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Aliases for TMEM89 Gene

Aliases for TMEM89 Gene

  • Transmembrane Protein 89 2 3 5

External Ids for TMEM89 Gene

Previous GeneCards Identifiers for TMEM89 Gene

  • GC03M048635
  • GC03M048658

Summaries for TMEM89 Gene

GeneCards Summary for TMEM89 Gene

TMEM89 (Transmembrane Protein 89) is a Protein Coding gene.

Additional gene information for TMEM89 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM89 Gene

Genomics for TMEM89 Gene

GeneHancer (GH) Regulatory Elements for TMEM89 Gene

Promoters and enhancers for TMEM89 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I048621 Promoter 0.5 EPDnew 550.8 +0.1 66 0.1 TMEM89 UQCRC1
GH03I048085 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.3 +534.0 533954 5.3 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 MAP4 ATRIP DHX30 ZNF589 ENSG00000235236 SETD2 PTPN23 TMEM89 KLHL18 ENSG00000260236
GH03I048186 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.9 +433.9 433940 2.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZNF143 FOS CDC25A ZNF589 QRICH1 ATRIP USP19 TMEM89 CCDC71 PTPN23 NME6 MRPS18AP1
GH03I048551 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.9 +62.6 62585 15.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B PFKFB4 UCN2 TMA7 NME6 QRICH1 ATRIP USP19 ZNF589 WDR6 TMEM89
GH03I048464 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.8 +151.8 151766 11.4 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SHISA5 TREX1 TMA7 ATRIP NME6 QRICH1 USP19 MRPS18AP1 TMEM89 RHOA-IT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM89 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM89 gene promoter:

Genomic Locations for TMEM89 Gene

Genomic Locations for TMEM89 Gene
chr3:48,620,759-48,621,855
(GRCh38/hg38)
Size:
1,097 bases
Orientation:
Minus strand
chr3:48,658,192-48,659,288
(GRCh37/hg19)

Genomic View for TMEM89 Gene

Genes around TMEM89 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM89 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM89 Gene

Proteins for TMEM89 Gene

  • Protein details for TMEM89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RUT3-TMM89_HUMAN
    Recommended name:
    Transmembrane protein 89
    Protein Accession:
    A2RUT3

    Protein attributes for TMEM89 Gene

    Size:
    159 amino acids
    Molecular mass:
    17572 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM89 Gene

Post-translational modifications for TMEM89 Gene

No Post-translational modifications

Other Protein References for TMEM89 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM89 Gene

Domains & Families for TMEM89 Gene

Gene Families for TMEM89 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM89 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM89 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM89: view

No data available for UniProtKB/Swiss-Prot for TMEM89 Gene

Function for TMEM89 Gene

Phenotypes From GWAS Catalog for TMEM89 Gene

genes like me logo Genes that share phenotypes with TMEM89: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM89 Gene

Localization for TMEM89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM89 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM89 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM89: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM89 Gene

Pathways & Interactions for TMEM89 Gene

SuperPathways for TMEM89 Gene

No Data Available

Interacting Proteins for TMEM89 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329557%0d%0a9606.ENSP00000396688%0d%0a
Selected Interacting proteins: A2RUT3-TMM89_HUMAN ENSP00000329557 for TMEM89 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMEM89 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM89 Gene

Drugs & Compounds for TMEM89 Gene

No Compound Related Data Available

Transcripts for TMEM89 Gene

mRNA/cDNA for TMEM89 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM89 Gene

Transmembrane protein 89:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM89 Gene

No ASD Table

Relevant External Links for TMEM89 Gene

GeneLoc Exon Structure for
TMEM89
ECgene alternative splicing isoforms for
TMEM89

Expression for TMEM89 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM89 Gene

This gene is overexpressed in Testis (x35.3).

Protein differential expression in normal tissues from HIPED for TMEM89 Gene

This gene is overexpressed in Testis (53.7) and Ovary (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM89 Gene



Protein tissue co-expression partners for TMEM89 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM89 Gene:

TMEM89

SOURCE GeneReport for Unigene cluster for TMEM89 Gene:

Hs.631922
genes like me logo Genes that share expression patterns with TMEM89: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM89 Gene

Orthologs for TMEM89 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM89 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM89 33 34
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia TMEM89 33 34
  • 80.29 (n)
cow
(Bos Taurus)
Mammalia TMEM89 33 34
  • 75.89 (n)
rat
(Rattus norvegicus)
Mammalia Tmem89 33
  • 72.96 (n)
mouse
(Mus musculus)
Mammalia Tmem89 33 16 34
  • 70.65 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM89 34
  • 29 (a)
OneToOne
Species where no ortholog for TMEM89 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM89 Gene

ENSEMBL:
Gene Tree for TMEM89 (if available)
TreeFam:
Gene Tree for TMEM89 (if available)

Paralogs for TMEM89 Gene

No data available for Paralogs for TMEM89 Gene

Variants for TMEM89 Gene

Sequence variations from dbSNP and Humsavar for TMEM89 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000503551 -- 48,620,734(-) T/G downstream_transcript_variant
rs1000671517 -- 48,621,173(-) T/C intron_variant
rs1002300500 -- 48,622,028(-) G/C upstream_transcript_variant
rs1002728801 -- 48,623,565(-) C/G upstream_transcript_variant
rs1004629272 -- 48,621,286(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM89 Gene

Variant ID Type Subtype PubMed ID
nsv523981 CNV loss 19592680
nsv590246 CNV loss 21841781
nsv818138 CNV gain 17921354
nsv834685 CNV loss 17160897
nsv954485 CNV deletion 24416366

Variation tolerance for TMEM89 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM89 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM89

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM89 Gene

Disorders for TMEM89 Gene

Additional Disease Information for TMEM89

No disorders were found for TMEM89 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM89 Gene

Publications for TMEM89 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TMEM89 Gene

Sources for TMEM89 Gene

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