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TMEM8B Gene(Protein Coding)

Transmembrane Protein 8B

GCID:
GC09P035785
GIFtS:
40
Genes Participants
UDN Logo

Aliases for TMEM8B Gene

Aliases for TMEM8B Gene

  • Transmembrane Protein 8B 2 3 5
  • Nasopharyngeal Carcinoma-Associated Gene 6 Protein 3 4
  • Nasopharyngeal Carcinoma Expressed 6 2 3
  • Protein NAG-5 3 4
  • Protein NGX6 3 4
  • C9orf127 3 4
  • NGX6 3 4
  • Nasopharyngeal Carcinoma Related Protein 3
  • Chromosome 9 Open Reading Frame 127 2
  • NAG-5 3
  • NAG5 3

External Ids for TMEM8B Gene

Previous HGNC Symbols for TMEM8B Gene

  • C9orf127

Previous GeneCards Identifiers for TMEM8B Gene

  • GC09P035814

Summaries for TMEM8B Gene

GeneCards Summary for TMEM8B Gene

TMEM8B (Transmembrane Protein 8B) is a Protein Coding gene. Diseases associated with TMEM8B include Nasopharyngeal Carcinoma and Pharynx Cancer. An important paralog of this gene is TMEM8A.

UniProtKB/Swiss-Prot for TMEM8B Gene

  • May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.

Gene Wiki entry for TMEM8B Gene

Additional gene information for TMEM8B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM8B Gene

Genomics for TMEM8B Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for TMEM8B Gene

Promoters and enhancers for TMEM8B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09I035813 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 571.6 +0.2 212 3.1 HDGF FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 TMEM8B HINT2 HMGB3P24 RNF38 SPAG8 C9orf131 ATP8B5P VCP CREB3
GH09I035828 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 589.2 +15.1 15147 2.2 HDGF PKNOX1 ATF1 FOXA2 SIN3A BMI1 ZNF48 ZNF335 POLR2B GLIS2 TMEM8B FAM221B TPM2 HINT2
GH09I035726 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31 -84.0 -84036 8.6 YBX1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D TLN1 CREB3 TMEM8B GBA2 ARHGEF39 TPM2 HMGB3P24 PIGO RN7SL22P ENSG00000228843
GH09I035831 Enhancer 1.3 Ensembl ENCODE dbSUPER 46 +19.7 19734 5 PKNOX1 SIN3A YY1 ATF7 RUNX3 RXRA REST PPARG KAT8 ATF4 FAM221B TMEM8B TPM2 OR13E1P
GH09I035679 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.4 -128.3 -128334 12.8 PKNOX1 ARID4B SIN3A POLR2B GLIS2 FOS SP3 REST SMARCB1 MIER3 TPM2 GBA2 TMEM8B TLN1 NPR2 CCDC107 SIT1 CREB3 RGP1 MSMP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM8B on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM8B Gene

Genomic Locations for TMEM8B Gene
chr9:35,814,451-35,865,518
(GRCh38/hg38)
Size:
51,068 bases
Orientation:
Plus strand
chr9:35,814,448-35,854,844
(GRCh37/hg19)

Genomic View for TMEM8B Gene

Genes around TMEM8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM8B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TMEM8B Gene

Proteins for TMEM8B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TMEM8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDV4-TMM8B_HUMAN
    Recommended name:
    Transmembrane protein 8B
    Protein Accession:
    A6NDV4
    Secondary Accessions:
    • B3KQF3
    • O75539
    • Q49AB1
    • Q4KMX5
    • Q5TCW5
    • Q9HBY2
    • Q9P0U7

    Protein attributes for TMEM8B Gene

    Size:
    472 amino acids
    Molecular mass:
    51941 Da
    Quaternary structure:
    • Isoform 2 (via its cytoplasmic part) interacts with EZR.
    SequenceCaution:
    • Sequence=AAC28644.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF34820.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF34820.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM8B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM8B Gene

Post-translational modifications for TMEM8B Gene

Other Protein References for TMEM8B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM8B Gene

Domains & Families for TMEM8B Gene

Gene Families for TMEM8B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM8B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM8B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NDV4

UniProtKB/Swiss-Prot:

TMM8B_HUMAN :
  • Belongs to the TMEM8 family.
Family:
  • Belongs to the TMEM8 family.
genes like me logo Genes that share domains with TMEM8B: view

Function for TMEM8B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TMEM8B Gene

UniProtKB/Swiss-Prot Function:
May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.
UniProtKB/Swiss-Prot Induction:
Isoform 2 is down-regulated in nasopharyngeal carcinoma cells.

Phenotypes From GWAS Catalog for TMEM8B Gene

Gene Ontology (GO) - Molecular Function for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15498789
genes like me logo Genes that share ontologies with TMEM8B: view
genes like me logo Genes that share phenotypes with TMEM8B: view

Animal Model Products

miRNA for TMEM8B Gene

miRTarBase miRNAs that target TMEM8B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM8B Gene

Localization for TMEM8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM8B Gene

Isoform 2: Cell membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Note=Also detected in mitochondrion and endoplasmic reticulum (PubMed:17641538).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM8B gene
Compartment Confidence
plasma membrane 5
nucleus 4
mitochondrion 3
endoplasmic reticulum 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IDA 15498789
genes like me logo Genes that share ontologies with TMEM8B: view

Pathways & Interactions for TMEM8B Gene

SuperPathways for TMEM8B Gene

PathCards logo More details on SuperPathways for TMEM8B
No Data Available

Interacting Proteins for TMEM8B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367227%0d%0a9606.ENSP00000338934%0d%0a
Selected Interacting proteins: A6NDV4-TMM8B_HUMAN ENSP00000367227 for TMEM8B Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion IMP 15498789
GO:0007346 regulation of mitotic cell cycle TAS 15498789
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with TMEM8B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM8B Gene

Drugs & Compounds for TMEM8B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TMEM8B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TMEM8B Gene

(21) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(107) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM8B Gene

Transmembrane protein 8B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM8B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^
SP1:
SP2:
SP3: - - - - - - - - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - - -
SP11: -
SP12:
SP13: - - - - - - - - -
SP14: - - - - - - - - - -

ExUns: 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for TMEM8B Gene

GeneLoc Exon Structure for
TMEM8B
ECgene alternative splicing isoforms for
TMEM8B

Expression for TMEM8B Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM8B Gene

mRNA expression in normal human tissues for TMEM8B Gene
mRNA expression by GTEx for TMEM8B GenemRNA expression by BioGPS for TMEM8B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM8B Gene:

TMEM8B

SOURCE GeneReport for Unigene cluster for TMEM8B Gene:

Hs.493808

Evidence on tissue expression from TISSUES for TMEM8B Gene

  • Nervous system(4.3)
  • Intestine(2)
genes like me logo Genes that share expression patterns with TMEM8B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM8B Gene

Orthologs for TMEM8B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TMEM8B 33 34
  • 99.65 (n)
dog
(Canis familiaris)
 Mammalia TMEM8B 33 34
  • 93.08 (n)
cow
(Bos Taurus)
 Mammalia TMEM8B 33 34
  • 91.38 (n)
rat
(Rattus norvegicus)
 Mammalia Tmem8b 33
  • 89.97 (n)
mouse
(Mus musculus)
 Mammalia Tmem8b 33 16 34
  • 89.83 (n)
oppossum
(Monodelphis domestica)
 Mammalia TMEM8B 34
  • 47 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia TMEM8B 34
  • 45 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TMEM8B 33 34
  • 75 (n)
lizard
(Anolis carolinensis)
 Reptilia TMEM8B 34
  • 76 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tmem8b 33
  • 69.66 (n)
zebrafish
(Danio rerio)
 Actinopterygii si:dkey-84j12.1 33 34
  • 69.21 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG13654 34
  • 14 (a)
 OneToMany
Species where no ortholog for TMEM8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM8B Gene

ENSEMBL:
Gene Tree for TMEM8B (if available)
TreeFam:
Gene Tree for TMEM8B (if available)

Paralogs for TMEM8B Gene

Paralogs for TMEM8B Gene

(2) SIMAP similar genes for TMEM8B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM8B: view

Variants for TMEM8B Gene

Sequence variations from dbSNP and Humsavar for TMEM8B Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000307321 -- 35,850,815(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000332561 -- 35,844,687(+) A/G intron_variant
rs1000462952 -- 35,857,492(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000469125 -- 35,861,324(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000480699 -- 35,833,069(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM8B Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv831546 CNV loss 17160897

Variation tolerance for TMEM8B Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM8B Gene

Disorders for TMEM8B Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM8B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
nasopharyngeal carcinoma
  • npca
pharynx cancer
  • pharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM8B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TMEM8B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM8B Gene

Publications for TMEM8B Gene

  1. The expression of ezrin in NPC and its interaction with NGX6, a novel candidate suppressor. (PMID: 17270023) Peng S … Li G (Cancer science 2007) 3 4 58
  2. The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells. (PMID: 17641538) Peng SP … Li GY (Oncology 2006) 3 4 58
  3. Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. (PMID: 15498789) Ma J … Li G (Carcinogenesis 2005) 3 4 58
  4. NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells. (PMID: 15723283) Wang L … Li G (Journal of cellular biochemistry 2005) 3 4 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58

Products for TMEM8B Gene

Sources for TMEM8B Gene

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