Aliases for TMEM71 Gene

Aliases for TMEM71 Gene

  • Transmembrane Protein 71 2 3 4 5
  • FLJ33069 2
  • TMEM71 5

External Ids for TMEM71 Gene

Previous GeneCards Identifiers for TMEM71 Gene

  • GC08M133792
  • GC08M129040
  • GC08M133697

Summaries for TMEM71 Gene

GeneCards Summary for TMEM71 Gene

TMEM71 (Transmembrane Protein 71) is a Protein Coding gene. Diseases associated with TMEM71 include Renal Cell Carcinoma, Papillary, 1.

Additional gene information for TMEM71 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TMEM71 Gene

Genomics for TMEM71 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TMEM71 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J132774 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 606.2 -0.2 -153 3.3 SP1 CREB1 REST TFE3 POLR2A BACH1 STAT3 LARP7 RBFOX2 PKNOX1 PHF20L1 TMEM71 ENSG00000223697 ENSG00000270137 TG
GH08J132758 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 643.2 +15.9 15871 4.2 RNF2 CEBPB JUND CTCF POLR2A BHLHE40 SPI1 JUN SP1 PKNOX1 TMEM71 lnc-TMEM71-3 PHF20L1 LRRC6 piR-46847-275
GH08J133080 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 42.2 -306.2 -306155 3.2 GABPA SP1 CEBPB NR2F2 CTCF CEBPG RAD21 RXRA POLR2A NR3C1 TMEM71 PHF20L1 CCN4 SLA ST3GAL1 TG lnc-NDRG1-4 5MWI_A-174
GH08J133147 Enhancer 1.1 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 37.5 -371.2 -371242 1.7 ATF7 RUNX3 ZNF184 CREM ATF3 ATF2 ZBTB21 CREB1 TMEM71 PHF20L1 CCN4 SLA TG ST3GAL1 HSALNG0068721 LOC105375769 HSALNG0068723
GH08J133077 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 41.7 -302.2 -302168 0.7 SPI1 MAX TMEM71 PHF20L1 CCN4 SLA ST3GAL1 5MWI_A-174 lnc-NDRG1-4 TG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM71 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TMEM71

Top Transcription factor binding sites by QIAGEN in the TMEM71 gene promoter:
  • AREB6
  • ATF-2
  • c-Jun
  • FOXL1
  • POU6F1 (c2)
  • SEF-1 (1)
  • Sox9
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for TMEM71 Gene

Genomic Locations for TMEM71 Gene
chr8:132,685,007-132,775,999
(GRCh38/hg38)
Size:
90,993 bases
Orientation:
Minus strand
chr8:133,697,253-133,772,958
(GRCh37/hg19)
Size:
75,706 bases
Orientation:
Minus strand

Genomic View for TMEM71 Gene

Genes around TMEM71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM71 Gene

Proteins for TMEM71 Gene

  • Protein details for TMEM71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5X7-TMM71_HUMAN
    Recommended name:
    Transmembrane protein 71
    Protein Accession:
    Q6P5X7
    Secondary Accessions:
    • Q3KRC2
    • Q8WVZ4
    • Q96LX9

    Protein attributes for TMEM71 Gene

    Size:
    295 amino acids
    Molecular mass:
    32983 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM71 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM71 Gene

Post-translational modifications for TMEM71 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM71 Gene

Domains & Families for TMEM71 Gene

Gene Families for TMEM71 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM71 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM71 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 71 (TMM71_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P5X7

UniProtKB/Swiss-Prot:

TMM71_HUMAN :
  • Belongs to the TMEM71 family.
Family:
  • Belongs to the TMEM71 family.
genes like me logo Genes that share domains with TMEM71: view

Function for TMEM71 Gene

Phenotypes From GWAS Catalog for TMEM71 Gene

genes like me logo Genes that share phenotypes with TMEM71: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM71

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM71 Gene

Localization for TMEM71 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM71 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM71 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM71: view

Pathways & Interactions for TMEM71 Gene

PathCards logo

SuperPathways for TMEM71 Gene

No Data Available

Interacting Proteins for TMEM71 Gene

Gene Ontology (GO) - Biological Process for TMEM71 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM71 Gene

Drugs & Compounds for TMEM71 Gene

No Compound Related Data Available

Transcripts for TMEM71 Gene

mRNA/cDNA for TMEM71 Gene

13 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TMEM71

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM71 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5: - -
SP6: -
SP7: - - - -
SP8: - - - -
SP9: - -

Relevant External Links for TMEM71 Gene

GeneLoc Exon Structure for
TMEM71

Expression for TMEM71 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM71 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM71 Gene

This gene is overexpressed in Whole Blood (x30.2) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for TMEM71 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM71 Gene



Protein tissue co-expression partners for TMEM71 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TMEM71

SOURCE GeneReport for Unigene cluster for TMEM71 Gene:

Hs.293842

Evidence on tissue expression from TISSUES for TMEM71 Gene

  • Lung(4.1)
  • Blood(2.8)
genes like me logo Genes that share expression patterns with TMEM71: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM71 Gene

Orthologs for TMEM71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM71 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TMEM71 30 31
  • 99.03 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TMEM71 30 31
  • 80 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TMEM71 30 31
  • 80 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tmem71 30 17 31
  • 77.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tmem71 30
  • 76.73 (n)
Oppossum
(Monodelphis domestica)
Mammalia TMEM71 31
  • 41 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TMEM71 31
  • 35 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TMEM71 30 31
  • 51.46 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TMEM71 31
  • 49 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii TMEM71 31
  • 28 (a)
OneToOne
Species where no ortholog for TMEM71 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TMEM71 Gene

ENSEMBL:
Gene Tree for TMEM71 (if available)
TreeFam:
Gene Tree for TMEM71 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM71: view image

Paralogs for TMEM71 Gene

No data available for Paralogs for TMEM71 Gene

Variants for TMEM71 Gene

Additional dbSNP identifiers (rs#s) for TMEM71 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM71 Gene

Variant ID Type Subtype PubMed ID
dgv256n6 CNV deletion 16902084
esv1274548 CNV deletion 17803354
esv2267942 CNV deletion 18987734
esv2494945 CNV insertion 19546169
esv2673001 CNV deletion 23128226
esv2737600 CNV deletion 23290073
esv2737601 CNV deletion 23290073
esv2737602 CNV deletion 23290073
esv3618878 CNV loss 21293372
esv3618882 CNV loss 21293372
nsv1121691 CNV deletion 24896259
nsv1128453 CNV deletion 24896259
nsv1130883 CNV deletion 24896259
nsv831463 CNV gain 17160897
nsv958464 CNV deletion 24416366

Variation tolerance for TMEM71 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM71 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM71

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TMEM71 Gene

Disorders for TMEM71 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM71 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary, 1
  • rccp1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM71

genes like me logo Genes that share disorders with TMEM71: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM71 Gene

Publications for TMEM71 Gene

  1. Sumoylation of ING2 regulates the transcription mediated by Sin3A. (PMID: 20676127) Ythier D … Pedeux R (Oncogene 2010) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 41

Products for TMEM71 Gene

Sources for TMEM71 Gene