Aliases for TMEM8B Gene

Aliases for TMEM8B Gene

  • Transmembrane Protein 8B 2 3 4 5
  • NGX6 2 3 4
  • Nasopharyngeal Carcinoma-Associated Gene 6 Protein 3 4
  • Nasopharyngeal Carcinoma Expressed 6 2 3
  • C9orf127 3 4
  • FP588 2 3
  • NAG-5 2 3
  • NGX6a 2 3
  • Long Intergenic Non-Protein Coding RNA 950 2
  • Nasopharyngeal Carcinoma Related Protein 3
  • Chromosome 9 Open Reading Frame 127 2
  • Protein NAG-5 4
  • Protein NGX6 4
  • LINC00950 3
  • TMEM8B 5
  • NAG5 3

External Ids for TMEM8B Gene

Previous HGNC Symbols for TMEM8B Gene

  • C9orf127
  • LINC00950

Previous GeneCards Identifiers for TMEM8B Gene

  • GC09P035785

Summaries for TMEM8B Gene

GeneCards Summary for TMEM8B Gene

TMEM8B (Transmembrane Protein 8B) is a Protein Coding gene. Diseases associated with TMEM8B include Nasopharyngeal Carcinoma. An important paralog of this gene is PGAP6.

UniProtKB/Swiss-Prot Summary for TMEM8B Gene

  • May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.

Gene Wiki entry for TMEM8B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM8B Gene

Genomics for TMEM8B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM8B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM8B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM8B

Genomic Locations for TMEM8B Gene

Latest Assembly
51,068 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
36,288 bases
Plus strand

(GRCh37/hg19 by Ensembl)
40,397 bases
Plus strand

Genomic View for TMEM8B Gene

Genes around TMEM8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM8B Gene

Proteins for TMEM8B Gene

  • Protein details for TMEM8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 8B
    Protein Accession:
    Secondary Accessions:
    • B3KQF3
    • O75539
    • Q49AB1
    • Q4KMX5
    • Q5TCW5
    • Q9HBY2
    • Q9P0U7

    Protein attributes for TMEM8B Gene

    472 amino acids
    Molecular mass:
    51941 Da
    Quaternary structure:
    • Isoform 2 (via its cytoplasmic part) interacts with EZR.
    • Sequence=AAC28644.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF34820.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAF34820.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM8B Gene


neXtProt entry for TMEM8B Gene

Post-translational modifications for TMEM8B Gene

No data available for DME Specific Peptides for TMEM8B Gene

Domains & Families for TMEM8B Gene

Gene Families for TMEM8B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TMEM8B Gene


Suggested Antigen Peptide Sequences for TMEM8B Gene

GenScript: Design optimal peptide antigens:
  • Chromosome 9 open reading frame 127 (Q5TCW0_HUMAN)
  • Protein NGX6 (TMM8B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM8 family.
  • Belongs to the TMEM8 family.
genes like me logo Genes that share domains with TMEM8B: view

Function for TMEM8B Gene

Molecular function for TMEM8B Gene

UniProtKB/Swiss-Prot Function:
May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.
UniProtKB/Swiss-Prot Induction:
Isoform 2 is down-regulated in nasopharyngeal carcinoma cells.

Phenotypes From GWAS Catalog for TMEM8B Gene

Gene Ontology (GO) - Molecular Function for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15498789
genes like me logo Genes that share ontologies with TMEM8B: view
genes like me logo Genes that share phenotypes with TMEM8B: view

Animal Models for research

  • Taconic Biosciences Mouse Models for TMEM8B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM8B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM8B Gene

Localization for TMEM8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM8B Gene

[Isoform 2]: Cell membrane. Multi-pass membrane protein. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Note=Also detected in mitochondrion and endoplasmic reticulum (PubMed:17641538).

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM8B gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
nucleus 3
endoplasmic reticulum 3
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane IDA 15498789
genes like me logo Genes that share ontologies with TMEM8B: view

Pathways & Interactions for TMEM8B Gene

PathCards logo

SuperPathways for TMEM8B Gene

No Data Available

Interacting Proteins for TMEM8B Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000367227 A6NDV4-TMM8B_HUMAN for TMEM8B Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion IMP 15498789
GO:0007346 regulation of mitotic cell cycle TAS 15498789
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with TMEM8B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM8B Gene

Drugs & Compounds for TMEM8B Gene

No Compound Related Data Available

Transcripts for TMEM8B Gene

mRNA/cDNA for TMEM8B Gene

16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM8B

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM8B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^
SP3: - - - - - - - - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - - - -
SP11: -
SP13: - - - - - - - - -
SP14: - - - - - - - - - -

ExUns: 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2: -
SP6: -

Relevant External Links for TMEM8B Gene

GeneLoc Exon Structure for

Expression for TMEM8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM8B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM8B

SOURCE GeneReport for Unigene cluster for TMEM8B Gene:


Evidence on tissue expression from TISSUES for TMEM8B Gene

  • Nervous system(4.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with TMEM8B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM8B Gene

Orthologs for TMEM8B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM8B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM8B 30 31
  • 99.65 (n)
(Canis familiaris)
Mammalia TMEM8B 30 31
  • 93.08 (n)
(Bos Taurus)
Mammalia TMEM8B 30 31
  • 91.38 (n)
(Rattus norvegicus)
Mammalia Tmem8b 30
  • 89.97 (n)
(Mus musculus)
Mammalia Tmem8b 30 17 31
  • 89.83 (n)
(Monodelphis domestica)
Mammalia TMEM8B 31
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM8B 31
  • 45 (a)
(Gallus gallus)
Aves TMEM8B 30 31
  • 75 (n)
(Anolis carolinensis)
Reptilia TMEM8B 31
  • 76 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem8b 30
  • 69.66 (n)
(Danio rerio)
Actinopterygii si:dkey-84j12.1 30 31
  • 69.21 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG13654 31
  • 14 (a)
Species where no ortholog for TMEM8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM8B Gene

Gene Tree for TMEM8B (if available)
Gene Tree for TMEM8B (if available)
Evolutionary constrained regions (ECRs) for TMEM8B: view image

Paralogs for TMEM8B Gene

Paralogs for TMEM8B Gene

(2) SIMAP similar genes for TMEM8B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM8B: view

Variants for TMEM8B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM8B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM8B Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259
nsv1125318 OTHER inversion 24896259
nsv831546 CNV loss 17160897
nsv831546 CNV loss 17160897

Variation tolerance for TMEM8B Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM8B Gene

Disorders for TMEM8B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM8B Gene - From: COP and GCD

Disorder Aliases PubMed IDs
nasopharyngeal carcinoma
  • npca
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM8B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TMEM8B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM8B Gene

Publications for TMEM8B Gene

  1. The expression of ezrin in NPC and its interaction with NGX6, a novel candidate suppressor. (PMID: 17270023) Peng S … Li G (Cancer science 2007) 3 4
  2. The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells. (PMID: 17641538) Peng SP … Li GY (Oncology 2006) 3 4
  3. Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. (PMID: 15498789) Ma J … Li G (Carcinogenesis 2005) 3 4
  4. NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells. (PMID: 15723283) Wang L … Li G (Journal of cellular biochemistry 2005) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4

Products for TMEM8B Gene

Sources for TMEM8B Gene