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Aliases for TMEM87A Gene

Aliases for TMEM87A Gene

  • Transmembrane Protein 87A 2 3 5

External Ids for TMEM87A Gene

Previous GeneCards Identifiers for TMEM87A Gene

  • GC15M040291
  • GC15M042502
  • GC15M019350

Summaries for TMEM87A Gene

GeneCards Summary for TMEM87A Gene

TMEM87A (Transmembrane Protein 87A) is a Protein Coding gene. An important paralog of this gene is TMEM87B.

UniProtKB/Swiss-Prot for TMEM87A Gene

  • May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).

Additional gene information for TMEM87A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM87A Gene

Genomics for TMEM87A Gene

GeneHancer (GH) Regulatory Elements for TMEM87A Gene

Promoters and enhancers for TMEM87A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I042270 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.8 774 5.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 GANC TMEM87A
GH15I042490 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.3 -216.7 -216710 2.5 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF106 SNAP23 LRRC57 TMEM87A GANC HAUS2 RPS3AP47 ENSG00000261684
GH15I043122 Promoter/Enhancer 1.4 Ensembl ENCODE 18.3 -848.5 -848539 1.7 PKNOX1 ATF1 SIN3A BRCA1 YY1 GLIS2 ATF7 MCM3 SP3 RXRA TMEM62 LRRC57 RPS3AP47 GANC WDR76 LOC105370795 TMEM87A CDAN1 VPS39 SNAP23
GH15I042493 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.6 -220.8 -220779 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 SNAP23 LRRC57 GANC HAUS2 LOC105370795 VPS39 CDAN1 TMEM87A ZSCAN29 ADAL
GH15I041401 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.8 +872.0 872025 1.8 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC NDUFAF1 DNAJC17 ENSG00000259211 INO80 GANC RAD51-AS1 LOC105370795 MGA CHST14 EHD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM87A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM87A gene promoter:

Genomic Locations for TMEM87A Gene

Genomic Locations for TMEM87A Gene
chr15:42,210,452-42,274,526
(GRCh38/hg38)
Size:
64,075 bases
Orientation:
Minus strand
chr15:42,502,726-42,565,861
(GRCh37/hg19)

Genomic View for TMEM87A Gene

Genes around TMEM87A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM87A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM87A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM87A Gene

Proteins for TMEM87A Gene

  • Protein details for TMEM87A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBN3-TM87A_HUMAN
    Recommended name:
    Transmembrane protein 87A
    Protein Accession:
    Q8NBN3
    Secondary Accessions:
    • Q6NT77
    • Q8NCA4
    • Q9BS46
    • Q9P103
    • Q9Y3Y7

    Protein attributes for TMEM87A Gene

    Size:
    555 amino acids
    Molecular mass:
    63430 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11598.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM87A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM87A Gene

Post-translational modifications for TMEM87A Gene

  • Ubiquitination at posLast=397397
  • Glycosylation at isoforms=2, 379, posLast=127127, isoforms=2, 3157, and isoforms=2, 3160
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM87A Gene

Domains & Families for TMEM87A Gene

Gene Families for TMEM87A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM87A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM87A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBN3

UniProtKB/Swiss-Prot:

TM87A_HUMAN :
  • Belongs to the LU7TM family. TMEM87 subfamily.
Family:
  • Belongs to the LU7TM family. TMEM87 subfamily.
genes like me logo Genes that share domains with TMEM87A: view

Function for TMEM87A Gene

Molecular function for TMEM87A Gene

UniProtKB/Swiss-Prot Function:
May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).

Phenotypes From GWAS Catalog for TMEM87A Gene

Phenotypes for TMEM87A Gene

genes like me logo Genes that share phenotypes with TMEM87A: view

Animal Model Products

CRISPR Products

miRNA for TMEM87A Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM87A Gene

Localization for TMEM87A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM87A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM87A gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
nucleus 2
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM87A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IDA 26157166
genes like me logo Genes that share ontologies with TMEM87A: view

Pathways & Interactions for TMEM87A Gene

SuperPathways for TMEM87A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM87A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042147 retrograde transport, endosome to Golgi IGI 26157166
genes like me logo Genes that share ontologies with TMEM87A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM87A Gene

Drugs & Compounds for TMEM87A Gene

No Compound Related Data Available

Transcripts for TMEM87A Gene

Unigene Clusters for TMEM87A Gene

Transmembrane protein 87A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM87A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: - -
SP3:

Relevant External Links for TMEM87A Gene

GeneLoc Exon Structure for
TMEM87A
ECgene alternative splicing isoforms for
TMEM87A

Expression for TMEM87A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM87A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM87A Gene

This gene is overexpressed in Islet of Langerhans (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM87A Gene



Protein tissue co-expression partners for TMEM87A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM87A Gene:

TMEM87A

SOURCE GeneReport for Unigene cluster for TMEM87A Gene:

Hs.744941

Evidence on tissue expression from TISSUES for TMEM87A Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Lung(3.3)
  • Kidney(2.9)
  • Adrenal gland(2.7)
  • Intestine(2.7)
  • Pancreas(2.7)
  • Stomach(2.7)
genes like me logo Genes that share expression patterns with TMEM87A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM87A Gene

Orthologs for TMEM87A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM87A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM87A 33 34
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia TMEM87A 33
  • 93.45 (n)
cow
(Bos Taurus)
Mammalia TMEM87A 33 34
  • 92.61 (n)
mouse
(Mus musculus)
Mammalia Tmem87a 33 16 34
  • 89.23 (n)
rat
(Rattus norvegicus)
Mammalia Tmem87a 33
  • 87.75 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM87A 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM87A 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM87A 33 34
  • 75.84 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM87A 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem87a 33
  • 68.53 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:162698 33
  • 59.7 (n)
TMEM87A 34
  • 47 (a)
OneToOne
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CG17660 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C52B9.4 34
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTM1 34
  • 17 (a)
ManyToMany
-- 34
  • 14 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3403 33
Species where no ortholog for TMEM87A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM87A Gene

ENSEMBL:
Gene Tree for TMEM87A (if available)
TreeFam:
Gene Tree for TMEM87A (if available)

Paralogs for TMEM87A Gene

Paralogs for TMEM87A Gene

(1) SIMAP similar genes for TMEM87A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TMEM87A: view

Variants for TMEM87A Gene

Sequence variations from dbSNP and Humsavar for TMEM87A Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000019196 -- 42,253,475(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000044449 -- 42,243,804(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000111738 -- 42,250,058(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000121375 -- 42,237,956(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000124764 -- 42,249,845(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM87A Gene

Variant ID Type Subtype PubMed ID
esv1006302 CNV deletion 20482838
nsv1054102 CNV gain 25217958
nsv471683 CNV gain+loss 15918152
nsv827308 CNV gain 20364138
nsv827310 CNV loss 20364138
nsv832985 CNV loss 17160897

Variation tolerance for TMEM87A Gene

Residual Variation Intolerance Score: 6.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM87A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM87A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM87A Gene

Disorders for TMEM87A Gene

Additional Disease Information for TMEM87A

No disorders were found for TMEM87A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM87A Gene

Publications for TMEM87A Gene

  1. Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport. (PMID: 26157166) Hirata T … Kinoshita T (Molecular biology of the cell 2015) 3 4 58
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TMEM87A Gene

Sources for TMEM87A Gene

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