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Aliases for TMEM74 Gene

Aliases for TMEM74 Gene

  • Transmembrane Protein 74 2 3 5
  • NET36 3

External Ids for TMEM74 Gene

Previous GeneCards Identifiers for TMEM74 Gene

  • GC08M109865
  • GC08M105116
  • GC08M109619

Summaries for TMEM74 Gene

GeneCards Summary for TMEM74 Gene

TMEM74 (Transmembrane Protein 74) is a Protein Coding gene. Diseases associated with TMEM74 include Fuchs' Endothelial Dystrophy. An important paralog of this gene is TMEM74B.

UniProtKB/Swiss-Prot for TMEM74 Gene

  • Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.

Additional gene information for TMEM74 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM74 Gene

Genomics for TMEM74 Gene

GeneHancer (GH) Regulatory Elements for TMEM74 Gene

Promoters and enhancers for TMEM74 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I108786 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 555.5 +0.2 219 1.2 MZF1 ZNF76 SIN3A ZNF335 GLIS2 ZNF366 EGR1 SCRT2 ZNF143 THAP11 TMEM74 PIR34407
GH08I108787 Promoter 0.7 EPDnew 555.5 +1.0 963 0.1 MZF1 EZH2 ZBTB17 TMEM74 PIR34407
GH08I108246 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.4 +539.7 539677 3.3 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 EIF3E AURKBPS1 TMEM74 EMC2 ENSG00000253754 GC08M108244
GH08I108744 Enhancer 0.3 ENCODE 25.2 +42.9 42906 1 CREB1 TMEM74 GC08P108730 GC08P108729 LOC102723368
GH08I108666 Enhancer 0.8 ENCODE 0.1 +120.7 120657 0.6 NCOA3 NFIB NEUROD1 NFXL1 CEBPG BMI1 ZBTB7B RFX5 ZKSCAN1 CTBP1 GC08P108652 GC08P108729 GC08P108730 TMEM74
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM74 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM74 gene promoter:

Genomic Locations for TMEM74 Gene

Genomic Locations for TMEM74 Gene
chr8:108,606,850-108,787,615
(GRCh38/hg38)
Size:
180,766 bases
Orientation:
Minus strand
chr8:109,619,079-109,799,844
(GRCh37/hg19)

Genomic View for TMEM74 Gene

Genes around TMEM74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM74 Gene

Proteins for TMEM74 Gene

  • Protein details for TMEM74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NL1-TMM74_HUMAN
    Recommended name:
    Transmembrane protein 74
    Protein Accession:
    Q96NL1

    Protein attributes for TMEM74 Gene

    Size:
    305 amino acids
    Molecular mass:
    33338 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM74 Gene

Post-translational modifications for TMEM74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM74 Gene

Domains & Families for TMEM74 Gene

Gene Families for TMEM74 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM74 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96NL1

UniProtKB/Swiss-Prot:

TMM74_HUMAN :
  • Belongs to the TMEM74 family.
Family:
  • Belongs to the TMEM74 family.
genes like me logo Genes that share domains with TMEM74: view

Function for TMEM74 Gene

Molecular function for TMEM74 Gene

UniProtKB/Swiss-Prot Function:
Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction.

Phenotypes From GWAS Catalog for TMEM74 Gene

Gene Ontology (GO) - Molecular Function for TMEM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM74: view
genes like me logo Genes that share phenotypes with TMEM74: view

Animal Model Products

CRISPR Products

miRNA for TMEM74 Gene

miRTarBase miRNAs that target TMEM74

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM74 Gene

Localization for TMEM74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM74 Gene

Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM74 gene
Compartment Confidence
lysosome 4
plasma membrane 3
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IEA --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM74: view

Pathways & Interactions for TMEM74 Gene

SuperPathways for TMEM74 Gene

No Data Available

Interacting Proteins for TMEM74 Gene

Gene Ontology (GO) - Biological Process for TMEM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0016236 macroautophagy IMP 18294959
genes like me logo Genes that share ontologies with TMEM74: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM74 Gene

Drugs & Compounds for TMEM74 Gene

No Compound Related Data Available

Transcripts for TMEM74 Gene

mRNA/cDNA for TMEM74 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM74 Gene

Transmembrane protein 74:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM74 Gene

No ASD Table

Relevant External Links for TMEM74 Gene

GeneLoc Exon Structure for
TMEM74
ECgene alternative splicing isoforms for
TMEM74

Expression for TMEM74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM74 Gene

Protein differential expression in normal tissues from HIPED for TMEM74 Gene

This gene is overexpressed in Adipocyte (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM74 Gene



Protein tissue co-expression partners for TMEM74 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM74 Gene:

TMEM74

SOURCE GeneReport for Unigene cluster for TMEM74 Gene:

Hs.99439

mRNA Expression by UniProt/SwissProt for TMEM74 Gene:

Q96NL1-TMM74_HUMAN
Tissue specificity: Expressed in heart, lung, and placenta.

Evidence on tissue expression from TISSUES for TMEM74 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM74: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM74 Gene

Orthologs for TMEM74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM74 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia TMEM74 33 34
  • 86.01 (n)
cow
(Bos Taurus)
Mammalia TMEM74 33 34
  • 85.79 (n)
mouse
(Mus musculus)
Mammalia Tmem74 33 16 34
  • 81.42 (n)
rat
(Rattus norvegicus)
Mammalia Tmem74 33
  • 80.55 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM74 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM74 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858101 33
  • 63.73 (n)
TMEM74 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM74 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem74 33
  • 52.89 (n)
Str.5572 33
zebrafish
(Danio rerio)
Actinopterygii LOC100331423 33
  • 56.28 (n)
TMEM74 (2 of 2) 34
  • 46 (a)
OneToMany
CABZ01021538.1 34
  • 40 (a)
OneToMany
Species where no ortholog for TMEM74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM74 Gene

ENSEMBL:
Gene Tree for TMEM74 (if available)
TreeFam:
Gene Tree for TMEM74 (if available)

Paralogs for TMEM74 Gene

Paralogs for TMEM74 Gene

(1) SIMAP similar genes for TMEM74 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM74: view

Variants for TMEM74 Gene

Sequence variations from dbSNP and Humsavar for TMEM74 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000010465 -- 108,698,710(-) A/G/T genic_downstream_transcript_variant, intron_variant
rs1000028390 -- 108,734,108(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000044768 -- 108,776,338(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000065466 -- 108,741,809(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000068837 -- 108,656,804(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM74 Gene

Variant ID Type Subtype PubMed ID
nsv831420 CNV gain 17160897

Variation tolerance for TMEM74 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM74 Gene

Disorders for TMEM74 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM74 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM74

genes like me logo Genes that share disorders with TMEM74: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM74 Gene

Publications for TMEM74 Gene

  1. TMEM74, a lysosome and autophagosome protein, regulates autophagy. (PMID: 18294959) Yu C … Wang L (Biochemical and biophysical research communications 2008) 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for TMEM74 Gene

Sources for TMEM74 Gene

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