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Aliases for TMEM62 Gene

Aliases for TMEM62 Gene

  • Transmembrane Protein 62 2 3 5

External Ids for TMEM62 Gene

Previous GeneCards Identifiers for TMEM62 Gene

  • GC15P041214
  • GC15P043425
  • GC15P020273
  • GC15P043415

Summaries for TMEM62 Gene

GeneCards Summary for TMEM62 Gene

TMEM62 (Transmembrane Protein 62) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding.

Additional gene information for TMEM62 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM62 Gene

Genomics for TMEM62 Gene

GeneHancer (GH) Regulatory Elements for TMEM62 Gene

Promoters and enhancers for TMEM62 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I043132 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.4 +10.5 10510 2.2 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B TMEM62 HYPK ADAL CATSPER2 GANC SPCS2P1 FDPSP10 EPB42
GH15I043122 Promoter/Enhancer 1.4 Ensembl ENCODE 550.8 -0.2 -214 1.7 PKNOX1 ATF1 SIN3A BRCA1 YY1 GLIS2 ATF7 MCM3 SP3 RXRA TMEM62 LRRC57 RPS3AP47 GANC WDR76 LOC105370795 TMEM87A CDAN1 VPS39 SNAP23
GH15I043124 Enhancer 0.8 ENCODE 0.8 +3.7 3727 4.3 ELF3 FOXA2 THRB RARA ZNF280A CBX5 SP5 CEBPB ZEB2 NFIL3 CCNDBP1 ZSCAN29 CDAN1 TGM7 KRT8P50 ADAL SPCS2P1 TMEM62 EPB42
GH15I043183 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.2 +62.1 62098 3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 POLR2B E2F8 ZNF207 ZNF143 CCNDBP1 ENSG00000261687 CATSPER2P1 ZSCAN29 ADAL EPB42 TMEM62
GH15I043169 Enhancer 0.8 FANTOM5 0.2 +46.7 46745 0.2 HDAC1 MEIS2 LEF1 PKNOX1 ATF1 TEAD4 TAL1 NCOA2 FOSL1 TCF12 CCNDBP1 FDPSP10 TMEM62 EPB42
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM62 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM62 gene promoter:

Genomic Locations for TMEM62 Gene

Genomic Locations for TMEM62 Gene
chr15:43,123,279-43,185,147
(GRCh38/hg38)
Size:
61,869 bases
Orientation:
Plus strand
chr15:43,415,477-43,477,344
(GRCh37/hg19)

Genomic View for TMEM62 Gene

Genes around TMEM62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM62 Gene

Proteins for TMEM62 Gene

  • Protein details for TMEM62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0P6H9-TMM62_HUMAN
    Recommended name:
    Transmembrane protein 62
    Protein Accession:
    Q0P6H9
    Secondary Accessions:
    • Q6I9Y5
    • Q9H5J6

    Protein attributes for TMEM62 Gene

    Size:
    643 amino acids
    Molecular mass:
    73133 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15630.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM62 Gene

Post-translational modifications for TMEM62 Gene

  • Glycosylation at posLast=180180, isoforms=467, and isoforms=626
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM62 Gene

Domains & Families for TMEM62 Gene

Gene Families for TMEM62 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM62 Gene

Suggested Antigen Peptide Sequences for TMEM62 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM62: view

No data available for UniProtKB/Swiss-Prot for TMEM62 Gene

Function for TMEM62 Gene

Gene Ontology (GO) - Molecular Function for TMEM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TMEM62: view

miRNA for TMEM62 Gene

miRTarBase miRNAs that target TMEM62

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM62 Gene

Localization for TMEM62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM62 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM62 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Nuclear bodies (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM62: view

Pathways & Interactions for TMEM62 Gene

SuperPathways for TMEM62 Gene

No Data Available

Interacting Proteins for TMEM62 Gene

Gene Ontology (GO) - Biological Process for TMEM62 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM62 Gene

Drugs & Compounds for TMEM62 Gene

No Compound Related Data Available

Transcripts for TMEM62 Gene

Unigene Clusters for TMEM62 Gene

Transmembrane protein 62:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM62 Gene

No ASD Table

Relevant External Links for TMEM62 Gene

GeneLoc Exon Structure for
TMEM62
ECgene alternative splicing isoforms for
TMEM62

Expression for TMEM62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM62 Gene

Protein differential expression in normal tissues from HIPED for TMEM62 Gene

This gene is overexpressed in Islet of Langerhans (47.5) and Retina (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM62 Gene



Protein tissue co-expression partners for TMEM62 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM62 Gene:

TMEM62

SOURCE GeneReport for Unigene cluster for TMEM62 Gene:

Hs.511175

Evidence on tissue expression from TISSUES for TMEM62 Gene

  • Liver(4.1)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with TMEM62: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM62 Gene

Orthologs for TMEM62 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM62 33 34
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia TMEM62 33 34
  • 89.99 (n)
cow
(Bos Taurus)
Mammalia TMEM62 33 34
  • 88.7 (n)
mouse
(Mus musculus)
Mammalia Tmem62 33 16 34
  • 85.43 (n)
rat
(Rattus norvegicus)
Mammalia Tmem62 33
  • 84.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM62 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM62 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM62 33 34
  • 69.34 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM62 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem62 33
  • 62.67 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem62 33 34
  • 61.51 (n)
Dr.26190 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010204 33
  • 47.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03305 33
  • 43.94 (n)
rice
(Oryza sativa)
Liliopsida Os01g0894000 33
  • 46.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for TMEM62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM62 Gene

ENSEMBL:
Gene Tree for TMEM62 (if available)
TreeFam:
Gene Tree for TMEM62 (if available)

Paralogs for TMEM62 Gene

No data available for Paralogs for TMEM62 Gene

Variants for TMEM62 Gene

Sequence variations from dbSNP and Humsavar for TMEM62 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000020246 -- 43,137,202(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000164823 -- 43,172,238(+) G/A intron_variant
rs1000176170 -- 43,168,173(+) C/G intron_variant
rs1000289051 -- 43,168,197(+) G/A intron_variant
rs1000395794 -- 43,185,269(+) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM62 Gene

Variant ID Type Subtype PubMed ID
dgv4500n54 CNV loss 21841781
esv2678276 CNV deletion 23128226
esv3636288 CNV loss 21293372
nsv515876 CNV gain+loss 19592680
nsv525461 CNV loss 19592680
nsv569241 CNV loss 21841781
nsv94791 CNV deletion 16902084
nsv952616 CNV deletion 24416366
nsv974566 CNV duplication 23825009
nsv984062 CNV duplication 23825009

Variation tolerance for TMEM62 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM62 Gene

Disorders for TMEM62 Gene

Additional Disease Information for TMEM62

No disorders were found for TMEM62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM62 Gene

Publications for TMEM62 Gene

  1. Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase. (PMID: 24767823) Jadoon A … McDermott LC (Placenta 2014) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TMEM62 Gene

Sources for TMEM62 Gene

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