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Aliases for TMEM82 Gene

Aliases for TMEM82 Gene

  • Transmembrane Protein 82 2 3 5

External Ids for TMEM82 Gene

Previous GeneCards Identifiers for TMEM82 Gene

  • GC01P015942
  • GC01P016068
  • GC01P014587

Summaries for TMEM82 Gene

GeneCards Summary for TMEM82 Gene

TMEM82 (Transmembrane Protein 82) is a Protein Coding gene.

Additional gene information for TMEM82 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM82 Gene

Genomics for TMEM82 Gene

GeneHancer (GH) Regulatory Elements for TMEM82 Gene

Promoters and enhancers for TMEM82 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I015740 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 -0.3 -262 2.6 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ARID2 ZNF143 KLF7 TMEM82 SLC25A34 PLEKHM2 ENSG00000237938 SLC25A34-AS1
GH01I015678 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.4 -60.1 -60065 8 PKNOX1 YBX1 POLR2B GLIS2 ZNF143 FOS ATF7 RUNX3 JUNB MEF2D PLEKHM2 ENSG00000271742 SPEN CROCCP3 CASP9 SLC25A34 LINC01772 CROCCP2 ZBTB17 RPL22P3
GH01I015749 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.4 +7.3 7272 1.1 ELF3 GATAD2A SAP130 JUN ZMYM3 MIER2 DMAP1 TEAD3 ZGPAT ETV4 SLC25A34-AS1 SLC25A34 TMEM82
GH01I015702 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 6.3 -38.5 -38534 2.6 CTCF FOXA2 RAD21 ZNF121 ZFHX2 ZNF316 ZNF366 EGR1 FOS PRDM10 SLC25A34 PLEKHM2 TMEM82 FAM131C PIR54516 PIR59281
GH01I015605 Enhancer 0.8 ENCODE 6 -136.3 -136332 1.2 FOXA2 ARID4B ZBTB40 RARA CREM THAP11 MIXL1 RXRA PPARG NFIL3 CHCHD2P6 GC01P015607 PIR54927 PIR62449 SLC25A34 AGMAT TMEM82 GC01P015603 RNU7-179P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM82 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM82 gene promoter:

Genomic Locations for TMEM82 Gene

Genomic Locations for TMEM82 Gene
chr1:15,742,422-15,747,982
(GRCh38/hg38)
Size:
5,561 bases
Orientation:
Plus strand
chr1:16,068,917-16,074,477
(GRCh37/hg19)

Genomic View for TMEM82 Gene

Genes around TMEM82 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM82 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM82 Gene

Proteins for TMEM82 Gene

  • Protein details for TMEM82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJX8-TMM82_HUMAN
    Recommended name:
    Transmembrane protein 82
    Protein Accession:
    A0PJX8
    Secondary Accessions:
    • B2RP27
    • Q5VVD4

    Protein attributes for TMEM82 Gene

    Size:
    343 amino acids
    Molecular mass:
    37222 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM82 Gene

Post-translational modifications for TMEM82 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM82 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM82 Gene

Domains & Families for TMEM82 Gene

Gene Families for TMEM82 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM82 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM82 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0PJX8

UniProtKB/Swiss-Prot:

TMM82_HUMAN :
  • Belongs to the TMEM82 family.
Family:
  • Belongs to the TMEM82 family.
genes like me logo Genes that share domains with TMEM82: view

Function for TMEM82 Gene

Phenotypes From GWAS Catalog for TMEM82 Gene

genes like me logo Genes that share phenotypes with TMEM82: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM82 Gene

Localization for TMEM82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM82 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM82 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM82: view

Pathways & Interactions for TMEM82 Gene

SuperPathways for TMEM82 Gene

No Data Available

Interacting Proteins for TMEM82 Gene

Gene Ontology (GO) - Biological Process for TMEM82 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM82 Gene

Drugs & Compounds for TMEM82 Gene

No Compound Related Data Available

Transcripts for TMEM82 Gene

mRNA/cDNA for TMEM82 Gene

Unigene Clusters for TMEM82 Gene

Transmembrane protein 82:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM82 Gene

No ASD Table

Relevant External Links for TMEM82 Gene

GeneLoc Exon Structure for
TMEM82
ECgene alternative splicing isoforms for
TMEM82

Expression for TMEM82 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM82 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM82 Gene

This gene is overexpressed in Liver (x26.8), Kidney - Cortex (x10.4), Small Intestine - Terminal Ileum (x7.3), and Colon - Transverse (x6.4).

Protein differential expression in normal tissues from HIPED for TMEM82 Gene

This gene is overexpressed in Gallbladder (52.3), Liver (9.7), and Kidney (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM82 Gene



Protein tissue co-expression partners for TMEM82 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM82 Gene:

TMEM82

SOURCE GeneReport for Unigene cluster for TMEM82 Gene:

Hs.454828
genes like me logo Genes that share expression patterns with TMEM82: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM82 Gene

Orthologs for TMEM82 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM82 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM82 33 34
  • 99.09 (n)
cow
(Bos Taurus)
Mammalia TMEM82 33 34
  • 86.43 (n)
dog
(Canis familiaris)
Mammalia TMEM82 33 34
  • 84.65 (n)
mouse
(Mus musculus)
Mammalia Tmem82 33 16 34
  • 80.6 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM82 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM82 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM82 33 34
  • 66.77 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM82 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem82 33
  • 66.46 (n)
Str.4345 33
zebrafish
(Danio rerio)
Actinopterygii LOC568809 33
  • 52.63 (n)
TMEM82 34
  • 43 (a)
OneToOne
Species where no ortholog for TMEM82 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM82 Gene

ENSEMBL:
Gene Tree for TMEM82 (if available)
TreeFam:
Gene Tree for TMEM82 (if available)

Paralogs for TMEM82 Gene

No data available for Paralogs for TMEM82 Gene

Variants for TMEM82 Gene

Sequence variations from dbSNP and Humsavar for TMEM82 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000512368 -- 15,742,729(+) C/T intron_variant
rs1000915865 -- 15,740,775(+) C/T upstream_transcript_variant
rs1002016956 -- 15,742,473(+) C/A upstream_transcript_variant
rs1002573247 -- 15,745,618(+) C/T intron_variant
rs1002757512 -- 15,741,075(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM82 Gene

Variant ID Type Subtype PubMed ID
dgv11n27 CNV gain 19166990
dgv151n54 CNV gain 21841781
esv3585317 CNV gain 21293372
esv3585319 CNV gain 21293372
nsv508925 CNV insertion 20534489
nsv524044 CNV loss 19592680
nsv545617 CNV loss 21841781
nsv954825 CNV deletion 24416366

Variation tolerance for TMEM82 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.70; 78.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM82 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM82

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM82 Gene

Disorders for TMEM82 Gene

Additional Disease Information for TMEM82

No disorders were found for TMEM82 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM82 Gene

Publications for TMEM82 Gene

  1. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TMEM82 Gene

Sources for TMEM82 Gene

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