Aliases for TMEM88 Gene

Aliases for TMEM88 Gene

  • Transmembrane Protein 88 2 3 4 5
  • MGC71744 2
  • FLJ20025 2
  • TMEM88A 4
  • TMEM88 5

External Ids for TMEM88 Gene

Previous GeneCards Identifiers for TMEM88 Gene

  • GC17P007705
  • GC17P007758

Summaries for TMEM88 Gene

GeneCards Summary for TMEM88 Gene

TMEM88 (Transmembrane Protein 88) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for TMEM88 Gene

  • Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.

Additional gene information for TMEM88 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM88 Gene

Genomics for TMEM88 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM88 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007853 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.5 1484 6.2 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 CTCF TEAD4 PRDM10 ZNF629 TFE3 CYB5D1 CHD3 NAA38 TMEM88 DVL2 CTC1 PFAS ENSG00000262089 WRAP53 CNTROB
GH17J007855 Enhancer 0.4 ENCODE 600.7 -1.8 -1758 0.2 RBFOX2 RBM22 POLR2A GLIS2 LOC107987244 TMEM88 KDM6B
GH17J007880 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 +30.6 30554 9.6 HNRNPL GATAD2A ARID3A PRDM10 ZNF629 TFE3 LEF1 IKZF1 KDM1A CTCF NAA38 CHD3 lnc-NAA38-2 CNTROB SCARNA21 CYB5D1 KDM6B SNORD10 CTC1 SNORA48
GH17J007914 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 11.5 +61.1 61055 2.9 PRDM10 ZNF629 RFX1 ZNF692 POLR2A BACH1 LARP7 ZNF143 ZIC2 RBFOX2 RNF227 lnc-RNF227-1 piR-59873 CNTROB POLR2A WRAP53 DVL2 ENSG00000265749 CTC1 PFAS
GH17J007989 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas 11.2 +135.3 135251 1.7 HNRNPL GATAD2A CTCF ZBTB33 ZNF629 TARDBP LARP7 MTA2 ZNF143 ZIC2 KCNAB3 ALOX15B CNTROB TRAPPC1 SCARNA21 CHD3 NAA38 CYB5D1 TMEM88 RNF227
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM88 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM88

Top Transcription factor binding sites by QIAGEN in the TMEM88 gene promoter:
  • c-Ets-1
  • CBF(2)
  • LCR-F1
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • NF-Y
  • Nkx2-5
  • Olf-1
  • Pax-6

Genomic Locations for TMEM88 Gene

Genomic Locations for TMEM88 Gene
chr17:7,854,886-7,856,099
(GRCh38/hg38)
Size:
1,214 bases
Orientation:
Plus strand
chr17:7,758,383-7,759,417
(GRCh37/hg19)
Size:
1,035 bases
Orientation:
Plus strand

Genomic View for TMEM88 Gene

Genes around TMEM88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM88 Gene

Proteins for TMEM88 Gene

  • Protein details for TMEM88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PEY1-TMM88_HUMAN
    Recommended name:
    Transmembrane protein 88
    Protein Accession:
    Q6PEY1

    Protein attributes for TMEM88 Gene

    Size:
    159 amino acids
    Molecular mass:
    17251 Da
    Quaternary structure:
    • Interacts (via C-terminus) with DVL1.

neXtProt entry for TMEM88 Gene

Post-translational modifications for TMEM88 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM88 Gene

No data available for DME Specific Peptides for TMEM88 Gene

Domains & Families for TMEM88 Gene

Gene Families for TMEM88 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM88 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM88 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 88 (TMM88_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6PEY1

UniProtKB/Swiss-Prot:

TMM88_HUMAN :
  • Belongs to the TMEM88 family.
Family:
  • Belongs to the TMEM88 family.
genes like me logo Genes that share domains with TMEM88: view

Function for TMEM88 Gene

Molecular function for TMEM88 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development.

Phenotypes From GWAS Catalog for TMEM88 Gene

Gene Ontology (GO) - Molecular Function for TMEM88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26359454
GO:0030165 PDZ domain binding IEA,ISS --
genes like me logo Genes that share ontologies with TMEM88: view
genes like me logo Genes that share phenotypes with TMEM88: view

Animal Model Products

CRISPR Products

miRNA for TMEM88 Gene

miRTarBase miRNAs that target TMEM88

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM88

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM88 Gene

Localization for TMEM88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM88 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM88 gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 1
cytoskeleton 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 26359454
GO:0005886 plasma membrane IDA 21044957
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM88: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM88 Gene

Pathways & Interactions for TMEM88 Gene

PathCards logo

SuperPathways for TMEM88 Gene

No Data Available

Interacting Proteins for TMEM88 Gene

Gene Ontology (GO) - Biological Process for TMEM88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0050821 protein stabilization IGI 26359454
GO:0072659 protein localization to plasma membrane IGI 21044957
GO:0090090 negative regulation of canonical Wnt signaling pathway IEA,IMP 21044957
genes like me logo Genes that share ontologies with TMEM88: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM88 Gene

Drugs & Compounds for TMEM88 Gene

No Compound Related Data Available

Transcripts for TMEM88 Gene

mRNA/cDNA for TMEM88 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM88

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM88 Gene

No ASD Table

Relevant External Links for TMEM88 Gene

GeneLoc Exon Structure for
TMEM88

Expression for TMEM88 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM88 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.3).

Protein differential expression in normal tissues from HIPED for TMEM88 Gene

This gene is overexpressed in Heart (47.0) and Placenta (22.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM88 Gene



Protein tissue co-expression partners for TMEM88 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM88

SOURCE GeneReport for Unigene cluster for TMEM88 Gene:

Hs.389669

Evidence on tissue expression from TISSUES for TMEM88 Gene

  • Heart(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with TMEM88: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM88 Gene

Orthologs for TMEM88 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM88 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM88 30 31
  • 99.79 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM88 30 31
  • 90.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM88 30 31
  • 88.26 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem88 30 17 31
  • 84.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem88 30
  • 83.23 (n)
Oppossum
(Monodelphis domestica)
Mammalia TMEM88 31
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM88 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM88 31
  • 37 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM88 31
  • 53 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tmem88b 30 31
  • 60.61 (n)
OneToMany
tmem88a 31
  • 34 (a)
OneToMany
Species where no ortholog for TMEM88 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM88 Gene

ENSEMBL:
Gene Tree for TMEM88 (if available)
TreeFam:
Gene Tree for TMEM88 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM88: view image

Paralogs for TMEM88 Gene

No data available for Paralogs for TMEM88 Gene

Variants for TMEM88 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM88 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs2270518 - p.Leu44Phe

Additional dbSNP identifiers (rs#s) for TMEM88 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM88 Gene

Variant ID Type Subtype PubMed ID
dgv510n67 CNV gain 20364138
nsv1070804 CNV deletion 25765185
nsv833351 CNV loss 17160897

Variation tolerance for TMEM88 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM88 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM88 Gene

Disorders for TMEM88 Gene

No disorders were found for TMEM88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM88 Gene

Publications for TMEM88 Gene

  1. Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. (PMID: 23924634) Palpant NJ … Murry CE (Development (Cambridge, England) 2013) 3 4
  2. Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. (PMID: 21044957) Lee HJ … Zheng JJ (The Journal of biological chemistry 2010) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. TMEM88 mediates inflammatory cytokines secretion by regulating JNK/P38 and canonical Wnt/β-catenin signaling pathway in LX-2 cells. (PMID: 29159713) Xu T … Li J (Inflammopharmacology 2018) 3

Products for TMEM88 Gene

Sources for TMEM88 Gene