Aliases for TMEM87A Gene

Aliases for TMEM87A Gene

  • Transmembrane Protein 87A 2 3 4 5

External Ids for TMEM87A Gene

Previous GeneCards Identifiers for TMEM87A Gene

  • GC15M040291
  • GC15M042502
  • GC15M019350

Summaries for TMEM87A Gene

GeneCards Summary for TMEM87A Gene

TMEM87A (Transmembrane Protein 87A) is a Protein Coding gene. Diseases associated with TMEM87A include Testicular Leukemia and Hermansky-Pudlak Syndrome 1. An important paralog of this gene is TMEM87B.

UniProtKB/Swiss-Prot Summary for TMEM87A Gene

  • May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).

Additional gene information for TMEM87A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM87A Gene

Genomics for TMEM87A Gene

GeneHancer (GH) Regulatory Elements for TMEM87A Gene

Promoters and enhancers for TMEM87A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM87A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM87A

Top Transcription factor binding sites by QIAGEN in the TMEM87A gene promoter:
  • aMEF-2
  • GATA-1
  • Lhx3a
  • LHX3b
  • Pax-6
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for TMEM87A Gene

Genomic Locations for TMEM87A Gene
64,080 bases
Minus strand
63,136 bases
Minus strand

Genomic View for TMEM87A Gene

Genes around TMEM87A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM87A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM87A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM87A Gene

Proteins for TMEM87A Gene

  • Protein details for TMEM87A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 87A
    Protein Accession:
    Secondary Accessions:
    • Q6NT77
    • Q8NCA4
    • Q9BS46
    • Q9P103
    • Q9Y3Y7

    Protein attributes for TMEM87A Gene

    555 amino acids
    Molecular mass:
    63430 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11598.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM87A Gene


neXtProt entry for TMEM87A Gene

Post-translational modifications for TMEM87A Gene

  • Glycosylation at Asn79, Asn62, Asn127, Asn157, and Asn160
  • Ubiquitination at Lys397 and Lys484
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TM87A_HUMAN (1854)

No data available for DME Specific Peptides for TMEM87A Gene

Domains & Families for TMEM87A Gene

Gene Families for TMEM87A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM87A Gene


Suggested Antigen Peptide Sequences for TMEM87A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58594 (B4DN92_HUMAN)
  • Transmembrane protein 87A (TM87A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LU7TM family. TMEM87 subfamily.
  • Belongs to the LU7TM family. TMEM87 subfamily.
genes like me logo Genes that share domains with TMEM87A: view

Function for TMEM87A Gene

Molecular function for TMEM87A Gene

UniProtKB/Swiss-Prot Function:
May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).

Phenotypes From GWAS Catalog for TMEM87A Gene

genes like me logo Genes that share phenotypes with TMEM87A: view

Animal Model Products

CRISPR Products

miRNA for TMEM87A Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM87A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM87A Gene

Localization for TMEM87A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM87A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM87A gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
nucleus 2
cytosol 2
endosome 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM87A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IDA 26157166
genes like me logo Genes that share ontologies with TMEM87A: view

Pathways & Interactions for TMEM87A Gene

PathCards logo

SuperPathways for TMEM87A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM87A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042147 retrograde transport, endosome to Golgi IGI 26157166
genes like me logo Genes that share ontologies with TMEM87A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM87A Gene

Drugs & Compounds for TMEM87A Gene

No Compound Related Data Available

Transcripts for TMEM87A Gene

mRNA/cDNA for TMEM87A Gene

20 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM87A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM87A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: - -

Relevant External Links for TMEM87A Gene

GeneLoc Exon Structure for

Expression for TMEM87A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM87A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM87A Gene

This gene is overexpressed in Islet of Langerhans (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM87A Gene

Protein tissue co-expression partners for TMEM87A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM87A

SOURCE GeneReport for Unigene cluster for TMEM87A Gene:


Evidence on tissue expression from TISSUES for TMEM87A Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Lung(3.3)
  • Kidney(2.9)
  • Adrenal gland(2.7)
  • Intestine(2.7)
  • Pancreas(2.7)
  • Stomach(2.7)
genes like me logo Genes that share expression patterns with TMEM87A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM87A Gene

Orthologs for TMEM87A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM87A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM87A 31 30
  • 99.82 (n)
(Canis familiaris)
Mammalia TMEM87A 30
  • 93.45 (n)
(Bos Taurus)
Mammalia TMEM87A 31 30
  • 92.61 (n)
(Mus musculus)
Mammalia Tmem87a 17 31 30
  • 89.23 (n)
(Rattus norvegicus)
Mammalia Tmem87a 30
  • 87.75 (n)
(Monodelphis domestica)
Mammalia TMEM87A 31
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM87A 31
  • 41 (a)
(Gallus gallus)
Aves TMEM87A 31 30
  • 75.84 (n)
(Anolis carolinensis)
Reptilia TMEM87A 31
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem87a 30
  • 68.53 (n)
(Danio rerio)
Actinopterygii zgc:162698 30
  • 59.7 (n)
TMEM87A 31
  • 47 (a)
-- 30
fruit fly
(Drosophila melanogaster)
Insecta CG17660 31
  • 39 (a)
(Caenorhabditis elegans)
Secernentea C52B9.4 31
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTM1 31
  • 17 (a)
-- 31
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.3403 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3403 30
Species where no ortholog for TMEM87A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM87A Gene

Gene Tree for TMEM87A (if available)
Gene Tree for TMEM87A (if available)
Evolutionary constrained regions (ECRs) for TMEM87A: view image

Paralogs for TMEM87A Gene

Paralogs for TMEM87A Gene

(1) SIMAP similar genes for TMEM87A Gene using alignment to 8 proteins:

  • H3BM87_HUMAN
genes like me logo Genes that share paralogs with TMEM87A: view

Variants for TMEM87A Gene

Additional dbSNP identifiers (rs#s) for TMEM87A Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM87A Gene

Variant ID Type Subtype PubMed ID
esv1006302 CNV deletion 20482838
nsv1054102 CNV gain 25217958
nsv471683 CNV gain+loss 15918152
nsv827308 CNV gain 20364138
nsv827310 CNV loss 20364138
nsv832985 CNV loss 17160897

Variation tolerance for TMEM87A Gene

Residual Variation Intolerance Score: 6.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM87A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM87A Gene

Disorders for TMEM87A Gene

MalaCards: The human disease database

(2) MalaCards diseases for TMEM87A Gene - From: DISEASES

Disorder Aliases PubMed IDs
testicular leukemia
hermansky-pudlak syndrome 1
  • hps1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM87A

genes like me logo Genes that share disorders with TMEM87A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM87A Gene

Publications for TMEM87A Gene

  1. Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport. (PMID: 26157166) Hirata T … Kinoshita T (Molecular biology of the cell 2015) 2 3 4 54
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3 54
  5. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. (PMID: 30194290) Adhikari H … Counter CM (Nature communications 2018) 3 54

Products for TMEM87A Gene

Sources for TMEM87A Gene