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Aliases for TMEM71 Gene

Aliases for TMEM71 Gene

  • Transmembrane Protein 71 2 3 5

External Ids for TMEM71 Gene

Previous GeneCards Identifiers for TMEM71 Gene

  • GC08M133792
  • GC08M129040
  • GC08M133697

Summaries for TMEM71 Gene

GeneCards Summary for TMEM71 Gene

TMEM71 (Transmembrane Protein 71) is a Protein Coding gene.

Additional gene information for TMEM71 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM71 Gene

Genomics for TMEM71 Gene

GeneHancer (GH) Regulatory Elements for TMEM71 Gene

Promoters and enhancers for TMEM71 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I132758 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 593.6 +0.6 584 4.2 CTCF JUND PKNOX1 RNF2 POLR2A JUN FOXP2 TMEM71 PHF20L1 LRRC6
GH08I133080 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 42.2 -321.4 -321442 3.2 CTCF RXRA POLR2A CEBPG RAD21 NR2F2 GABPA TMEM71 PHF20L1 WISP1 SLA ST3GAL1 TG GC08P133070
GH08I133147 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 37.6 -386.5 -386529 1.7 ZBTB21 CREB1 ATF7 RUNX3 ATF2 TMEM71 PHF20L1 WISP1 SLA TG ST3GAL1 LOC105375769 GC08M133177
GH08I133077 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 41.7 -317.5 -317455 0.7 MAX TMEM71 PHF20L1 WISP1 SLA ST3GAL1 GC08P133070 TG
GH08I133149 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 26 -390.0 -389989 2.2 POLR2A CREB1 ATF2 YY1 GABPA TMEM71 PHF20L1 WISP1 SLA ST3GAL1 LOC105375769 GC08M133177
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM71 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM71 gene promoter:

Genomic Locations for TMEM71 Gene

Genomic Locations for TMEM71 Gene
chr8:132,685,007-132,760,712
(GRCh38/hg38)
Size:
75,706 bases
Orientation:
Minus strand
chr8:133,697,253-133,772,958
(GRCh37/hg19)

Genomic View for TMEM71 Gene

Genes around TMEM71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM71 Gene

Proteins for TMEM71 Gene

  • Protein details for TMEM71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5X7-TMM71_HUMAN
    Recommended name:
    Transmembrane protein 71
    Protein Accession:
    Q6P5X7
    Secondary Accessions:
    • Q3KRC2
    • Q8WVZ4
    • Q96LX9

    Protein attributes for TMEM71 Gene

    Size:
    295 amino acids
    Molecular mass:
    32983 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM71 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM71 Gene

Post-translational modifications for TMEM71 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM71 Gene

Domains & Families for TMEM71 Gene

Gene Families for TMEM71 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM71 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM71 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P5X7

UniProtKB/Swiss-Prot:

TMM71_HUMAN :
  • Belongs to the TMEM71 family.
Family:
  • Belongs to the TMEM71 family.
genes like me logo Genes that share domains with TMEM71: view

Function for TMEM71 Gene

Phenotypes From GWAS Catalog for TMEM71 Gene

genes like me logo Genes that share phenotypes with TMEM71: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM71 Gene

Localization for TMEM71 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM71 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM71 gene
Compartment Confidence
mitochondrion 4
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM71: view

Pathways & Interactions for TMEM71 Gene

SuperPathways for TMEM71 Gene

No Data Available

Interacting Proteins for TMEM71 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349296%0d%0a9606.ENSP00000353622%0d%0a9606.ENSP00000307183%0d%0a
Selected Interacting proteins: ENSP00000349296 Q6P5X7-TMM71_HUMAN for TMEM71 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM71 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM71 Gene

Drugs & Compounds for TMEM71 Gene

No Compound Related Data Available

Transcripts for TMEM71 Gene

Unigene Clusters for TMEM71 Gene

Transmembrane protein 71:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM71 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5: - -
SP6: -
SP7: - - - -
SP8: - - - -
SP9: - -

Relevant External Links for TMEM71 Gene

GeneLoc Exon Structure for
TMEM71
ECgene alternative splicing isoforms for
TMEM71

Expression for TMEM71 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM71 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM71 Gene

This gene is overexpressed in Whole Blood (x30.2) and Heart - Left Ventricle (x4.5).

Protein differential expression in normal tissues from HIPED for TMEM71 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM71 Gene



Protein tissue co-expression partners for TMEM71 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM71 Gene:

TMEM71

SOURCE GeneReport for Unigene cluster for TMEM71 Gene:

Hs.293842

Evidence on tissue expression from TISSUES for TMEM71 Gene

  • Lung(4.1)
  • Blood(2.8)
genes like me logo Genes that share expression patterns with TMEM71: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM71 Gene

Orthologs for TMEM71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM71 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM71 33 34
  • 99.03 (n)
cow
(Bos Taurus)
Mammalia TMEM71 33 34
  • 80 (n)
dog
(Canis familiaris)
Mammalia TMEM71 33 34
  • 80 (n)
mouse
(Mus musculus)
Mammalia Tmem71 33 16 34
  • 77.78 (n)
rat
(Rattus norvegicus)
Mammalia Tmem71 33
  • 76.73 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM71 34
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM71 34
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM71 33 34
  • 51.46 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM71 34
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TMEM71 34
  • 28 (a)
OneToOne
Species where no ortholog for TMEM71 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM71 Gene

ENSEMBL:
Gene Tree for TMEM71 (if available)
TreeFam:
Gene Tree for TMEM71 (if available)

Paralogs for TMEM71 Gene

No data available for Paralogs for TMEM71 Gene

Variants for TMEM71 Gene

Sequence variations from dbSNP and Humsavar for TMEM71 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000064989 -- 132,737,594(-) T/C intron_variant
rs1000077506 -- 132,709,689(-) G/C downstream_transcript_variant
rs1000083696 -- 132,747,734(-) T/G intron_variant
rs1000234543 -- 132,725,585(-) T/C intron_variant
rs1000300962 -- 132,720,595(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM71 Gene

Variant ID Type Subtype PubMed ID
nsv958464 CNV deletion 24416366
nsv831463 CNV gain 17160897
nsv1130883 CNV deletion 24896259
nsv1128453 CNV deletion 24896259
nsv1121691 CNV deletion 24896259
esv3618882 CNV loss 21293372
esv3618878 CNV loss 21293372
esv2737602 CNV deletion 23290073
esv2737601 CNV deletion 23290073
esv2737600 CNV deletion 23290073
esv2673001 CNV deletion 23128226
esv2494945 CNV insertion 19546169
esv2267942 CNV deletion 18987734
esv1274548 CNV deletion 17803354
dgv256n6 CNV deletion 16902084

Variation tolerance for TMEM71 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM71 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM71

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM71 Gene

Disorders for TMEM71 Gene

Additional Disease Information for TMEM71

No disorders were found for TMEM71 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM71 Gene

Publications for TMEM71 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan RS … Benjamin EJ (BMC medical genetics 2007) 44 58

Products for TMEM71 Gene

Sources for TMEM71 Gene

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