.6 CREB1 FOS KLF1 TMEM9 CACNA1S ASCL5 IGFN1 PKP1 lnc-ASCL5-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM9 gene promoter:
  • AML1a
  • FAC1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • FOXO4
  • Lmo2
  • Spz1
  • Tal-1

Genomic Locations for TMEM9 Gene

Genomic Locations for TMEM9 Gene
36,812 bases
Minus strand
36,803 bases
Minus strand

Genomic View for TMEM9 Gene

Genes around TMEM9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM9 Gene

Proteins for TMEM9 Gene

  • Protein details for TMEM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 9
    Protein Accession:
    Secondary Accessions:
    • B1ALM6
    • Q96NQ9
    • Q9BQF5

    Protein attributes for TMEM9 Gene

    183 amino acids
    Molecular mass:
    20574 Da
    Quaternary structure:
    • Dimer.

neXtProt entry for TMEM9 Gene

Post-translational modifications for TMEM9 Gene

  • N-glycosylated.
  • Glycosylation at Asn21, Asn38, and Asn47
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TMEM9_HUMAN (1857)

No data available for DME Specific Peptides for TMEM9 Gene

Domains & Families for TMEM9 Gene

Gene Families for TMEM9 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM9 Gene


Suggested Antigen Peptide Sequences for TMEM9 Gene

GenScript: Design optimal peptide antigens:
  • TMEM9 protein (Q6FIF9_HUMAN)
  • TMEM9 protein (Q6IAJ3_HUMAN)
  • Dermal papilla-derived protein 4 (TMEM9_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM9 family.
  • Belongs to the TMEM9 family.
genes like me logo Genes that share domains with TMEM9: view

Function for TMEM9 Gene

Molecular function for TMEM9 Gene

UniProtKB/Swiss-Prot Function:
May be involved in intracellular transport.

Phenotypes From GWAS Catalog for TMEM9 Gene

Gene Ontology (GO) - Molecular Function for TMEM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TMEM9: view
genes like me logo Genes that share phenotypes with TMEM9: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM9 Gene

Localization for TMEM9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM9 Gene

Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM9 gene
Compartment Confidence
endosome 5
lysosome 5
plasma membrane 2
extracellular 2

Gene Ontology (GO) - Cellular Components for TMEM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA,IDA 12359240
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005770 late endosome IDA 12359240
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMEM9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM9 Gene

Pathways & Interactions for TMEM9 Gene

PathCards logo

SuperPathways for TMEM9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TMEM9: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM9 Gene

Drugs & Compounds for TMEM9 Gene

No Compound Related Data Available

Transcripts for TMEM9 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM9 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - -
SP9: - - -

Relevant External Links for TMEM9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM9 Gene

This gene is overexpressed in Testis (13.0), Frontal cortex (10.5), and Fetal Liver (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM9 Gene

Protein tissue co-expression partners for TMEM9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM9 Gene:


SOURCE GeneReport for Unigene cluster for TMEM9 Gene:


mRNA Expression by UniProt/SwissProt for TMEM9 Gene:

Tissue specificity: Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expression was detected in hematopoietic cell lines including those of myeloid, erythroid, B- and T-cell origin.

Evidence on tissue expression from TISSUES for TMEM9 Gene

  • Nervous system(4.9)
  • Kidney(4.4)
  • Skin(4.2)
  • Blood(4.1)
  • Lung(3.2)
  • Eye(2.9)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with TMEM9: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM9 Gene

Orthologs for TMEM9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM9 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia -- 33
  • 96 (a)
-- 33
  • 94 (a)
TMEM9 32
  • 91.76 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM9 33
  • 96 (a)
(Pan troglodytes)
Mammalia TMEM9 33 32
  • 95.37 (n)
(Mus musculus)
Mammalia Tmem9 17 33 32
  • 90.89 (n)
(Rattus norvegicus)
Mammalia Tmem9 32
  • 90.16 (n)
(Bos Taurus)
Mammalia TMEM9 33 32
  • 87.48 (n)
(Monodelphis domestica)
Mammalia TMEM9 33
  • 84 (a)
(Gallus gallus)
Aves TMEM9 33 32
  • 80.6 (n)
(Anolis carolinensis)
Reptilia TMEM9 33
  • 67 (a)
(Danio rerio)
Actinopterygii tmem9 33 32
  • 75.58 (n)
wufi33g11 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9265 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007259 32
  • 52.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1161 32
  • 47.07 (n)
(Caenorhabditis elegans)
Secernentea R12C12.6 33 32
  • 46.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 33 (a)
Species where no ortholog for TMEM9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM9 Gene

Gene Tree for TMEM9 (if available)
Gene Tree for TMEM9 (if available)
Evolutionary constrained regions (ECRs) for TMEM9: view image

Paralogs for TMEM9 Gene

Paralogs for TMEM9 Gene

(1) SIMAP similar genes for TMEM9 Gene using alignment to 8 proteins:

  • F2Z389_HUMAN
genes like me logo Genes that share paralogs with TMEM9: view

Variants for TMEM9 Gene

Sequence variations from dbSNP and Humsavar for TMEM9 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000204387 -- 201,138,097(-) A/C intron_variant
rs1000274154 -- 201,159,228(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000317074 -- 201,147,093(-) C/A intron_variant
rs1000344153 -- 201,147,941(-) A/C intron_variant
rs1000418202 -- 201,153,165(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM9 Gene

Variant ID Type Subtype PubMed ID
nsv428301 CNV gain 18775914

Variation tolerance for TMEM9 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM9 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM9 Gene

Disorders for TMEM9 Gene

Additional Disease Information for TMEM9

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM9 Gene

Publications for TMEM9 Gene

  1. TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling. (PMID: 30374053) Jung YS … Park JI (Nature cell biology 2018) 2 3 56
  2. TMEM9 mediates IL-6 and IL-1β secretion and is modulated by the Wnt pathway. (PMID: 30119033) Wei W … Su Q (International immunopharmacology 2018) 2 3 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways. (PMID: 18541524) Dodeller F … Cenni B (The Journal of biological chemistry 2008) 2 3 56
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 56

Products for TMEM9 Gene

Sources for TMEM9 Gene