Aliases for TMEM86A Gene

Aliases for TMEM86A Gene

  • Transmembrane Protein 86A 2 3 4 5
  • Lysoplasmalogenase-Like Protein TMEM86A 3 4

External Ids for TMEM86A Gene

Previous GeneCards Identifiers for TMEM86A Gene

  • GC11P018677
  • GC11P018405
  • GC11P018714

Summaries for TMEM86A Gene

GeneCards Summary for TMEM86A Gene

TMEM86A (Transmembrane Protein 86A) is a Protein Coding gene. An important paralog of this gene is TMEM86B.

Additional gene information for TMEM86A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM86A Gene

Genomics for TMEM86A Gene

GeneHancer (GH) Regulatory Elements for TMEM86A Gene

Promoters and enhancers for TMEM86A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J018697 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 758.1 +6.2 6151 3.9 NR2F1 NR2F6 NFYC L3MBTL2 MAX MNT NKRF ZFX SP1 CREM TMEM86A piR-52172 GTF2H1 SPTY2D1 SAAL1 HPS5 IGSF22 ENSG00000254966 YWHABP2 UEVLD
GH11J018693 Enhancer 0.8 Ensembl 750.6 +0.3 279 0.8 SMARCE1 RUNX1 TEAD4 SP1 CBFA2T2 MLLT1 SMARCA4 TRIM24 MTA1 IKZF1 TMEM86A piR-52172
GH11J018691 Enhancer 0.7 Ensembl 750.6 -1.2 -1221 0.2 SMARCE1 ZKSCAN8 BACH1 SMARCA4 ZNF639 RFX1 ATF1 ZNF740 NFE2 CTBP1 TMEM86A SAAL1 GTF2H1 SPTY2D1 RF00017-882
GH11J018668 Enhancer 1 Ensembl ENCODE 21.2 -24.7 -24721 3.6 SMARCE1 ZNF652 ZNF148 CBFA2T2 SMARCA4 IKZF1 CREB1 RNF2 REST ZNF512 TMEM86A SPTY2D1 ENSG00000254966 IGSF22 ENSG00000256282 SPTY2D1OS ENSG00000257043 piR-32214-085
GH11J018578 Promoter/Enhancer 1.2 Ensembl ENCODE 10.4 -113.8 -113794 1.3 ATF1 CREB1 MNT MAFK MLLT1 SMARCA4 ZNF24 HNF1A KAT8 GATAD2A HE856003 ENSG00000256282 SPTY2D1 TMEM86A ENSG00000254966 IGSF22 TSG101 SERGEF UEVLD lnc-UEVLD-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM86A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM86A gene promoter:
  • AP-4
  • E47
  • NF-1
  • NF-1/L
  • PPAR-alpha
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Tal-1beta
  • USF1

Genomic Locations for TMEM86A Gene

Genomic Locations for TMEM86A Gene
chr11:18,693,122-18,704,785
(GRCh38/hg38)
Size:
11,664 bases
Orientation:
Plus strand
chr11:18,714,669-18,726,332
(GRCh37/hg19)
Size:
11,664 bases
Orientation:
Plus strand

Genomic View for TMEM86A Gene

Genes around TMEM86A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM86A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM86A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM86A Gene

Proteins for TMEM86A Gene

  • Protein details for TMEM86A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2M4-TM86A_HUMAN
    Recommended name:
    Lysoplasmalogenase-like protein TMEM86A
    Protein Accession:
    Q8N2M4
    Secondary Accessions:
    • Q96AJ0

    Protein attributes for TMEM86A Gene

    Size:
    240 amino acids
    Molecular mass:
    26398 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM86A Gene

Post-translational modifications for TMEM86A Gene

No Post-translational modifications

Other Protein References for TMEM86A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM86A Gene

Domains & Families for TMEM86A Gene

Gene Families for TMEM86A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM86A Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM86A Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 86A (TM86A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N2M4

UniProtKB/Swiss-Prot:

TM86A_HUMAN :
  • Belongs to the TMEM86 family.
Family:
  • Belongs to the TMEM86 family.
genes like me logo Genes that share domains with TMEM86A: view

Function for TMEM86A Gene

Phenotypes From GWAS Catalog for TMEM86A Gene

Gene Ontology (GO) - Molecular Function for TMEM86A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047408 alkenylglycerophosphocholine hydrolase activity IBA 21873635
GO:0047409 alkenylglycerophosphoethanolamine hydrolase activity IBA 21873635
genes like me logo Genes that share ontologies with TMEM86A: view
genes like me logo Genes that share phenotypes with TMEM86A: view

Animal Models for TMEM86A Gene

MGI Knock Outs for TMEM86A:

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM86A Gene

Localization for TMEM86A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM86A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM86A gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM86A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM86A: view

Pathways & Interactions for TMEM86A Gene

PathCards logo

SuperPathways for TMEM86A Gene

No Data Available

Interacting Proteins for TMEM86A Gene

Gene Ontology (GO) - Biological Process for TMEM86A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046485 ether lipid metabolic process IBA 21873635
genes like me logo Genes that share ontologies with TMEM86A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM86A Gene

Drugs & Compounds for TMEM86A Gene

No Compound Related Data Available

Transcripts for TMEM86A Gene

mRNA/cDNA for TMEM86A Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM86A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - - - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for TMEM86A Gene

GeneLoc Exon Structure for
TMEM86A
ECgene alternative splicing isoforms for
TMEM86A

Expression for TMEM86A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM86A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM86A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of TMEM86A Gene:

TMEM86A

SOURCE GeneReport for Unigene cluster for TMEM86A Gene:

Hs.502100

Evidence on tissue expression from TISSUES for TMEM86A Gene

  • Intestine(4)
genes like me logo Genes that share expression patterns with TMEM86A: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM86A Gene

Orthologs for TMEM86A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM86A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM86A 33 32
  • 99.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM86A 33 32
  • 91.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM86A 33 32
  • 88.89 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem86a 17 33 32
  • 87.36 (n)
rat
(Rattus norvegicus)
Mammalia Tmem86a 32
  • 85.63 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM86A 33
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM86A 33 32
  • 72.77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM86A 33
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135356 32
  • 71.87 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem86a 33 32
  • 70.35 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7582 33 32
  • 49.53 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010616 32
  • 42.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 33 (a)
ManyToMany
CSA.837 33
  • 30 (a)
ManyToMany
Species where no ortholog for TMEM86A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM86A Gene

ENSEMBL:
Gene Tree for TMEM86A (if available)
TreeFam:
Gene Tree for TMEM86A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM86A: view image

Paralogs for TMEM86A Gene

Paralogs for TMEM86A Gene

(1) SIMAP similar genes for TMEM86A Gene using alignment to 1 proteins:

  • TM86A_HUMAN
genes like me logo Genes that share paralogs with TMEM86A: view

Variants for TMEM86A Gene

Sequence variations from dbSNP and Humsavar for TMEM86A Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000613868 -- 18,699,299(+) A/G intron_variant
rs1001396426 -- 18,703,020(+) A/G 3_prime_UTR_variant
rs1001686025 -- 18,697,155(+) G/C upstream_transcript_variant
rs1001759657 -- 18,697,554(+) G/A upstream_transcript_variant
rs1001790798 -- 18,697,963(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM86A Gene

Variant ID Type Subtype PubMed ID
nsv525192 CNV loss 19592680
nsv553633 CNV gain 21841781
nsv7696 CNV insertion 18451855

Variation tolerance for TMEM86A Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM86A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM86A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM86A Gene

Disorders for TMEM86A Gene

Additional Disease Information for TMEM86A

No disorders were found for TMEM86A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM86A Gene

Publications for TMEM86A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Systematic identification of pathological lamin A interactors. (PMID: 24623722) Dittmer TA … Misteli T (Molecular biology of the cell 2014) 3 56
  4. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women. (PMID: 22116950) Schuh-Huerta SM … Reijo Pera RA (Human reproduction (Oxford, England) 2012) 3 56
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56

Products for TMEM86A Gene

Sources for TMEM86A Gene