This gene encodes a transmembrane protein which may be expressed specifically in the kidney. [provided by RefSeq, Sep 2016] See more...

Aliases for TMEM72 Gene

Aliases for TMEM72 Gene

  • Transmembrane Protein 72 2 3 4 5
  • KSP37 2 3 4
  • Kidney-Specific Secretory Protein Of 37 KDa 3 4
  • C10orf127 3 4
  • Chromosome 10 Open Reading Frame 127 2
  • BA285G1.3 2
  • TMEM72 5

External Ids for TMEM72 Gene

Previous HGNC Symbols for TMEM72 Gene

  • C10orf127

Previous GeneCards Identifiers for TMEM72 Gene

  • GC10P044731
  • GC10P045406
  • GC10P041931

Summaries for TMEM72 Gene

Entrez Gene Summary for TMEM72 Gene

  • This gene encodes a transmembrane protein which may be expressed specifically in the kidney. [provided by RefSeq, Sep 2016]

GeneCards Summary for TMEM72 Gene

TMEM72 (Transmembrane Protein 72) is a Protein Coding gene.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM72 Gene

Genomics for TMEM72 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM72 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM72 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM72

Top Transcription factor binding sites by QIAGEN in the TMEM72 gene promoter:
  • AREB6
  • S8
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B

Genomic Locations for TMEM72 Gene

Latest Assembly
25,704 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
25,674 bases
Plus strand

(GRCh37/hg19 by Ensembl)
25,803 bases
Plus strand

Genomic View for TMEM72 Gene

Genes around TMEM72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM72 Gene

Proteins for TMEM72 Gene

  • Protein details for TMEM72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 72
    Protein Accession:
    Secondary Accessions:
    • A1L181
    • Q5T740

    Protein attributes for TMEM72 Gene

    275 amino acids
    Molecular mass:
    29891 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM72 Gene


neXtProt entry for TMEM72 Gene

Post-translational modifications for TMEM72 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM72 Gene

No data available for DME Specific Peptides for TMEM72 Gene

Domains & Families for TMEM72 Gene

Gene Families for TMEM72 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM72 Gene


Suggested Antigen Peptide Sequences for TMEM72 Gene

GenScript: Design optimal peptide antigens:
  • Kidney-specific secretory protein of 37 kDa (TMM72_HUMAN)
genes like me logo Genes that share domains with TMEM72: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TMEM72 Gene

Function for TMEM72 Gene

Phenotypes From GWAS Catalog for TMEM72 Gene

Gene Ontology (GO) - Molecular Function for TMEM72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with TMEM72: view
genes like me logo Genes that share phenotypes with TMEM72: view

Animal Models for TMEM72 Gene

MGI Knock Outs for TMEM72:
  • Tmem72 Tmem72<tm1b(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM72

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM72 Gene

Localization for TMEM72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM72 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM72 gene
Compartment Confidence
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 0

Gene Ontology (GO) - Cellular Components for TMEM72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM72: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM72 Gene

Pathways & Interactions for TMEM72 Gene

PathCards logo

SuperPathways for TMEM72 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM72 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM72 Gene

Drugs & Compounds for TMEM72 Gene

No Compound Related Data Available

Transcripts for TMEM72 Gene

mRNA/cDNA for TMEM72 Gene

5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM72

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM72 Gene

No ASD Table

Relevant External Links for TMEM72 Gene

GeneLoc Exon Structure for

Expression for TMEM72 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM72 Gene

This gene is overexpressed in Kidney - Cortex (x33.0) and Colon - Transverse (x8.4).

Protein differential expression in normal tissues from HIPED for TMEM72 Gene

This gene is overexpressed in Ovary (63.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM72 Gene

Protein tissue co-expression partners for TMEM72 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM72

SOURCE GeneReport for Unigene cluster for TMEM72 Gene:


Evidence on tissue expression from TISSUES for TMEM72 Gene

  • Kidney(2.2)
genes like me logo Genes that share expression patterns with TMEM72: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM72 Gene

Orthologs for TMEM72 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM72 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM72 30 31
  • 99.15 (n)
(Canis familiaris)
Mammalia TMEM72 30 31
  • 86.79 (n)
(Bos Taurus)
Mammalia TMEM72 30 31
  • 86.37 (n)
(Rattus norvegicus)
Mammalia Tmem72 30
  • 84.73 (n)
(Mus musculus)
Mammalia Tmem72 30 17 31
  • 84.48 (n)
(Monodelphis domestica)
Mammalia TMEM72 31
  • 76 (a)
(Gallus gallus)
Aves TMEM72 30 31
  • 65.55 (n)
(Anolis carolinensis)
Reptilia TMEM72 31
  • 48 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tmem72 30
  • 56.45 (n)
(Danio rerio)
Actinopterygii tmem72 30 31
  • 50.89 (n)
Species where no ortholog for TMEM72 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM72 Gene

Gene Tree for TMEM72 (if available)
Gene Tree for TMEM72 (if available)
Evolutionary constrained regions (ECRs) for TMEM72: view image

Paralogs for TMEM72 Gene

No data available for Paralogs for TMEM72 Gene

Variants for TMEM72 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM72 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs587777896 Not Provided: not provided 44,934,719(+) C/A
NM_001123376.3(TMEM72):c.413C>A (p.Ala138Asp)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TMEM72 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TMEM72 Gene

Variant ID Type Subtype PubMed ID
dgv438n106 CNV deletion 24896259
esv2678805 CNV deletion 23128226
esv2736094 CNV deletion 23290073
esv2762860 CNV loss 21179565
esv3546235 CNV deletion 23714750
esv3576560 CNV gain 25503493
esv3623075 CNV loss 21293372
esv3623076 CNV gain 21293372
nsv1068307 CNV deletion 25765185
nsv1120219 CNV tandem duplication 24896259
nsv1153452 CNV deletion 26484159
nsv466909 CNV gain 19166990
nsv517161 CNV gain+loss 19592680
nsv550714 CNV gain 21841781
nsv818757 CNV loss 17921354
nsv831844 CNV gain 17160897
nsv831845 CNV gain 17160897
nsv831846 CNV loss 17160897

Variation tolerance for TMEM72 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM72 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM72 Gene

Disorders for TMEM72 Gene

Additional Disease Information for TMEM72

No disorders were found for TMEM72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM72 Gene

Publications for TMEM72 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors. (PMID: 26169495) Wrzesiński T … Wesoly J (BMC cancer 2015) 3
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for TMEM72 Gene

Sources for TMEM72 Gene