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Aliases for TMEM86B Gene

Aliases for TMEM86B Gene

  • Transmembrane Protein 86B 2 3 4 5
  • Alkenylglycerophosphoethanolamine Hydrolase 2 3
  • Alkenylglycerophosphocholine Hydrolase 2 3
  • Lysoplasmalogenase 3
  • EC 4

External Ids for TMEM86B Gene

Previous GeneCards Identifiers for TMEM86B Gene

  • GC19M060430
  • GC19M055738
  • GC19M052061

Summaries for TMEM86B Gene

GeneCards Summary for TMEM86B Gene

TMEM86B (Transmembrane Protein 86B) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include alkenylglycerophosphocholine hydrolase activity and alkenylglycerophosphoethanolamine hydrolase activity. An important paralog of this gene is TMEM86A.

UniProtKB/Swiss-Prot for TMEM86B Gene

  • Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.

Additional gene information for TMEM86B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM86B Gene

Genomics for TMEM86B Gene

GeneHancer (GH) Regulatory Elements for TMEM86B Gene

Promoters and enhancers for TMEM86B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055227 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 563.2 -0.6 -557 5 ELF3 FOXA2 ARID4B THRB RAD21 RARA YY1 RCOR1 THAP11 PAF1 TMEM86B ENSG00000276570 MIR6804 PPP6R1
GH19I055246 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 19.4 -24.6 -24595 14.5 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP6R1 LENG8 U2AF2 ZNF581 LENG8-AS1 ENSG00000235681 ENSG00000267523 BRSK1 HSPBP1 FIZ1
GH19I055337 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -110.6 -110564 4 CLOCK MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 ZNF548 SP3 NFYC KMT5C ENSG00000276831 LENG8-AS1 U2AF2 LENG8 ZNF628 ENSG00000235681 ENSG00000267523 ENSG00000267096 FAM71E2
GH19I055300 Promoter/Enhancer 1.4 Ensembl ENCODE 17.5 -72.6 -72583 2 SIN3A ZBTB7B POLR2B GLIS2 ZNF207 ZNF143 ATF7 RUNX3 KLF13 SP3 TMEM86B TMEM150B KMT5C HSPBP1 PPP6R1 RPL28 TMEM238 UBE2S TMEM190 ZNF628
GH19I055382 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 -157.6 -157600 8.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 RPL28 MIR6805 PIR44435 TMEM238 ZNF628 LENG8-AS1 ZNF581 U2AF2 COX6B2 BRSK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM86B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM86B gene promoter:

Genomic Locations for TMEM86B Gene

Genomic Locations for TMEM86B Gene
2,631 bases
Minus strand

Genomic View for TMEM86B Gene

Genes around TMEM86B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM86B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM86B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM86B Gene

Proteins for TMEM86B Gene

  • Protein details for TMEM86B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for TMEM86B Gene

    226 amino acids
    Molecular mass:
    24352 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for TMEM86B Gene

Post-translational modifications for TMEM86B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM86B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM86B Gene

Domains & Families for TMEM86B Gene

Gene Families for TMEM86B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for TMEM86B Gene


Suggested Antigen Peptide Sequences for TMEM86B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM86 family.
  • Belongs to the TMEM86 family.
genes like me logo Genes that share domains with TMEM86B: view

Function for TMEM86B Gene

Molecular function for TMEM86B Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=45 uM for lysoplasmenyl-choline {ECO:0000269 PubMed:21515882}; KM=53 uM for lysoplasmenyl-ethanolamine {ECO:0000269 PubMed:21515882}; pH dependence: Optimum pH is 6.95 and 7.05 with lysoplasmenyl-ethanolamine and lysoplasmenyl-choline as substrates, respectively. {ECO:0000269 PubMed:21515882};
UniProtKB/Swiss-Prot CatalyticActivity:
1-(1-alkenyl)-sn-glycero-3-phosphocholine + H(2)O = an aldehyde + sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H(2)O = an aldehyde + sn-glycero-3-phosphoethanolamine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Competitively inhibited by lysophosphatidic acid.
UniProtKB/Swiss-Prot Function:
Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.

Enzyme Numbers (IUBMB) for TMEM86B Gene

Phenotypes From GWAS Catalog for TMEM86B Gene

Gene Ontology (GO) - Molecular Function for TMEM86B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0016803 ether hydrolase activity TAS --
GO:0047408 alkenylglycerophosphocholine hydrolase activity IEA,IDA 21515882
GO:0047409 alkenylglycerophosphoethanolamine hydrolase activity IDA,IEA 21515882
genes like me logo Genes that share ontologies with TMEM86B: view
genes like me logo Genes that share phenotypes with TMEM86B: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM86B Gene

Localization for TMEM86B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM86B Gene

Membrane; Multi-pass membrane protein. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM86B gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Midbody (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM86B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 21515882
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA,IEA 21515882
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM86B: view

Pathways & Interactions for TMEM86B Gene

genes like me logo Genes that share pathways with TMEM86B: view

Pathways by source for TMEM86B Gene

Gene Ontology (GO) - Biological Process for TMEM86B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036151 phosphatidylcholine acyl-chain remodeling TAS --
GO:0046485 ether lipid metabolic process IDA 21515882
genes like me logo Genes that share ontologies with TMEM86B: view

No data available for SIGNOR curated interactions for TMEM86B Gene

Drugs & Compounds for TMEM86B Gene

(2) Drugs for TMEM86B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Choline alfoscerate Experimental, Investigational Pharma 0

(1) Additional Compounds for TMEM86B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMEM86B: view

Transcripts for TMEM86B Gene

mRNA/cDNA for TMEM86B Gene

Unigene Clusters for TMEM86B Gene

Transmembrane protein 86B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM86B Gene

No ASD Table

Relevant External Links for TMEM86B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM86B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM86B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM86B Gene

This gene is overexpressed in Fetal gut (36.1) and Fetal Liver (32.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM86B Gene

Protein tissue co-expression partners for TMEM86B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM86B Gene:


SOURCE GeneReport for Unigene cluster for TMEM86B Gene:

genes like me logo Genes that share expression patterns with TMEM86B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM86B Gene

Orthologs for TMEM86B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM86B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM86B 33 34
  • 98.82 (n)
(Rattus norvegicus)
Mammalia Tmem86b 33
  • 75.96 (n)
(Mus musculus)
Mammalia Tmem86b 33 16 34
  • 75.22 (n)
(Canis familiaris)
Mammalia TMEM86B 33 34
  • 74.04 (n)
(Bos Taurus)
Mammalia TMEM86B 33 34
  • 71.58 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM86B 34
  • 51 (a)
(Monodelphis domestica)
Mammalia TMEM86B 34
  • 44 (a)
(Anolis carolinensis)
Reptilia TMEM86B 34
  • 38 (a)
(Danio rerio)
Actinopterygii tmem86b 34
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7582 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
CSA.837 34
  • 24 (a)
Species where no ortholog for TMEM86B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM86B Gene

Gene Tree for TMEM86B (if available)
Gene Tree for TMEM86B (if available)

Paralogs for TMEM86B Gene

Paralogs for TMEM86B Gene

(1) SIMAP similar genes for TMEM86B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM86B: view

Variants for TMEM86B Gene

Sequence variations from dbSNP and Humsavar for TMEM86B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000070664 -- 55,227,215(-) G/A coding_sequence_variant, missense_variant
rs1000668015 -- 55,230,441(-) G/A upstream_transcript_variant
rs1000786698 -- 55,226,286(-) G/T downstream_transcript_variant
rs1001625710 -- 55,231,113(-) C/G/T upstream_transcript_variant
rs1002041841 -- 55,226,462(-) G/A downstream_transcript_variant

Variation tolerance for TMEM86B Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM86B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM86B Gene

Disorders for TMEM86B Gene

Additional Disease Information for TMEM86B

No disorders were found for TMEM86B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM86B Gene

Publications for TMEM86B Gene

  1. Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen. (PMID: 21515882) Wu LC … Jurkowitz MS (The Journal of biological chemistry 2011) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for TMEM86B Gene

Sources for TMEM86B Gene

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