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TMEM72 Gene(Protein Coding)

Transmembrane Protein 72

GCID:
GC10P044914
GIFtS:
35
Genes Participants
UDN Logo

Aliases for TMEM72 Gene

Aliases for TMEM72 Gene

  • Transmembrane Protein 72 2 3 4 5
  • Kidney-Specific Secretory Protein Of 37 KDa 3 4
  • C10orf127 3 4
  • KSP37 3 4
  • Chromosome 10 Open Reading Frame 127 2

External Ids for TMEM72 Gene

Previous HGNC Symbols for TMEM72 Gene

  • C10orf127

Previous GeneCards Identifiers for TMEM72 Gene

  • GC10P044731
  • GC10P045406
  • GC10P041931

Summaries for TMEM72 Gene

Entrez Gene Summary for TMEM72 Gene

  • This gene encodes a transmembrane protein which may be expressed specifically in the kidney. [provided by RefSeq, Sep 2016]

GeneCards Summary for TMEM72 Gene

TMEM72 (Transmembrane Protein 72) is a Protein Coding gene.

Additional gene information for TMEM72 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM72 Gene

Genomics for TMEM72 Gene

GeneHancer (GH) Regulatory Elements for TMEM72 Gene

Promoters and enhancers for TMEM72 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM72 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM72 gene promoter:
  • AREB6
  • S8
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B

Genomic Locations for TMEM72 Gene

Genomic Locations for TMEM72 Gene
chr10:44,911,308-44,937,010
(GRCh38/hg38)
Size:
25,703 bases
Orientation:
Plus strand
chr10:45,406,648-45,432,450
(GRCh37/hg19)
Size:
25,803 bases
Orientation:
Plus strand

Genomic View for TMEM72 Gene

Genes around TMEM72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM72 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TMEM72 Gene

Proteins for TMEM72 Gene

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  • Protein details for TMEM72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PK05-TMM72_HUMAN
    Recommended name:
    Transmembrane protein 72
    Protein Accession:
    A0PK05
    Secondary Accessions:
    • A1L181
    • Q5T740

    Protein attributes for TMEM72 Gene

    Size:
    275 amino acids
    Molecular mass:
    29891 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM72 Gene

Protein Expression for TMEM72 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TMEM72 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM72 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM72 Gene

Domains & Families for TMEM72 Gene

Gene Families for TMEM72 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM72 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM72 Gene

GenScript: Design optimal peptide antigens:
  • Kidney-specific secretory protein of 37 kDa (TMM72_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM72: view

No data available for UniProtKB/Swiss-Prot for TMEM72 Gene

Function for TMEM72 Gene

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Phenotypes From GWAS Catalog for TMEM72 Gene

Phenotypes for TMEM72 Gene

GenomeRNAi human phenotypes for TMEM72:
genes like me logo Genes that share phenotypes with TMEM72: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM72

Clone Products

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  • * TMEM72 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM72 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM72 Gene

Localization for TMEM72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM72 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM72 gene
Compartment Confidence
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0
cytosol 0

Gene Ontology (GO) - Cellular Components for TMEM72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM72: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM72 Gene

Pathways & Interactions for TMEM72 Gene

GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
PathCards logo

SuperPathways for TMEM72 Gene

No Data Available

Interacting Proteins for TMEM72 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000374234%0d9606.ENSP00000482442%0d9606.ENSP00000376278%0d9606.ENSP00000432688%0d
Selected Interacting proteins: ENSP00000374234 for TMEM72 Gene via STRING

GPS-Prot Interaction Network for TMEM72

Gene Ontology (GO) - Biological Process for TMEM72 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM72 Gene

Drugs & Compounds for TMEM72 Gene

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  1. Drug
GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards
No Compound Related Data Available

Transcripts for TMEM72 Gene

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mRNA/cDNA for TMEM72 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for TMEM72 Gene

Transmembrane protein 72:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM72

Clone Products

  • Applied Biological Materials (abm): Clones for TMEM72 - Now 50% OFF >
  • * TMEM72 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TMEM72 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM72 Gene

No ASD Table

Relevant External Links for TMEM72 Gene

GeneLoc Exon Structure for
TMEM72
ECgene alternative splicing isoforms for
TMEM72

Expression for TMEM72 Gene

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  1. Primer
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GeneAnalytics - gene set analysis. Cells, Diseases, Pathways, Function and Compounds, relevant to your gene set. Powered by GeneCards

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM72 Gene

mRNA expression in normal human tissues for TMEM72 Gene
mRNA expression by GTEx for TMEM72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM72 Gene

This gene is overexpressed in Kidney - Cortex (x33.0) and Colon - Transverse (x8.4).

Protein differential expression in normal tissues from HIPED for TMEM72 Gene

This gene is overexpressed in Ovary (63.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM72 Gene



Protein tissue co-expression partners for TMEM72 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM72 Gene:

TMEM72

SOURCE GeneReport for Unigene cluster for TMEM72 Gene:

Hs.292788
genes like me logo Genes that share expression patterns with TMEM72: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM72 Gene

Orthologs for TMEM72 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM72 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TMEM72 35 34
  • 99.15 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia TMEM72 35 34
  • 86.79 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia TMEM72 35 34
  • 86.37 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tmem72 34
  • 84.73 (n)
mouse
(Mus musculus)
 Mammalia Tmem72 17 35 34
  • 84.48 (n)
oppossum
(Monodelphis domestica)
 Mammalia TMEM72 35
  • 76 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TMEM72 35 34
  • 65.55 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia TMEM72 35
  • 48 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tmem72 34
  • 56.45 (n)
zebrafish
(Danio rerio)
 Actinopterygii tmem72 35 34
  • 50.89 (n)
 OneToOne
Species where no ortholog for TMEM72 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM72 Gene

ENSEMBL:
Gene Tree for TMEM72 (if available)
TreeFam:
Gene Tree for TMEM72 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM72: view image

Paralogs for TMEM72 Gene

No data available for Paralogs for TMEM72 Gene

Variants for TMEM72 Gene

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  1. SNP Genotyping and Copy Number Assay
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Sequence variations from dbSNP and Humsavar for TMEM72 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs587777896 not-provided, not provided 44,934,719(+) C/A coding_sequence_variant, missense_variant
rs1000060769 -- 44,915,276(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000178908 -- 44,911,828(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000195169 -- 44,921,122(+) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000344360 -- 44,926,643(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM72 Gene

Variant ID Type Subtype PubMed ID
dgv438n106 CNV deletion 24896259
esv2678805 CNV deletion 23128226
esv2736094 CNV deletion 23290073
esv2762860 CNV loss 21179565
esv3546235 CNV deletion 23714750
esv3576560 CNV gain 25503493
esv3623075 CNV loss 21293372
esv3623076 CNV gain 21293372
nsv1068307 CNV deletion 25765185
nsv1120219 CNV tandem duplication 24896259
nsv1153452 CNV deletion 26484159
nsv466909 CNV gain 19166990
nsv517161 CNV gain+loss 19592680
nsv550714 CNV gain 21841781
nsv818757 CNV loss 17921354
nsv831844 CNV gain 17160897
nsv831845 CNV gain 17160897
nsv831846 CNV loss 17160897

Variation tolerance for TMEM72 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM72 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM72 Gene

Disorders for TMEM72 Gene

Additional Disease Information for TMEM72

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TMEM72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM72 Gene

Publications for TMEM72 Gene

  1. Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors. (PMID: 26169495) Wrzesiński T … Wesoly J (BMC cancer 2015) 3 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

ExternalLinks

View latest publications for TMEM72 gene in Mastermind

Products for TMEM72 Gene

Sources for TMEM72 Gene

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